Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 1040

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HXB2 Location	Nef(117-128) DNA(9145..9180)	Nef Epitope Map
Author Location	Nef(117-128 BRU)
Epitope	TQGYFPDWQNYT	Epitope Alignment
Species (MHC/HLA)	human(B17, B37)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• Nef CTL clones from HIV+ donors.

References

Culmann1991 B. Culmann, E. Gomard, M.-P. Kieny, B. Guy, F. Dreyfus, A.-D. Saimot, D. Sereni, D. Sicard, and J.-P. Levy. Six Epitopes with Human Cytotoxic CD8+ Cells in the Central Region of the HIV-1 Nef Protein. J. Immunol., 146:1560-1565, 1991. Nef-specific CTL were generated from six seropositive donors. Six epitopes were defined, all localized to two regions in the central part of Nef. Some epitopes could be recognized in the contexts of several HLA class I molecules. Peptides were based on BRU epitopes: QVPLRPMTYK, HLA A3, A11, B35; AAVDLSHFLKEK, HLA A11; HTQGYFPQWQ, HLA B17;TQGYFPQWQNYT, HLA B17, B37, NYTPGPGVRYPLT, HLA B7; and GVRYPLTFGWCYKLVP, HLA B18). PubMed ID: 1704397. Show all entries for this paper.

Displaying record number 61661

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HXB2 Location	Nef(117-128) DNA(9145..9180)	Nef Epitope Map
Author Location	Nef(117-128)
Epitope	TQGYFPDWQNYT	Epitope Alignment
Epitope Name	TT12
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	AC1: A*02:01, A*30:01, B*37:01, B*38:01, C*06:02, C*12:03; VP1: A*02:01, A*03:01, B*41:01, B*52:01, C*03:03, C*17:01
Country	United States
Experimental methods	Other, Relative replication capacity assay
Keywords	NK cells, transmission pair

Notes

• A transmission pair were studied to compare fitness of HIV isolates between the partners. Virus from both subjects were replication competent and transmissible. The female recipient of virus did not have known protective HLA but protective KIR alleles and was a controller with <100 copies virus/ml during acute infection. Suppressive capacity of her CTLs did not change, but there was a marked decrease in NK cell reponse with the onset of viremic breakthrough at 9 months.
• Nef (117-128) TT12, TQGYFPDWQNYT, was present in transmitting subject, VP1 and recipient pre- and post-loss of viremic control. No variant was detected. Presumed restricting allele was B*37.

References

Walker-Sperling2017 Victoria E. Walker-Sperling, Christopher W. Pohlmeyer, Rebecca T. Veenhuis, Megan May, Krystle A. Luna, Allison R. Kirkpatrick, Oliver Laeyendecker, Andrea L. Cox, Mary Carrington, Justin R. Bailey, Roberto C. Arduino, and Joel N. Blankson. Factors Associated with the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller. EBioMedicine, 16:141-149, Feb 2017. PubMed ID: 28159573. Show all entries for this paper.