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Displaying record number 61805

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HXB2 Location	Pol(273-281) RT(118-126) DNA(2901..2927)	Pol Epitope Map
Author Location
Epitope	VPLDEGFRK	Epitope Alignment
Epitope Name	VK9
Species (MHC/HLA)	human(C*12:03)
Immunogen	HIV-1 infection, vaccine
Patient MHC/HLA	VID421: A*02:01, A*11:01, B*35:03, B*40:02, C*02:02, C*12:03
Country	United Kingdom
Experimental methods	Intracellular cytokine staining, Other
Keywords	vaccine-induced immune responses, optimal epitope, novel epitope

Notes

• Since CTL response in natural HIV-1 infections is mostly against variable but immunodominant epitopes, lymphocytes from 12 vaccine(HIVconsv)-exposed subjects of the HIV-CORE 002 study were used to determine and define 14 less variable but typically subdominant, optimal novel epitopes.
• Epitope VPLDEGFRK (VK9) is within peptide YFSVPLDEGFRKYTA (HC078) that was recognized by VID421, 1/12 vaccinated subjects. VK9 is novel and restricted by HLA-Cw*1203 though it can be weakly presented by A*1101. Thus it is an A-list candidate for the Los Alamos HIV Immunology database.

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.