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HXB2 Location	Gag(180-188) p24(48-56) DNA(1327..1353)	Gag Epitope Map
Author Location	p24
Epitope	TPQDLNQML	Epitope Alignment
Species (MHC/HLA)	human(B53)
Immunogen
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS), HIV-2

Notes

• CTL responses in seronegative highly HIV-exposed African female sex workers in Gambia and Nairobi were studied -- these women had no delta 32 deletion in CCR5.
• In Gambia there is exposure to both HIV-1 and HIV-2. CTL responses to B*35 epitopes in exposed, uninfected women are cross-reactive, and the B*35 allele seems to be protective.
• HIV-2 sequence: TPYDINQML, no cross-reactivity, Gotch1993
• Database note: First author "Rowland-Jones" is also found as "RowlandJones" on annotated papers in this database.

References

Gotch1993 F. Gotch, S. N. McAdam, and C. E. Allsopp et al. Cytotoxic T Cells in HIV-2 Seropositive Gambians. Identification of a Virus-Specific MHC-Restricted Peptide Epitope. J. Immunol., 151:3361-3369, 1993. PubMed ID: 7690804. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.