HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 53007

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HXB2 Location Pol(131-140)
Protease(75-84)
DNA(2475..2504)
Pol Epitope Map
Author Location Protease(175-184 MN)
Epitope VLVGPTPVNI Epitope Alignment
VLVGPTPVNI epitope logo
Subtype B
Species (MHC/HLA) humanized mouse(A*02:01)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing, vaccine-induced immune responses, immunodominance, immunotherapy

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain B clade MN
Vaccine component gp120, Protease, RT
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Isaguliants2004 Maria G. Isaguliants, Bartek Zuber, Andreas Boberg, Dan Sjöstrand, Sergey V. Belikov, Erik Rollman, Anne Kjerrström Zuber, Vladimir O. Rechinsky, Ann-Sofie Rytting, Clas F. R. Källander, Jorma Hinkula, Sergey N. Kochetkov, Margaret Liu, and Britta Wahren. Reverse Transcriptase-Based DNA Vaccines against Drug-Resistant HIV-1 Tested in a Mouse Model. Vaccine, 22(13-14):1810-1819, 16 Apr 2004. PubMed ID: 15068865. Show all entries for this paper.


Displaying record number 53442

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HXB2 Location Pol(131-140)
Protease(75-84)
DNA(2475..2504)
Pol Epitope Map
Author Location Pol(75-84 IIIB)
Epitope VLVGPTPVNI Epitope Alignment
VLVGPTPVNI epitope logo
Show epitope variants
Epitope Name pol75-84
Subtype B
Species (MHC/HLA) humanized mouse(A*02:01)
Immunogen vaccine
Experimental methods Intracellular cytokine staining
Keywords epitope processing, vaccine-induced immune responses, immunodominance, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type DNA
Vaccine strain B clade IIIB
Vaccine component Gag-Pol

Notes

References

Singh2004 Rana A K Singh and Michael A Barry. Repertoire and Immunofocusing of CD8 T Cell Responses Generated by HIV-1 gag-pol and Expression Library Immunization Vaccines. J. Immunol., 173(7):4387-4393, 1 Oct 2004. PubMed ID: 15383568. Show all entries for this paper.


Displaying record number 54494

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HXB2 Location Pol(131-140)
Protease(75-84)
DNA(2475..2504)
Pol Epitope Map
Author Location Protease(75-84)
Epitope VLVGPTPVNI Epitope Alignment
VLVGPTPVNI epitope logo
Species (MHC/HLA) transgenic mouse(A*02:01)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords vaccine-induced immune responses, drug resistance

Vaccine Details

Vaccine type peptide, other
Vaccine strain multiple epitope immunogen
Vaccine component Protease
Adjuvant Incomplete Freund's Adjuvant (IFA), Other

Notes

References

Boberg2006 Andreas Boberg, Dan Sjöstrand, Erik Rollman, Jorma Hinkula, Bartek Zuber, and Britta Wahren. Immunological Cross-Reactivity against a Drug Mutated HIV-1 Protease Epitope after DNA Multi-CTL Epitope Construct Immunization. Vaccine, 24(21):4527-4530, 22 May 2006. PubMed ID: 16181710. Show all entries for this paper.


Displaying record number 58875

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HXB2 Location Pol(131-140)
Protease(75-84)
DNA(2475..2504)
Pol Epitope Map
Author Location Protease(75-84 MN)
Epitope VLVGPTPVNI Epitope Alignment
VLVGPTPVNI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, HLA binding, Other
Keywords binding affinity

Notes

References

Konya1997 J. Konya, G. Stuber, A. Bjorndal, E. M. Fenyo, and J. Dillner. Primary induction of human cytotoxic lymphocytes against a synthetic peptide of the human immunodeficiency virus type 1 protease. J. Gen. Virol., 78:2217-2224, 1997. PubMed ID: 9292009. Show all entries for this paper.


Displaying record number 61316

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HXB2 Location Pol(131-140)
Protease(75-84)
DNA(2475..2504)
Pol Epitope Map
Author Location  
Epitope VLVGPTPVNI Epitope Alignment
VLVGPTPVNI epitope logo
Show epitope variants
Subtype A, B, C, D
Species (MHC/HLA) humanized mouse(A*02:01)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type modified vaccinia Ankara (MVA), adenovirus
Vaccine strain A clade, B clade, other, C clade

Notes

References

Abdul-Jawad2016 Sultan Abdul-Jawad, Beatrice Ondondo, Andy van Hateren, Andrew Gardner, Tim Elliott, Bette Korber, and Tomáš Hanke. Increased Valency of Conserved-Mosaic Vaccines Enhances the Breadth and Depth of Epitope Recognition. Mol. Ther., 24(2):375-384, Feb 2016. PubMed ID: 26581160. Show all entries for this paper.


Displaying record number 57779

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HXB2 Location Pol(131-140)
Protease(75-84)
DNA(2475..2504)
Pol Epitope Map
Author Location ( H2d)
Epitope VLVGPTPVNI Epitope Alignment
VLVGPTPVNI epitope logo
Species (MHC/HLA) mouse, transgenic mouse
Immunogen vaccine
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, T-cell Elispot
Keywords vaccine-induced immune responses, variant cross-reactivity, drug resistance

Vaccine Details

Vaccine type DNA
Vaccine strain B clade LAI
Vaccine component Protease

Notes

References

Hallengard2011 David Hallengärd, B. Kristian Haller, Sarah Petersson, Andreas Boberg, Anna-Karin Maltais, Maria Isaguliants, Britta Wahren, and Andreas Bråve. Increased Expression and Immunogenicity of HIV-1 Protease Following Inactivation of the Enzymatic Activity. Vaccine, 29(4):839-348, 17 Jan 2011. PubMed ID: 21109032. Show all entries for this paper.


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