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Displaying record number 54961

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HXB2 Location	gp160(37-46) gp120(37-46) DNA(6333..6362)	gp160 Epitope Map
Author Location	Env(37-46)
Epitope	TVYYGVPVMK	Epitope Alignment
Species (MHC/HLA)	(A11, A3, A68)
Immunogen	peptide-HLA interaction
Experimental methods	HLA binding
Keywords	binding affinity, immunodominance

Notes

• Interaction between purified HLA-A3 molecules and several dominant CD8 epitopes was characterized. Amplitude, stability, and kinetic parameters of the interaction between HLA-A3, peptides, and anti-HLA mAbs were tested.
• Epitopes tested bound strongly to HLA-A3 and formed very stable complexes.
• Gag epitope RLRPGGKKK and Nef epitope RLAFHHVAR complexes with HLA-A3 were not recognized by the A11.1 MAb specific to HLA-A3 alleles. The proposed explanation was that Arg at position P1 of the peptide may push the α2 helix residue and affect MAb recognition.

References

Racape2006a Judith Racape, Francine Connan, Johan Hoebeke, Jeannine Choppin, and Jean-Gérard Guillet. Influence of Dominant HIV-1 Epitopes on HLA-A3/Peptide Complex Formation. Proc. Natl. Acad. Sci. U.S.A., 103(48):18208-18213, 28 Nov 2006. PubMed ID: 17116886. Show all entries for this paper.