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Displaying record number 55069

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HXB2 Location	Tat(40-47) DNA(5948..5971)	Tat Epitope Map
Author Location	Tat
Epitope	TKGLGISY	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*15:03)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, rate of progression, immunodominance, characterizing CD8+ T cells

Notes

• CTL responses restricted by HLA-B*1503 were analyzed in HIV-1 subtype B and C-infected patients. An association between HLA-B*1503 and reduced viral loads in individuals infected with clade B was found. No such correlation was found in clade C infected subjects inspite of the same immunodominant responses in subjects infected with either subtype. Clade B viral control was associated with several subdominanat CTL epitopes lacking in clade C, suggesting that subdominant responses can contribute to viral control.
• TKGLGISY of clade B is a potential HLA-B*1503-restricted epitope, with epitope qTKGLGISY found in clade C.

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.