HIV molecular immunology database
Found 53 matching records:
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10 | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Other | |
Keywords | characterizing CD8+ T cells, elite controllers |
Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(126-135) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, acute/early infection |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*07) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | ||
Keywords | immunodominance, dendritic cells, Th1 |
Haas1996 G. Haas, U. Plikat, P. Debre, M. Lucchiari, C. Katlama, Y. Dudoit, O. Bonduelle, M. Bauer, H. Ihlenfeldt, G. Jung, B. Maier, A. Meyerhans, and B. Autran. Dynamics of Viral Variants in HIV-1 Nef and Specific Cytotoxic T Lymphocytes In Vivo. J. Immunol., 157:4212-4221, 1996. PubMed ID: 8892659. Show all entries for this paper.
Wilson1999b C. C. Wilson, W. C. Olson, T. Tuting, C. R. Rinaldo, M. T. Lotze, and W. J. Storkus. HIV-1-Specific CTL Responses Primed In Vitro by Blood-Derived Dendritic Cells and Th1-Biasing Cytokines. J. Immunol., 162:3070-3078, 1999. PubMed ID: 10072560. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | Nef-TL10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HAART, ART |
Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Country | Germany | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | elite controllers |
Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*07, B*42) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | escape, HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, optimal epitope |
Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | computational epitope prediction, HLA associated polymorphism |
Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Country | South Africa, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | computational epitope prediction, optimal epitope |
ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Country | Australia | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | escape, optimal epitope, HLA associated polymorphism |
Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.
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HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137 LAI) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137 LAI) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | ||
Keywords | epitope processing |
LucchiariHartz2000 M. Lucchiari-Hartz, P. M. van Endert, G. Lauvau, R. Maier, A. Meyerhans, D. Mann, K. Eichmann, and G. Niedermann. Cytotoxic T lymphocyte epitopes of HIV-1 Nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes. J. Exp. Med., 191(2):239-52, 17 Jan 2000. URL: http://www.jem.org/cgi/content/full/191/2/239. PubMed ID: 10637269. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*07:02, B*42:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HLA cross-presentation, characterizing CD8+ T cells |
Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*07:02, B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*32:04, A*74:12, B*07:02, B*44:03, C*02:10, C*07:02 | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | rate of progression, immunodominance |
Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.
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HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137 BRU) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | binding affinity, epitope processing |
Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 41325: A*29:02, A*32:01, B*35:01, B*44:03, C*04:01, C*16:01; 57604: A*02:01, A*02:01, B*13:02, B*35:01, C*04:19, C*06:02 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
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HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(127-136) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | Nef-TL10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 8183A: A*02:01, A*03:01, B*35:01, B*51, C*04, C*06 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining | |
Keywords | dynamics, acute/early infection |
Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10 | |
Species (MHC/HLA) | human(B*35:02, B*35:03, B*53:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | Nef-TL10 | |
Subtype | C | |
Species (MHC/HLA) | human(B*42) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 021-C: A*02:05, A*29:02, B*42:01, B*44:03, C*02:10, C*17:01; 021-M: A*02:05, A*33:01, B*42:01, B*44:03, C*02:10, C*17:01 | |
Country | South Africa, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | dynamics, responses in children, mother-to-infant transmission, rate of progression, escape |
Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.
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HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(382-411) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | Nef-TL10 | |
Subtype | C | |
Species (MHC/HLA) | human(B*42:01) | |
Immunogen | HIV-1 infection | |
Country | Botswana, South Africa, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other, Tetramer binding | |
Keywords | immunodominance |
Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10 | |
Species (MHC/HLA) | human(B*42:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | Intracellular cytokine staining, Proliferation, Tetramer binding | |
Keywords |
Day2006 Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela, Julia A. Brown, Eshia S. Moodley, Sharon Reddy, Elizabeth W. Mackey, Joseph D. Miller, Alasdair J. Leslie, Chantal DePierres, Zenele Mncube, Jaikumar Duraiswamy, Baogong Zhu, Quentin Eichbaum, Marcus Altfeld, E. John Wherry, Hoosen M. Coovadia, Philip J. R. Goulder, Paul Klenerman, Rafi Ahmed, Gordon J. Freeman, and Bruce D. Walker. PD-1 Expression on HIV-Specific T Cells Is Associated with T-Cell Exhaustion and Disease Progression. Nature, 443(7109):350-354, 21 Sep 2006. PubMed ID: 16921384. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10-Nef | |
Subtype | C | |
Species (MHC/HLA) | human(B*42:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding, Tetramer binding | |
Keywords | TCR usage, characterizing CD8+ T cells |
Kloverpris2014a Henrik N. Kløverpris, Reuben McGregor, James E McLaren, Kristin Ladell, Anette Stryhn, Catherine Koofhethile, Jacqui Brener, Fabian Chen, Lynn Riddell, Luzzi Graziano, Paul Klenerman, Alasdair Leslie, Søren Buus, David A. Price, and Philip Goulder. Programmed Death-1 Expression on HIV-1-Specific CD8+ T Cells Is Shaped by Epitope Specificity, T-Cell Receptor Clonotype Usage and Antigen Load. AIDS, 28(14):2007-2021, 10 Sep 2014. PubMed ID: 24906112. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*42:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, optimal epitope |
Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.
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HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137 LAI) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*42:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | C | |
Species (MHC/HLA) | human(B*42:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*30, A*30:01, B*15:03, B*42:01, C*02:02, C*17:01; A*03:01, A*30:01, B*42:01, B*58:02, C*06:02, C*17:01 | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | responses in children, mother-to-infant transmission, escape, acute/early infection |
Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | Nef-TL10 | |
Subtype | C | |
Species (MHC/HLA) | human(B*42:01, B*42:02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*30:01, B*42:01, C*17:01; A*30:01, B*42:02, C*17:01 | |
Country | Botswana, South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding, Tetramer binding | |
Keywords | HLA associated polymorphism, novel epitope |
Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Species (MHC/HLA) | (B*42:02) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10 | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding | |
Keywords | superinfection |
Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | acute/early infection |
Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137 LAI) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Haas1996 G. Haas, U. Plikat, P. Debre, M. Lucchiari, C. Katlama, Y. Dudoit, O. Bonduelle, M. Bauer, H. Ihlenfeldt, G. Jung, B. Maier, A. Meyerhans, and B. Autran. Dynamics of Viral Variants in HIV-1 Nef and Specific Cytotoxic T Lymphocytes In Vivo. J. Immunol., 157:4212-4221, 1996. PubMed ID: 8892659. Show all entries for this paper.
Haas1997 G. Haas, A. Hosmalin, F. Hadida, J. Duntze, P. Debre, and B. Autran. Dynamics of HIV Variants and Specific Cytotoxic T Cell Recognition in Nonprogressors and Progressors. Immunol. Lett., 57:63-68, 1997. PubMed ID: 9232427. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 exposed seronegative | |
Experimental methods | ||
Keywords | subtype comparisons, HIV exposed persistently seronegative (HEPS) |
RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef( subtype B) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 exposed seronegative | |
Experimental methods | ||
Keywords | subtype comparisons |
Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137 SF2) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS), immunodominance |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137 BRU) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | binding affinity, epitope processing |
Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | B7-TL10 | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B7, Cw7 | |
Experimental methods | ||
Keywords | dynamics, supervised treatment interruptions (STI), acute/early infection |
Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A2, A3, B7, Bw6 | |
Experimental methods | ||
Keywords | HAART, ART |
Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B, C | |
Species (MHC/HLA) | human, macaque(B7) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | ||
Keywords | subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance |
Vaccine type | DNA prime with modified vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade |
Vaccine component | p17 Gag, p24 Gag |
Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.
Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HIV exposed persistently seronegative (HEPS) |
Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.
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HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | ( B consensus) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10 | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A31, A68, B7, B70, Cw1, Cw7 | |
Country | United States | |
Experimental methods | Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | assay or method development, memory cells, characterizing CD8+ T cells |
Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | Intracellular cytokine staining, T-cell Elispot, Tetramer binding | |
Keywords | rate of progression, acute/early infection, characterizing CD8+ T cells |
Papagno2004 Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Victor Appay. Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol., 2(2):E20, Feb 2004. PubMed ID: 14966528. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | binding affinity, immunodominance, optimal epitope |
Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Liu2009c Yi Liu, John McNevin, Morgane Rolland, Hong Zhao, Wenjie Deng, Janine Maenza, Claire E. Stevens, Ann C. Collier, M. Juliana McElrath, and James I. Mullins. Conserved HIV-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-Lymphocyte Responses. J. Infect. Dis., 200(12):1825-1833, 15 Dec 2009. PubMed ID: 19909083. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10 | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, TCR binding | |
Keywords | rate of progression, TCR usage, optimal epitope |
Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.
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HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137 subtype B) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*81:01, B7) | |
Immunogen | HIV-1 exposed seronegative | |
Experimental methods | ||
Keywords |
Kaul2000 R. Kaul, F. A. Plummer, J. Kimani, T. Dong, P. Kiama, T. Rostron, E. Njagi, K. S. MacDonald, J. J. Bwayo, A. J. McMichael, and S. L. Rowland-Jones. HIV-1-Specific Mucosal CD8+ Lymphocyte Responses in the Cervix of HIV-1-Resistant Prostitutes in Nairobi. J. Immunol., 164:1602-1611, 2000. PubMed ID: 10640781. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef( subtype B) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*81:01, B7) | |
Immunogen | HIV-1 exposed seronegative | |
Experimental methods | ||
Keywords | subtype comparisons |
Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7 supertype) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation | |
Keywords | vaccine-induced immune responses, variant cross-reactivity |
Vaccine type | lipopeptide |
---|---|
Vaccine strain | B clade LAI |
Vaccine component | Env, Gag, Nef |
Adjuvant | QS21 |
Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*81:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*01:01, A*30:01, B*42:02, B*81:01, C*17:01, C*18:01 | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, acute/early infection |
Mlotshwa2010 Mandla Mlotshwa, Catherine Riou, Denis Chopera, Debra de Assis Rosa, Roman Ntale, Florette Treunicht, Zenda Woodman, Lise Werner, Francois van Loggerenberg, Koleka Mlisana, Salim Abdool Karim, Carolyn Williamson, Clive M Gray, and CAPRISA 002 Study Team. Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression. J. Virol., 84(22):12018-12029, Nov 2010. PubMed ID: 20826686. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10 | |
Species (MHC/HLA) | human(C*17) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(128-137) DNA(9178..9207) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(128-137) | |
Epitope |
TPGPGVRYPL
|
Epitope Alignment
|
Epitope Name | TL10 | |
Subtype | C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other, Tetramer binding | |
Keywords | supertype, HLA cross-presentation, TCR usage, HLA associated polymorphism |
Leslie2006 Alasdair Leslie, David A. Price, Pamela Mkhize, Karen Bishop, Almas Rathod, Cheryl Day, Hayley Crawford, Isobella Honeyborne, Tedi E. Asher, Graz Luzzi, Anne Edwards, Christine M. Rousseau, James I. Mullins, Gareth Tudor-Williams, Vas Novelli, Christian Brander, Daniel C. Douek, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol., 177(7):4699-4708, 1 Oct 2006. PubMed ID: 16982909. Show all entries for this paper.