Search CTL/CD8+ T-Cell Epitope Database

Found 11 matching records:

Displaying record number 60343

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HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef(133-141)
Epitope	`TRYPLTFGW`	Epitope Alignment
Epitope Name	TW9
Species (MHC/HLA)	human(A*03)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
TRYPLTFGW had a significantly positive association with HLA A*03; it was recognized by 8/44 A*03-positive subjects and 3/126 A*03-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 60341

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HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef(133-141)
Epitope	`TRYPLTFGW`	Epitope Alignment
Epitope Name	TW9
Species (MHC/HLA)	human(A*23)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
TRYPLTFGW had a significantly positive association with HLA A*23; it was recognized by 11/19 A*23-positive subjects and 41/241 A*23-negative subjects.

References

Displaying record number 60338

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HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef(133-141)
Epitope	`TRYPLTFGW`	Epitope Alignment
Epitope Name	TW9
Species (MHC/HLA)	human(A*24)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
TRYPLTFGW had a significantly positive association with HLA A*24; it was recognized by 12/25 A*24-positive subjects and 17/190 A*24-negative subjects.

References

Displaying record number 60344

Download this epitope record as JSON.

HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef(133-141)
Epitope	`TRYPLTFGW`	Epitope Alignment
Epitope Name	TW9
Species (MHC/HLA)	human(A*29)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
TRYPLTFGW had a significantly positive association with HLA A*29; it was recognized by 6/20 A*29-positive subjects and 11/170 A*29-negative subjects.

References

Displaying record number 56401

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HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef(133-141)
Epitope	`TRYPLTFGW`	Epitope Alignment
Epitope Name	TW9
Subtype	B
Species (MHC/HLA)	human(A*33)
Immunogen	HIV-1 infection
Country	Australia, Canada, Germany, United States
Experimental methods
Keywords	HLA associated polymorphism

Notes

98 newly infected patients were studied to track early host HLA and Gag/Pol/Nef epitope immune responses' association with viral evolution. Response hierarchies were the same as those for later infection, and 50% of the most rapidly substituting epitopes were restricted by protective HLA, e.g. Gag B*57-associated mutations which were the most rapidly reverting upon transmission to a non-B*57-host. While there are great differences in mutation rates and reversions across the HIV proteome, most early viral change is driven by immune pressure.
HLA-driven epitope evolution was seen in 80% of published CTL epitopes.
HLA-A*33-associated substitution within optimally defined epitope TRYPLTFGW is at position Y3, TRyPLTFGW.

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.

Displaying record number 52545

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HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef(133-141)
Epitope	`TRYPLTFGW`	Epitope Alignment
Species (MHC/HLA)	human(A33)
Immunogen	HIV-1 infection
Experimental methods
Keywords	optimal epitope, A-list

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 60340

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HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef(133-141)
Epitope	`TRYPLTFGW`	Epitope Alignment
Epitope Name	TW9
Species (MHC/HLA)	human(A*68:02)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
TRYPLTFGW had a significantly positive association with HLA A*6802; it was recognized by 14/24 A*6802-positive subjects and 52/260 A*6802-negative subjects.

References

Displaying record number 60339

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HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef(133-141)
Epitope	`TRYPLTFGW`	Epitope Alignment
Epitope Name	TW9
Species (MHC/HLA)	human(B*18)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
TRYPLTFGW had a significantly positive association with HLA B*18; it was recognized by 14/20 B*18-positive subjects and 66/284 B*18-negative subjects.

References

Displaying record number 60342

Download this epitope record as JSON.

HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef(133-141)
Epitope	`TRYPLTFGW`	Epitope Alignment
Epitope Name	TW9
Species (MHC/HLA)	human(B35:01, B35:08)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
TRYPLTFGW had a significantly positive association with HLA B*3501,B*3508; it was recognized by 12/26 B*3501,B*3508-positive subjects and 29/215 B*3501,B*3508-negative subjects.

References

Displaying record number 60337

Download this epitope record as JSON.

HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef(133-141)
Epitope	`TRYPLTFGW`	Epitope Alignment
Epitope Name	TW9
Species (MHC/HLA)	human(B35:02, B35:03, B*53:01)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
TRYPLTFGW had a significantly positive association with HLA B*3502,B*3503,B*5301; it was recognized by 26/37 B*3502,B*3503,B*5301-positive subjects and 80/304 B*3502,B*3503,B*5301-negative subjects.

References

Displaying record number 60345

Download this epitope record as JSON.

HXB2 Location	Nef(133-141) DNA(9193..9219)	Nef Epitope Map
Author Location	Nef(133-141)
Epitope	`TRYPLTFGW`	Epitope Alignment
Epitope Name	TW9
Species (MHC/HLA)	human(B*42:01)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
TRYPLTFGW had a significantly positive association with HLA B*4201; it was recognized by 2/5 B*4201-positive subjects and 1/121 B*4201-negative subjects.