Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 54286

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HXB2 Location	Pol(147-155) Protease(91-99) DNA(2523..2549)	Pol Epitope Map
Author Location	Pol(2529-)
Epitope	`TQIGCTLNF`	Epitope Alignment
Epitope Name	B*1501 TF9
Subtype	B, C, CRF01_AE
Species (MHC/HLA)	human(B*15:01)
Immunogen	HIV-1 infection
Country	Australia
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, HLA associated polymorphism

Notes

Host HLA associated mutational patterns in HIV can be a consequence of immune escape, but to cleanly resolve whether or not such patterns are the result of lineage effects or immune pressure, it is helpful to incorporate the phylogenetic history of the virus into the test statistics. Most of the HLA associations that appeared to result from immune escape in an earlier study (Moore et al., Science 296:1439 2002) were found to be a consequence of the phylogenetic history of the virus, not immune escape. Other HLA associations were validated, and some additional HLA-associated mutations were identified through incorporating the viral phylogenetic tree in the analysis.
The mutational pattern in the third position in this epitope TQiGCTLNF, is correlated with the host carrying HLA B*1501.
This epitope was experimentally tested using Interferon-g Elispot and functional avidity studies. For one of six patients tested, the form TQ(L)GCTLNF showed decreased functional avidity relative to TQiGCTLNF. In all other patients, the form TQ(L)GCTLNF had greater functional avidity than the form TQiGCTLNF.

References

Bhattacharya2007 Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber. Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations. Science, 315(5818):1583-1586, 16 Mar 2007. PubMed ID: 17363674. Show all entries for this paper.

Displaying record number 55070

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HXB2 Location	Pol(147-155) Protease(91-99) DNA(2523..2549)	Pol Epitope Map
Author Location	Protease
Epitope	`TQIGCTLNF`	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(B*15:03)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, rate of progression, immunodominance

Notes

CTL responses restricted by HLA-B*1503 were analyzed in HIV-1 subtype B and C-infected patients. An association between HLA-B*1503 and reduced viral loads in individuals infected with clade B was found. No such correlation was found in clade C infected subjects inspite of the same immunodominant responses in subjects infected with either subtype. Clade B viral control was associated with several subdominanat CTL epitopes lacking in clade C, suggesting that subdominant responses can contribute to viral control.
TQIGCTLNF of clade B is a potential HLA-B*1503-restricted epitope, with epitope TQlGCTLNF found in clade C.

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.

Displaying record number 63033

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HXB2 Location	Pol(147-155) Protease(91-99)	Pol Epitope Map
Author Location	( SUMA)
Epitope	`TQIGCTLNF`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	SUMA: A11:03, A24:02, B14:02, B15:01, C08:02, C12:03
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	dynamics, acute/early infection, autologous responses

Notes

Yang2019 developed mathematical models with the Jones2004 dataset & concluded that, in general, relative CTL response breadth increased moderately during the first symptomatic month and then remained relatively stable through the first 400 days post-infection. Analysis also suggested slow expansion kinetics for most HIV-specific CTL responses and the presence of intra- and interclonal competition.
The patient SUMA maintained low viral loads and stable CD4 T cell counts through seven years of follow up. In contrast to more rapid progressors, WEAU and BORI, SUMA had a broader response, with little immunodominance.
The dynamics of a TQIGCTLNF-specific CTL response in patient SUMA are shown in Fig. S1 of Yang2019 but this response was not published in Jones2004.

References

Jones2004 Nicola A. Jones, Xiping Wei, Darren R. Flower, MaiLee Wong, Franziska Michor, Michael S. Saag, Beatrice H. Hahn, Martin A. Nowak, George M. Shaw, and Persephone Borrow. Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med., 200(10):1243-1256, 15 Nov 2004. PubMed ID: 15545352. Show all entries for this paper.

Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.