Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 61602

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HXB2 Location	Gag(241-249) p24(109-117) DNA(1510..1536)	Gag Epitope Map
Author Location	Gag(241-249)
Epitope	SSVDEQIQW	Epitope Alignment
Species (MHC/HLA)	macaque(Mamu A1*065:01)
Immunogen	SIV infection
Experimental methods
Keywords	review, SIV

Notes

• The authors review the interaction between HLA-B alleles and epitopes that are able to control viral evolution.
• SIV Gag epitope SSVDEQIQW is Mamu A1*065:01(90-120-Ia)-restricted [Nomura and Matano Front. Microbiol. 3:234(2012)].

References

Goulder2012 Philip J. R. Goulder and Bruce D. Walker. HIV and HLA Class I: An Evolving Relationship. Immunity, 37(3):426-440, 21 Sep 2012. PubMed ID: 22999948. Show all entries for this paper.

Displaying record number 61591

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HXB2 Location	Gag(241-249) p24(109-117) DNA(1510..1536)	Gag Epitope Map
Author Location	Gag(241-249)
Epitope	SSVDEQIQW	Epitope Alignment
Species (MHC/HLA)	macaque(Mamu A*90120-5)
Immunogen	vaccine
Experimental methods	Other
Keywords	review, rate of progression, vaccine-induced immune responses, vaccine antigen design, SIV, protective allele

Notes

• This review refocuses attention on host protective HLA/ MHC class I molecules after the failure of the 2007 Merck & Co. Inc. as well as the impending 2008 Vaccine Research Center (VRC) vaccines.
• Macaque Mamu A*90120-5-restricted Gag epitope SSVDEQIQW is associated with slow progression and low viral set point [Tsukamoto et al. AIDS 22: 993-994 (2008)].

References

Goulder2008 Philip J. R. Goulder and David I. Watkins. Impact of MHC Class I Diversity on Immune Control of Immunodeficiency Virus Replication. Nat. Rev. Immunol., 8(8):619-630, Aug 2008. PubMed ID: 18617886. Show all entries for this paper.

Tsukamoto2008 Tetsuo Tsukamoto, Sachi Dohki, Takamasa Ueno, Miki Kawada, Akiko Takeda, Michio Yasunami, Taeko Naruse, Akinori Kimura, Masafumi Takiguchi, and Tetsuro Matano. Determination of a Major Histocompatibility Complex Class I Restricting Simian Immunodeficiency Virus Gag241--249 epitope. AIDS, 22(8):993-994, 11 May 2008. PubMed ID: 18453861. Show all entries for this paper.