HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 15 matching records:

Displaying record number 59140

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HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Integrase
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Show epitope variants
Epitope Name SW10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 60282

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HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Pol(838-847)
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Epitope Name SW10
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54392

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HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Integrase
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Epitope Name B57-SW10(Int)
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 61010

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HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Integrase(123-132)
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA 21746: A*01:01, A*68:01, B*40:01, B*57:01, C*03:04, C*06:02, DQB1*03:02, DQB1*03:03
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 53139

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HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Integrase
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Epitope Name SW10
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords epitope processing, supervised treatment interruptions (STI), rate of progression, immunodominance

Notes

References

Rodriguez2004 William R. Rodriguez, Marylyn M. Addo, Almas Rathod, Cecily A. Fitzpatrick, Xu G. Yu, Beth Perkins, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. CD8+ T Lymphocyte Responses Target Functionally Important Regions of Protease and Integrase in HIV-1 Infected Subjects. J. Transl. Med., 2(1):15, 21 May 2004. PubMed ID: 15154967. Show all entries for this paper.


Displaying record number 52596

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HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Integrase(123-132)
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Species (MHC/HLA) human(B57)
Immunogen  
Experimental methods  
Keywords optimal epitope, A-list

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53490

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HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Pol
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Epitope Name SW10
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53651

Download this epitope record as JSON.

HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location  
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Species (MHC/HLA) human(B*58:01, B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords responses in children, mother-to-infant transmission, characterizing CD8+ T cells

Notes

References

Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.


Displaying record number 58979

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HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Integrase(123-132)
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Subtype B
Species (MHC/HLA) human(B*57:01)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 57955

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HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Integrase(128-132)
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Show epitope variants
Epitope Name SW10
Subtype B
Species (MHC/HLA) human(B*57:01)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA associated polymorphism

Notes

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 60283

Download this epitope record as JSON.

HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Pol(838-847)
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Epitope Name SW10
Species (MHC/HLA) human(B*58:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57205

Download this epitope record as JSON.

HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Integrase(123-132)
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Epitope Name SW9
Subtype B
Species (MHC/HLA) human(B*58:01)
Immunogen HIV-1 infection
Patient MHC/HLA A*30:01:01, A*68:01:01, B*58:01, B*58:02
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection, mutation acquisition, elite controllers

Notes

References

OConnell2009 Karen A. O'Connell, Jie Xu, Anna P. Durbin, Linda G. Apuzzo, Hejab Imteyaz, Thomas M. Williams, Stuart C. Ray, Joseph B. Margolick, Robert F. Siliciano, and Joel N. Blankson. HIV-1 Evolution Following Transmission to an HLA-B*5801-Positive Patient. J. Infect. Dis., 200(12):1820-1824, 15 Dec 2009. PubMed ID: 19909081. Show all entries for this paper.


Displaying record number 60284

Download this epitope record as JSON.

HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Pol(838-847)
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Epitope Name SW10
Species (MHC/HLA) human(C*12)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62851

Download this epitope record as JSON.

HXB2 Location Pol(838-847)
Integrase(123-132)
DNA(4596..4625)
Pol Epitope Map
Author Location Integrase(123-132)
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Epitope Name SW10
Subtype B, C
Species (MHC/HLA) human
Immunogen HIV-1 infection, engineered
Experimental methods Other, Relative replication capacity assay
Keywords acute/early infection, HLA associated polymorphism, chronic infection, protective allele

Notes

References

Ojwach2018 Doty B. A. Ojwach, Daniel MacMillan, Tarylee Reddy, Vladimir Novitsky, Zabrina L. Brumme, Mark A. Brockman, Thumbi Ndung'u, and Jaclyn K. Mann. Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection. J. Virol., 92(19), 1 Oct 2018. PubMed ID: 29997209. Show all entries for this paper.


Displaying record number 62894

Download this epitope record as JSON.

HXB2 Location Pol(838-847)
Integrase(123-132)
Pol Epitope Map
Author Location Integrase(123-132)
Epitope STTVKAACWW Epitope Alignment
STTVKAACWW epitope logo
Show epitope variants
Epitope Name SW10
Subtype B, C
Species (MHC/HLA) human
Immunogen HIV-1 infection, engineered
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design

Notes

References

Ojwach2021 Doty B. A. Ojwach, Paradise Madlala, Michelle Gordon, Thumbi Ndung'u, and Jaclyn K. Mann. Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design. Virology, 554:1-8 doi, Feb 2021. PubMed ID: 33316731 Show all entries for this paper.


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