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Displaying record number 54975

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HXB2 Location	Nef(15-23) DNA(8839..8865)	Nef Epitope Map
Author Location	Nef(15-23)
Epitope	TVRERMRRA	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, peptide-HLA interaction
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, T-cell crossreactivity to human proteins

Notes

• Resemblance between viral and host peptides may preclude immune reactivity against such epitopes. This was shown using ELISpot to test recognition against the entire viral genome in 314 HIV-infected subjects. Also, 944 overlapping Nef variants were tested for 30 patients. This inverse relationship between similarity of HIV epitope to host proteome and its immunogenicity has implications in vaccine design.
• Other factors, however, like entropy effects and forbidden residue usage or even hydrophobicity or disorder prediction scores were more influential than this similarity to self, with regards to immunogenicity of HIV-1. Also, forbidden aa ratios at the C-terminus of CTL epitopes and similarity to host proteins are positively correlated. Low disorder peptides elicit broader CTL responses and are better recognized.
• This HIV-1 epitope, TVRERMRRA, is similar to human protein Rhomboid protein, sequence TTVRsRMRRA.

References

Rolland2007a Morgane Rolland, David C. Nickle, Wenjie Deng, Nicole Frahm, Christian Brander, Gerald H. Learn, David Heckerman, Nebosja Jojic, Vladimir Jojic, Bruce D. Walker, and James I. Mullins. Recognition of HIV-1 Peptides by Host CTL Is Related to HIV-1 Similarity to Human Proteins. PLoS ONE, 2(9):e823, 2007. PubMed ID: 17786195. Show all entries for this paper.