HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 7 matching records:

Displaying record number 53962

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HXB2 Location Gag(143-152)
p24(11-20)
DNA(1216..1245)
Gag Epitope Map
Author Location ( C consensus)
Epitope VHQAISPRTL Epitope Alignment
VHQAISPRTL epitope logo
Subtype C
Species (MHC/HLA) human(B*15:10)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 56467

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HXB2 Location Gag(143-152)
p24(11-20)
DNA(1216..1245)
Gag Epitope Map
Author Location p24
Epitope VHQAISPRTL Epitope Alignment
VHQAISPRTL epitope logo
Subtype C
Species (MHC/HLA) human(B*15:10)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 53293

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HXB2 Location Gag(143-152)
p24(11-20)
DNA(1216..1245)
Gag Epitope Map
Author Location ( C consensus)
Epitope VHQAISPRTL Epitope Alignment
VHQAISPRTL epitope logo
Subtype C
Species (MHC/HLA) human(B*15:10)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 60621

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HXB2 Location Gag(143-152)
p24(11-20)
DNA(1216..1245)
Gag Epitope Map
Author Location p24(11-20)
Epitope VHQAISPRTL Epitope Alignment
VHQAISPRTL epitope logo
Epitope Name VL-10
Subtype B, C
Species (MHC/HLA) human(B*15:10, C*03)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 59425

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HXB2 Location Gag(143-152)
p24(11-20)
DNA(1216..1245)
Gag Epitope Map
Author Location Gag(143-152)
Epitope VHQAISPRTL Epitope Alignment
VHQAISPRTL epitope logo
Epitope Name Gag143-152
Species (MHC/HLA) human(C*03:04)
Immunogen in vitro stimulation or selection
Experimental methods Degranulation, CD107a and b cell surface mobilization, Other, T2 stabilization assay
Keywords computational epitope prediction, NK cells

Notes

References

vanTeijlingen2014 Nienke H. van Teijlingen, Angelique Hölzemer, Christian Körner, Wilfredo F. García-Beltrán, Jamie L. Schafer, Lena Fadda, Todd J. Suscovich, Christian Brander, Mary Carrington, David T Evans, Debbie van Baarle, and Marcus Altfeld. Sequence Variations in HIV-1 p24 Gag-Derived Epitopes Can Alter Binding of KIR2DL2 to HLA-C*03:04 and Modulate Primary Natural Killer Cell Function. AIDS, 28(10):1399-1408, 19 Jun 2014. PubMed ID: 24785948. Show all entries for this paper.


Displaying record number 58955

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HXB2 Location Gag(143-152)
p24(11-20)
DNA(1216..1245)
Gag Epitope Map
Author Location Gag(143-152)
Epitope VHQAISPRTL Epitope Alignment
VHQAISPRTL epitope logo
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA CAP210: A*68:02, B*15:10, C*03:04
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords escape, acute/early infection

Notes

References

Abrahams2013 Melissa-Rose Abrahams, Florette K. Treurnicht, Nobubelo K. Ngandu, Sarah A. Goodier, Jinny C. Marais, Helba Bredell, Ruwayhida Thebus, Debra de Assis Rosa, Koleka Mlisana, Cathal Seoighe, Salim Abdool Karim, Clive M. Gray, and Carolyn Williamson. Rapid, Complex Adaptation of Transmitted HIV-1 Full-Length Genomes in Subtype C-Infected Individuals with Differing Disease Progression. AIDS, 27(4):507-518, 20 Feb 2013. PubMed ID: 23370465. Show all entries for this paper.


Displaying record number 61043

Download this epitope record as JSON.

HXB2 Location Gag(143-152)
p24(11-20)
DNA(1216..1245)
Gag Epitope Map
Author Location p24(11-20)
Epitope VHQAISPRTL Epitope Alignment
VHQAISPRTL epitope logo
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA CAP210: A*68:02, B*15:10, C*03:04
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords computational epitope prediction, escape, acute/early infection, mutation acquisition

Notes

References

Barton2016 John P. Barton, Nilu Goonetilleke, Thomas C. Butler, Bruce D. Walker, Andrew J. McMichael, and Arup K. Chakraborty. Relative Rate and Location of Intra-Host HIV Evolution to Evade Cellular Immunity Are Predictable. Nat. Commun., 7:11660, 23 May 2016. PubMed ID: 27212475. Show all entries for this paper.


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