Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 53061

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HXB2 Location	Gag(303-312) p24(171-180) DNA(1696..1725)	Gag Epitope Map
Author Location	p24
Epitope	TLRAEQATQD	Epitope Alignment
Epitope Name	TD-10
Subtype	C
Species (MHC/HLA)	human(C*03:04)
Immunogen	HIV-1 infection
Country	South Africa
Experimental methods	CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords	subtype comparisons, epitope processing, immunodominance, HLA cross-presentation

Notes

• Highly targeted regions in Gag for CD8+ T-cells were defined for individuals with C clade infections in South Africa. 9 specific epitopes within the most reactive regions were characterized. This is 1 of 5 novel epitopes that were found among subtype C HIV-1 from African patients who hadn't previously been identified in B clade infections. Some epitopes were shown to be promiscuous, presented by multiple class I restricting alleles.
• TLRAEQATQD was presented by Cw*03 and newly identified in this study; Cw*03 is more common in Zulus than Caucasians (0.157 versus 0.101).

References

Masemola2004a Agatha M. Masemola, Tumelo N. Mashishi, Greg Khoury, Helba Bredell, Maria Paximadis, Tiyani Mathebula, Debra Barkhan, Adrian Puren, Efthyia Vardas, Mark Colvin, Lynn Zijenah, David Katzenstein, Rosemary Musonda, Susan Allen, Newton Kumwenda, Taha Taha, Glenda Gray, James McIntyre, Salim Abdool Karim, Haynes W. Sheppard, and Clive M. Gray. Novel and Promiscuous CTL Epitopes in Conserved Regions of Gag Targeted by Individuals with Early Subtype C HIV Type 1 Infection from Southern Africa. J. Immunol., 173(7):4607-4617, 1 Oct 2004. PubMed ID: 15383595. Show all entries for this paper.

Displaying record number 58206

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HXB2 Location	Gag(303-312) p24(171-180) DNA(1696..1725)	Gag Epitope Map
Author Location	Gag/Pol(302- CDC-451)
Epitope	TLRAEQATQD	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	computer prediction
Experimental methods
Keywords	T-cell crossreactivity to human proteins

Notes

• The paper defines potential crossreactivity between HIV-1 and human host proteins. HIV B-clade strain CDC-451 shares 50 7mers and 3 8mers with the human proteome. Of these, 35 are within experimentally-validated epitopes targeted by human immune responses to HIV. The number of common 7mers between the proteomes is 3.7-fold higher than would be expected by chance.
• The 7mers in common with HIV are present in human proteins that, when altered, are associated with AIDS-related symptoms, suggesting that disease symptoms may be caused by autoimmune responses.
• Previously-documented CTL epitope TLRAEQATQD contains 7mer TLRAEQA, which occurs in human genes Q4UJ75, Q5TYW2, and Q5VUR7: Ankyrin repeat domain-containing proteins. This protein may be associated with myopathies.

References

Lucchese2011 Guglielmo Lucchese, Angela Stufano, Michele Calabro, and Darja Kanduc. Charting the Peptide Crossreactome between HIV-1 and the Human Proteome. Front. Biosci. (Elite Ed.), 3E:1385-1400, 2011. PubMed ID: 21622144. Show all entries for this paper.