HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 24 matching records:

Displaying record number 60329

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60330

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60334

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11
Species (MHC/HLA) human(A*31)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60335

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11
Species (MHC/HLA) human(A*66)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62495

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11
Species (MHC/HLA) human(B*15)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay
Keywords assay or method development, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Balamurugan2018 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones. J. Virol., 92(16), 15 Aug 2018. PubMed ID: 29899094. Show all entries for this paper.


Displaying record number 58279

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location  
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11
Subtype B
Species (MHC/HLA) human(B*15)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Conrad2011 Joseph A. Conrad, Ramesh K. Ramalingam, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Jie Wei, Brenna C. Simons, Shanmugalakshmi Sadagopal, Dirk Meyer-Olson, and Spyros A. Kalams. Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1 High and CD127 Low and Display Reduced Variant Cross-Reactivity. J. Immunol., 186(12):6871-6885, 15 Jun 2011. PubMed ID: 21562156. Show all entries for this paper.


Displaying record number 58762

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name Nef-TY11
Subtype B
Species (MHC/HLA) human(B*15)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 58802

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location  
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name B*15-TY11
Subtype B
Species (MHC/HLA) human(B*15)
Immunogen HIV-1 infection
Country United States
Experimental methods Other, Tetramer binding
Keywords  

Notes

References

Conrad2012 Joseph A. Conrad, Ramesh K. Ramalingam, Coley B. Duncan, Rita M. Smith, Jie Wei, Louise Barnett, Brenna C. Simons, Shelly L. Lorey, and Spyros A. Kalams. Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance. J. Virol., 86(8):4213-4221, Apr 2012. PubMed ID: 22258246. Show all entries for this paper.


Displaying record number 56230

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location  
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Subtype C
Species (MHC/HLA) human(B15)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 54352

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name B15-TY11(Nef)
Species (MHC/HLA) human(B15)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 55997

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11(Nef)
Subtype B
Species (MHC/HLA) human(B15)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 57103

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127 DU422)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Subtype B
Species (MHC/HLA) human(B*15:01)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding
Keywords dendritic cells

Notes

References

Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.


Displaying record number 61500

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name NefTY11
Subtype B
Species (MHC/HLA) human(B*15:01)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords optimal epitope, chronic infection

Notes

References

Murakoshi2015 Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes. J. Virol., 89(10):5330-5339, May 2015. PubMed ID: 25741000. Show all entries for this paper.


Displaying record number 52520

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127 NL-43)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Subtype B
Species (MHC/HLA) human(B*15:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords class I down-regulation by Nef, escape

Notes

References

Ali2003 Ayub Ali, Satish Pillai, Hwee Ng, Rachel Lubong, Douglas D. Richman, Beth D. Jamieson, Yan Ding, M. Juliana McElrath, John C. Guatelli, and Otto O. Yang. Broadly Increased Sensitivity to Cytotoxic T Lymphocytes Resulting from Nef Epitope Escape Mutations. J. Immunol., 171(8):3999-4005, Oct 2003. PubMed ID: 14530319. Show all entries for this paper.


Displaying record number 60333

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11
Species (MHC/HLA) human(B*15:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1039

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127 LAI)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Subtype B
Species (MHC/HLA) human(B*15:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 60331

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60332

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11
Species (MHC/HLA) human(B*49)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1814

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Species (MHC/HLA) human(B*62)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 1038

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127 LAI)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Subtype B
Species (MHC/HLA) human(B62)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

CulmannPerCom B. Culmann. Personal communication, 1998. Show all entries for this paper.


Displaying record number 60336

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11
Species (MHC/HLA) human(B*81)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60328

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Epitope Name TY11
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1042

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef(117-127)
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 57499

Download this epitope record as JSON.

HXB2 Location Nef(117-127)
DNA(9145..9177)
Nef Epitope Map
Author Location Nef
Epitope TQGYFPDWQNY Epitope Alignment
TQGYFPDWQNY epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords assay or method development, HLA associated polymorphism, chronic infection

Notes

References

Almeida2010 Coral-Ann M. Almeida, Steven G. Roberts, Rebecca Laird, Elizabeth McKinnon, Imran Ahmad, Niamh M. Keane, Abha Chopra, Carl Kadie, David Heckerman, Simon Mallal, and Mina John. Exploiting Knowledge of Immune Selection in HIV-1 to Detect HIV-Specific CD8 T-Cell Responses. Vaccine, 28(37):6052-6057, 23 Aug 2010. PubMed ID: 20619380. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health