Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 1496

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HXB2 Location	Gag(353-363) p24(221-231) DNA(1846..1878)	Gag Epitope Map
Author Location	p24(353-363 LAI)
Epitope	VGGPGHKARVL	Epitope Alignment
Epitope Name	G1
Subtype	B
Species (MHC/HLA)	human(B*07)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HAART, ART

Notes

• A panel of 16 epitopes covering 15 class I alleles was tested in 14 HIV+ patients from an unselected Caucasian population treated with HAART, using CD8+ cell IFNgamma production to measure responses.
• In general, during the first month of treatment viral load decreased and frequencies of HIV-specific CTL tripled and broadened -- eight new HIV specificities that were not previously detectable were newly detected, as were CMV specific CD8+ PBL -- but with continued viral suppression, HIV-specific responses diminished.
• Viral rebounds gave different patterns of response: increases or decreases in pre-existing response, new specificities, or no change.

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.

Displaying record number 55886

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HXB2 Location	Gag(353-363) p24(221-231) DNA(1846..1878)	Gag Epitope Map
Author Location	Gag
Epitope	VGGPGHKARVL	Epitope Alignment
Subtype	C, CRF01_AE
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B7-restricted epitope VGGPGHKARVL is from a subtype C peptide library, and is reactive as part of peptide QGVGGPGHKARVL in a subtype AE-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.