Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 959

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HXB2 Location	Nef(66-80) DNA(8992..9036)	Nef Epitope Map
Author Location	Nef(66-80 BRU)
Epitope	VGFPVTPQVPLRMT	Epitope Alignment
Species (MHC/HLA)	human(A1, B8)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• HIV-1 specific CTLs detected in lymphoid organs of HIV-1 infected patients.

References

Hadida1992 F. Hadida, A. Parrot, M. P. Kieny, B. Sadat-Sowti, C. Mayaud, and P. Debre. Carboxyl-Terminal and Central Regions of Human Immunodeficiency Virus-1 NEF Recognized by Cytotoxic T Lymphocytes from Lymphoid Organs. An In Vitro Limiting Dilution Analysis. J. Clin. Invest., 89:53-60, 1992. HIV-1-specific CTL can be detected in lymph nodes and spleens. The carboxyl-terminal domain of Nef is recognized by CTL in association with HLA-A1 and B8, with clonal frequencies of one CTL per $10^-5$ to $10^-6$ splenic lymphocytes. PubMed ID: 1370302. Show all entries for this paper.

Displaying record number 1414

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HXB2 Location	Nef(66-80) DNA(8992..9036)	Nef Epitope Map
Author Location	Nef(64-78)
Epitope	VGFPVTPQVPLRMT	Epitope Alignment
Species (MHC/HLA)	human(A1, B8)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• One of the 51 HIV-1 epitopes selected by Ferrari et al. as good candidate CTL epitopes for vaccines by virtue of being conserved and presented by common HLA alleles.

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.