HIV molecular immunology database
Found 20 matching records:
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Epitope Name | TM9 | |
Species (MHC/HLA) | human(A*30) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Epitope Name | TM9 | |
Species (MHC/HLA) | human(A*34) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Epitope Name | TM9 | |
Species (MHC/HLA) | human(A*68:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Epitope Name | TM9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | escape, HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, acute/early infection |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79 LAI) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Epitope Name | Nef 71-79 | |
Subtype | B | |
Species (MHC/HLA) | human(B*35) | |
Immunogen | vaccine | |
Country | France | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding | |
Keywords | vaccine-induced immune responses |
Vaccine type | lipopeptide |
---|
Figueiredo2014 Suzanne Figueiredo, Benedicte Charmeteau, Mathieu Surenaud, Dominique Salmon, Odile Launay, Jean-Gérard Guillet, Anne Hosmalin, and Hanne Gahery. Memory CD8+ T Cells Elicited by HIV-1 Lipopeptide Vaccines Display Similar Phenotypic Profiles but Differences in Term of Magnitude and Multifunctionality Compared with FLU- or EBV-Specific Memory T Cells in Humans. Vaccine, 32(4):492-501, 16 Jan 2014. PubMed ID: 24291199. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79 BRU) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | binding affinity, epitope processing |
Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B42) | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | mother-to-infant transmission |
Lohman-Payne2009 B. Lohman-Payne, J. A. Slyker, B. A. Richardson, C. Farquhar, M. Majiwa, E. Maleche-Obimbo, D. Mbori-Ngacha, J. Overbaugh, S. Rowland-Jones, and G. John-Stewart. Infants with Late Breast Milk Acquisition of HIV-1 Generate Interferon-gamma Responses More Rapidly than Infants with Early Peripartum Acquisition. Clin. Exp. Immunol., 156(3):511-517, Jun 2009. PubMed ID: 19438605. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supertype, HLA cross-presentation, optimal epitope |
Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Epitope Name | B7-TM9 | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B7, Cw7 | |
Experimental methods | ||
Keywords | dynamics, supervised treatment interruptions (STI), acute/early infection |
Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Liu2009c Yi Liu, John McNevin, Morgane Rolland, Hong Zhao, Wenjie Deng, Janine Maenza, Claire E. Stevens, Ann C. Collier, M. Juliana McElrath, and James I. Mullins. Conserved HIV-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-Lymphocyte Responses. J. Infect. Dis., 200(12):1825-1833, 15 Dec 2009. PubMed ID: 19909083. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Epitope Name | TM9 | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, TCR binding | |
Keywords | rate of progression, TCR usage, optimal epitope |
Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79 SF2) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.
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HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(180-187) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A3, B57, B7, Cw6, Cw7 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Epitope Name | B7-TM9(Nef) | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79 BRU) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | binding affinity, epitope processing |
Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Epitope Name | B7-TM9(Nef) | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A32, B14, B7; A24, B27, B7 | |
Experimental methods | ||
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Altfeld2002 Marcus Altfeld, Jan van Lunzen, Nicole Frahm, Xu G. Yu, Claus Schneider, Robert L. Eldridge, Margaret E. Feeney, Dirk Meyer-Olson, Hans-Juergen Stellbrink, and Bruce D. Walker. Expansion of Pre-existing, Lymph Node-localized CD8+ T Cells During Supervised Treatment Interruptions in Chronic HIV-1 Infection. J. Clin. Invest., 109(6):837-843, Mar 2002. PubMed ID: 11901192. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Epitope Name | TM9 | |
Species (MHC/HLA) | human(B*78) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-79) DNA(9007..9033) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-79) | |
Epitope |
TPQVPLRPM
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7 supertype) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation | |
Keywords | vaccine-induced immune responses, variant cross-reactivity |
Vaccine type | lipopeptide |
---|---|
Vaccine strain | B clade LAI |
Vaccine component | Env, Gag, Nef |
Adjuvant | QS21 |
Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.