HIV molecular immunology database
Found 16 matching records:
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(178-187) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A2, B49, B8, Cw7 | |
Country | Germany | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, mutation acquisition |
Maurer2008 Katja Maurer, Ellen G. Harrer, Andreas Goldwich, Kathrin Eismann, Silke Bergmann, Matthias Schmitt-Haendle, Bernd Spriewald, Sandra M. Mueller, Thomas Harrer, and German Competence Network for HIV/AIDS. Role of Cytotoxic T-Lymphocyte-Mediated Immune Selection in a Dominant Human Leukocyte Antigen-B8-Restricted Cytotoxic T-Lymphocyte Epitope in Nef. J. Acquir. Immune Defic. Syndr., 48(2):133-141, 1 Jun 2008. PubMed ID: 18391752. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-189 HXB2) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B, CRF01_AE | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Country | Viet Nam | |
Experimental methods | HLA binding | |
Keywords | subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design |
Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-189) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | VL10 | |
Subtype | B | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | Intracellular cytokine staining, Other | |
Keywords | rate of progression, escape, mutation acquisition |
Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-189 LAI) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Epitope Name | N3 | |
Subtype | B | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART |
Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(179-188 93TH253 subtype CRF01) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | CRF01_AE | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | subtype comparisons |
Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-189) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, acute/early infection |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-189) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*02) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | ||
Keywords | binding affinity, dendritic cells, Th1 |
Wilson1999b C. C. Wilson, W. C. Olson, T. Tuting, C. R. Rinaldo, M. T. Lotze, and W. J. Storkus. HIV-1-Specific CTL Responses Primed In Vitro by Blood-Derived Dendritic Cells and Th1-Biasing Cytokines. J. Immunol., 162:3070-3078, 1999. PubMed ID: 10072560. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-189) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*02) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | DNA prime with vaccinia boost |
---|
Woodberry1999 T. Woodberry, J. Gardner, L. Mateo, D. Eisen, J. Medveczky, I. A. Ramshaw, S. A. Thomson, R. A. Ffrench, S. L. Elliott, H. Firat, F. A. Lemonnier, and A. Suhrbier. Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine. J. Virol., 73:5320-5325, 1999. PubMed ID: 10364278. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-189 LAI) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Haas1996 G. Haas, U. Plikat, P. Debre, M. Lucchiari, C. Katlama, Y. Dudoit, O. Bonduelle, M. Bauer, H. Ihlenfeldt, G. Jung, B. Maier, A. Meyerhans, and B. Autran. Dynamics of Viral Variants in HIV-1 Nef and Specific Cytotoxic T Lymphocytes In Vivo. J. Immunol., 157:4212-4221, 1996. PubMed ID: 8892659. Show all entries for this paper.
Haas1997 G. Haas, A. Hosmalin, F. Hadida, J. Duntze, P. Debre, and B. Autran. Dynamics of HIV Variants and Specific Cytotoxic T Cell Recognition in Nonprogressors and Progressors. Immunol. Lett., 57:63-68, 1997. PubMed ID: 9232427. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-189 LAI) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(190-198) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(A*02:01) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | epitope processing, vaccine-induced immune responses, immunodominance |
Vaccine type | DNA |
---|---|
Vaccine component | HIV-1 |
Singh2002 Rana A. K. Singh, Lei Wu, and Michael A. Barry. Generation of Genome-Wide CD8 T Cell Responses in HLA-A*0201 Transgenic Mice by an HIV-1 Ubiquitin Expression Library Immunization Vaccine. J. Immunol., 168(1):379-391, 1 Jan 2002. PubMed ID: 11751984. Show all entries for this paper.
Sykes1999 Kathryn F. Sykes and Stephen Albert Johnston. Genetic live vaccines mimic the antigenicity but not pathogenicity of live viruses. DNA Cell Biol., 18(7):521-531, Jul 1999. PubMed ID: 10433551. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-189) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B | |
Keywords | Th1, characterizing CD8+ T cells |
Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Epitope Name | A2-VL10(Nef) | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-189) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding | |
Keywords | acute/early infection, optimal epitope |
Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(180-189) DNA(9334..9363) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-189) | |
Epitope |
VLEWRFDSRL
|
Epitope Alignment
|
Epitope Name | VL10 | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.