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Displaying record number 53397

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HXB2 Location	Pol(334-342) RT(179-187) DNA(3084..3110)	Pol Epitope Map
Author Location	Pol
Epitope	VIYQMDDL	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 exposed seronegative
Patient MHC/HLA	A*02, A*30, B*15, B*44:02
Experimental methods	T-cell Elispot, Tetramer binding
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• HIV-specific T-cell response was tested in patients exposed to blood from a patient with highly replicating HIV; these patients were nosocomially infected with HBV, but uninfected with HIV. HIV-specific T-cell responses were directed to structural and non-structural HIV proteins in 2 patients, suggesting that the virus replicated in these patients sufficiently to prime a cell-mediated immune response that protected them from HIV infection.
• This patient responded to 4/8 HIV epitopes tested in an IFNgamma EliSpot assay or tetramer assay. Responses were detected 8 and 28 weeks after exposure. No response to this epitope was detected by IFNgamma EliSpot, but a response was detected by tetramer staining.

References

Missale2004 Gabriele Missale, Laura Papagno, Amalia Penna, Massimo Pilli, Alessandro Zerbini, Piero Vitali, Giovanni Pieroni, Simona Urbani, Jacopo Uggeri, Susana Pinheiro, Sarah Rowland-Jones, and Carlo Ferrari. Parenteral Exposure to High HIV Viremia Leads to Virus-Specific T Cell Priming without Evidence of Infection. Eur. J. Immunol., 34(11):3208-3215, Nov 2004. PubMed ID: 15459901. Show all entries for this paper.