HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 11 matching records:

Displaying record number 61973

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location Gag(180-188)
Epitope TPQDLNMML Epitope Alignment
TPQDLNMML epitope logo
Subtype A, D
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Patient MHC/HLA 2257: A*2301, A*3002, B*0702, B*1801, Cw*0702, Cw*1505
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords HIV exposed persistently seronegative (HEPS), assay or method development

Notes

References

Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.


Displaying record number 61229

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location Gag
Epitope TPQDLNMML Epitope Alignment
TPQDLNMML epitope logo
Epitope Name TL9
Subtype A
Species (MHC/HLA) human(B*42, B*81)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, TCR usage

Notes

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.


Displaying record number 61246

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location Gag
Epitope TPQDLNMML Epitope Alignment
TPQDLNMML epitope logo
Show epitope variants
Epitope Name TL9M7
Subtype A, CRF01_AE, CRF02_AG
Species (MHC/HLA) human(B*4201, B*8101)
Immunogen HIV-1 infection
Country Kenya, Tanzania
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other, Tetramer binding
Keywords subtype comparisons, escape, variant cross-reactivity, HLA associated polymorphism

Notes

References

Geldmacher2009 Christof Geldmacher, Ian S. Metzler, Sodsai Tovanabutra, Tedi E. Asher, Emma Gostick, David R. Ambrozak, Constantinos Petrovas, Alexandra Schuetz, Njabulo Ngwenyama, Gustavo Kijak, Leonard Maboko, Michael Hoelscher, Francine McCutchan, David A. Price, Daniel C. Douek, and Richard A. Koup. Minor Viral and Host Genetic Polymorphisms Can Dramatically Impact the Biologic Outcome of an Epitope-Specific CD8 T-Cell Response. Blood, 114(8):1553-1562, 20 Aug 2009. PubMed ID: 19542300. Show all entries for this paper.


Displaying record number 55054

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location Gag
Epitope TPQDLNMML Epitope Alignment
TPQDLNMML epitope logo
Show epitope variants
Species (MHC/HLA) human(B*4202)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords subtype comparisons, HLA cross-presentation, variant cross-reactivity

Notes

References

Currier2006 Jeffrey R. Currier, Unchalee Visawapoka, Sodsai Tovanabutra, Carl J. Mason, Deborah L. Birx, Francine E. McCutchan, and Josephine H. Cox. CTL Epitope Distribution Patterns in the Gag and Nef Proteins of HIV-1 from Subtype A Infected Subjects in Kenya: Use of Multiple Peptide Sets Increases the Detectable Breadth of the CTL Response. BMC Immunol, 7:8, 2006. PubMed ID: 16620386. Show all entries for this paper.


Displaying record number 58607

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location p24(180-188)
Epitope TPQDLNMML Epitope Alignment
TPQDLNMML epitope logo
Subtype A
Species (MHC/HLA) human(B*53)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 55686

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location Gag
Epitope TPQDLNMML Epitope Alignment
TPQDLNMML epitope logo
Subtype A, CRF02_AG
Species (MHC/HLA) human(B53)
Immunogen HIV-1 infection, HIV-1 or HIV-2 infection
Country Gambia
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons, variant cross-reactivity, HIV-2

Notes

References

Ondondo2008 Beatrice O. Ondondo, Sarah L. Rowland-Jones, Lucy Dorrell, Kevin Peterson, Matthew Cotten, Hilton Whittle, and Assan Jaye. Comprehensive Analysis of HIV Gag-Specific IFN-gamma Response in HIV-1- and HIV-2-Infected Asymptomatic Patients from a Clinical Cohort in The Gambia. Eur. J. Immunol., 38(12):3549-3560, Dec 2008. PubMed ID: 19016530. Show all entries for this paper.


Displaying record number 52730

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location p24
Epitope TPQDLNMML Epitope Alignment
TPQDLNMML epitope logo
Species (MHC/HLA) human(B53)
Immunogen HIV-1 infection
Experimental methods Intracellular cytokine staining
Keywords immunodominance, genital and mucosal immunity

Notes

References

Kaul2003 Rupert Kaul, Paul Thottingal, Joshua Kimani, Peter Kiama, Charles W. Waigwa, Job J. Bwayo, Francis A. Plummer, and Sarah L. Rowland-Jones. Quantitative Ex Vivo Analysis of Functional Virus-Specific CD8 T Lymphocytes in the Blood and Genital Tract of HIV-Infected Women. AIDS, 17(8):1139-1144, May 2003. PubMed ID: 12819514. Show all entries for this paper.


Displaying record number 53710

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location Gag(180-188)
Epitope TPQDLNMML Epitope Alignment
TPQDLNMML epitope logo
Epitope Name TPQ
Species (MHC/HLA) human(B53)
Immunogen HIV-1 infection
Country Gambia
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells, HIV-2

Notes

References

Gillespie2005a Geraldine M. A. Gillespie, Susana Pinheiro, Mohammad Sayeid-Al-Jamee, Abraham Alabi, Steve Kaye, Sehu Sabally, Ramu Sarge-Njie, Harr Njai, Ken Joof, Assan Jaye, Hilton Whittle, Sarah Rowland-Jones, and Lucy Dorrell. CD8+ T Cell Responses to Human Immunodeficiency Viruses Type 2 (HIV-2) and Type 1 (HIV-1) Gag Proteins are Distinguishable by Magnitude and Breadth but not Cellular Phenotype. Eur. J. Immunol., 35(5):1445-1453, May 2005. PubMed ID: 15832290. Show all entries for this paper.


Displaying record number 1712

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location p24(180-188 subtype A consensus)
Epitope TPQDLNMML Epitope Alignment
TPQDLNMML epitope logo
Show epitope variants
Subtype A
Species (MHC/HLA) human(B53)
Immunogen HIV-1 infection
Country Gambia
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding, Other
Keywords subtype comparisons, immunodominance, TCR usage, optimal epitope, novel epitope

Notes

References

Dorrell2001 L. Dorrell, B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol., 31(6):1747-56, Jun 2001. PubMed ID: 11385619. Show all entries for this paper.


Displaying record number 54746

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location p24
Epitope TPQDLNMML Epitope Alignment
TPQDLNMML epitope logo
Species (MHC/HLA) human(B*5301)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords binding affinity

Notes

References

Gillespie2007 Geraldine M. A. Gillespie, Arman Bashirova, Tao Dong, Daniel W. McVicar, Sarah L. Rowland-Jones, and Mary Carrington. Lack of KIR3DS1 Binding to MHC Class I Bw4 Tetramers in Complex with CD8+ T Cell Epitopes. AIDS Res. Hum. Retroviruses, 23(3):451-455, Mar 2007. PubMed ID: 17411378. Show all entries for this paper.


Displaying record number 61142

HXB2 Location Gag(180-188)
p24(48-56)
DNA(1327..1353)
Gag Epitope Map
Author Location  
Epitope TPQDLNMML Epitope Alignment
TPQDLNMML epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human, mouse(B*6701)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA), adenovirus
Vaccine strain B clade

Notes

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


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