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Displaying record number 55357

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HXB2 Location	Gag(151-159) p24(19-27) DNA(1240..1266)	Gag Epitope Map
Author Location	p24(19-27)
Epitope	TLNAWVKLV	Epitope Alignment
		Show epitope variants
Epitope Name	8L
Species (MHC/HLA)	human(A*02:01)
Immunogen	in vitro stimulation or selection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	binding affinity, immunodominance, dendritic cells, variant cross-reactivity, HIV-2

Notes

• CTL responses to the rarely recognized, subdominant HLA-A2-restricted Gag p24 epitope TLNAWKVV (TV9) were studied since its functional sensitivity and viral suppression is relatively high compared to other, dominant HLA-A2-restricted HIV-1 epitopes. Subdominant CTL responses to TV9 were not related to immunogenicity, availability of cognate TCR repertoires or HLA-epitope binding avidity.
• This epitope, 8L (TLNAWVKLV), is the HIV-2 Gag homolog of HIV-1 TV9(TLNAWVKVV). Relative binding of 8L was comparable to that of TV9 in T2 stabilization assays. TV9-specific CTL cultures cross-recognized 8L.

References

Schaubert2007 Keri L. Schaubert, David A. Price, Nicole Frahm, Jinzhu Li, Hwee L. Ng, Aviva Joseph, Elyse Paul, Biswanath Majumder, Velpandi Ayyavoo, Emma Gostick, Sharon Adams, Francesco M. Marincola, Andrew K. Sewell, Marcus Altfeld, Jason M. Brenchley, Daniel C. Douek, Otto O. Yang, Christian Brander, Harris Goldstein, and June Kan-Mitchell. Availability of a Diversely Avid CD8+ T Cell Repertoire Specific for the Subdominant HLA-A2-Restricted HIV-1 Gag p24(19-27) Epitope. J. Immunol., 178(12):7756-7766, 15 Jun 2007. PubMed ID: 17548613. Show all entries for this paper.