HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 16 matching records:

Displaying record number 53097

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(178-187)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 55859

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A2, B49, B8, Cw7
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, mutation acquisition

Notes

References

Maurer2008 Katja Maurer, Ellen G. Harrer, Andreas Goldwich, Kathrin Eismann, Silke Bergmann, Matthias Schmitt-Haendle, Bernd Spriewald, Sandra M. Mueller, Thomas Harrer, and German Competence Network for HIV/AIDS. Role of Cytotoxic T-Lymphocyte-Mediated Immune Selection in a Dominant Human Leukocyte Antigen-B8-Restricted Cytotoxic T-Lymphocyte Epitope in Nef. J. Acquir. Immune Defic. Syndr., 48(2):133-141, 1 Jun 2008. PubMed ID: 18391752. Show all entries for this paper.


Displaying record number 53772

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(180-189 HXB2)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Show epitope variants
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Viet Nam
Experimental methods HLA binding
Keywords subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.


Displaying record number 54566

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(180-189)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Show epitope variants
Epitope Name VL10
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 1509

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(180-189 LAI)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Epitope Name N3
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.


Displaying record number 1755

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(179-188 93TH253 subtype CRF01)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Show epitope variants
Subtype CRF01_AE
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


Displaying record number 1772

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(180-189)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 1083

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(180-189)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords binding affinity, dendritic cells, Th1

Notes

References

Wilson1999b C. C. Wilson, W. C. Olson, T. Tuting, C. R. Rinaldo, M. T. Lotze, and W. J. Storkus. HIV-1-Specific CTL Responses Primed In Vitro by Blood-Derived Dendritic Cells and Th1-Biasing Cytokines. J. Immunol., 162:3070-3078, 1999. PubMed ID: 10072560. Show all entries for this paper.


Displaying record number 1109

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(180-189)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type DNA prime with vaccinia boost

Notes

References

Woodberry1999 T. Woodberry, J. Gardner, L. Mateo, D. Eisen, J. Medveczky, I. A. Ramshaw, S. A. Thomson, R. A. Ffrench, S. L. Elliott, H. Firat, F. A. Lemonnier, and A. Suhrbier. Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine. J. Virol., 73:5320-5325, 1999. PubMed ID: 10364278. Show all entries for this paper.


Displaying record number 1082

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(180-189 LAI)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Haas1996 G. Haas, U. Plikat, P. Debre, M. Lucchiari, C. Katlama, Y. Dudoit, O. Bonduelle, M. Bauer, H. Ihlenfeldt, G. Jung, B. Maier, A. Meyerhans, and B. Autran. Dynamics of Viral Variants in HIV-1 Nef and Specific Cytotoxic T Lymphocytes In Vivo. J. Immunol., 157:4212-4221, 1996. PubMed ID: 8892659. Show all entries for this paper.

Haas1997 G. Haas, A. Hosmalin, F. Hadida, J. Duntze, P. Debre, and B. Autran. Dynamics of HIV Variants and Specific Cytotoxic T Cell Recognition in Nonprogressors and Progressors. Immunol. Lett., 57:63-68, 1997. PubMed ID: 9232427. Show all entries for this paper.


Displaying record number 1108

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(180-189 LAI)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 52356

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(190-198)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA
Vaccine component HIV-1

Notes

References

Singh2002 Rana A. K. Singh, Lei Wu, and Michael A. Barry. Generation of Genome-Wide CD8 T Cell Responses in HLA-A*0201 Transgenic Mice by an HIV-1 Ubiquitin Expression Library Immunization Vaccine. J. Immunol., 168(1):379-391, 1 Jan 2002. PubMed ID: 11751984. Show all entries for this paper.

Sykes1999 Kathryn F. Sykes and Stephen Albert Johnston. Genetic live vaccines mimic the antigenicity but not pathogenicity of live viruses. DNA Cell Biol., 18(7):521-531, Jul 1999. PubMed ID: 10433551. Show all entries for this paper.


Displaying record number 53019

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(180-189)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords Th1, characterizing CD8+ T cells

Notes

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.


Displaying record number 54235

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Epitope Name A2-VL10(Nef)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 53576

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(180-189)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 60380

HXB2 Location Nef(180-189)
DNA(9334..9363)
Nef Epitope Map
Author Location Nef(180-189)
Epitope VLEWRFDSRL Epitope Alignment
VLEWRFDSRL epitope logo
Epitope Name VL10
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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