Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 55953

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HXB2 Location	gp160(767-780) gp41(256-269) DNA(8523..8564)	gp160 Epitope Map
Author Location	gp41
Epitope	SYHRLRDLLLIVTR	Epitope Alignment
Epitope Name	SR14(gp41)
Subtype	B
Species (MHC/HLA)	human(A3, A31)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

• 49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
• An inverse correlation was found between CTL response and viral load.
• Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
• Previously described HLA-A3- and -A31-restricted epitope SYHRLRDLLLIVTR elicited an immune response in Chinese HIV-1 positive subjects as part of peptide SLCLFSYHRLRDLLLIV.

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.

Displaying record number 861

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HXB2 Location	gp160(767-780) gp41(256-269) DNA(8523..8564)	gp160 Epitope Map
Author Location	gp41(606-614 LAI)
Epitope	SYHRLRDLLLIVTR	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A31)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• Peptide only processed by a TAP-1/2-dependent pathway.
• CTL from an acute seroconverter.

References

Hammond1995 S. A. Hammond, R. P. Johnson, S. A. Kalams, B. D. Walker, M. Takiguchi, J. T. Safrit, R. A. Koup, and R. F. Siliciano. An Epitope-Selective Transporter Associated with Antigen Presentation TAP-1/2-Independent Pathway and a More General TAP-1/2-Dependent Antigen-Processing Pathway Allow Recognition of the HIV-1 Envelope Glycoprotein by CD8+ CTL. J. Immunol., 154:6140-6156, 1995. Two peptide-processing pathways are utilized for MHC class I presentation of HIV-1 Env epitopes. The previously characterized TAP-1 and TAP-2 dependent pathway can generate all Env epitopes and uses Env protein mislocalized in the cytosol to produce peptides. The second, novel pathway uses a TAP-1/2 independent pathway, and allows a subset of MHC-restricted epitopes to be processed in the endoplasmic reticulum or a Golgi compartment. PubMed ID: 7538543. Show all entries for this paper.