HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 14 matching records:

Displaying record number 61329

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location Gag
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Epitope Name TL8
Subtype A, B, C, D
Species (MHC/HLA) human(A*4002)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, immunodominance

Notes

References

Ahmed2016 Tina Ahmed, Nicola J. Borthwick, Jill Gilmour, Peter Hayes, Lucy Dorrell, and Tomáš Hanke. Control of HIV-1 Replication In Vitro by Vaccine-Induced Human CD8+ T Cells through Conserved Subdominant Pol Epitopes. Vaccine, 34(9):1215-1224, 24 Feb 2016. PubMed ID: 26784683. Show all entries for this paper.


Displaying record number 56033

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location p2p7p1p6
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Epitope Name TL8(p2p7p1p6)
Subtype B
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 56380

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location p2p7p1p6(427-434)
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Epitope Name TL8
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 57395

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location Gag(427-434)
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Epitope Name TL8
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 58498

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location Gag(427-434)
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 55260

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location p15(64-71)
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords assay or method development, optimal epitope

Notes

References

Wang2007 Shaoyang Wang, Yongtao Sun, Song Zhai, Yan Zhuang, Shuguang Zhao, Whenzhen Kang, Xinhong Li, Dedong Huang, Xu G. Yu, Bruce D. Walker, and Marcus A. Altfeld. Identification of HLA-A11-Restricted HIV-1-Specific Cytotoxic T-Lymphocyte Epitopes in China. Curr. HIV Res., 5(1):119-128, Jan 2007. PubMed ID: 17266563. Show all entries for this paper.


Displaying record number 60300

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location Gag(427-434)
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Epitope Name TL8
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 52571

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location p15(64-71)
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Species (MHC/HLA) human(B*4002)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 1962

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location p24-p2p7p1p6(64-71)
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Epitope Name Gag-TL8, p7-TL8
Subtype B
Species (MHC/HLA) human(B*4002)
Immunogen HIV-1 infection
Patient MHC/HLA 01RCH59: A*0201, A*3201, B*4002, B*5301, Cw*0202, Cw*0401
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART, novel epitope

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 61012

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location p2p7p1p6(64-71)
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Subtype B
Species (MHC/HLA) human(B*4002)
Immunogen HIV-1 infection
Patient MHC/HLA 20786: A*0201, A*1101, B*2705, B*4002, Cw*0202, Cw*0202
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 61793

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location  
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Epitope Name TL8
Subtype B
Species (MHC/HLA) human(B*4002)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining
Keywords vaccine-induced immune responses, variant cross-reactivity

Notes

References

Murakoshi2018 Hayato Murakoshi, Chengcheng Zou, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. CD8+ T Cells Specific for Conserved, Cross-Reactive Gag Epitopes with Strong Ability to Suppress HIV-1 Replication. Retrovirology, 15(1):46, 3 Jul 2018. PubMed ID: 29970102. Show all entries for this paper.


Displaying record number 60299

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location Gag(427-434)
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Epitope Name TL8
Species (MHC/HLA) human(B*41)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61796

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location  
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Epitope Name TL8
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA VID421: A*0201, A*1101, B*3503, B*4002, Cw*0202, Cw*1203; VID421: A*0201, A*1101, B*3503, B*4002, Cw*0202, Cw*1203
Country United Kingdom
Experimental methods Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, optimal epitope

Notes

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.


Displaying record number 59404

HXB2 Location Gag(427-434)
p2p7p1p6(64-71)
DNA(2068..2091)
Gag Epitope Map
Author Location Gag
Epitope TERQANFL Epitope Alignment
TERQANFL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA LTNP/EC-18: A*03, A*68, B*40, B*53, Cw*02, Cw*04
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


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