HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 51 matching records:

Displaying record number 58519

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 1057

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Species (MHC/HLA) human(B*07)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords immunodominance, dendritic cells, Th1

Notes

References

Haas1996 G. Haas, U. Plikat, P. Debre, M. Lucchiari, C. Katlama, Y. Dudoit, O. Bonduelle, M. Bauer, H. Ihlenfeldt, G. Jung, B. Maier, A. Meyerhans, and B. Autran. Dynamics of Viral Variants in HIV-1 Nef and Specific Cytotoxic T Lymphocytes In Vivo. J. Immunol., 157:4212-4221, 1996. PubMed ID: 8892659. Show all entries for this paper.

Wilson1999b C. C. Wilson, W. C. Olson, T. Tuting, C. R. Rinaldo, M. T. Lotze, and W. J. Storkus. HIV-1-Specific CTL Responses Primed In Vitro by Blood-Derived Dendritic Cells and Th1-Biasing Cytokines. J. Immunol., 162:3070-3078, 1999. PubMed ID: 10072560. Show all entries for this paper.


Displaying record number 1790

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 53105

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(126-135)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 59151

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 1991

HXB2 Location Nef(128-137)
DNA(9178..9204)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name Nef-TL10
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 60310

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56405

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10
Subtype B
Species (MHC/HLA) human(B*07, B*42)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 1053

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137 LAI)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54079

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location ( C consensus)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype C
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 57806

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 57994

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location  
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype C
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords computational epitope prediction, optimal epitope

Notes

References

ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.


Displaying record number 1829

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137 LAI)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords epitope processing

Notes

References

LucchiariHartz2000 M. Lucchiari-Hartz, P. M. van Endert, G. Lauvau, R. Maier, A. Meyerhans, D. Mann, K. Eichmann, and G. Niedermann. Cytotoxic T lymphocyte epitopes of HIV-1 Nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes. J. Exp. Med., 191(2):239-52, 17 Jan 2000. URL: http://www.jem.org/cgi/content/full/191/2/239. PubMed ID: 10637269. Show all entries for this paper.


Displaying record number 58863

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords escape, optimal epitope, HLA associated polymorphism

Notes

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 53301

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location ( C consensus)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype C
Species (MHC/HLA) human(B*0702, B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA cross-presentation, characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 56234

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location  
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype C
Species (MHC/HLA) human(B*0702, B7)
Immunogen HIV-1 infection
Patient MHC/HLA A*3204, A*7412, B*0702, B*4403, Cw*0210, Cw*0702
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression, immunodominance

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 61013

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Patient MHC/HLA 41325: A*2902, A*3201, B*3501, B*4403, Cw*0401, Cw*1601; 57604: A*0201, A*0201, B*1302, B*3501, Cw*0419, Cw*0602
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 52130

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137 BRU)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, epitope processing

Notes

References

Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.


Displaying record number 60312

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53829

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Show epitope variants
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Patient MHC/HLA A*30, A*3001, B*1503, B*4201, Cw*0202, Cw*1701; A*0301, A*3001, B*4201, B*5802, Cw*0602, Cw*1701
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 59445

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(382-411)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name Nef-TL10
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country Botswana, South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords immunodominance

Notes

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 55174

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location  
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords  

Notes

References

Day2006 Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela, Julia A. Brown, Eshia S. Moodley, Sharon Reddy, Elizabeth W. Mackey, Joseph D. Miller, Alasdair J. Leslie, Chantal DePierres, Zenele Mncube, Jaikumar Duraiswamy, Baogong Zhu, Quentin Eichbaum, Marcus Altfeld, E. John Wherry, Hoosen M. Coovadia, Philip J. R. Goulder, Paul Klenerman, Rafi Ahmed, Gordon J. Freeman, and Bruce D. Walker. PD-1 Expression on HIV-Specific T Cells Is Associated with T-Cell Exhaustion and Disease Progression. Nature, 443(7109):350-354, 21 Sep 2006. PubMed ID: 16921384. Show all entries for this paper.


Displaying record number 1058

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137 LAI)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B*4201)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59161

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10-Nef
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Tetramer binding
Keywords TCR usage, characterizing CD8+ T cells

Notes

References

Kloverpris2014a Henrik N. Kløverpris, Reuben McGregor, James E McLaren, Kristin Ladell, Anette Stryhn, Catherine Koofhethile, Jacqui Brener, Fabian Chen, Lynn Riddell, Luzzi Graziano, Paul Klenerman, Alasdair Leslie, Søren Buus, David A. Price, and Philip Goulder. Programmed Death-1 Expression on HIV-1-Specific CD8+ T Cells Is Shaped by Epitope Specificity, T-Cell Receptor Clonotype Usage and Antigen Load. AIDS, 28(14):2007-2021, 10 Sep 2014. PubMed ID: 24906112. Show all entries for this paper.


Displaying record number 54078

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location ( C consensus)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 58719

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name Nef-TL10
Subtype C
Species (MHC/HLA) human(B*4201, B*4202)
Immunogen HIV-1 infection
Patient MHC/HLA A*3001, B*4201, Cw*1701; A*3001, B*4202, Cw*1701
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Tetramer binding
Keywords HLA associated polymorphism, novel epitope

Notes

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 58628

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location  
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Species (MHC/HLA) (B*4202)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53403

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods Intracellular cytokine staining, T-cell Elispot, Tetramer binding
Keywords rate of progression, acute/early infection, characterizing CD8+ T cells

Notes

References

Papagno2004 Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Victor Appay. Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol., 2(2):E20, Feb 2004. PubMed ID: 14966528. Show all entries for this paper.


Displaying record number 1051

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location  
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.


Displaying record number 1052

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137 LAI)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Haas1996 G. Haas, U. Plikat, P. Debre, M. Lucchiari, C. Katlama, Y. Dudoit, O. Bonduelle, M. Bauer, H. Ihlenfeldt, G. Jung, B. Maier, A. Meyerhans, and B. Autran. Dynamics of Viral Variants in HIV-1 Nef and Specific Cytotoxic T Lymphocytes In Vivo. J. Immunol., 157:4212-4221, 1996. PubMed ID: 8892659. Show all entries for this paper.

Haas1997 G. Haas, A. Hosmalin, F. Hadida, J. Duntze, P. Debre, and B. Autran. Dynamics of HIV Variants and Specific Cytotoxic T Cell Recognition in Nonprogressors and Progressors. Immunol. Lett., 57:63-68, 1997. PubMed ID: 9232427. Show all entries for this paper.


Displaying record number 1054

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Show epitope variants
Species (MHC/HLA) human(B7)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 1056

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef( subtype B)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons

Notes

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.


Displaying record number 1573

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137 SF2)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1669

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Show epitope variants
Species (MHC/HLA) human(B7)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS), immunodominance

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1704

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.


Displaying record number 52129

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137 BRU)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, epitope processing

Notes

References

Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.


Displaying record number 52170

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name B7-TL10
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B7, Cw7
Experimental methods  
Keywords dynamics, supervised treatment interruptions (STI), acute/early infection

Notes

References

Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.


Displaying record number 52360

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B7, Bw6
Experimental methods  
Keywords HAART, ART

Notes

References

Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.


Displaying record number 52443

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B, C
Species (MHC/HLA) human, macaque(B7)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 53040

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.


Displaying record number 53383

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location ( B consensus)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A31, A68, B7, B70, Cw1, Cw7
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 55033

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location  
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 55491

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords superinfection

Notes

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.


Displaying record number 57175

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location  
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Liu2009c Yi Liu, John McNevin, Morgane Rolland, Hong Zhao, Wenjie Deng, Janine Maenza, Claire E. Stevens, Ann C. Collier, M. Juliana McElrath, and James I. Mullins. Conserved HIV-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-Lymphocyte Responses. J. Infect. Dis., 200(12):1825-1833, 15 Dec 2009. PubMed ID: 19909083. Show all entries for this paper.


Displaying record number 57831

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 1050

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137 subtype B)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B*8101, B7)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords  

Notes

References

Kaul2000 R. Kaul, F. A. Plummer, J. Kimani, T. Dong, P. Kiama, T. Rostron, E. Njagi, K. S. MacDonald, J. J. Bwayo, A. J. McMichael, and S. L. Rowland-Jones. HIV-1-Specific Mucosal CD8+ Lymphocyte Responses in the Cervix of HIV-1-Resistant Prostitutes in Nairobi. J. Immunol., 164:1602-1611, 2000. PubMed ID: 10640781. Show all entries for this paper.


Displaying record number 1055

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef( subtype B)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B*8101, B7)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons

Notes

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.


Displaying record number 52962

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype B
Species (MHC/HLA) human(B7 supertype)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type lipopeptide
Vaccine strain B clade LAI
Vaccine component Env, Gag, Nef
Adjuvant QS21

Notes

References

Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.


Displaying record number 57762

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Subtype C
Species (MHC/HLA) human(B*8101)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*3001, B*4202, B*8101, Cw*1701, Cw*1801
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Mlotshwa2010 Mandla Mlotshwa, Catherine Riou, Denis Chopera, Debra de Assis Rosa, Roman Ntale, Florette Treunicht, Zenda Woodman, Lise Werner, Francois van Loggerenberg, Koleka Mlisana, Salim Abdool Karim, Carolyn Williamson, Clive M Gray, and CAPRISA 002 Study Team. Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression. J. Virol., 84(22):12018-12029, Nov 2010. PubMed ID: 20826686. Show all entries for this paper.


Displaying record number 60311

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10
Species (MHC/HLA) human(C*17)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54195

HXB2 Location Nef(128-137)
DNA(9178..9207)
Nef Epitope Map
Author Location Nef(128-137)
Epitope TPGPGVRYPL Epitope Alignment
TPGPGVRYPL epitope logo
Epitope Name TL10
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords supertype, HLA cross-presentation, TCR usage, HLA associated polymorphism

Notes

References

Leslie2006 Alasdair Leslie, David A. Price, Pamela Mkhize, Karen Bishop, Almas Rathod, Cheryl Day, Hayley Crawford, Isobella Honeyborne, Tedi E. Asher, Graz Luzzi, Anne Edwards, Christine M. Rousseau, James I. Mullins, Gareth Tudor-Williams, Vas Novelli, Christian Brander, Daniel C. Douek, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol., 177(7):4699-4708, 1 Oct 2006. PubMed ID: 16982909. Show all entries for this paper.


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