HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 33 matching records:

Displaying record number 60356

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name TK10
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59302

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name TK10
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.


Displaying record number 1988

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location  
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name Env-VK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 1778

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 59215

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name Env 37-46
Subtype B
Species (MHC/HLA) human(A*03, A*11)
Immunogen vaccine
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type lipopeptide

Notes

References

Figueiredo2014 Suzanne Figueiredo, Benedicte Charmeteau, Mathieu Surenaud, Dominique Salmon, Odile Launay, Jean-Gérard Guillet, Anne Hosmalin, and Hanne Gahery. Memory CD8+ T Cells Elicited by HIV-1 Lipopeptide Vaccines Display Similar Phenotypic Profiles but Differences in Term of Magnitude and Multifunctionality Compared with FLU- or EBV-Specific Memory T Cells in Humans. Vaccine, 32(4):492-501, 16 Jan 2014. PubMed ID: 24291199. Show all entries for this paper.


Displaying record number 631

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(37-46 LAI)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Johnson1994 R. P. Johnson, S. A. Hammond, A. Trocha, R. F. Siliciano, and B. D. Walker. Induction of a Major Histocompatibility Complex Class I-Restricted Cytotoxic T-Lymphocyte Response to a Highly Conserved Region of Human Immunodeficiency Virus Type 1 (HIV-1) gp120 in Seronegative Humans Immunized with a Candidate HIV-1 Vaccine. J. Virol., 68:3145-3153, 1994. In two volunteers, immunization with a single strain of HIV-1 induced CD4+ and CD8+ CTL that are specific for multiple conserved regions of HIV-1 and would be expected to recognize a broad range of viral isolates. The immunodominant gp120 epitope, gp120 TVYYGVPVWK, elicited CD8+ HLA-A3.1 restricted CTL, and this epitope is highly conserved. CTL specific for this epitope could lyse target cells sensitized with all known natural sequence variants. Additionally, CD8+ HLA-B35 and CD8+ HLA-B18 restricted epitopes were defined as well as two CD4+ cytotoxic T-cell gp120 epitopes: ITQACPKVSFEPIPHYCAPAGFAI and NNTLKQIDSKLREQFG. PubMed ID: 7908700. Show all entries for this paper.


Displaying record number 633

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(38-41 LAI)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Johnson1994c R. P. Johnson, S. A. Hammond, A. Trocha, R. F. Siliciano, and B. D. Walker. Epitope Specificity of MHC Restricted Cytotoxic T Lymphocytes Induced by Candidate HIV-1 Vaccine. AIDS Res. Hum. Retroviruses, 10, Supp 2:S73-S75, 1994. Volunteers were immunized with recombinant vaccinia virus expressing HIV-1 gp160 (vac-env) and boosted with recombinant gp160 (rgp160). CTL clones were analyzed for HLA restriction and specificity. An immunodominant HLA-A3.1 restricted epitope was observed that showed very little sequence variation among B subtype sequences, (TVYYGVPVWK). Naturally occurring variants of this peptide were able to stimulate reactivity. Two additional CD8+ CTL epitopes from vaccinees were characterized, as well as two CD4+ CTL epitopes. PubMed ID: 7532425. Show all entries for this paper.


Displaying record number 634

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(37-46 LAI)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Ferris1999 R. L. Ferris, C. Hall, N. V. Sipsas, J. T. Safrit, A. Trocha, R. A. Koup, R. P. Johnson, and R. F. Siliciano. Processing of HIV-1 Envelope Glycoprotein for Class I-Restricted Recognition: Dependence on TAP1/2 and Mechanisms for Cytosolic Localization. J. Immunol., 162:1324-1332, 1999. PubMed ID: 9973386. Show all entries for this paper.

Hammond1995 S. A. Hammond, R. P. Johnson, S. A. Kalams, B. D. Walker, M. Takiguchi, J. T. Safrit, R. A. Koup, and R. F. Siliciano. An Epitope-Selective Transporter Associated with Antigen Presentation TAP-1/2-Independent Pathway and a More General TAP-1/2-Dependent Antigen-Processing Pathway Allow Recognition of the HIV-1 Envelope Glycoprotein by CD8+ CTL. J. Immunol., 154:6140-6156, 1995. Two peptide-processing pathways are utilized for MHC class I presentation of HIV-1 Env epitopes. The previously characterized TAP-1 and TAP-2 dependent pathway can generate all Env epitopes and uses Env protein mislocalized in the cytosol to produce peptides. The second, novel pathway uses a TAP-1/2 independent pathway, and allows a subset of MHC-restricted epitopes to be processed in the endoplasmic reticulum or a Golgi compartment. PubMed ID: 7538543. Show all entries for this paper.


Displaying record number 1119

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(37-46 LAI)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen vaccine
Experimental methods  
Keywords optimal epitope

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 1120

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(37-46 LAI)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.


Displaying record number 52432

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Subtype A, B, C, D
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 55150

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(430-440)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen vaccine
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Proliferation
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade consensus
Vaccine component Gag

Notes

References

Goonetilleke2006 Nilu Goonetilleke, Stephen Moore, Len Dally, Nicola Winstone, Inese Cebere, Abdul Mahmoud, Susana Pinheiro, Geraldine Gillespie, Denise Brown, Vanessa Loach, Joanna Roberts, Ana Guimaraes-Walker, Peter Hayes, Kelley Loughran, Carole Smith, Jan De Bont, Carl Verlinde, Danii Vooijs, Claudia Schmidt, Mark Boaz, Jill Gilmour, Pat Fast, Lucy Dorrell, Tomas Hanke, and Andrew J. McMichael. Induction of Multifunctional Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T Cells Capable of Proliferation in Healthy Subjects by Using a Prime-Boost Regimen of DNA- and Modified Vaccinia Virus Ankara-Vectored Vaccines Expressing HIV-1 Gag Coupled to CD8+ T-Cell Epitopes. J. Virol., 80(10):4717-4728, May 2006. PubMed ID: 16641265. Show all entries for this paper.


Displaying record number 55759

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Liang2008 Binhua Liang, Ma Luo, T Blake Ball, Xiaojian Yao, Gary Van Domselaar, Wilfred R. Cuff, Mary Cheang, Steven J. M. Jones, and Francis A. Plummer. Systematic Analysis of Host Immunological Pressure on the Envelope Gene of Human Immunodeficiency Virus Type 1 by an Immunobioinformatics Approach. Curr. HIV Res., 6(4):370-379, Jun 2008. PubMed ID: 18691035. Show all entries for this paper.


Displaying record number 61161

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Show epitope variants
Epitope Name TK10
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 55125

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Show epitope variants
Species (MHC/HLA) human(A*0301, A*6801)
Immunogen  
Experimental methods  
Keywords subtype comparisons, viral fitness and reversion

Notes

References

Queiroz2007 Artur Trancoso Lopo de Queiroz, Luciane Amorim Santos, Domingos Ramon Moreau, Tulio de Oliveira, David I. Watkins, Bernardo Galvão-Castro, and Luiz Carlos Junior Alcantara. Identification and Characterization of Previously Described Epitopes in HIV-1 Subtypes B, C, F and BF in Brazil. Braz. J. Infect. Dis., 11(1):27-30, Feb 2007. PubMed ID: 17625722. Show all entries for this paper.


Displaying record number 636

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Species (MHC/HLA) transgenic mouse(A11)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type DNA

Notes

References

Ishioka1999 G. Y. Ishioka, J. Fikes, G. Hermanson, B. Livingston, C. Crimi, M. Qin, M. F. del Guercio, C. Oseroff, C. Dahlberg, J. Alexander, R. W. Chesnut, and A. Sette. Utilization of MHC Class I Transgenic Mice for Development of Minigene. J. Immunol., 162:3915-3925, 1999. PubMed ID: 10201910. Show all entries for this paper.


Displaying record number 52865

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name 1283
Subtype multiple
Species (MHC/HLA) human(A*6801, A11, A2, A3, B18)
Immunogen HIV-1 infection
Patient MHC/HLA A25, A68, B18, B27; A11, A3, B14, B51, Cw13, Cw8
Country United States
Experimental methods T-cell Elispot
Keywords binding affinity, computational epitope prediction, HLA cross-presentation

Notes

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.


Displaying record number 57942

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp160(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name TK10
Subtype A1, B, C
Species (MHC/HLA) human(A11, A3)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus
Vaccine strain B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component Env, Gag-Pol

Notes

References

Friedrich2011 David Friedrich, Emilie Jalbert, Warren L. Dinges, John Sidney, Alex Sette, Yunda Huang, M. Juliana McElrath, and Helen Horton. Vaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1. J. Acquir. Immune Defic. Syndr., 58(3):248-252, 1 Nov 2011. PubMed ID: 21709567. Show all entries for this paper.


Displaying record number 54254

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name A3-TK11(gp120)
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 56464

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp160
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name TK10(gp160)
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 57678

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Show epitope variants
Epitope Name EnvTK10
Subtype A, B
Species (MHC/HLA) human(A3)
Immunogen vaccine
Patient MHC/HLA A2, A3, B15, B7, Cw3, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords subtype comparisons, vaccine-induced immune responses

Vaccine Details

Vaccine type DNA prime with Ad5 boost
Vaccine strain A clade, B clade, C clade

Notes

References

Koup2010 Richard A. Koup, Mario Roederer, Laurie Lamoreaux, Jennifer Fischer, Laura Novik, Martha C. Nason, Brenda D. Larkin, Mary E. Enama, Julie E. Ledgerwood, Robert T. Bailer, John R. Mascola, Gary J. Nabel, Barney S. Graham, VRC 009 Study Team, and VRC 010 Study Team. Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses. PLoS One, 5(2):e9015, 2010. PubMed ID: 20126394. Show all entries for this paper.


Displaying record number 53394

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 exposed seronegative
Patient MHC/HLA A1, A3, B39, B44, Cw4, Cw6
Experimental methods T-cell Elispot
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Missale2004 Gabriele Missale, Laura Papagno, Amalia Penna, Massimo Pilli, Alessandro Zerbini, Piero Vitali, Giovanni Pieroni, Simona Urbani, Jacopo Uggeri, Susana Pinheiro, Sarah Rowland-Jones, and Carlo Ferrari. Parenteral Exposure to High HIV Viremia Leads to Virus-Specific T Cell Priming without Evidence of Infection. Eur. J. Immunol., 34(11):3208-3215, Nov 2004. PubMed ID: 15459901. Show all entries for this paper.


Displaying record number 635

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(37-46 LAI)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA 003: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 632

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Species (MHC/HLA) human(A3)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type canarypox
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag, gp120, gp41, Protease

Notes

References

Carruth1999 L. M. Carruth, T. F. Greten, C. E. Murray, M. G. Castro, S. N. Crone, W. Pavlat, J. P. Schneck, and R. F. Siliciano. An Algorithm for Evaluating Human Cytotoxic T Lymphocyte Responses to Candidate AIDS Vaccines. AIDS Res. Hum. Retroviruses, 15:1021-1034, 1999. PubMed ID: 10445814. Show all entries for this paper.


Displaying record number 1437

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(36-45)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 52985

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp160(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A3, A32, B15, B51, Cw03, Cw6, DQ7, DR4, DR8
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, escape

Notes

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 60354

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name TK10
Species (MHC/HLA) human(A*32)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60357

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name TK10
Species (MHC/HLA) human(A*34)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60355

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name TK10
Species (MHC/HLA) human(A*36)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1614

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env(49-58)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Species (MHC/HLA) human(A3 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, rate of progression

Notes

References

Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.


Displaying record number 60359

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name TK10
Species (MHC/HLA) human(B*1540)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60360

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name TK10
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60358

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location Env(37-46)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Epitope Name TK10
Species (MHC/HLA) human(B*4202)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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