HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 1516

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HXB2 Location Gag(239-247)
p24(107-115)
DNA(1504..1530)
Gag Epitope Map
Author Location Gag(239-247 SF2)
Epitope TTSTLQEQI Epitope Alignment
TTSTLQEQI epitope logo
Species (MHC/HLA) mouse(H-2Kd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type Listeria monocytogenes
Vaccine strain B clade HXB2
Vaccine component Gag

Notes

References

Mata1998 M. Mata, P. J. Travers, Q. Liu, F. R. Frankel, and Y. Paterson. The MHC Class I-Restricted Immune Response to HIV-gag in BALB/c Mice Selects a Single Epitope That Does Not Have a Predictable MHC-Binding Motif and Binds to Kd through Interactions between a Glutamine at P3 and Pocket D. J. Immunol., 161:2985-2993, 1998. PubMed ID: 9743362. Show all entries for this paper.


Displaying record number 55329

Download this epitope record as JSON.

HXB2 Location Gag(239-247)
p24(107-115)
DNA(1504..1530)
Gag Epitope Map
Author Location Gag
Epitope TTSTLQEQI Epitope Alignment
TTSTLQEQI epitope logo
Epitope Name T
Subtype A, B, C
Species (MHC/HLA) mouse(H-2Kd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, antagonism

Vaccine Details

Vaccine type DNA with CMV promotor, modified vaccinia Ankara (MVA), DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade, B clade, C clade Du422, other
Vaccine component Gag, Nef, RT

Notes

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


Displaying record number 57938

Download this epitope record as JSON.

HXB2 Location Gag(239-247)
p24(107-115)
DNA(1504..1530)
Gag Epitope Map
Author Location  
Epitope TTSTLQEQI Epitope Alignment
TTSTLQEQI epitope logo
Epitope Name G2
Subtype A
Species (MHC/HLA) mouse(H-2Kd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, HLA binding, Intracellular cytokine staining
Keywords immunodominance, vaccine antigen design, optimal epitope

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA)
Vaccine strain A clade, multiple epitope immunogen
Vaccine component p17 Gag, p24 Gag, other

Notes

References

Im2011 Eung-Jun Im, Jessie P. Hong, Yaowaluck Roshorm, Anne Bridgeman, Sven Létourneau, Peter Liljeström, Mary Jane Potash, David J. Volsky, Andrew J. McMichael, and Tomáš Hanke. Protective Efficacy of Serially Up-Ranked Subdominant CD8+ T Cell Epitopes against Virus Challenges. PLoS Pathog., 7(5):e1002041, May 2011. PubMed ID: 21625575. Show all entries for this paper.


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