HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 20 matching records:

Displaying record number 60324

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Epitope Name TM9
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60323

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Epitope Name TM9
Species (MHC/HLA) human(A*34)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60326

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Epitope Name TM9
Species (MHC/HLA) human(A*6802)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56403

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Epitope Name TM9
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 1788

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 1141

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79 LAI)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59220

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Epitope Name Nef 71-79
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen vaccine
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type lipopeptide

Notes

References

Figueiredo2014 Suzanne Figueiredo, Benedicte Charmeteau, Mathieu Surenaud, Dominique Salmon, Odile Launay, Jean-Gérard Guillet, Anne Hosmalin, and Hanne Gahery. Memory CD8+ T Cells Elicited by HIV-1 Lipopeptide Vaccines Display Similar Phenotypic Profiles but Differences in Term of Magnitude and Multifunctionality Compared with FLU- or EBV-Specific Memory T Cells in Humans. Vaccine, 32(4):492-501, 16 Jan 2014. PubMed ID: 24291199. Show all entries for this paper.


Displaying record number 52125

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79 BRU)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, epitope processing

Notes

References

Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.


Displaying record number 57223

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Species (MHC/HLA) human(B42)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords mother-to-infant transmission

Notes

References

Lohman-Payne2009 B. Lohman-Payne, J. A. Slyker, B. A. Richardson, C. Farquhar, M. Majiwa, E. Maleche-Obimbo, D. Mbori-Ngacha, J. Overbaugh, S. Rowland-Jones, and G. John-Stewart. Infants with Late Breast Milk Acquisition of HIV-1 Generate Interferon-gamma Responses More Rapidly than Infants with Early Peripartum Acquisition. Clin. Exp. Immunol., 156(3):511-517, Jun 2009. PubMed ID: 19438605. Show all entries for this paper.


Displaying record number 55214

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location  
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation, optimal epitope

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 52166

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Epitope Name B7-TM9
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B7, Cw7
Experimental methods  
Keywords dynamics, supervised treatment interruptions (STI), acute/early infection

Notes

References

Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.


Displaying record number 57176

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location  
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Liu2009c Yi Liu, John McNevin, Morgane Rolland, Hong Zhao, Wenjie Deng, Janine Maenza, Claire E. Stevens, Ann C. Collier, M. Juliana McElrath, and James I. Mullins. Conserved HIV-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-Lymphocyte Responses. J. Infect. Dis., 200(12):1825-1833, 15 Dec 2009. PubMed ID: 19909083. Show all entries for this paper.


Displaying record number 57833

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Epitope Name TM9
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 1571

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79 SF2)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 53556

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(180-187)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B57, B7, Cw6, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 54335

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Epitope Name B7-TM9(Nef)
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 52124

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79 BRU)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, epitope processing

Notes

References

Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.


Displaying record number 52271

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Epitope Name B7-TM9(Nef)
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A32, B14, B7; A24, B27, B7
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Altfeld2002 Marcus Altfeld, Jan van Lunzen, Nicole Frahm, Xu G. Yu, Claus Schneider, Robert L. Eldridge, Margaret E. Feeney, Dirk Meyer-Olson, Hans-Juergen Stellbrink, and Bruce D. Walker. Expansion of Pre-existing, Lymph Node-localized CD8+ T Cells During Supervised Treatment Interruptions in Chronic HIV-1 Infection. J. Clin. Invest., 109(6):837-843, Mar 2002. PubMed ID: 11901192. Show all entries for this paper.


Displaying record number 60325

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Epitope Name TM9
Species (MHC/HLA) human(B*78)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 52950

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope TPQVPLRPM Epitope Alignment
TPQVPLRPM epitope logo
Subtype B
Species (MHC/HLA) human(B7 supertype)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type lipopeptide
Vaccine strain B clade LAI
Vaccine component Env, Gag, Nef
Adjuvant QS21

Notes

References

Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.


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