Search CTL/CD8+ T-Cell Epitope Database

Found 16 matching records:

Displaying record number 53097

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(178-187)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Country	Spain
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords	HAART, ART, supervised treatment interruptions (STI)

Notes

Structured treatment interruption (STI) alone is not able to control viral replication in chronically infected patients, probably due to lack of strong, maintained T-helper cell responses. HIV-1 specific CD8+ T-cell responses were shown to increase significantly until the end of the follow up, but were not correlated with viral load.
5/19 patients recognized this epitope.

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.

Displaying record number 55859

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef
Epitope	`VLEWRFDSRL`	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A2, B49, B8, Cw7
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, mutation acquisition

Notes

The Nef HLA-B8-restricted dominant epitope FL8, FLKEKGGL, was studied both longitudinally over time as well as horizontally in a 56 subject cohort of HIV-1 infected patients to chart FL8 variants. FL8 mutants were associated with higher pVL and lower CD4 cell counts.
Patient 01 who was studied over time accumulated mutations in VLEWRFDSRL to VLkWRFDSRL and VLEWkFDSRL, concomitant with a strong viremic increase but did not react to this epitope.
HLA restrictions in this study are previously published and correlate with the subject's HLA.

References

Maurer2008 Katja Maurer, Ellen G. Harrer, Andreas Goldwich, Kathrin Eismann, Silke Bergmann, Matthias Schmitt-Haendle, Bernd Spriewald, Sandra M. Mueller, Thomas Harrer, and German Competence Network for HIV/AIDS. Role of Cytotoxic T-Lymphocyte-Mediated Immune Selection in a Dominant Human Leukocyte Antigen-B8-Restricted Cytotoxic T-Lymphocyte Epitope in Nef. J. Acquir. Immune Defic. Syndr., 48(2):133-141, 1 Jun 2008. PubMed ID: 18391752. Show all entries for this paper.

Displaying record number 53772

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189 HXB2)
Epitope	`VLEWRFDSRL`	Epitope Alignment
		Show epitope variants
Subtype	B, CRF01_AE
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Country	Viet Nam
Experimental methods	HLA binding
Keywords	subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

The most common HLA-alleles in the Vietnamese population were found to be HLA-A*11, A*02, A*33, B*75, B*46, and B*62. Several epitopes cluster in short regions in Gag and Nef that are presented by these HLA molecules; these epitopes may be useful targets for vaccine antigens. In a comparison of CRF01_AE sequences to HXB2, 14 mutations were found in epitopes in these Gag and Nef pluriepitopic regions; 7 did not affect the HLA binding score, 3 increased it, and 4 reduced it.
CRF01_AE variant LmWkFDSaL had a higher HLA-binding score than the HXB2 epitope, which isn't predicted to bind to A*02.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.

Displaying record number 54566

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189)
Epitope	`VLEWRFDSRL`	Epitope Alignment
		Show epitope variants
Epitope Name	VL10
Subtype	B
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Intracellular cytokine staining, Other
Keywords	rate of progression, escape, mutation acquisition

Notes

To correlate evolving HIV-1 populations with HLA-A2 restricted immune responses for epitopes in Gag, Pol, Env and Nef, 11 treatment-naive subjects were longitudinally studied. Results show that increased viral load is often associated with broad CTL responses early in infection that persist as an "immunological footprint". Conversely, early, restricted responses may help limit viral load. Phylogenetic and functional evidence of viral escape is seen in Gag, Nef and Pol. Gag and Nef show flanking epitope changes restricted by non-HLA-A2 alleles. As far as modes of viral adaptation, CTL responses were seen to develop both against static viral populations resulting in viral evolution to HLA-A2 as well as against existing mutants resulting in reselection of consensus B-like variants. This study reinforces that CTL immune responses detected are not necessarily beneficial to patients, but may be "footprints" from early effective responses that the virus has since escaped.
This epitope, VLEWRFDSRL, was primarily recognized as wild type. Other variants seen were VLEWRFDSsL, VLEWRFgSRL and the 184K emerging variant VLEWkFDSRL. Position 184 fell under 2 overlapping CTL responses restricted by HLAs A2 and B15.
In Table 2, epitope VLvWRFDSRL is printed as the epitope studied. We chose to record the epitope as VLEWRFDSRL seen twice elsewhere in this paper, as it is more commonly annotated as such in the literature.

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.

Displaying record number 1509

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189 LAI)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Epitope Name	N3
Subtype	B
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HAART, ART

Notes

A panel of 16 epitopes covering 15 class I alleles was tested in 14 HIV+ patients from an unselected Caucasian population treated with HAART, using CD8+ cell IFNgamma production to measure responses.
In general, during the first month of treatment viral load decreased and frequencies of HIV-specific CTL tripled and broadened -- eight new HIV specificities that were not previously detectable were newly detected, as were CMV specific CD8+ PBL -- but with continued viral suppression, HIV-specific responses diminished.
Viral rebounds gave different patterns of response: increases or decreases in pre-existing response, new specificities, or no change.

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.

Displaying record number 1755

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(179-188 93TH253 subtype CRF01)
Epitope	`VLEWRFDSRL`	Epitope Alignment
		Show epitope variants
Subtype	CRF01_AE
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Experimental methods
Keywords	subtype comparisons

Notes

More than half of a cohort of HIV+ female sex workers (FSW) from Northern Thailand were HLA-A*11 positive, and this study concentrated on A*11 epitopes in this group, although E clade versions of previously defined B-clade A*02 and A*24 epitopes were also tested.
0/4 tested FSWs recognized the E clade version of this epitope VLIWKFDSAL, which differs from the previously defined B clade version by three amino acids, VLEWRFDSRL.

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.

Displaying record number 1772

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Experimental methods
Keywords	rate of progression, acute/early infection

Notes

The CTL response to optimally defined CTL epitopes restricted by HLA class I A and B alleles in individuals who coexpressed HLA A*02, A*03, and B*07 was studied in eight HIV-1-infected subjects, two with acute infection, five with chronic, and one long-term non-progressor (LTNP)
2 to 17 epitopes were recognized in a given individual, A*02-restricted CTL response tended to be narrow and never dominated the response, and 25/27 epitopes were targeted by at least one person.

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.

Displaying record number 1083

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Species (MHC/HLA)	human(A*02)
Immunogen	in vitro stimulation or selection
Experimental methods
Keywords	binding affinity, dendritic cells, Th1

Notes

Dendritic cells are the most potent for priming T cell responses -- DCs can stimulate autologous CTL responses from T cells cultured from HIV negative donors.
Th1-biasing cytokines IL-12 or IFN alpha enhance CTL responses in vitro whether the epitope is delivered by pulsing from peptide, or expressed from within.
B*07 and A*02 Nef epitopes were studied and the relative binding affinity of A*02 epitopes for A*02 was: PLTFGWCYKL greater than VLEWRFDSRL which was much greater than AFHHVAREL.

References

Wilson1999b C. C. Wilson, W. C. Olson, T. Tuting, C. R. Rinaldo, M. T. Lotze, and W. J. Storkus. HIV-1-Specific CTL Responses Primed In Vitro by Blood-Derived Dendritic Cells and Th1-Biasing Cytokines. J. Immunol., 162:3070-3078, 1999. PubMed ID: 10072560. Show all entries for this paper.

Displaying record number 1109

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Species (MHC/HLA)	human(A*02)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	DNA prime with vaccinia boost

Notes

A polyepitope vaccine was generated in a vaccinia construct that contiguously encoded seven epitopes, all presented by HLA-A*02.
HHD mice have a transgene of HLA-A*02 linked to the transmembrane and cytotoxic domains of H-2D^d -- this transgene is the only MHC molecule expressed in the mice.
CTL responses to Gag (77-85) SLYNTVATL, Pol (476-484) ILKEPVHGV, gp120 (120-128) KLTPLCVTL, and Nef (190-198) AFHHVAREL were observed in HIV polytope HHD-vaccinated mice, and these responses were enhanced with vaccinia boost.
No CTL immune responses were generated against HLA-A*02-restricted HIV epitopes Nef 157-166 (PLTFGWCYKL), Pol 346-354 (VIYQYMDDL), and Nef 180-189 (VLEWRFDSRL)
Sixteen HLA-A*02+ patients were tested for their ability to make CTL responses by peptide restimulation in culture with the epitopes selected for inclusion in the polytope -- one individual recognized all seven of these epitopes; 7 patients had CTL cultures able to recognize at least one of the epitopes, and 6 of those 7 recognized more than one epitope, but they were not able to test all peptides for all patients; many patients only had three peptides tested.
VLEWRFDSRL was recognized by 2 of the HLA-A*02 patients.

References

Woodberry1999 T. Woodberry, J. Gardner, L. Mateo, D. Eisen, J. Medveczky, I. A. Ramshaw, S. A. Thomson, R. A. Ffrench, S. L. Elliott, H. Firat, F. A. Lemonnier, and A. Suhrbier. Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine. J. Virol., 73:5320-5325, 1999. PubMed ID: 10364278. Show all entries for this paper.

Displaying record number 1082

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189 LAI)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*02:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

There was a high degree of variation in three CTL epitopes in Nef in four slow and non-progressors, and variant specific CTLs arose over time to eliminate variants, indicating immune selection.
Noted in Brander et al., 1999 this database, to be A*0201.

References

Haas1996 G. Haas, U. Plikat, P. Debre, M. Lucchiari, C. Katlama, Y. Dudoit, O. Bonduelle, M. Bauer, H. Ihlenfeldt, G. Jung, B. Maier, A. Meyerhans, and B. Autran. Dynamics of Viral Variants in HIV-1 Nef and Specific Cytotoxic T Lymphocytes In Vivo. J. Immunol., 157:4212-4221, 1996. PubMed ID: 8892659. Show all entries for this paper.

Haas1997 G. Haas, A. Hosmalin, F. Hadida, J. Duntze, P. Debre, and B. Autran. Dynamics of HIV Variants and Specific Cytotoxic T Cell Recognition in Nonprogressors and Progressors. Immunol. Lett., 57:63-68, 1997. PubMed ID: 9232427. Show all entries for this paper.

Displaying record number 1108

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189 LAI)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*02:01)
Immunogen
Experimental methods
Keywords	optimal epitope, A-list

Notes

C. Brander notes this is an A*0201 epitope.

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 52356

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(190-198)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Species (MHC/HLA)	mouse(A*02:01)
Immunogen	vaccine
Experimental methods
Keywords	epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type	DNA
Vaccine component	HIV-1

Notes

C3H (H-2k) transgenic mice carrying a fused HLA-A*0201 alpha1 and alpha2 and H-2Dk alpha3 hybrid class I molecule were immunized using an epidermal gene gun with an ubiquitin expression library of 32 plasmids that spanned the HIV-1 genome. Ubiquitin targets the expressed HIV-1 peptides to the proteasome.
A single immunization with the UB-HIV-1 library vaccine induced potent, stable and multivalent CTL responses against all library members.
Immunodominant epitopes SLYNTVATL (Gag), ILKEPVHGV (Pol), RIQRGPGRAFVTIGK (Env) and AFHHVAREK (Nef) elicited strong CD8+/IFN- responses and stimulated CTL that were functional in a Cr-release assay and against wild type antigen.
The presence of multiple plasmids HLA-A*0201-restricted CTL epitopes did not decrease CTL immunogenicity, and CTL responses to single peptide immunizations were comparable to responses based on mixtures of either 16 or 32 peptides.

References

Singh2002 Rana A. K. Singh, Lei Wu, and Michael A. Barry. Generation of Genome-Wide CD8 T Cell Responses in HLA-A*0201 Transgenic Mice by an HIV-1 Ubiquitin Expression Library Immunization Vaccine. J. Immunol., 168(1):379-391, 1 Jan 2002. PubMed ID: 11751984. Show all entries for this paper.

Sykes1999 Kathryn F. Sykes and Stephen Albert Johnston. Genetic live vaccines mimic the antigenicity but not pathogenicity of live viruses. DNA Cell Biol., 18(7):521-531, Jul 1999. PubMed ID: 10433551. Show all entries for this paper.

Displaying record number 53019

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*02:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
Three of seven patients responded to this peptide with GzB producing cells, while one of the three patients responded with IFN-gamma producing cells.

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.

Displaying record number 54235

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef
Epitope	`VLEWRFDSRL`	Epitope Alignment
Epitope Name	A2-VL10(Nef)
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, immunodominance, early-expressed proteins

Notes

Immunodominant HIV epitopes in early, primary infection of CTLs were identified and the relative contributions of immune responses restricted to individual HLA class I molecules were studied.
This epitope-HLA combination was recognized. The most frequently recognized epitopes also elicited the greatest CTL response.
HIV-1 Epitope sequence variability was not correlated with immunodominant versus immune sub-dominant responses.
HLA-B*57 and HLA-B*27 restricted responses were the strongest in these early and acute infections - due to dominant responses to a single epitope in each case (TW10 for B*57 and KK10 for B*27).
In the presence of HLA-B*57 and HLA-B*27 restricted responses, the relative contributions of other restricting HLA dropped greatly.

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.

Displaying record number 53576

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	acute/early infection, optimal epitope

Notes

The most frequently targeted HLA-A*02-restricted CD8+ T-cell epitopes in chronic infection were significantly less frequently recognized during primary infection. This epitope was only recognized in chronic infection, and even then was recognized infrequently.

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.

Displaying record number 60380

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HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Epitope Name	VL10
Species (MHC/HLA)	human(B*40)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
VLEWRFDSRL had a significantly positive association with HLA B*40; it was recognized by 3/28 B*40-positive subjects and 7/313 B*40-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.