HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 119 matching records:

Displaying record number 57351

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag( NL4-3)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen virus
Country United States
Experimental methods Relative replication capacity assay
Keywords rate of progression, elite controllers

Notes

References

Miura2009 Toshiyuki Miura, Mark A. Brockman, Zabrina L Brumme, Chanson J. Brumme, Florencia Pereyra, Alicja. Trocha, Brian L. Block, Arne Schneidewind, Todd M. Allen, David Heckerman, and Bruce D. Walker. HLA-Associated Alterations in Replication Capacity of Chimeric NL4-3 Viruses Carrying gag-protease from Elite Controllers of Human Immunodeficiency Virus Type 1. J. Virol., 83(1):140-149, Jan 2009. PubMed ID: 18971283. Show all entries for this paper.


Displaying record number 56715

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24( HIV-1 NL4-3.1)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen virus
Experimental methods CTL suppression of replication
Keywords  

Notes

References

Cruz2009 Justin De La Cruz, Ayub Ali, Hwee L Ng, and Otto O Yang. Disruption of an env Tyrosine-Dependent Sorting Signal Does Not Affect Susceptibility of HIV-1 to Cytotoxic T Lymphocytes. AIDS, 23(11):1449-1451, 17 Jul 2009. PubMed ID: 19564727. Show all entries for this paper.


Displaying record number 57524

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Tetramer binding
Keywords  

Notes

References

Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.


Displaying record number 60350

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(A*66)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60348

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(A*6802)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58779

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249 NL4-3)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords elite controllers

Notes

References

Chen2012a Huabiao Chen, Zaza M. Ndhlovu, Dongfang Liu, Lindsay C. Porter, Justin W. Fang, Sam Darko, Mark A. Brockman, Toshiyuki Miura, Zabrina L. Brumme, Arne Schneidewind, Alicja Piechocka-Trocha, Kevin T. Cesa, Jennifer Sela, Thai D. Cung, Ildiko Toth, Florencia Pereyra, Xu G. Yu, Daniel C. Douek, Daniel E. Kaufmann, Todd M. Allen, and Bruce D. Walker. TCR Clonotypes Modulate the Protective Effect of HLA Class I Molecules in HIV-1 Infection. Nat. Immunol., 13(7):691-700, Jul 2012. PubMed ID: 22683743. Show all entries for this paper.


Displaying record number 54803

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name B57-TW10
Species (MHC/HLA) (B57)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, vaccine antigen design

Notes

References

Altfeld2006a Marcus Altfeld and Todd M. Allen. Hitting HIV Where It Hurts: An Alternative Approach to HIV Vaccine Design. Trends Immunol., 27(11):504-510, Nov 2006. PubMed ID: 16997629. Show all entries for this paper.


Displaying record number 1461

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 52323

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TST
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.


Displaying record number 57599

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, genital and mucosal immunity

Notes

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.


Displaying record number 55501

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 55621

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction

Notes

References

Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.


Displaying record number 1295

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag( SF2)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 52196

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2002 Rupert Kaul, Sarah L. Rowland-Jones, Geraldine Gillespie, Joshua Kimani, Tao Dong, Peter Kiama, J. Neil Simonsen, Job J. Bwayo, Andrew J. McMichael, and Francis A. Plummer. Gonococcal Cervicitis is Associated with Reduced Systemic CD8+ T Cell Responses in Human Immunodeficiency Virus Type 1-Infected and Exposed, Uninfected Sex Workers. J. Infect. Dis., 185(10):1525-1529, 15 May 2002. PubMed ID: 11992292. Show all entries for this paper.


Displaying record number 55104

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, escape, mutation acquisition, viral fitness and reversion, optimal epitope

Notes

References

Streeck2007a Hendrik Streeck, Mathias Lichterfeld, Galit Alter, Angela Meier, Nickolas Teigen, Bader Yassine-Diab, Harlyn K. Sidhu, Susan Little, Anthony Kelleher, Jean-Pierre Routy, Eric S. Rosenberg, Rafick-Pierre Sekaly, Bruce D. Walker, and Marcus Altfeld. Recognition of a Defined Region within p24 Gag by CD8+ T Cells during Primary Human Immunodeficiency Virus Type 1 Infection in Individuals Expressing Protective HLA Class I Alleles. J. Virol., 81(14):7725-7731, Jul 2007. PubMed ID: 17494064. Show all entries for this paper.


Displaying record number 53488

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 57676

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B57)
Immunogen vaccine
Patient MHC/HLA A1, A26, B*5601, B57, Cw1, Cw6
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords subtype comparisons, vaccine-induced immune responses

Vaccine Details

Vaccine type DNA prime with Ad5 boost
Vaccine strain A clade, B clade, C clade

Notes

References

Koup2010 Richard A. Koup, Mario Roederer, Laurie Lamoreaux, Jennifer Fischer, Laura Novik, Martha C. Nason, Brenda D. Larkin, Mary E. Enama, Julie E. Ledgerwood, Robert T. Bailer, John R. Mascola, Gary J. Nabel, Barney S. Graham, VRC 009 Study Team, and VRC 010 Study Team. Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses. PLoS One, 5(2):e9015, 2010. PubMed ID: 20126394. Show all entries for this paper.


Displaying record number 1378

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TST
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 53203

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location ( B consensus)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords immunodominance, escape, characterizing CD8+ T cells

Notes

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.


Displaying record number 54378

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name B57-TW10(p24)
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 224

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(233-252)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Bernard1998 N. F. Bernard, K. Pederson, F. Chung, L. Ouellet, M. A. Wainberg, and C. M. Tsoukas. HIV-Specific Cytotoxic T-Lymphocyte Activity in Immunologically Normal HIV-Infected Persons. AIDS, 12:2125-2139, 1998. PubMed ID: 9833853. Show all entries for this paper.


Displaying record number 53672

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods Other
Keywords rate of progression, escape

Notes

References

Gao2005 Xiaojiang Gao, Arman Bashirova, Astrid K. N. Iversen, John Phair, James J. Goedert, Susan Buchbinder, Keith Hoots, David Vlahov, Marcus Altfeld, Stephen J. O'Brien, and Mary Carrington. AIDS Restriction HLA Allotypes Target Distinct Intervals of HIV-1 Pathogenesis. Nat. Med., 11(12):1290-1292, Dec 2005. PubMed ID: 16288280. Show all entries for this paper.


Displaying record number 54535

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B57, B58)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, subtype comparisons, acute/early infection

Notes

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 1693

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(235-243)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human(B57, B58)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 53387

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name gag 240-9
Species (MHC/HLA) human(B57, B58)
Immunogen HIV-1 infection, HIV-2 infection
Country Gambia
Experimental methods Intracellular cytokine staining
Keywords escape, TCR usage, variant cross-reactivity, characterizing CD8+ T cells, HIV-2

Notes

References

Lopes2003 A. Ross Lopes, Assan Jaye, Lucy Dorrell, Sehu Sabally, Abraham Alabi, Nicola A. Jones, Darren R. Flower, Anne De Groot, Phillipa Newton, R. Monica Lascar, Ian Williams, Hilton Whittle, Antonio Bertoletti, Persephone Borrow, and Mala K. Maini. Greater CD8+ TCR Heterogeneity and Functional Flexibility in HIV-2 Compared to HIV-1 Infection. J. Immunol., 171(1):307-316, 1 Jul 2003. PubMed ID: 12817012. Show all entries for this paper.


Displaying record number 52619

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human(B57, B58)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A26, B35, B57, Cw*0601, Cw4; A1, A30, B42, B52, Cw17, Cw7; A*0201, A1, B44, B57, Cw5, Cw6
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins, HLA cross-presentation

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 57952

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype A1, B, C
Species (MHC/HLA) human(B57, B58)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus
Vaccine strain B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component Env, Gag-Pol

Notes

References

Friedrich2011 David Friedrich, Emilie Jalbert, Warren L. Dinges, John Sidney, Alex Sette, Yunda Huang, M. Juliana McElrath, and Helen Horton. Vaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1. J. Acquir. Immune Defic. Syndr., 58(3):248-252, 1 Nov 2011. PubMed ID: 21709567. Show all entries for this paper.


Displaying record number 53656

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B, C
Species (MHC/HLA) human(B57, B58, B63)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, HLA cross-presentation, optimal epitope

Notes

References

Frahm2005a Nicole Frahm, Sharon Adams, Photini Kiepiela, Caitlyn H. Linde, Hannah S. Hewitt, Mathias Lichterfeld, Kaori Sango, Nancy V. Brown, Eunice Pae, Alysse G. Wurcel, Marcus Altfeld, Margaret E. Feeney, Todd M. Allen, Timothy Roach, M. Anne St. John, Eric S. Daar, Eric Rosenberg, Bette Korber, Francesco Marincola, Bruce D. Walker, Philip J. R. Goulder, and Christian Brander. HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load. J. Virol., 79(16):10218-10225, Aug 2005. PubMed ID: 16051815. Show all entries for this paper.


Displaying record number 53214

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, rate of progression, immunodominance, escape, acute/early infection, viral fitness and reversion

Notes

References

Goulder2004 Philip J R Goulder and David I Watkins. HIV and SIV CTL Escape: Implications for Vaccine Design. Nat. Rev. Immunol., 4(8):630-640, Aug 2004. PubMed ID: 15286729. Show all entries for this paper.


Displaying record number 53640

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords responses in children, mother-to-infant transmission, escape

Notes

References

Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.


Displaying record number 56143

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Subtype C
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Rousseau2008 Christine M. Rousseau, Marcus G. Daniels, Jonathan M. Carlson, Carl Kadie, Hayley Crawford, Andrew Prendergast, Philippa Matthews, Rebecca Payne, Morgane Rolland, Dana N. Raugi, Brandon S. Maust, Gerald H. Learn, David C. Nickle, Hoosen Coovadia, Thumbi Ndung'u, Nicole Frahm, Christian Brander, Bruce D. Walker, Philip J. R. Goulder, Tanmoy Bhattacharya, David E. Heckerman, Bette T. Korber, and James I. Mullins. HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load. J. Virol., 82(13):6434-6446, Jul 2008. PubMed ID: 18434400. Show all entries for this paper.


Displaying record number 53788

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) (B*5801, B57)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion

Notes

References

Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.


Displaying record number 58744

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag( NL4-3)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining
Keywords elite controllers

Notes

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58008

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Cytotoxicity assay, Other
Keywords epitope processing, escape

Notes

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 58173

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name OLP 47
Subtype CRF01_AE
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Thailand
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape

Notes

References

Mori2011 Masahiko Mori, Busarawan Sriwanthana, Nuanjun Wichukchinda, Chetsada Boonthimat, Naho Tsuchiya, Toshiyuki Miura, Panita Pathipvanich, Koya Ariyoshi, and Pathom Sawanpanyalert. Unique CRF01\_AE Gag CTL Epitopes Associated with Lower HIV-Viral Load and Delayed Disease Progression in a Cohort of HIV-Infected Thais. PLoS One, 6(8):e22680, 2011. PubMed ID: 21826201. Show all entries for this paper.


Displaying record number 61196

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human, mouse(B*57)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA), adenovirus
Vaccine strain B clade

Notes

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 58356

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication
Keywords escape, elite controllers

Notes

References

OConnell2011 Karen A. O'Connell, Robert W. Hegarty, Robert F. Siliciano, and Joel N. Blankson. Viral Suppression of Multiple Escape Mutants by De Novo CD8+ T Cell Responses in a Human Immunodeficiency Virus-1 Infected Elite Suppressor. Retrovirology, 8:63, 2011. PubMed ID: 21812985. Show all entries for this paper.


Displaying record number 58359

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name B57 TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection, in vitro stimulation or selection, vaccine
Country South Africa, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords vaccine antigen design

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine strain B clade, C clade
Vaccine component Gag

Notes

References

Ndhlovu2011 Zaza M. Ndhlovu, Alicja Piechocka-Trocha, Seanna Vine, Ashley McMullen, Kegakilwe C. Koofhethile, Phillip J. R. Goulder, Thumbi Ndung'u, Dan H. Barouch, and Bruce D. Walker. Mosaic HIV-1 Gag Antigens Can Be Processed and Presented to Human HIV-Specific CD8+ T Cells. J. Immunol., 186(12):6914-6924, 15 Jun 2011. PubMed ID: 21576505. Show all entries for this paper.


Displaying record number 58503

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 58556

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name B57-TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 62097

HXB2 Location Gag(240-249)
p24(108-117)
Gag Epitope Map
Author Location p24(240-249 NL4-3)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B*57)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design, viral fitness and reversion

Notes

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 53124

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 54217

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape

Notes

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.


Displaying record number 61563

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name B57-TW10(p24)
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Patient MHC/HLA MS: A*02, A*31, B*51, B*57; OP246: A*01, A*02, B*51, B*57, Cw*06; P1004: A*02, B*08, B*57, Cw*06, Cw*07; AC-43: A*24, A*31, B*14, B*57, Cw*07, Cw*08; AC-75: A*02, A*26, B*53, B*57, Cw*04, Cw*18; AC-38: A*01, A*03, B*07, B*57, Cw*06, Cw*07; AC-109: A*01, A*02, B*14, B*57, Cw*07, Cw*08
Country Canada, Germany, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords acute/early infection, protective allele

Notes

References

Altfeld2003a Marcus Altfeld, Marylyn M. Addo, Eric S. Rosenberg, Frederick M. Hecht, Paul K. Lee, Martin Vogel, Xu G. Yu, Rika Draenert, Mary N. Johnston, Daryld Strick, Todd M. Allen, Margaret E. Feeney, James O. Kahn, Rafick P. Sekaly, Jay A. Levy, Jürgen K. Rockstroh, Philip J. Goulder, and Bruce D. Walker. Influence of HLA-B57 on Clinical Presentation and Viral Control during Acute HIV-1 Infection. AIDS, 17(18):2581-2591, 5 Dec 2003. PubMed ID: 14685052. Show all entries for this paper.


Displaying record number 60346

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59310

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.


Displaying record number 54818

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-118)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Kenya, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords TCR usage, structure, characterizing CD8+ T cells

Notes

References

Gillespie2006 Geraldine M. A. Gillespie, Guillaume Stewart-Jones, Jaya Rengasamy, Tara Beattie, Job J. Bwayo, Francis A. Plummer, Rupert Kaul, Andrew J. McMichael, Philippa Easterbrook, Tao Dong, E. Yvonne Jones, and Sarah L. Rowland-Jones. Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection. J. Immunol., 177(6):3893-3902, 15 Sep 2006. PubMed ID: 16951352. Show all entries for this paper.


Displaying record number 59192

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117 NL4.3)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods In vitro proteasome digestion, Other
Keywords epitope processing

Notes

References

Kourjian2014 Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain, and Sylvie Le Gall. Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. J. Immunol., 192(8):3496-3506, 15 Apr 2014. PubMed ID: 24616479. Show all entries for this paper.


Displaying record number 55219

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(241-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Patient MHC/HLA A*310102, A*6603, B*440302, B*570301, Cw*040101, Cw*07
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords rate of progression, escape, viral fitness and reversion, drug resistance, elite controllers

Notes

References

Bailey2007 Justin R. Bailey, Haili Zhang, Barbara W. Wegweiser, Hung-Chih Yang, Laura Herrera, Aima Ahonkhai, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Evolution of HIV-1 in an HLA-B*57-Positive Patient during Virologic Escape. J. Infect. Dis., 196(1):50-55, 1 Jul 2007. PubMed ID: 17538883. Show all entries for this paper.


Displaying record number 55221

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(241-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Patient MHC/HLA A*310102, A*6603, B*440302, B*570301, Cw*040101, Cw*07
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords escape, viral fitness and reversion, drug resistance, elite controllers

Notes

References

Bailey2007 Justin R. Bailey, Haili Zhang, Barbara W. Wegweiser, Hung-Chih Yang, Laura Herrera, Aima Ahonkhai, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Evolution of HIV-1 in an HLA-B*57-Positive Patient during Virologic Escape. J. Infect. Dis., 196(1):50-55, 1 Jul 2007. PubMed ID: 17538883. Show all entries for this paper.


Displaying record number 59143

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 56159

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, compensatory mutation, elite controllers

Notes

References

Bailey2008 Justin R. Bailey, Karen O'Connell, Hung-Chih Yang, Yefei Han, Jie Xu, Benjamin Jilek, Thomas M. Williams, Stuart C. Ray, Robert F. Siliciano, and Joel N. Blankson. Transmission of Human Immunodeficiency Virus Type 1 from a Patient Who Developed AIDS to an Elite Suppressor. J. Virol., 82(15):7395-7410, Aug 2008. PubMed ID: 18495769. Show all entries for this paper.


Displaying record number 56341

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B, C
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Canada, South Africa
Experimental methods  
Keywords escape

Notes

References

Carlson2008 Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, Philippa Matthews, Carl Kadie, James I. Mullins, Bruce D. Walker, P. Richard Harrigan, Philip J. R. Goulder, and David Heckerman. Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag. PLoS Comput Biol, 4(11):e1000225, Nov 2008. PubMed ID: 19023406. Show all entries for this paper.


Displaying record number 57043

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL neutralization assay, Chromium-release assay, Other
Keywords elite controllers, neutralization by CTL

Notes

References

Chen2009a Huabiao Chen, Alicja Piechocka-Trocha, Toshiyuki Miura, Mark A. Brockman, Boris D. Julg, Brett M. Baker, Alissa C. Rothchild, Brian L. Block, Arne Schneidewind, Tomohiko Koibuchi, Florencia Pereyra, Todd M. Allen, and Bruce D. Walker. Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes. J. Virol., 83(7):3138-3149, Apr 2009. PubMed ID: 19158248. Show all entries for this paper.


Displaying record number 59131

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117 NL4.3)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infected monocyte-derived, HIV-1 infection
Country United States
Experimental methods Chromium-release assay, Other
Keywords epitope processing, dendritic cells

Notes

References

Dinter2014 Jens Dinter, Pauline Gourdain, Nicole Y. Lai, Ellen Duong, Edith Bracho-Sanchez, Marijana Rucevic, Paul H. Liebesny, Yang Xu, Mariko Shimada, Musie Ghebremichael, Daniel G. Kavanagh, and Sylvie Le Gall. Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition. J. Immunol., 193(9):4322-4334, 1 Nov 2014. PubMed ID: 25230751. Show all entries for this paper.


Displaying record number 57183

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape, acute/early infection, elite controllers

Notes

References

Schneidewind2009a Arne Schneidewind, Zabrina L. Brumme, Chanson J. Brumme, Karen A. Power, Laura L. Reyor, Kristin. O'Sullivan, Adrianne Gladden, Ursula Hempel, Thomas Kuntzen, Yaoyu E. Wang, Cesar Oniangue-Ndza, Heiko Jessen, Martin Markowitz, Eric S. Rosenberg, Rafick-Pierre Sékaly, Anthony D. Kelleher, Bruce D. Walker, and Todd M. Allen. Transmission and Long-Term Stability of Compensated CD8 Escape Mutations. J. Virol., 83(8):3993-3997, Apr 2009. PubMed ID: 19091871. Show all entries for this paper.


Displaying record number 59115

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype CRF01_AE
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Patient MHC/HLA N094: A*0201, A*3201, B*1302, B*1401, Cw*0602, Cw*0802; N107: A*0201, A*0201, B*2705, B*5701, Cw*0102, Cw*0602
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords rate of progression

Notes

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.


Displaying record number 57244

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Barbados, Haiti, Jamaica
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords mother-to-infant transmission, elite controllers

Notes

References

Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.


Displaying record number 57349

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART, supervised treatment interruptions (STI), early treatment, elite controllers

Notes

References

Streeck2009 Hendrik Streeck, Heiko Jessen, Claudia Kuecherer, Bin Li, Arne B. Jessen, Stephan Dupke, Axel Baumgarten, Ingrid Stahmer, Jan van Lunzen, Marcus Altfeld, Bruce D. Walker, and Todd M. Allen. Epidemiologically Linked Transmission of HIV-1 Illustrates the Impact of Host Genetics on Virological Outcome. AIDS, 23(2):259-262, 14 Jan 2009. PubMed ID: 19098497. Show all entries for this paper.


Displaying record number 58972

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(240-249 NL4-3)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen in vitro stimulation or selection
Experimental methods CTL suppression of replication, In vitro proteasome digestion, Other
Keywords epitope processing, class I down-regulation by Nef, kinetics

Notes

References

Balamurugan2013 Arumugam Balamurugan, Ayub Ali, Julie Boucau, Sylvie Le Gall, Hwee L. Ng, and Otto O. Yang. HIV-1 Gag Cytotoxic T Lymphocyte Epitopes Vary in Presentation Kinetics Relative to HLA Class I Downregulation. J. Virol., 87(15):8726-8734, Aug 2013. PubMed ID: 23740989. Show all entries for this paper.


Displaying record number 57380

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 57382

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape, acute/early infection

Notes

References

Durand2010 Christine M. Durand, Karen A. O'Connell, Linda G. Apuzzo, Susan J. Langan, Hejab Imteyaz, Aima A. Ahonkhai, Christina M. Ceccato, Thomas M. Williams, Joseph B. Margolick, and Joel N. Blankson. HIV-1 Gag Evolution in Recently Infected Human Leukocyte Antigen-B*57 Patients with Low-Level Viremia. AIDS, 24(15):2405-2408, 24 Sep 2010. PubMed ID: 20671542. Show all entries for this paper.


Displaying record number 57418

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.


Displaying record number 58769

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name Gag-TW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 57648

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods Relative replication capacity assay
Keywords escape, acute/early infection, HLA associated polymorphism, elite controllers

Notes

References

Miura2010 Toshiyuki Miura, Zabrina L. Brumme, Mark A. Brockman, Pamela Rosato, Jennifer Sela, Chanson J. Brumme, Florencia Pereyra, Daniel E. Kaufmann, Alicja Trocha, Brian L. Block, Eric S. Daar, Elizabeth Connick, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, Martin Markowitz, Kim Schafer, Florin Vaida, Aikichi Iwamoto, Susan Little, and Bruce D. Walker. Impaired Replication Capacity of Acute/Early Viruses in Persons Who Become HIV Controllers. J. Virol., 84(15):7581-7591, Aug 2010. PubMed ID: 20504921. Show all entries for this paper.


Displaying record number 57693

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Buranapraditkun2011 Supranee Buranapraditkun, Ursula Hempel, Patrawadee Pitakpolrat, Rachel L. Allgaier, Pattarawat Thantivorasit, Sven-Iver Lorenzen, Sunee Sirivichayakul, William H. Hildebrand, Marcus Altfeld, Christian Brander, Bruce D. Walker, Praphan Phanuphak, Pokrath Hansasuta, Sarah L. Rowland-Jones, Todd M. Allen, and Kiat Ruxrungtham. A Novel Immunodominant CD8+ T Cell Response Restricted by a Common HLA-C Allele Targets a Conserved Region of Gag HIV-1 clade CRF01\_AE Infected Thais. PLoS One, 6(8):e23603, 2011. PubMed ID: 21887282. Show all entries for this paper.


Displaying record number 61475

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag( NL4-3)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods Other
Keywords escape, structure, viral fitness and reversion

Notes

References

Schommers2016 P. Schommers, G. Martrus, U. Matschl, M. Sirignano, M. Lütgehetmann, L. Richert, T. J. Hope, G. Fätkenheuer, and M. Altfeld. Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations. J. Virol., 90(16):7579-7586, 15 Aug 2016. PubMed ID: 27279617. Show all entries for this paper.


Displaying record number 60643

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW-10
Subtype B, C
Species (MHC/HLA) human(B*57, B*5701, B*5703, B*58, B*5801, B*63)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 57593

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) (B*57, B*58)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 56378

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57, B*58)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, mutation acquisition, viral fitness and reversion, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 54619

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57, B*58)
Immunogen HIV-1 infection
Country Switzerland
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, viral fitness and reversion, HLA associated polymorphism, elite controllers

Notes

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 54216

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection, in vitro stimulation or selection
Experimental methods Other
Keywords escape, viral fitness and reversion

Notes

References

Martinez-Picado2006 Javier Martinez-Picado, Julia G. Prado, Elizabeth E. Fry, Katja Pfafferott, Alasdair Leslie, Senica Chetty, Christina Thobakgale, Isobel Honeyborne, Hayley Crawford, Philippa Matthews, Tilly Pillay, Christine Rousseau, James I. Mullins, Christian Brander, Bruce D. Walker, David I. Stuart, Photini Kiepiela, and Philip Goulder. Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1. J. Virol., 80(7):3617-3623, Apr 2006. PubMed ID: 16537629. Show all entries for this paper.


Displaying record number 57188

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(239-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Patient MHC/HLA B*27, B57; B*27, B*5801; B*57; B*57; B*57
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, autologous responses, elite controllers

Notes

References

OConnell2010 Karen A. O'Connell, Timothy P. Brennan, Justin R. Bailey, Stuart C. Ray, Robert F. Siliciano, and Joel N. Blankson. Control of HIV-1 in Elite Suppressors Despite Ongoing Replication and Evolution in Plasma Virus. J. Virol., 84(14):7018-7028, Jul 2010. PubMed ID: 20444904. Show all entries for this paper.


Displaying record number 57353

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Relative replication capacity assay
Keywords escape, mutation acquisition, elite controllers

Notes

References

Miura2009a Toshiyuki Miura, Mark A. Brockman, Arne Schneidewind, Michael Lobritz, Florencia Pereyra, Almas Rathod, Brian L. Block, Zabrina L. Brumme, Chanson J. Brumme, Brett Baker, Alissa C. Rothchild, Bin Li, Alicja Trocha, Emily Cutrell, Nicole Frahm, Christian Brander, Ildiko Toth, Eric J. Arts, Todd M. Allen, and Bruce D. Walker. HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition. J Virol, 83(6):2743-2755, Mar 2009. PubMed ID: 19116253. Show all entries for this paper.


Displaying record number 54287

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(1513-)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA associated polymorphism

Notes

References

Bhattacharya2007 Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber. Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations. Science, 315(5818):1583-1586, 16 Mar 2007. PubMed ID: 17363674. Show all entries for this paper.


Displaying record number 52083

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Migueles2001 Stephen A. Migueles and Mark Connors. Frequency and Function of HIV-Specific CD8(+) T Cells. Immunol. Lett., 79(1-2):141-150, 1 Nov 2001. PubMed ID: 11595301. Show all entries for this paper.


Displaying record number 52087

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Migueles2001 Stephen A. Migueles and Mark Connors. Frequency and Function of HIV-Specific CD8(+) T Cells. Immunol. Lett., 79(1-2):141-150, 1 Nov 2001. PubMed ID: 11595301. Show all entries for this paper.


Displaying record number 220

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(240-249 LAI)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 55004

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TST
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, TCR usage, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


Displaying record number 56673

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*2301, B*1402, B*5701, Cw*0701, Cw*0802
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords escape, acute/early infection

Notes

References

Goonetilleke2009 Nilu Goonetilleke, Michael K. P. Liu, Jesus F. Salazar-Gonzalez, Guido Ferrari, Elena Giorgi, Vitaly V. Ganusov, Brandon F. Keele, Gerald H. Learn, Emma L. Turnbull, Maria G Salazar, Kent J Weinhold, Stephen Moore, CHAVI Clinical Core B, Norman Letvin, Barton F. Haynes, Myron S. Cohen, Peter Hraber, Tanmoy Bhattacharya, Persephone Borrow, Alan S. Perelson, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, and Andrew J. McMichael. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med., 206(6):1253-1272, 8 Jun 2009. PubMed ID: 19487423. Show all entries for this paper.


Displaying record number 57379

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10 wt
Species (MHC/HLA) human(B*5701)
Immunogen in vitro stimulation or selection, peptide-HLA interaction
Country United States
Experimental methods Other
Keywords binding affinity, escape

Notes

References

Yang2010 Yue Yang, Jinghe Huang, Ildiko Toth, Mathias Lichterfeld, and Xu G. Yu. Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors. PLoS One, 5(12):e15084, 2010. PubMed ID: 21170342. Show all entries for this paper.


Displaying record number 57857

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords rate of progression, early treatment

Notes

References

Cellerai2011 Cristina Cellerai, Alexandre Harari, Hans Stauss, Sabine Yerly, Anna-Maria Geretti, Anne Carroll, Thynn Yee, Jonathan Ainsworth, Ian Williams, John Sweeney, Andrew Freedman, Margaret Johnson, Giuseppe Pantaleo, and Sabine Kinloch-de Loes. Early and Prolonged Antiretroviral Therapy Is Associated with an HIV-1-Specific T-Cell Profile Comparable to That of Long-Term Non-Progressors. PLoS One, 6(4):e18164, 2011. PubMed ID: 21483676. Show all entries for this paper.


Displaying record number 57913

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Species (MHC/HLA) human(B*5701)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords  

Notes

References

Fadda2011 Lena Fadda, Geraldine M. O'Connor, Swati Kumar, Alicja Piechocka-Trocha, Clair M. Gardiner, Mary Carrington, Daniel W. McVicar, and Marcus Altfeld. Common HIV-1 Peptide Variants Mediate Differential Binding of KIR3DL1 to HLA-Bw4 Molecules. J Virol, 85(12):5970-5974, Jun 2011. PubMed ID: 21471246. Show all entries for this paper.


Displaying record number 58229

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*2301, B*1402, B*5701, Cw*0701, Cw*0802
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords escape, acute/early infection, autologous responses, characterizing CD8+ T cells

Notes

References

Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.


Displaying record number 58842

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*0301, B*2705, B*5701; A*0101, A*2402, B*4002, B*5701; A*2402, A*3201, B*4002, B*5701; A*0101, A*0201, B*5101, B*5701; A*0101, A*0101, B*0801, B*5701; A*0301, A*2402, B*3501, B*5701
Country United States
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression

Notes

References

Norstrom2012 Melissa M. Norström, Marcus Buggert, Johanna Tauriainen, Wendy Hartogensis, Mattia C. Prosperi, Mark A. Wallet, Frederick M. Hecht, Marco Salemi, and Annika C. Karlsson. Combination of Immune and Viral Factors Distinguishes Low-Risk Versus High-Risk HIV-1 Disease Progression in HLA-B*5701 Subjects. J. Virol., 86(18):9802-9816, Sep 2012. PubMed ID: 22761389. Show all entries for this paper.


Displaying record number 58973

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 59166

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name gag 240-249
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 59210

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA P1: B*5701; P2: B*5701; P3: B*5701; P4: B*5701; P5: B*5701; P6: B*5701
Country United States
Experimental methods Other
Keywords elite controllers

Notes

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 61015

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA 21746: A*0101, A*4801, B*4001, B*5701, Cw*0304, Cw*0602; 44091: A*0201, A*2401, B*4401, B*5701, Cw*0501, Cw*6002
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 61652

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods Other
Keywords binding affinity, structure, HLA associated polymorphism, NK cells, contact residues

Notes

References

Pymm2017 Phillip Pymm, Patricia T. Illing, Sri H. Ramarathinam, Geraldine M. O'Connor, Victoria A. Hughes, Corinne Hitchen, David A. Price, Bosco K. Ho, Daniel W. McVicar, Andrew G. Brooks, Anthony W. Purcell, Jamie Rossjohn, and Julian P. Vivian. MHC-I Peptides Get out of the Groove and Enable a Novel Mechanism of HIV-1 Escape. Nat. Struct. Mol. Biol., 24(4):387-394, Apr 2017. PubMed ID: 28218747. Show all entries for this paper.


Displaying record number 61670

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-171)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Species (MHC/HLA) human(B*5701)
Immunogen peptide-HLA interaction
Experimental methods Other, Tetramer binding
Keywords structure, NK cells, protective allele

Notes

References

OConnor2015 Geraldine M. O'Connor, Julian P. Vivian, Emma Gostick, Phillip Pymm, Bernard A. P. Lafont, David A. Price, Jamie Rossjohn, Andrew G. Brooks, and Daniel W. McVicar. Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1. J. Virol., 89(10):5213-5221, May 2015. PubMed ID: 25740999. Show all entries for this paper.


Displaying record number 59315

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen HIV-1 infection
Experimental methods In vitro proteasome digestion, Intracellular cytokine staining, Tap-binding assay
Keywords subtype comparisons, epitope processing, rate of progression

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 59194

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*5701, B*58)
Immunogen HIV-1 infection
Patient MHC/HLA CH058: A*0101, A*2301, B*1402, B*57, Cw*0701, Cw*0802; CH077: A*0205, B*5301, B*57, Cw*0401, Cw*1801; CH040: A*0201, A*3101, B*4001, B*4402, Cw*0302, Cw*0501; CH131: A*2301, A*29, B*1503, B*4501, Cw*0202, Cw*0602; CH470: A*0101, A*0301, B*0801, B*4901, Cw*0701
Country Malawi, United States
Experimental methods Relative replication capacity assay
Keywords escape, viral fitness and reversion, compensatory mutation

Notes

References

Liu2014a Donglai Liu, Tao Zuo, Bhavna Hora, Hongshuo Song, Wei Kong, Xianghui Yu, Nilu Goonetilleke, Tanmoy Bhattacharya, Alan S. Perelson, Barton F. Haynes, Andrew J. McMichael, and Feng Gao. Preexisting Compensatory Amino Acids Compromise Fitness Costs of a HIV-1 T Cell Escape Mutation. Retrovirology, 11:101, 2014. PubMed ID: 25407514. Show all entries for this paper.


Displaying record number 61630

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country Barbados, Botswana, Spain, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Relative replication capacity assay, TCR binding
Keywords subtype comparisons, variant cross-reactivity

Notes

References

Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.


Displaying record number 57442

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TST
Species (MHC/HLA) human(B*5703)
Immunogen peptide-HLA interaction
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords structure

Notes

References

Stewart-Jones2005 Guillaume B. E. Stewart-Jones, Geraldine Gillespie, Ian M. Overton, Rupert Kaul, Philippe Roche, Andrew J. McMichael, Sarah Rowland-Jones, and E. Yvonne Jones. Structures of Three HIV-1 HLA-B*5703-Peptide Complexes and Identification of Related HLAs Potentially Associated with Long-Term Nonprogression. J. Immunol., 175(4):2459-2468, 15 Aug 2005. PubMed ID: 16081817. Show all entries for this paper.


Displaying record number 57846

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords acute/early infection, NK cells

Notes

References

Brackenridge2011 Simon Brackenridge, Edward J. Evans, Mireille Toebes, Nilu Goonetilleke, Michael K. P. Liu, Kati di Gleria, Ton N. Schumacher, Simon J. Davis, Andrew J. McMichael, and Geraldine M. Gillespie. An Early HIV Mutation within an HLA-B*57-Restricted T Cell Epitope Abrogates Binding to the Killer Inhibitory Receptor 3DL1. J. Virol., 85(11):5415-5422, Jun 2011. PubMed ID: 21430058. Show all entries for this paper.


Displaying record number 62154

HXB2 Location Gag(240-249)
p24(108-117)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Subtype D
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country Uganda
Experimental methods HLA binding, Relative replication capacity assay
Keywords escape, HLA associated polymorphism, subtype comparisons

Notes

References

Kinloch2019 Natalie N. Kinloch, Guinevere Q. Lee, Jonathan M. Carlson, Steven W. Jin, Chanson J. Brumme, Helen Byakwaga, Conrad Muzoora, Mwebesa B. Bwana, Kyle D. Cobarrubias, Peter W. Hunt, Jeff N. Martin, Mary Carrington, David R. Bangsberg, P. Richard Harrigan, Mark A. Brockman, and Zabrina L. Brumme. Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity. J Virol, 93(1):JVI01502-18 doi, Jan 2019. PubMed ID: 30305354 Show all entries for this paper.


Displaying record number 1552

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(240-249 SF2)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human(B58)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 56051

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10(p24)
Subtype B
Species (MHC/HLA) human(B58)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 1821

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B58)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Goulder2001b P. J. Goulder, C. Pasquier, E. C. Holmes, B. Liang, Y. Tang, J. Izopet, K. Saune, E. S. Rosenberg, S. K. Burchett, K. McIntosh, M. Barnardo, M. Bunce, B. D. Walker, C. Brander, and R. E. Phillips. Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation. Immunol. Lett., 79(1-2):109-16, 1 Nov 2001. PubMed ID: 11595297. Show all entries for this paper.


Displaying record number 62113

HXB2 Location Gag(240-249)
p24(108-117)
Gag Epitope Map
Author Location p24(240-249 NL4-3)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B*58)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design, viral fitness and reversion

Notes

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 225

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B
Species (MHC/HLA) human(B*58)
Immunogen HIV-1 or HIV-2 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, rate of progression, immunodominance, variant cross-reactivity, HIV-2

Notes

References

Bertoletti1998 A. Bertoletti, F. Cham, S. McAdam, T. Rostron, S. Rowland-Jones, S. Sabally, T. Corrah, K. Ariyoshi, and H. Whittle. Cytotoxic T cells from human immunodeficiency virus type 2-infected patients frequently cross-react with different human immunodeficiency virus type 1 clades. J. Virol., 72:2439-2448, 1998. PubMed ID: 9499105. Show all entries for this paper.

Goulder1996 P. J. R. Goulder, M. Bunce, P. Krausa, K. McIntyre, S. Crowley, B. Morgan, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Novel, Cross-Restricted, Conserved and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow HIV Type 1 Infection. AIDS Res. Hum. Retroviruses, 12:1691-1698, 1996. HLA-B*57 is over-represented in slow progressors. HLA*5801 is a closely related molecule, and while the defined anchor residues of HLA*5801 can be used to predict epitopes in HIV-1 proteins, the CTL from HLA-B*57 positive individuals have limited cross-presentation capacity with HLA*5801 targets. In this paper five new HLA-B*57 epitopes were defined. PubMed ID: 8959245. Show all entries for this paper.


Displaying record number 57186

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Patient MHC/HLA A*300101, A*680101, B*5801, B*5802
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection, mutation acquisition, elite controllers

Notes

References

OConnell2009 Karen A. O'Connell, Jie Xu, Anna P. Durbin, Linda G. Apuzzo, Hejab Imteyaz, Thomas M. Williams, Stuart C. Ray, Joseph B. Margolick, Robert F. Siliciano, and Joel N. Blankson. HIV-1 Evolution Following Transmission to an HLA-B*5801-Positive Patient. J. Infect. Dis., 200(12):1820-1824, 15 Dec 2009. PubMed ID: 19909081. Show all entries for this paper.


Displaying record number 61773

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining
Keywords vaccine-induced immune responses, variant cross-reactivity

Notes

References

Murakoshi2018 Hayato Murakoshi, Chengcheng Zou, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. CD8+ T Cells Specific for Conserved, Cross-Reactive Gag Epitopes with Strong Ability to Suppress HIV-1 Replication. Retrovirology, 15(1):46, 3 Jul 2018. PubMed ID: 29970102. Show all entries for this paper.


Displaying record number 54747

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human(B*5801)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords binding affinity

Notes

References

Gillespie2007 Geraldine M. A. Gillespie, Arman Bashirova, Tao Dong, Daniel W. McVicar, Sarah L. Rowland-Jones, and Mary Carrington. Lack of KIR3DS1 Binding to MHC Class I Bw4 Tetramers in Complex with CD8+ T Cell Epitopes. AIDS Res. Hum. Retroviruses, 23(3):451-455, Mar 2007. PubMed ID: 17411378. Show all entries for this paper.


Displaying record number 60347

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54402

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(1513-)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA associated polymorphism

Notes

References

Bhattacharya2007 Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber. Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations. Science, 315(5818):1583-1586, 16 Mar 2007. PubMed ID: 17363674. Show all entries for this paper.


Displaying record number 53713

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TSTL
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Country Gambia
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells, HIV-2

Notes

References

Gillespie2005a Geraldine M. A. Gillespie, Susana Pinheiro, Mohammad Sayeid-Al-Jamee, Abraham Alabi, Steve Kaye, Sehu Sabally, Ramu Sarge-Njie, Harr Njai, Ken Joof, Assan Jaye, Hilton Whittle, Sarah Rowland-Jones, and Lucy Dorrell. CD8+ T Cell Responses to Human Immunodeficiency Viruses Type 2 (HIV-2) and Type 1 (HIV-1) Gag Proteins are Distinguishable by Magnitude and Breadth but not Cellular Phenotype. Eur. J. Immunol., 35(5):1445-1453, May 2005. PubMed ID: 15832290. Show all entries for this paper.


Displaying record number 62001

HXB2 Location Gag(240-249)
p24(108-117)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Epitope Name TW10
Species (MHC/HLA) human(B*5801)
Immunogen peptide-HLA interaction
Experimental methods Other
Keywords structure, protective allele

Notes

References

Li2017b Xiaolong Li, Pedro A. Lamothe, Bruce D. Walker, and Jia-Huai Wang. Crystal Structure of HLA-B*5801 with a TW10 HIV Gag Epitope Reveals a Novel Mode of Peptide Presentation. Cell. Mol. Immunol., 14(7):631-634, Jul 2017. PubMed ID: 28552904. Show all entries for this paper.


Displaying record number 1154

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(240-249 LAI)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54671

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HAART, ART, escape, viral fitness and reversion

Notes

References

Asquith2006 Becca Asquith, Charles T. T. Edwards, Marc Lipsitch, and Angela R. McLean. Inefficient Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo. PLoS Biol., 4(4):e90, Apr 2006. PubMed ID: 16515366. Show all entries for this paper.


Displaying record number 60349

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag(240-249)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human(C*17)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62167

HXB2 Location Gag(240-249)
p24(108-117)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Carlson2015 Jonathan M. Carlson, Anh Q. Le, Aniqa Shahid, and Zabrina L. Brumme. HIV-1 adaptation to HLA: a window into virus-host immune interactions. Trends Microbiol, 23(4):212-24 doi, Apr 2015. PubMed ID: 25613992 Show all entries for this paper.


Displaying record number 57555

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords escape, acute/early infection

Notes

References

Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.


Displaying record number 61641

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Canada
Experimental methods Chromium-release assay, Other
Keywords epitope processing, escape

Notes

References

Zhang2012 Shao Chong Zhang, Eric Martin, Mariko Shimada, Sasha Blue Godfrey, Jennifer Fricke, Shirley Locastro, Nicole Y. Lai, Paul Liebesny, Jonathan M. Carlson, Chanson J. Brumme, Oluwatobi Awele Ogbechie, Huabiao Chen, Bruce D. Walker, Zabrina L. Brumme, Daniel G. Kavanagh, and Sylvie Le Gall. Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals. J. Immunol., 188(12):5924-5934, 15 Jun 2012. PubMed ID: 22586036. Show all entries for this paper.


Displaying record number 57352

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Epitope Name TW10
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords escape, elite controllers

Notes

References

Miura2009b Toshiyuki Miura, Chanson J. Brumme, Mark A. Brockman, Zabrina L. Brumme, Florencia Pereyra, Brian L. Block, Alicja Trocha, Mina John, Simon Mallal, P. Richard Harrigan, and Bruce D. Walker. HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers. J Virol, 83(7):3407-3412, Apr 2009. PubMed ID: 19153230. Show all entries for this paper.


Displaying record number 54909

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location  
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*2902; B*1501, B*5701
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


Displaying record number 61339

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location Gag
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Species (MHC/HLA) human
Immunogen vaccine
Country Australia, Brazil, Canada, Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, assay or method development, optimal epitope

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine component Gag, Nef, Pol

Notes

References

Fiore-Gartland2016 Andrew Fiore-Gartland, Bryce A. Manso, David P. Friedrich, Erin E. Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C. De Rosa, Nicole Frahm, Peter B. Gilbert, and M Juliana McElrath. Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. PLoS One, 11(2):e0147812, 2016. PubMed ID: 26863315. Show all entries for this paper.


Displaying record number 61061

HXB2 Location Gag(240-249)
p24(108-117)
DNA(1507..1536)
Gag Epitope Map
Author Location p24(108-117)
Epitope TSTLQEQIGW Epitope Alignment
TSTLQEQIGW epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA CH058: A*0101, A*2301, B*1402, B*57, Cw*0701, Cw*0802
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords computational epitope prediction, escape, acute/early infection, mutation acquisition

Notes

References

Barton2016 John P. Barton, Nilu Goonetilleke, Thomas C. Butler, Bruce D. Walker, Andrew J. McMichael, and Arup K. Chakraborty. Relative Rate and Location of Intra-Host HIV Evolution to Evade Cellular Immunity Are Predictable. Nat. Commun., 7:11660, 23 May 2016. PubMed ID: 27212475. Show all entries for this paper.


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