HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 21 matching records:

Displaying record number 60384

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-282)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name VY10
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60383

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-282)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name VY10
Species (MHC/HLA) human(B*1502)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54360

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name B35-VY10(RT)
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 431

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT(273-282 IIIB)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Show epitope variants
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 1561

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT(273-282 SF2)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 428

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT(273-282 IIIB)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Species (MHC/HLA) human(B*3501, B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.


Displaying record number 56391

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT(118-127)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name VY10
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 57608

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location  
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name VY10
Subtype B
Species (MHC/HLA) (B*35)
Immunogen HIV-1 infection
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords acute/early infection

Notes

References

Heath2011 Sonya L. Heath, Steffanie Sabbaj, Anju Bansal, J Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Proliferative Capacity Is Compromised in Primary HIV-1 Infection. J. Acquir. Immune Defic. Syndr., 56(3):213-221, Mar 2011. PubMed ID: 21079516. Show all entries for this paper.


Displaying record number 53332

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location ( C consensus)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Subtype C
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 53112

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT Pol(273-282)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 2001

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name Pol-VY10; RT-VY10
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 57720

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Show epitope variants
Epitope Name VY10
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Willberg2010 Christian B. Willberg, Keith E. Garrison, R. Brad Jones, Duncan J. Meiklejohn, Gerald Spotts, Teri J. Liegler, Mario A. Ostrowski, Annika C. Karlsson, Frederick M. Hecht, and Douglas F. Nixon. Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes. PLoS One, 5(4):e10249, 2010. PubMed ID: 20422053. Show all entries for this paper.


Displaying record number 52615

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT(118-127)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Patient MHC/HLA A*2301, B*1503, B*3501, Cw2, Cw7
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 53606

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-282)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name VY10
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*0301, B*3501, B*51, Cw*04, Cw*06
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords acute/early infection

Notes

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


Displaying record number 58657

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-282)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name RT VY10
Subtype C
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country Barbados, Botswana, Haiti, Japan, Mexico, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords optimal epitope, novel epitope

Notes

References

Matthews2012 Philippa C. Matthews, Madoka Koyanagi, Henrik N. Kløverpris, Mikkel Harndahl, Anette Stryhn, Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, Claudia Juarez Molina, Humberto Valenzuela Ponce, Santiago Avila Rios, David Cole, Jonathan Carlson, Rebecca P. Payne, Anthony Ogwu, Alfred Bere, Thumbi Ndung'u, Kamini Gounder, Fabian Chen, Lynn Riddell, Graz Luzzi, Roger Shapiro, Christian Brander, Bruce Walker, Andrew K. Sewell, Gustavo Reyes Teran, David Heckerman, Eric Hunter, Søren Buus, Masafumi Takiguchi, and Philip J. R. Goulder. Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope. J. Virol., 86(23):12643-12654, Dec 2012. PubMed ID: 22973023. Show all entries for this paper.


Displaying record number 1345

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location ( SF2)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name HIV-B3501-SF2-4
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tomiyama2000b H. Tomiyama, N. Yamada, H. Komatsu, K. Hirayama, and M. Takiguchi. A single CTL clone can recognize a naturally processed HIV-1 epitope presented by two different HLA class I molecules. Eur. J. Immunol., 30(9):2521-30, Sep 2000. PubMed ID: 11009085. Show all entries for this paper.


Displaying record number 432

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT(273-282 IIIB)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 60381

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-282)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name VY10
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60385

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-282)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name VY10
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60382

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-282)
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Epitope Name VY10
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56212

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT
Epitope VPLDEDFRKY Epitope Alignment
VPLDEDFRKY epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords  

Notes

References

Garrison2007 Keith E. Garrison, R. Brad Jones, Duncan A. Meiklejohn, Naveed Anwar, Lishomwa C. Ndhlovu, Joan M. Chapman, Ann L. Erickson, Ashish Agrawal, Gerald Spotts, Frederick M. Hecht, Seth Rakoff-Nahoum, Jack Lenz, Mario A. Ostrowski, and Douglas F. Nixon. T Cell Responses to Human Endogenous Retroviruses in HIV-1 Infection. PLoS Pathog., 3(11):e165, Nov 2007. PubMed ID: 17997601. Show all entries for this paper.


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