HIV molecular immunology database
Found 15 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | SW10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | Germany | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | elite controllers |
Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(838-847) | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Epitope Name | SW10 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Epitope Name | B57-SW10(Int) | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(123-132) | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 21746: A*01:01, A*68:01, B*40:01, B*57:01, C*03:04, C*06:02, DQB1*03:02, DQB1*03:03 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Epitope Name | SW10 | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | epitope processing, supervised treatment interruptions (STI), rate of progression, immunodominance |
Rodriguez2004 William R. Rodriguez, Marylyn M. Addo, Almas Rathod, Cecily A. Fitzpatrick, Xu G. Yu, Beth Perkins, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. CD8+ T Lymphocyte Responses Target Functionally Important Regions of Protease and Integrase in HIV-1 Infected Subjects. J. Transl. Med., 2(1):15, 21 May 2004. PubMed ID: 15154967. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(123-132) | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Epitope Name | SW10 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*58:01, B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | responses in children, mother-to-infant transmission, characterizing CD8+ T cells |
Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(123-132) | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Spain, Switzerland | |
Experimental methods | Other | |
Keywords | mutation acquisition |
Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(128-132) | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | SW10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Country | Australia | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, HLA associated polymorphism |
Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(838-847) | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Epitope Name | SW10 | |
Species (MHC/HLA) | human(B*58:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(123-132) | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Epitope Name | SW9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*58:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*30:01:01, A*68:01:01, B*58:01, B*58:02 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, acute/early infection, mutation acquisition, elite controllers |
OConnell2009 Karen A. O'Connell, Jie Xu, Anna P. Durbin, Linda G. Apuzzo, Hejab Imteyaz, Thomas M. Williams, Stuart C. Ray, Joseph B. Margolick, Robert F. Siliciano, and Joel N. Blankson. HIV-1 Evolution Following Transmission to an HLA-B*5801-Positive Patient. J. Infect. Dis., 200(12):1820-1824, 15 Dec 2009. PubMed ID: 19909081. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(838-847) | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Epitope Name | SW10 | |
Species (MHC/HLA) | human(C*12) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) DNA(4596..4625) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(123-132) | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Epitope Name | SW10 | |
Subtype | B, C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | acute/early infection, HLA associated polymorphism, chronic infection, protective allele |
Ojwach2018 Doty B. A. Ojwach, Daniel MacMillan, Tarylee Reddy, Vladimir Novitsky, Zabrina L. Brumme, Mark A. Brockman, Thumbi Ndung'u, and Jaclyn K. Mann. Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection. J. Virol., 92(19), 1 Oct 2018. PubMed ID: 29997209. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(838-847) Integrase(123-132) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(123-132) | |
Epitope |
STTVKAACWW
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | SW10 | |
Subtype | B, C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | vaccine antigen design |
Ojwach2021 Doty B. A. Ojwach, Paradise Madlala, Michelle Gordon, Thumbi Ndung'u, and Jaclyn K. Mann. Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design. Virology, 554:1-8 doi, Feb 2021. PubMed ID: 33316731 Show all entries for this paper.