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Displaying record number 53519

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HXB2 Location	Vpr(19-28) DNA(5613..5642)	Vpr Epitope Map
Author Location	Vpr
Epitope	TLEILEELKN	Epitope Alignment
		Show epitope variants
Epitope Name	TN10
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

• Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
• One mutation, at position 1, Aleileelkn,occurred over time. This is a novel unmapped epitope, possibly associated with A3 supertype.

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.

Displaying record number 55792

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HXB2 Location	Vpr(19-28) DNA(5613..5642)	Vpr Epitope Map
Author Location	Vpr(19-28)
Epitope	TLEILEELKN	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	computational epitope prediction, HLA associated polymorphism

Notes

• 976 Vpr sequences were studied from global HIV-1 isolates to comprehensively analyze amino acid polymorphisms. Since several polymorphic residues were part of CTL epitopes, HIV-1 immune evasion in Vpr is noted.
• 51 possible amino acid polymorphisms were defined in this previously published CTL epitope, TLEILEELKN.
• Using half-time estimates of disassociation of the molecule containing the epitope from specific HLA Class I molecules, 12 additional CTL epitopes were predicted across Vpr (Table 17).

References

Srinivasan2008 Alagarsamy Srinivasan, Velpandi Ayyavoo, Sundarasamy Mahalingam, Aarthi Kannan, Anne Boyd, Debduti Datta, Vaniambadi S. Kalyanaraman, Anthony Cristillo, Ronald G. Collman, Nelly Morellet, Bassel E. Sawaya, and Ramachandran Murali. A Comprehensive Analysis of the Naturally Occurring Polymorphisms in HIV-1 Vpr: Potential Impact on CTL Epitopes. Virol. J., 5:99, 2008. PubMed ID: 18721481. Show all entries for this paper.