HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 59066

Download this epitope record as JSON.

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTVEEQIQW Epitope Alignment
TSTVEEQIQW epitope logo
Subtype HIV-2
Species (MHC/HLA) human(B*58)
Immunogen HIV-2 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, rate of progression, immunodominance, HIV-2

Notes

References

Bertoletti1998 A. Bertoletti, F. Cham, S. McAdam, T. Rostron, S. Rowland-Jones, S. Sabally, T. Corrah, K. Ariyoshi, and H. Whittle. Cytotoxic T cells from human immunodeficiency virus type 2-infected patients frequently cross-react with different human immunodeficiency virus type 1 clades. J. Virol., 72:2439-2448, 1998. PubMed ID: 9499105. Show all entries for this paper.

Goulder1996 P. J. R. Goulder, M. Bunce, P. Krausa, K. McIntyre, S. Crowley, B. Morgan, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Novel, Cross-Restricted, Conserved and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow HIV Type 1 Infection. AIDS Res. Hum. Retroviruses, 12:1691-1698, 1996. HLA-B*57 is over-represented in slow progressors. HLA*5801 is a closely related molecule, and while the defined anchor residues of HLA*5801 can be used to predict epitopes in HIV-1 proteins, the CTL from HLA-B*57 positive individuals have limited cross-presentation capacity with HLA*5801 targets. In this paper five new HLA-B*57 epitopes were defined. PubMed ID: 8959245. Show all entries for this paper.


Displaying record number 53712

Download this epitope record as JSON.

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTVEEQIQW Epitope Alignment
TSTVEEQIQW epitope logo
Epitope Name TSTV
Subtype HIV-2
Species (MHC/HLA) human(B*58:01)
Immunogen HIV-2 infection
Country Gambia
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells, HIV-2

Notes

References

Gillespie2005a Geraldine M. A. Gillespie, Susana Pinheiro, Mohammad Sayeid-Al-Jamee, Abraham Alabi, Steve Kaye, Sehu Sabally, Ramu Sarge-Njie, Harr Njai, Ken Joof, Assan Jaye, Hilton Whittle, Sarah Rowland-Jones, and Lucy Dorrell. CD8+ T Cell Responses to Human Immunodeficiency Viruses Type 2 (HIV-2) and Type 1 (HIV-1) Gag Proteins are Distinguishable by Magnitude and Breadth but not Cellular Phenotype. Eur. J. Immunol., 35(5):1445-1453, May 2005. PubMed ID: 15832290. Show all entries for this paper.


Displaying record number 55525

Download this epitope record as JSON.

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(241-250 HIV-2 ROD)
Epitope TSTVEEQIQW Epitope Alignment
TSTVEEQIQW epitope logo
Epitope Name TSTV
Subtype HIV-2
Species (MHC/HLA) human(B*58:01)
Immunogen HIV-2 infection
Patient MHC/HLA A*01:01, A*24:02, B*07, B*58:01
Country India
Experimental methods  
Keywords escape, HIV-2

Notes

References

Kageyama2008 Seiji Kageyama, Janak K. Maniar, Dattatray G. Saple, Kei Numazaki, Takashi Kurimura, and Hiroshi Ichimura. HIV-2 Amino Acid Substitutions in Gag and Env Proteins Occurring Simultaneously with Viral Load Upsurge in a Drug-Naïve Patient. J. Infect. Chemother., 14(2):151-155, Apr 2008. PubMed ID: 18622680. Show all entries for this paper.


Displaying record number 63096

Download this epitope record as JSON.

HXB2 Location Gag(240-249)
p24(108-117)
Gag Epitope Map
Author Location Gag(241-250)
Epitope TSTVEEQIQW Epitope Alignment
TSTVEEQIQW epitope logo
Show epitope variants
Species (MHC/HLA) human
Immunogen HIV-2 infection
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords autologous responses, HIV-2, HLA associated polymorphism

Notes

References

deSilva2018 Thushan I. de Silva, Aleksandra Leligdowicz, Jonathan Carlson, Miguel Garcia-Knight, Clayton Onyango, Nicholas Miller, Louis-Marie Yindom, Stephane Hue, Assan Jaye, Tao Dong, Matthew Cotten, and Sarah L. Rowland-Jones. HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation. AIDS, 32(6):709-714 doi, Mar 2018. PubMed ID: 29369160 Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health