HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 43 matching records:

Displaying record number 1748

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(339-347 93TH253 subtype CRF01)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Subtype CRF01_AE
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


Displaying record number 1767

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(179-187)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 54572

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(179-187)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name VL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 469

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(346-354)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type DNA prime with vaccinia boost

Notes

References

Woodberry1999 T. Woodberry, J. Gardner, L. Mateo, D. Eisen, J. Medveczky, I. A. Ramshaw, S. A. Thomson, R. A. Ffrench, S. L. Elliott, H. Firat, F. A. Lemonnier, and A. Suhrbier. Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine. J. Virol., 73:5320-5325, 1999. PubMed ID: 10364278. Show all entries for this paper.


Displaying record number 60370

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(334-342)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name VL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59148

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name VL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 58378

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(179-187)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Show epitope variants
Epitope Name VL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country France, Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords drug resistance

Notes

References

Pacheco2011 Yovana Pacheco, Clotilde Allavena, Yannick Guilloux, Sandra M. Mueller-Schmucker, Angela G. Hueckelhoven, Elisabeth André-Garnier, François Cleon, Virginie Ferré, Audrey Rodallec, Eric Billaud, Thomas Harrer, François Raffi, and Dorian McIlroy. The Immune Response to the RT181-189 Epitope in HIV-1-Infected Patients Is Associated with Viral Sequence Polymorphism Flanking the Epitope. J. Clin. Immunol., 31(4):681-689, Aug 2011. PubMed ID: 21491096. Show all entries for this paper.


Displaying record number 468

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia

Notes

References

Hanke1998b T. Hanke, T. J. Blanchard, J. Schneider, G. S. Ogg, R. Tan, M. Becker, S. C. Gilbert, A. V. Hill, G. L. Smith, and A. McMichael. Immunogenicities of Intravenous and Intramuscular Administrations of Modified Vaccinia Virus Ankara-Based Multi-CTL Epitope Vaccine for Human Immunodeficiency Virus Type 1 in Mice. J. Gen. Virol., 79:83-90, 1998. PubMed ID: 9460927. Show all entries for this paper.

Hanke1998c T. Hanke, J. Schneider, S. G. Gilbert, A. V. S. Hill, and A. McMichael. DNA Multi-CTL Epitope Vaccines for HIV and Plasmodium falciparum: Immunogenicity in Mice. Vaccine, 16:426-435, 1998. PubMed ID: 9607066. Show all entries for this paper.


Displaying record number 52264

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(346-354)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, immunodominance

Notes

References

Sewell2002 Andrew K. Sewell, Bruce L. Booth, Jr., Vincenzo Cerundolo, Rodney E. Phillips, and David A. Price. Differential Processing of HLA A2-Restricted HIV Type 1 Cytotoxic T Lymphocyte Epitopes. Viral Immunol., 15(1):193-196, 2002. PubMed ID: 11952141. Show all entries for this paper.


Displaying record number 52296

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(346-354 LAI)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name LR26
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords binding affinity, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type peptide
Vaccine strain B clade LAI
Adjuvant Incomplete Freund's Adjuvant (IFA), Montanide (ISA 720), P30, PLG

Notes

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.


Displaying record number 52297

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(346-354 LAI)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name LR26
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type peptide
Vaccine strain B clade LAI
Adjuvant Incomplete Freund's Adjuvant (IFA), IL-12, P30

Notes

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.

Peter2002 Katrin Peter, Michael J. Brunda, and Giampietro Corradin. IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1-Restricted CTL Response in Transgenic Mice. J. Immunol., 169(1):63-67, 1 Jul 2002. PubMed ID: 12077229. Show all entries for this paper.


Displaying record number 52442

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Subtype A, B, C, D
Species (MHC/HLA) human, macaque(A*0201)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 1355

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(346-354)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name VL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

DelaCruz2000 C. S. Dela Cruz, R. Tan, S. L. Rowland-Jones, and B. H. Barber. Creating HIV-1 reverse transcriptase cytotoxic T lymphocyte target structures by HLA-A2 heavy chain modifications. Int. Immunol., 12(9):1293-302, Sep 2000. URL: http://intimm.oupjournals.org/cgi/content/full/12/9/1293. PubMed ID: 10967024. Show all entries for this paper.


Displaying record number 470

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tan1999 R. Tan, X. Xu, G. S. Ogg, P. Hansasuta, T. Dong, T. Rostron, G. Luzzi, C. P. Conlon, G. R. Screaton, A. J. McMichael, and S. Rowland-Jones. Rapid Death of Adoptively Transferred T Cells in Acquired Immunodeficiency Syndrome. Blood, 93:1506-1510, 1999. PubMed ID: 10029578. Show all entries for this paper.


Displaying record number 471

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(346-354)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, immunodominance, escape

Notes

References

Sewell1999 A. K. Sewell, D. A. Price, H. Teisserenc, B. L. Booth, U. Gileadi, F. M. Flavin, J. Trowsdale, R. E. Phillips, and V. Cerundolo. IFN-gamma Exposes a Cryptic Cytotoxic T Lymphocyte Epitope in HIV-1 Reverse Transcriptase. J. Immunol., 162:7075-7079, 1999. PubMed ID: 10358150. Show all entries for this paper.


Displaying record number 473

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(346-354 LAI)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Harrer1996 E. Harrer, T. Harrer, P. Barbosa, M. Feinberg, R. P. Johnson, S. Buchbinder, and B. D. Walker. Recognition of the Highly Conserved YMDD Region in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by HLA-A2-Restricted Cytotoxic T Lymphocytes from an Asymptomatic Long-Term Nonprogresser. J. Infect. Dis., 173:476-479, 1996. The amino acid stretch YMDD is a critical functional domain of reverse transcriptase, and is highly conserved. This sequence is also part of an HLA-A2-restricted epitope. The substitution YMDD to YVDD confers drug resistance to FTC and dideoxyinosine, and also abolishes the CTL specific response. PubMed ID: 8568316. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 474

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(346-354 LAI)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 477

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(346-354)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Show epitope variants
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Brander1998 Christian Brander, Kelly E. Hartman, Alicja K. Trocha, Norman G. Jones, R. Paul Johnson, Bette Korber, Peggy Wentworth, Susan P. Buchbinder, Steve Wolinsky, Bruce D. Walker, and Spyros A. Kalams. Lack of Strong Immune Selection Pressure by the Immunodominant, HLA-A*0201-Restricted Cytotoxic T Lymphocyte Response in Chronic Human Immunodeficiency Virus-1 Infection. J. Clin. Invest., 101(11):2559-2566, 1 Jun 1998. PubMed ID: 9616227. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 1315

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name RT VL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, computational epitope prediction

Notes

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.


Displaying record number 52766

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(179-187)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Patient MHC/HLA A2.1
Experimental methods Chromium-release assay, Cytokine production
Keywords binding affinity, vaccine-induced immune responses

Vaccine Details

Vaccine type peptide
Vaccine component RT
Adjuvant Incomplete Freund's Adjuvant (IFA), IL-12

Notes

References

Okazaki2003 Takahiro Okazaki, C. David Pendleton, François Lemonnier, and Jay A. Berzofsky. Epitope-Enhanced Conserved HIV-1 Peptide Protects HLA-A2-Transgenic Mice Against Virus Expressing HIV-1 Antigen. J. Immunol., 171(5):2548-2555, Sep 2003. PubMed ID: 12928405. Show all entries for this paper.


Displaying record number 53004

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(179-187 MN)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Subtype B
Species (MHC/HLA) humanized mouse(A*0201)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing, vaccine-induced immune responses, immunodominance, immunotherapy

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain B clade MN
Vaccine component gp120, Protease, RT
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Isaguliants2004 Maria G. Isaguliants, Bartek Zuber, Andreas Boberg, Dan Sjöstrand, Sergey V. Belikov, Erik Rollman, Anne Kjerrström Zuber, Vladimir O. Rechinsky, Ann-Sofie Rytting, Clas F. R. Källander, Jorma Hinkula, Sergey N. Kochetkov, Margaret Liu, and Britta Wahren. Reverse Transcriptase-Based DNA Vaccines against Drug-Resistant HIV-1 Tested in a Mouse Model. Vaccine, 22(13-14):1810-1819, 16 Apr 2004. PubMed ID: 15068865. Show all entries for this paper.


Displaying record number 53026

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(346-354)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords Th1, characterizing CD8+ T cells

Notes

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.


Displaying record number 54001

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location ( C consensus)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Subtype C
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 54314

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(179-187)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, HLA binding, Other
Keywords vaccine-induced immune responses, HLA cross-presentation, HLA associated polymorphism

Notes

References

Reche2006 Pedro A. Reche, Derin B. Keskin, Rebecca E. Hussey, Petronela Ancuta, Dana Gabuzda, and Ellis L. Reinherz. Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed against Conserved HIV-1 Epitopes. Med. Immunol., 5:1, 2006. PubMed ID: 16674822. Show all entries for this paper.


Displaying record number 61870

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location  
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name VL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.


Displaying record number 55288

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*0201, A2)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A19, B*3501, B44, Cw16, Cw7; A*0201, A19, B14, B44, Cw16, Cw8
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART, mother-to-infant transmission, rate of progression, escape, co-receptor, mutation acquisition, HLA associated polymorphism

Notes

References

Reinis2007 Milan Reinis, Barbara Weiser, Carla Kuiken, Tao Dong, Dorothy Lang, Sharon Nachman, Yonghong Zhang, Sarah Rowland-Jones, and Harold Burger. Genomic Analysis of HIV Type 1 Strains Derived from a Mother and Child Pair of Long-Term Nonprogressors. AIDS Res. Hum. Retroviruses, 23(2):309-315, Feb 2007. PubMed ID: 17331038. Show all entries for this paper.


Displaying record number 53624

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(179-187 HXB2)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name 51F
Subtype B
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA
Vaccine strain multiple epitope immunogen
Vaccine component p17/p24 Gag, Pol
Adjuvant IL-12

Notes

References

Bolesta2005a Elizabeth Bolesta, Jaroslaw Gzyl, Andrzej Wierzbicki, Dariusz Kmieciak, Aleksandra Kowalczyk, Yutaro Kaneko, Alagarsamy Srinivasan, and Danuta Kozbor. Clustered Epitopes within the Gag-Pol Fusion Protein DNA Vaccine Enhance Immune Responses and Protection against Challenge with Recombinant Vaccinia Viruses Expressing HIV-1 Gag and Pol Antigens. Virology, 332(2):467-479, 20 Feb 2005. PubMed ID: 15680412. Show all entries for this paper.


Displaying record number 53860

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(346-354)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name VL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART, optimal epitope

Notes

References

Schmitt-Haendle2005 Matthias Schmitt-Haendle, Oliver Bachmann, Ellen Harrer, Barbara Schmidt, Michael Bäuerle, and Thomas Harrer. Recognition Patterns of HLA-A2-Restricted Human Immunodeficiency Virus-1-Specific Cytotoxic T-Lymphocytes in a Cohort of HIV-1-Infected Individuals. Viral Immunol., 18(4):627-636, 2005. PubMed ID: 16359229. Show all entries for this paper.


Displaying record number 472

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(179-187)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Show epitope variants
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape, immunotherapy

Notes

References

Schmitt2000 M. Schmitt, E. Harrer, A. Goldwich, M. Bauerle, I. Graedner, J. R. Kalden, and T. Harrer. Specific Recognition of Lamivudine-Resistant HIV-1 by Cytotoxic T Lymphocytes. AIDS, 14:653-658, 2000. PubMed ID: 10807188. Show all entries for this paper.


Displaying record number 52178

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(346-354 LAI)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, epitope processing

Notes

References

Kelleher2001a A. D. Kelleher, B. L. Booth, Jr., A. K. Sewell, A. Oxenius, V. Cerundolo, A. J. McMichael, R. E. Phillips, and D. A. Price. Effects of Retroviral Protease Inhibitors on Proteasome Function and Processing of HIV-Derived MHC Class I-Restricted Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 17(11):1063-1066, 20 Jul 2001. PubMed ID: 11485623. Show all entries for this paper.


Displaying record number 53054

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(179-187)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Canada
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART, immunotherapy, variant cross-reactivity

Notes

References

Mason2004 Rosemarie D. Mason, M. Ian Bowmer, Constance M. Howley, Maureen Gallant, Jennifer C. E. Myers, and Michael D. Grant. Antiretroviral Drug Resistance Mutations Sustain or Enhance CTL Recognition of Common HIV-1 Pol Epitopes. J. Immunol., 172(11):7212-7219, 1 Jun 2004. PubMed ID: 15153547. Show all entries for this paper.


Displaying record number 475

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(179-187)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Haas1998 G. Haas, A. Samri, E. Gomard, A. Hosmalin, J. Duntze, J. M. Bouley, H. G. Ihlenfeldt, C. Katlama, and B. Autran. Cytotoxic T Cell Responses to HIV-1 Reverse Transcriptase, Integrase and Protease. AIDS, 12(12):1427-1436, 1998. PubMed ID: 9727563. Show all entries for this paper.


Displaying record number 53574

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT(179-187)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 55396

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location  
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name Pol 334
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords  

Notes

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55906

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name VL9(RT)
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 56062

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(433-)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name Pol334
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression, acute/early infection

Notes

References

Fomsgaard2008 Anders Fomsgaard, Lasse Vinner, Dominic Therrien, Louise B. Jørgensen, Claus Nielsen, Lars Mathiesen, Court Pedersen, and Sylvie Corbet. Full-Length Characterization of A1/D Intersubtype Recombinant Genomes from a Therapy-Induced HIV Type 1 Controller during Acute Infection and His Noncontrolling Partner. AIDS Res. Hum. Retroviruses, 24(3):463-472, Mar 2008. PubMed ID: 18373434. Show all entries for this paper.


Displaying record number 56211

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location RT
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Garrison2007 Keith E. Garrison, R. Brad Jones, Duncan A. Meiklejohn, Naveed Anwar, Lishomwa C. Ndhlovu, Joan M. Chapman, Ann L. Erickson, Ashish Agrawal, Gerald Spotts, Frederick M. Hecht, Seth Rakoff-Nahoum, Jack Lenz, Mario A. Ostrowski, and Douglas F. Nixon. T Cell Responses to Human Endogenous Retroviruses in HIV-1 Infection. PLoS Pathog., 3(11):e165, Nov 2007. PubMed ID: 17997601. Show all entries for this paper.


Displaying record number 57626

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location  
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name VIY
Subtype A, B, C
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods Flow cytometric T-cell cytokine assay
Keywords epitope processing, vaccine antigen design

Vaccine Details

Vaccine type DNA prime with vaccinia boost, polyepitope
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol, Vpr

Notes

References

Bazhan2010 S. I. Bazhan, L. I. Karpenko, T. N. Ilyicheva, P. A. Belavin, S. V. Seregin, N. K. Danilyuk, D. V. Antonets, and A. A. Ilyichev. Rational Design Based Synthetic Polyepitope DNA Vaccine for Eliciting HIV-Specific CD8+ T Cell Responses. Mol Immunol, 47(7-8):1507-1515, Apr 2010. PubMed ID: 20189249. Show all entries for this paper.


Displaying record number 52698

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(334-)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name Pol334
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords binding affinity, subtype comparisons, computational epitope prediction

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


Displaying record number 1731

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(339-347 93TH253 subtype CRF01)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name P334-342
Subtype CRF01_AE
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.


Displaying record number 52967

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(334-342)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2, B35, Bw62
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, memory cells

Notes

References

Gamberg2004 Jane Gamberg, Lisa Barrett, Ian Bowmer, Constance Howley, and Michael Grant. Immune Reconstitution and Viral Stimulation Are Required to Restore HIV-Specific CD8 T Cell Responses Following Advanced Infection. J. Clin. Immunol., 24(2):115-124, Mar 2004. PubMed ID: 15024178. Show all entries for this paper.


Displaying record number 60371

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(334-342)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name VL9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60369

HXB2 Location Pol(334-342)
RT(179-187)
DNA(3084..3110)
Pol Epitope Map
Author Location Pol(334-342)
Epitope VIYQYMDDL Epitope Alignment
VIYQYMDDL epitope logo
Epitope Name VL9
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Operated by Los Alamos National Security, LLC, for the U.S. Department of Energy's National Nuclear Security Administration
Copyright © 2006-2017 LANS LLC All rights reserved | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health