Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 61734

HXB2 Location	Pol(272-281) RT(117-126) DNA(2898..2927)	Pol Epitope Map
Author Location	RT(117-126)
Epitope	SVPLDEGFRK	Epitope Alignment
Epitope Name	SK10
Species (MHC/HLA)	human(A*1101)
Immunogen
Experimental methods
Keywords	optimal epitope

Notes

• C. Brander notes this as an A*1101-restricted RT epitope (Ahmed2016).

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 61755

HXB2 Location	Pol(272-281) RT(117-126) DNA(2898..2927)	Pol Epitope Map
Author Location	RT(117-126)
Epitope	SVPLDEGFRK	Epitope Alignment
Epitope Name	SK10
Species (MHC/HLA)	human(A*1101)
Immunogen
Experimental methods
Keywords	optimal epitope

Notes

• C. Brander notes this as an A*1101-restricted RT epitope (Borthwick2017).

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 61804

HXB2 Location	Pol(272-281) RT(117-126) DNA(2898..2927)	Pol Epitope Map
Author Location
Epitope	SVPLDEGFRK	Epitope Alignment
Epitope Name	SK10
Species (MHC/HLA)	human(A*1101)
Immunogen	HIV-1 infection, vaccine
Patient MHC/HLA	VID421: A*0201, A*1101, B*3503, B*4002, Cw*0202, Cw*1203; VID421: A*0201, A*1101, B*3503, B*4002, Cw*0202, Cw*1203
Country	United Kingdom
Experimental methods	Intracellular cytokine staining, Other
Keywords	vaccine-induced immune responses, optimal epitope, novel epitope

Notes

• Since CTL response in natural HIV-1 infections is mostly against variable but immunodominant epitopes, lymphocytes from 12 vaccine(HIVconsv)-exposed subjects of the HIV-CORE 002 study were used to determine and define 14 less variable but typically subdominant, optimal novel epitopes.
• Epitope SVPLDEGFRK (SK10) is within peptide YFSVPLDEGFRKYTA (HC078) that was recognized by VID421, 1/12 vaccinated subjects. SK10 was previously reported to be an HLA-A*11 restricted epitope but is now shown to be restricted by HLA-A*1101, and thus an A-list candidate for the Los Alamos HIV Immunology database. A variant, SVPLDEsFRK, was reported in HIV-1 exposed uninfected sex workers from Thailand (Sriwanthana2001).

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.

Displaying record number 61327

HXB2 Location	Pol(272-281) RT(117-126) DNA(2898..2927)	Pol Epitope Map
Author Location	Pol
Epitope	SVPLDEGFRK	Epitope Alignment
Epitope Name	SK10
Subtype	A, B, C, D
Species (MHC/HLA)	human
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords	vaccine-induced immune responses, immunodominance

Notes

• Previous studies of the HIVconsv vaccine containing a chimeric protein with alternating HIV-1 Clade A, B, C, D conserved regions showed that subdominant epitopes could induce strong CTL response correlating with Gag and Pol-specific IFN-γ production. Here the specificity i.e. the epitopes themselves were characterized as well as the functionality, (i.e. cytokine production) of CTL from 3 subjects of the HIV-CORE 002 trial.
• CTL elicited by HIVconsv from healthy human volunteer421 (A*0201, A*1101/ B*3503, B*4002/ Cw*0202, Cw*1203) when expanded upon stimulation with peptide Pol 78, YPSVPLDEGFRKYTA (Pol 270-284), gave a strongly hierarchical immune response of a maximum of 2367 sfc/ml. It contained the mapped epitope SVPLDEGFRK.

References

Ahmed2016 Tina Ahmed, Nicola J. Borthwick, Jill Gilmour, Peter Hayes, Lucy Dorrell, and Tomáš Hanke. Control of HIV-1 Replication In Vitro by Vaccine-Induced Human CD8+ T Cells through Conserved Subdominant Pol Epitopes. Vaccine, 34(9):1215-1224, 24 Feb 2016. PubMed ID: 26784683. Show all entries for this paper.