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Displaying record number 53705

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HXB2 Location	Gag(180-191) p24(48-59) DNA(1327..1362)	Gag Epitope Map
Author Location	p24
Epitope	TPQDLNQMLNTV	Epitope Alignment
		Show epitope variants
Subtype	B, G
Species (MHC/HLA)	human(B58)
Immunogen	HIV-1 infection
Patient MHC/HLA	A2, A36, B45, B58, Cw3, Cw6; M13371: A*02, A*36, B*45, B*58, C*03, C*06
Country	Nigeria
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, variant cross-reactivity

Notes

• Cross-clade CTL responses in 10 non-B HIV-1 infected individuals were evaluated. T-cell reactivity was tested against peptide pools of clade B Gag, Pol, Nef, Rev and Tat. Nine individuals demonstrated cross-reactive T-cell responses to clade A, B, and C Gag pools; 6/7 patients that responded to Nef-B also reacted to clade A and C Nef pools. An inverse correlation was observed between the sequence divergence of the HLA class I restricted epitopes and the height of the T-cell responses, which in Gag could be explained through variations in the HLA-anchor residues. 42% of the responses were directed to regions containing new epitopes.
• This previously described epitope was embedded in a B clade peptide that was recognized by T-cells from an infected person carrying subtype G Gag. The autologous epitope sequence in this person differed from the known epitope in one position, Q7T, TPQDLNtMLNTV

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.