Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 678

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HXB2 Location	gp160(192-200) gp120(192-200) DNA(6798..6824)	gp160 Epitope Map
Author Location	gp120(199-207)
Epitope	TLTSCNTSV	Epitope Alignment
Species (MHC/HLA)	human(A*02:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• This epitope was recognized by PBMC from 6/14 HIV+ asymptomatic patients.
• This epitope was used along with pol CTL epitope ALQDSGLEV and a tetanus toxin T helper epitope for a synthetic vaccine.
• This vaccine failed to induce a CTL response, although a helper response was evident.

References

Brander1996b C. Brander, G. Corradin, T. Hasler, and W. J. Pichler. Peptide Immunization in Humans: A Combined CD8+/CD4+ T Cell-Targeted Vaccine Restimulates the Memory CD4 T Cell Response but Fails to Induce Cytotoxic T Lymphocytes (CTL). Clin. Exp. Immunol., 105:18-25, 1996. PubMed ID: 8697628. Show all entries for this paper.

Displaying record number 677

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HXB2 Location	gp160(192-200) gp120(192-200) DNA(6798..6824)	gp160 Epitope Map
Author Location	gp120(197-205)
Epitope	TLTSCNTSV	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	peptide-HLA interaction
Experimental methods
Keywords

Notes

• Crystallization of HLA-A2 molecules complexed with antigenic peptides -- refers to Dadaglio et al. 1991.

References

Garboczi1992 D. N. Garboczi, D. T. Hung, and D. C. Wiley. HLA-A2-Peptide Complexes: Refolding and Crystallization of Molecules Expressed in Escherichia coli and Complexed with Single Antigenic Peptides. Proc. Natl. Acad. Sci. U.S.A., 89:3429-3433, 1992. PubMed ID: 1565634. Show all entries for this paper.