HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 16 matching records:

Displaying record number 846

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp41(605-615 LAI)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Johnson1994 R. P. Johnson, S. A. Hammond, A. Trocha, R. F. Siliciano, and B. D. Walker. Induction of a Major Histocompatibility Complex Class I-Restricted Cytotoxic T-Lymphocyte Response to a Highly Conserved Region of Human Immunodeficiency Virus Type 1 (HIV-1) gp120 in Seronegative Humans Immunized with a Candidate HIV-1 Vaccine. J. Virol., 68:3145-3153, 1994. In two volunteers, immunization with a single strain of HIV-1 induced CD4+ and CD8+ CTL that are specific for multiple conserved regions of HIV-1 and would be expected to recognize a broad range of viral isolates. The immunodominant gp120 epitope, gp120 TVYYGVPVWK, elicited CD8+ HLA-A3.1 restricted CTL, and this epitope is highly conserved. CTL specific for this epitope could lyse target cells sensitized with all known natural sequence variants. Additionally, CD8+ HLA-B35 and CD8+ HLA-B18 restricted epitopes were defined as well as two CD4+ cytotoxic T-cell gp120 epitopes: ITQACPKVSFEPIPHYCAPAGFAI and NNTLKQIDSKLREQFG. PubMed ID: 7908700. Show all entries for this paper.


Displaying record number 848

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp41(606-614 LAI)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Johnson1994c R. P. Johnson, S. A. Hammond, A. Trocha, R. F. Siliciano, and B. D. Walker. Epitope Specificity of MHC Restricted Cytotoxic T Lymphocytes Induced by Candidate HIV-1 Vaccine. AIDS Res. Hum. Retroviruses, 10, Supp 2:S73-S75, 1994. Volunteers were immunized with recombinant vaccinia virus expressing HIV-1 gp160 (vac-env) and boosted with recombinant gp160 (rgp160). CTL clones were analyzed for HLA restriction and specificity. An immunodominant HLA-A3.1 restricted epitope was observed that showed very little sequence variation among B subtype sequences, (TVYYGVPVWK). Naturally occurring variants of this peptide were able to stimulate reactivity. Two additional CD8+ CTL epitopes from vaccinees were characterized, as well as two CD4+ CTL epitopes. PubMed ID: 7532425. Show all entries for this paper.


Displaying record number 849

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp41(606-614 LAI)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Hammond1995 S. A. Hammond, R. P. Johnson, S. A. Kalams, B. D. Walker, M. Takiguchi, J. T. Safrit, R. A. Koup, and R. F. Siliciano. An Epitope-Selective Transporter Associated with Antigen Presentation TAP-1/2-Independent Pathway and a More General TAP-1/2-Dependent Antigen-Processing Pathway Allow Recognition of the HIV-1 Envelope Glycoprotein by CD8+ CTL. J. Immunol., 154:6140-6156, 1995. Two peptide-processing pathways are utilized for MHC class I presentation of HIV-1 Env epitopes. The previously characterized TAP-1 and TAP-2 dependent pathway can generate all Env epitopes and uses Env protein mislocalized in the cytosol to produce peptides. The second, novel pathway uses a TAP-1/2 independent pathway, and allows a subset of MHC-restricted epitopes to be processed in the endoplasmic reticulum or a Golgi compartment. PubMed ID: 7538543. Show all entries for this paper.


Displaying record number 851

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp41(606-614)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferris1999 R. L. Ferris, C. Hall, N. V. Sipsas, J. T. Safrit, A. Trocha, R. A. Koup, R. P. Johnson, and R. F. Siliciano. Processing of HIV-1 Envelope Glycoprotein for Class I-Restricted Recognition: Dependence on TAP1/2 and Mechanisms for Cytosolic Localization. J. Immunol., 162:1324-1332, 1999. PubMed ID: 9973386. Show all entries for this paper.


Displaying record number 852

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp41( subtype B)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons

Notes

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.


Displaying record number 1682

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp41(606-614)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 52628

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp41(606-614)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Patient MHC/HLA A3, A33, B14, B35, Cw*0401, Cw*0802
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 56021

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp41
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Epitope Name TW9(gp41)
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 61011

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp160(606-614)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Patient MHC/HLA 32645: A*0101, A*0201, B*0801, B*3503, Cw*0401, Cw*0701
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 53116

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location Env(96-104)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 61901

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location Env(606-614)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Epitope Name TW9
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Keywords escape, HLA associated polymorphism

Notes

References

Murakoshi2018a Hayato Murakoshi, Madoka Koyanagi, Tomohiro Akahoshi, Takayuki Chikata, Nozomi Kuse, Hiroyuki Gatanaga, Sarah L. Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi. Impact of a Single HLA-A*24:02-Associated Escape Mutation on the Detrimental Effect of HLA-B*35:01 in HIV-1 Control. EBioMedicine, 36:103-112, Oct 2018. PubMed ID: 30249546. Show all entries for this paper.


Displaying record number 58673

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location Env(606-614)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Epitope Name Env TW9
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country Barbados, Botswana, Haiti, Japan, Mexico, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Matthews2012 Philippa C. Matthews, Madoka Koyanagi, Henrik N. Kløverpris, Mikkel Harndahl, Anette Stryhn, Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, Claudia Juarez Molina, Humberto Valenzuela Ponce, Santiago Avila Rios, David Cole, Jonathan Carlson, Rebecca P. Payne, Anthony Ogwu, Alfred Bere, Thumbi Ndung'u, Kamini Gounder, Fabian Chen, Lynn Riddell, Graz Luzzi, Roger Shapiro, Christian Brander, Bruce Walker, Andrew K. Sewell, Gustavo Reyes Teran, David Heckerman, Eric Hunter, Søren Buus, Masafumi Takiguchi, and Philip J. R. Goulder. Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope. J. Virol., 86(23):12643-12654, Dec 2012. PubMed ID: 22973023. Show all entries for this paper.


Displaying record number 850

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp41(606-614 HXB2)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing

Notes

References

Ferris1996 R. L. Ferris, C. Buck, S. A. Hammond, A. S. Woods, R. J. Cotter, M. Takiguchi, Y. Igarashi, Y. Ichikawa, and R. F. Siliciano. Class I-Restricted Presentation of an HIV-1 gp41 Epitope Containing an N-Linked Glycosylation Site. J. Immunol., 156:834-840, 1996. The class I processing pathway usually begins in the cytosol. Env proteins are co-translationally located in the endoplasmic reticulum, where they are glycosylated, and in general are not found in the cytosol. The N-linked glycosylation site was not occupied in the TAVPWNASW naturally processed peptide presented by B*3501, and the non-glycosylated form was the form recognized by an env-specific CTL clone. This suggests that there may be limited failure of translocation, resulting in synthesis and degradation in the cytosol, and entry in the normal class I processing pathway. PubMed ID: 8543840. Show all entries for this paper.


Displaying record number 847

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp41(605-615 LAI)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen vaccine
Experimental methods  
Keywords optimal epitope

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 60298

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location Env(606-614)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Epitope Name TW9
Species (MHC/HLA) human(B*3501, B*3508)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60297

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location Env(606-614)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Epitope Name TW9
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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