Search CTL/CD8+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 415

Download this epitope record as JSON.

HXB2 Location	Pol(194-202) RT(39-47) DNA(2664..2690)	Pol Epitope Map
Author Location	RT
Epitope	`TEMEKEGKI`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2K^k)
Immunogen
Experimental methods
Keywords

Notes

Epitope variants were examined for CTL response in concert with H-2K^k MHC class I binding -- all of the following combinations were observed: (i) two single mutations which did not alone abrogated CTL activity did abrogate activity when combined, (ii) loss of recognition of a single substitution could be restored by an additional substitution, and (iii) sometimes there was recognition of two single substitutions as well as the combination of those substitutions.
2E and 9I are anchor residues for H-2K^k---if you have M in the third position, it enhances H-2K^k binding 10-fold, but polymorphism at this site is important for the overall conformation of the peptide and can influence T cell recognition.

References

Leggatt1998 G. R. Leggatt, A. Hosmalin, C. D. Pendleton, A. Kumar, S. Hoffman, and J. A. Berzofsky. The Importance of Pairwise Interactions between Peptide Residues in the Delineation of TCR specificity. J. Immunol., 161:4728-4735, 1998. PubMed ID: 9794403. Show all entries for this paper.