HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 17 matching records:

Displaying record number 150

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24(151-159)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, immunodominance

Notes

References

Huang2000 X. L. Huang, Z. Fan, C. Kalinyak, J. W. Mellors, and C. R. Rinaldo. CD8+ T Cell Gamma Interferon Production Specific for Human Immunodeficiency Virus Type 1 (HIV-1) in HIV-1-Infected Subjects. Clin. Diagn. Lab. Immunol., 7:279-287, 2000. PubMed ID: 10702505. Show all entries for this paper.


Displaying record number 1403

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24(151-159)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Rinaldo2000 C. R. Rinaldo, Jr., X. L. Huang, Z. Fan, J. B. Margolick, L. Borowski, A. Hoji, C. Kalinyak, D. K. McMahon, S. A. Riddler, W. H. Hildebrand, R. B. Day, and J. W. Mellors. Anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) T-lymphocyte reactivity during combination antiretroviral therapy in HIV-1-infected patients with advanced immunodeficiency. J. Virol., 74(9):4127-38, May 2000. URL: http://jvi.asm.org/cgi/content/full/74/9/4127. PubMed ID: 10756025. Show all entries for this paper.


Displaying record number 54557

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location Gag(151-159)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 58524

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24(19-27)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 58756

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location Gag(151-159)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Epitope Name Gag-TV9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 60602

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24(19-27)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Epitope Name TV-9
Subtype B, C
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 57650

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location  
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Show epitope variants
Epitope Name TV9
Species (MHC/HLA) (A*02:01)
Immunogen in vitro stimulation or selection
Experimental methods Flow cytometric T-cell cytokine assay, HLA binding, TCR binding, Tetramer binding
Keywords binding affinity, immunodominance, TCR usage, mimotopes

Notes

References

Schaubert2010 Keri L. Schaubert, David A. Price, Janelle R. Salkowitz, Andrew K. Sewell, John Sidney, Tedi E. Asher, Sylvie E. Blondelle, Sharon Adams, Francesco M. Marincola, Aviva Joseph, Alessandro Sette, Daniel C. Douek, Velpandi Ayyavoo, Walter Storkus, Ming-Ying Leung, Hwee L. Ng, Otto O. Yang, Harris Goldstein, Darcy B. Wilson, and June Kan-Mitchell. Generation of Robust CD8+ T-Cell Responses Against Subdominant Epitopes in Conserved Regions of HIV-1 by Repertoire Mining with Mimotopes. Eur. J. Immunol., 40(7):1950-1962, Jul 2010. PubMed ID: 20432235. Show all entries for this paper.


Displaying record number 55352

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location ( LAI)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Epitope Name T9V
Subtype B
Species (MHC/HLA) human, transgenic mouse(A*02:01)
Immunogen HIV-1 infection, vaccine
Country France
Experimental methods CD4 T-cell Elispot - IFNγ, Chromium-release assay, Other, Proliferation
Keywords computational epitope prediction, Th1

Vaccine Details

Vaccine type protein
Vaccine strain B clade
Vaccine component p24 Gag
Adjuvant Other

Notes

References

Pajot2007 Anthony Pajot, Aurélie Schnuriger, Arnaud Moris, Audrey Rodallec, David M. Ojcius, Brigitte Autran, François A. Lemonnier, and Yu-Chun Lone. The Th1 Immune Response against HIV-1 Gag p24-Derived Peptides in Mice Expressing HLA-A02.01 and HLA-DR1. Eur. J. Immunol., 37(9):2635-2644, Sep 2007. PubMed ID: 17668896. Show all entries for this paper.


Displaying record number 59244

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24(19-27)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Patient MHC/HLA Subject 8: A*02:01, A*24:02, B*07:02, B*40:01, C*03:04, C*07:02
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords dynamics, acute/early infection, dendritic cells

Notes

References

Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.


Displaying record number 55359

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24(19-27)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Epitope Name TV9
Species (MHC/HLA) human(A*02:01)
Immunogen in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding, Tetramer binding
Keywords binding affinity, immunodominance, dendritic cells

Notes

References

Schaubert2007 Keri L. Schaubert, David A. Price, Nicole Frahm, Jinzhu Li, Hwee L. Ng, Aviva Joseph, Elyse Paul, Biswanath Majumder, Velpandi Ayyavoo, Emma Gostick, Sharon Adams, Francesco M. Marincola, Andrew K. Sewell, Marcus Altfeld, Jason M. Brenchley, Daniel C. Douek, Otto O. Yang, Christian Brander, Harris Goldstein, and June Kan-Mitchell. Availability of a Diversely Avid CD8+ T Cell Repertoire Specific for the Subdominant HLA-A2-Restricted HIV-1 Gag p24(19-27) Epitope. J. Immunol., 178(12):7756-7766, 15 Jun 2007. PubMed ID: 17548613. Show all entries for this paper.


Displaying record number 152

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24( subtype B)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Subtype B
Species (MHC/HLA) human(A*02:02, A2)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons

Notes

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.


Displaying record number 53399

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24( A02, A30, B4402, B15)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 exposed seronegative
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords HIV exposed persistently seronegative (HEPS), characterizing CD8+ T cells

Notes

References

Missale2004 Gabriele Missale, Laura Papagno, Amalia Penna, Massimo Pilli, Alessandro Zerbini, Piero Vitali, Giovanni Pieroni, Simona Urbani, Jacopo Uggeri, Susana Pinheiro, Sarah Rowland-Jones, and Carlo Ferrari. Parenteral Exposure to High HIV Viremia Leads to Virus-Specific T Cell Priming without Evidence of Infection. Eur. J. Immunol., 34(11):3208-3215, Nov 2004. PubMed ID: 15459901. Show all entries for this paper.


Displaying record number 56141

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24(19-27)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Show epitope variants
Epitope Name TV9
Subtype B
Species (MHC/HLA) human, transgenic mouse(A2)
Immunogen in vitro stimulation or selection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords variant cross-reactivity

Vaccine Details

Vaccine type peptide
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Blondelle2008 Sylvie E. Blondelle, Rosa Moya-Castro, Keiko Osawa, Kim Schroder, and Darcy B. Wilson. Immunogenically Optimized Peptides Derived from Natural Mutants of HIV CTL Epitopes and Peptide Combinatorial Libraries. Biopolymers, 90(5):683-694, 2008. PubMed ID: 18481808. Show all entries for this paper.


Displaying record number 56726

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location  
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Epitope Name TV9
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type peptide, polyepitope

Notes

References

Blondelle2009 Sylvie E. Blondelle, Rosa Moya, Kim Schroder, Keiko Osawa, and Darcy B. Wilson. Natural Mutants of HIV CTL Epitopes with Enhanced Immunogenicity as Potential Vaccine Candidates. Adv. Exp. Med. Biol., 611:379-382, 2009. PubMed ID: 19400233. Show all entries for this paper.


Displaying record number 151

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24(151-159)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Parker1992 K. C. Parker, M. A. Bednarek, L. K. Hull, U. Utz, B. Cunningham H. J. Zweerink, W. E. Biddison, and J. E. Coligan. Sequence Motifs Important for Peptide Binding to the Human MHC Class I Molecule, HLA-A2. J. Immunol., 149, 1992. PubMed ID: 1331239. Show all entries for this paper.

Parker1994 K. C. Parker, M. A. Bednarek, and J. E. Coligan. Scheme for Ranking Potential HLA-A2 Binding Peptides Based on Independent Binding of Individual Peptide Side-Chains. J. Immunol., 152, 1994. The authors conclude that peptide amino acid side-chain binding to the HLA-A2 molecule is independent of the sequence of the peptide, and developed a table of coefficients that can be used to help predict peptide binding to HLA-A2. PubMed ID: 8254189. Show all entries for this paper.


Displaying record number 1439

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24(19-27)
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 60503

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HXB2 Location Gag(151-159)
p24(19-27)
DNA(1240..1266)
Gag Epitope Map
Author Location p24
Epitope TLNAWVKVV Epitope Alignment
TLNAWVKVV epitope logo
Subtype B, C, CRF01_AE
Species (MHC/HLA) human
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing

Notes

References

Steers2014 Nicholas J. Steers, Jeffrey R. Currier, Ousman Jobe, Sodsai Tovanabutra, Silvia Ratto-Kim, Mary A. Marovich, Jerome H. Kim, Nelson L. Michael, Carl R. Alving, and Mangala Rao. Designing the Epitope Flanking Regions for Optimal Generation of CTL Epitopes. Vaccine, 32(28):3509-3516, 12 Jun 2014. PubMed ID: 24795226. Show all entries for this paper.


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