HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 56 matching records:

Displaying record number 53605

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-290)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*0301, B*3501, B*51, Cw*04, Cw*06
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords acute/early infection

Notes

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


Displaying record number 61324

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Subtype A, B, C, D
Species (MHC/HLA) human(A*0201, B*5101)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, immunodominance

Notes

References

Ahmed2016 Tina Ahmed, Nicola J. Borthwick, Jill Gilmour, Peter Hayes, Lucy Dorrell, and Tomáš Hanke. Control of HIV-1 Replication In Vitro by Vaccine-Induced Human CD8+ T Cells through Conserved Subdominant Pol Epitopes. Vaccine, 34(9):1215-1224, 24 Feb 2016. PubMed ID: 26784683. Show all entries for this paper.


Displaying record number 1960

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name Pol-TI8; RT-TO8
Subtype B
Species (MHC/HLA) human(A*0217, B*5101)
Immunogen HIV-1 infection
Patient MHC/HLA 01RCH46: A*0201, A*0217, B*0801, B*4002, Cw*0303, Cw*0701
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART, novel epitope

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 60295

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-290)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Species (MHC/HLA) human(A*23)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60296

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-290)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60294

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-290)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Species (MHC/HLA) human(A*66)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60293

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-290)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60290

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-290)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 52995

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Patient MHC/HLA A3, A32, B15, B51, Cw03, Cw6, DQ7, DR4, DR8
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape

Notes

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 53499

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53634

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(295-302)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A31, B51, B58w4
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords HAART, ART, escape, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.


Displaying record number 54374

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name B51-TI8(RT)
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 57970

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance, elite controllers

Notes

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.


Displaying record number 55513

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 55213

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location  
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 55660

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location  
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords TCR usage, characterizing CD8+ T cells

Notes

References

Alter2008 Galit Alter, Suzannah Rihn, Hendrik Streeck, Nickolas Teigen, Alicja Piechocka-Trocha, Kristin Moss, Kristen Cohen, Angela Meier, Florencia Pereyra, Bruce Walker, and Marcus Altfeld. Ligand-Independent Exhaustion of Killer Immunoglobulin-Like Receptor-Positive CD8+ T Cells in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 82(19):9668-9677, Oct 2008. PubMed ID: 18579582. Show all entries for this paper.


Displaying record number 56045

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8(RT)
Subtype B
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 434

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(295-302 IIIB)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 1387

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(295-302)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TAF
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 435

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(295-302)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 52254

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Subtype B
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A3, B35, B51
Experimental methods  
Keywords mother-to-infant transmission

Notes

References

Sabbaj2002a Steffanie Sabbaj, Bradley H. Edwards, Mrinal K. Ghosh, Katherine Semrau, Sanford Cheelo, Donald M. Thea, Louise Kuhn, G. Douglas Ritter, Mark J. Mulligan, Paul A. Goepfert, and Grace M. Aldrovandi. Human Immunodeficiency Virus-Specific CD8(+) T Cells in Human Breast Milk. J. Virol., 76(15):7365-7373, Aug 2002. PubMed ID: 12097549. Show all entries for this paper.


Displaying record number 52648

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Subtype B
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A11, B51, B61, Cw*14, Cw2
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 61250

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-289)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Epitope Name TI8
Subtype B, CRF01_AE
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Patient MHC/HLA YA131: B*51; YA133: B*51; YA33: B*51; YA59: B*51; YA13: B*51; YA103: B*51; YA86: B*51
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords escape, acute/early infection, kinetics

Notes

References

Sun2016a Jianping Sun, Yan Zhao, Yanchun Peng, Zhen Han, Guihai Liu, Ling Qin, Sai Liu, Huanhuan Sun, Hao Wu, Tao Dong, and Yonghong Zhang. Multiple T-Cell Responses Are Associated with Better Control of Acute HIV-1 Infection: An Observational Study. Medicine, 95(30):e4429, Jul 2016. PubMed ID: 27472741. Show all entries for this paper.


Displaying record number 1502

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(295-302 LAI)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name P5
Subtype B
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.


Displaying record number 54617

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Country Switzerland
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, HLA associated polymorphism, elite controllers

Notes

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 56397

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 57127

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Experimental methods HLA binding, Intracellular cytokine staining, Relative replication capacity assay
Keywords binding affinity, escape, HLA associated polymorphism

Notes

References

Kawashima2009 Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung'u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, and Philip Goulder. Adaptation of HIV-1 to Human Leukocyte Antigen Class I. Nature, 458(7238):641-645, 2 Apr 2009. PubMed ID: 19242411. Show all entries for this paper.


Displaying record number 57328

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Subtype A, CRF02_AG, CRF06_cpx, CRF09_cpx
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Country Burkina Faso
Experimental methods Other
Keywords drug resistance

Notes

References

Tebit2009 Denis M. Tebit, Lassana Sangaré, Fabrice Tiba, Yameogo Saydou, Aline Makamtse, Hermann Somlare, Guillaume Bado, Boris G. Kouldiaty, Inoussa Zabsonre, Sibiri L. Yameogo, Kanokporn Sathiandee, Joseph Y. Drabo, and Hans-Georg Kräusslich. Analysis of the Diversity of the HIV-1 pol Gene and Drug Resistance Associated Changes among Drug-Naïve Patients in Burkina Faso. J. Med. Virol., 81(10):1691-701, Oct 2009. PubMed ID: 19697403. Show all entries for this paper.


Displaying record number 57505

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Country Japan
Experimental methods  
Keywords escape, drug resistance

Notes

References

Gatanaga2010 Hiroyuki Gatanaga, Hirotaka Ode, Atsuko Hachiya, Tsunefusa Hayashida, Hironori Sato, Masafumi Takiguchi, and Shinichi Oka. Impact of Human Leukocyte Antigen-B*51-Restricted Cytotoxic T-Lymphocyte Pressure on Mutation Patterns of Nonnucleoside Reverse Transcriptase Inhibitor Resistance. AIDS, 24(5):F15-F22, 13 Mar 2010. PubMed ID: 20160632. Show all entries for this paper.


Displaying record number 60291

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-290)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62170

HXB2 Location Pol(283-290)
RT(128-135)
Pol Epitope Map
Author Location RT
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Species (MHC/HLA) human(B*51, B*52)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Carlson2015 Jonathan M. Carlson, Anh Q. Le, Aniqa Shahid, and Zabrina L. Brumme. HIV-1 adaptation to HLA: a window into virus-host immune interactions. Trends Microbiol, 23(4):212-24 doi, Apr 2015. PubMed ID: 25613992 Show all entries for this paper.


Displaying record number 58151

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection

Notes

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 58988

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 59083

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion

Notes

References

Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.


Displaying record number 57636

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-288)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Epitope Name Pol 283-8
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords rate of progression

Notes

References

Kawashima2010 Yuka Kawashima, Nozomi Kuse, Hiroyuki Gatanaga, Takuya Naruto, Mamoru Fujiwara, Sachi Dohki, Tomohiro Akahoshi, Katsumi Maenaka, Philip Goulder, Shinichi Oka, and Masafumi Takiguchi. Long-Term Control of HIV-1 in Hemophiliacs Carrying Slow-Progressing Allele HLA-B*5101. J. Virol., 84(14):7151-7160, Jul 2010. PubMed ID: 20410273. Show all entries for this paper.


Displaying record number 61169

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-290)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61212

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, escape, HLA associated polymorphism

Notes

References

Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.


Displaying record number 61238

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Epitope Name TI8
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, TCR usage

Notes

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.


Displaying record number 437

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-290 SF2)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, rate of progression

Notes

References

Tomiyama1999 H. Tomiyama, T. Sakaguchi, K. Miwa, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Identification of multiple HIV-1 CTL epitopes presented by HLA-B*5101. Hum. Immunol., 60:177-86, 1999. PubMed ID: 10321954. Show all entries for this paper.


Displaying record number 436

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(295-302 IIIB)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 61499

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-288)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name KM2, SF2-Pol-283-8
Species (MHC/HLA) human(B*5101)
Immunogen peptide-HLA interaction
Experimental methods Other
Keywords structure, protective allele

Notes

References

Maenaka2000 Katsumi Maenaka, Taeko Maenaka, Hiroko Tomiyama, Masafumi Takiguchi, David I. Stuart, and E. Yvonne Jones. Nonstandard Peptide Binding Revealed by Crystal Structures of HLA-B*5101 Complexed with HIV Immunodominant Epitopes. J. Immunol., 165(6):3260-3267, 15 Sep 2000. PubMed ID: 10975842. Show all entries for this paper.


Displaying record number 61574

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Species (MHC/HLA) human(B*5101)
Immunogen vaccine
Experimental methods Other
Keywords review, vaccine-induced immune responses, vaccine antigen design, protective allele

Notes

References

Goulder2008 Philip J. R. Goulder and David I. Watkins. Impact of MHC Class I Diversity on Immune Control of Immunodeficiency Virus Replication. Nat. Rev. Immunol., 8(8):619-630, Aug 2008. PubMed ID: 18617886. Show all entries for this paper.


Displaying record number 59273

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Country Japan
Experimental methods Other, TCR binding, Tetramer binding
Keywords immunodominance, structure

Notes

References

Motozono2014a Chihiro Motozono, Nozomi Kuse, Xiaoming Sun, Pierre J. Rizkallah, Anna Fuller, Shinichi Oka, David K. Cole, Andrew K. Sewell, and Masafumi Takiguchi. Molecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-Mer Epitope Presented by the Protective Allele HLA-B*51:01. J. Immunol., 192(7):3428-34, 1 Apr 2014. PubMed ID: 24600035. Show all entries for this paper.


Displaying record number 62166

HXB2 Location Pol(283-290)
RT(128-135)
Pol Epitope Map
Author Location RT(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name RT-TI8
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape, HLA associated polymorphism, review

Notes

References

Avila-Rios2019 Santiago Avila-Rios, Jonathan M. Carlson, Mina John, Simon Mallal, and Zabrina L. Brumme. Clinical and evolutionary consequences of HIV adaptation to HLA: implications for vaccine and cure. Curr Opin HIV AIDS, 14(3):194-204 doi, May 2019. PubMed ID: 30925534 Show all entries for this paper.


Displaying record number 54307

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-288 NL-432)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords binding affinity, class I down-regulation by Nef, rate of progression

Notes

References

Tomiyama2005 Hiroko Tomiyama, Mamoru Fujiwara, Shinichi Oka, and Masafumi Takiguchi. Cutting Edge: Epitope-Dependent Effect of Nef-Mediated HLA Class I Down-Regulation on Ability of HIV-1-Specific CTLs to Suppress HIV-1 Replication. J. Immunol., 174(1):36-40, 1 Jan 2005. PubMed ID: 15611225. Show all entries for this paper.


Displaying record number 61852

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location  
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.


Displaying record number 54151

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135 HXB2)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, mutation acquisition, optimal epitope

Notes

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


Displaying record number 52065

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(128-135 IIIB)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, escape

Notes

References

Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.


Displaying record number 1473

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT(295-302)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name P5
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, escape

Notes

References

Samri2000 A. Samri, G. Haas, J. Duntze, J. M. Bouley, V. Calvez, C. Katlama, and B. Autran. Immunogenicity of mutations induced by nucleoside reverse transcriptase inhibitors for human immunodeficiency virus type 1-specific cytotoxic T cells. J. Virol., 74(19):9306-12, Oct 2000. URL: http://jvi.asm.org/cgi/content/full/74/19/9306. PubMed ID: 10982378. Show all entries for this paper.


Displaying record number 61523

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-290)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Epitope Name Pol283-8, TI8
Subtype B
Species (MHC/HLA) human(B*5101, B*5201)
Immunogen HIV-1 infection
Patient MHC/HLA KI-069: A*2402, B*4006, B*5201, Cw*0304, Cw*1202; KI-090: A*2402, B*5201, B*5501; KI-076: A*0201, A*2401, B*4001, B*5201; KI-037: A*2402, B*4002, B*5201
Country Australia, Canada, Japan, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other, Relative replication capacity assay, Tetramer binding
Keywords escape, HLA cross-presentation, structure, chronic infection

Notes

References

Yagita2013 Yuichi Yagita, Nozomi Kuse, Kimiko Kuroki, Hiroyuki Gatanaga, Jonathan M. Carlson, Takayuki Chikata, Zabrina L. Brumme, Hayato Murakoshi, Tomohiro Akahoshi, Nico Pfeifer, Simon Mallal, Mina John, Toyoyuki Ose, Haruki Matsubara, Ryo Kanda, Yuko Fukunaga, Kazutaka Honda, Yuka Kawashima, Yasuo Ariumi, Shinichi Oka, Katsumi Maenaka, and Masafumi Takiguchi. Distinct HIV-1 Escape Patterns Selected by Cytotoxic T Cells with Identical Epitope Specificity. J. Virol., 87(4):2253-2263, Feb 2013. PubMed ID: 23236061. Show all entries for this paper.


Displaying record number 61851

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location  
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Subtype B
Species (MHC/HLA) human(B*5201)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.


Displaying record number 60292

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-290)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Species (MHC/HLA) human(C*12)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54686

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT Pol(128-135)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A3, A32, B15, B51
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HAART, ART, escape, viral fitness and reversion

Notes

References

Asquith2006 Becca Asquith, Charles T. T. Edwards, Marc Lipsitch, and Angela R. McLean. Inefficient Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo. PLoS Biol., 4(4):e90, Apr 2006. PubMed ID: 16515366. Show all entries for this paper.


Displaying record number 56206

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location RT
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Garrison2007 Keith E. Garrison, R. Brad Jones, Duncan A. Meiklejohn, Naveed Anwar, Lishomwa C. Ndhlovu, Joan M. Chapman, Ann L. Erickson, Ashish Agrawal, Gerald Spotts, Frederick M. Hecht, Seth Rakoff-Nahoum, Jack Lenz, Mario A. Ostrowski, and Douglas F. Nixon. T Cell Responses to Human Endogenous Retroviruses in HIV-1 Infection. PLoS Pathog., 3(11):e165, Nov 2007. PubMed ID: 17997601. Show all entries for this paper.


Displaying record number 59181

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location Pol(283-288 NL-432)
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Show epitope variants
Epitope Name TI8
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA KI-021: A*2402, A*2602, B*5101, B*6701, C*0702, C*1402; KI-051: B*5101; KI-124: B*5101
Country Japan
Experimental methods CTL suppression of replication, Chromium-release assay, Growth competition assay, Tetramer binding
Keywords binding affinity, escape, variant cross-reactivity, mutation acquisition, elite controllers

Notes

References

Kuse2014 Nozomi Kuse, Tomohiro Akahoshi, Hiroyuki Gatanaga, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi. Selection of TI8-8V Mutant Associated with Long-Term Control of HIV-1 by Cross-Reactive HLA-B*51:01-Restricted Cytotoxic T Cells. J. Immunol., 193(10):4814-4822, 15 Nov 2014. PubMed ID: 25305317. Show all entries for this paper.


Displaying record number 61809

HXB2 Location Pol(283-290)
RT(128-135)
DNA(2931..2954)
Pol Epitope Map
Author Location  
Epitope TAFTIPSI Epitope Alignment
TAFTIPSI epitope logo
Epitope Name TI8
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA VID411: A*0201, B*0801, B*5101, Cw*0303, Cw*0701; VID411: A*0201, B*0801, B*5101, Cw*0303, Cw*0701
Country United Kingdom
Experimental methods Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.


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