Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 61497

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HXB2 Location	Pol(654-661) RT(499-506) DNA(4044..4067)	Pol Epitope Map
Author Location	Pol
Epitope	SQYALGII	Epitope Alignment
Epitope Name	SI8
Subtype	B
Species (MHC/HLA)	human(B*52:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

• HLA-B*5201-C*1202 haplotype which has strong linkage disequilibrium and is found in approximately 20% Japanese,, is protective during HIV-1 infection by suppression of HIV-1 replication via CTL and NK cells. Cw*1202 is known to work with KIR2DL2 in NK-cell mediated control.
• HLA-B*5201-restricted HIV-1 SI8(SQYALGII) was correlated inversely with pVL (plasma viral load) and positively with CD4+ T cell count in HLA-B*5201-Cw*1202 responders versus non-responders. EliSpot responses were strong.

References

Chikata2017 Takayuki Chikata, Hayato Murakoshi, Madoka Koyanagi, Kazutaka Honda, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Control of HIV-1 by an HLA-B*52:01-C*12:02 Protective Haplotype. J. Infect. Dis., 216(11):1415-1424, 12 Dec 2017. PubMed ID: 28968792. Show all entries for this paper.

Displaying record number 61515

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HXB2 Location	Pol(654-661) RT(499-506) DNA(4044..4067)	Pol Epitope Map
Author Location	Gag(654-661)
Epitope	SQYALGII	Epitope Alignment
Epitope Name	GagSI8
Subtype	B
Species (MHC/HLA)	human(B*52:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords	optimal epitope, novel epitope, chronic infection

Notes

• CTL controlling HIV-1 and variants were identified from 401 subtype B chronically-infected, treatment-naive Japanese patients. 7 novel epitopes were identified (paper reports 9, correction made via author communication). 9/13 CTL-specific epitopes were conserved among the above subjects and 3/13 were cross-recognized by CTL. 5/13 epitopes were B*5201, 3/13 were B*6701-restricted, both HLA were found to play a predominant role in control of HIV-1. This is the first study to identify HIV-1-specific T cells clinically controlling HIV-1 in a population in whom protective HLA-B*57 and HLA-B*27 are very rare.
• Breadth of response of all 13 epitope-specific CTL had synergistic effects on control, directly correlating to CD4 cell count and inversely to plasma viral load (pVL).
• Novel epitope, HLA-B*5201-restricted PolSI8, SQYALGII, had 43/393 responding subjects and did significantly correlate with pVL or CD4 count, confirming B*5201 as a protective allele. SI8 is a conserved epitope.

References

Murakoshi2015 Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes. J. Virol., 89(10):5330-5339, May 2015. PubMed ID: 25741000. Show all entries for this paper.

Displaying record number 61880

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HXB2 Location	Pol(654-661) RT(499-506) DNA(4044..4067)	Pol Epitope Map
Author Location
Epitope	SQYALGII	Epitope Alignment
		Show epitope variants
Epitope Name	Gag SI8
Subtype	B
Species (MHC/HLA)	human(B*52:01)
Immunogen	HIV-1 infection, vaccine
Patient MHC/HLA	KI-774: B*52:01; KI-628: B*52:01
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords	vaccine-induced immune responses, viral replication

Notes

• CTL specific for 10 epitopes that are associated with good clinical outcomes (Murakoshi2018, Zou2019) were shown to have strong ability to suppress HIV-1 replication. These CTL could recognize HIV-1-infected cells and most circulating HIV-1 in Japan as the 5 HLA-alleles restricting these 10 epitopes are represented in >50% of the Japanese population surveyed.
• B*5201-restricted protective epitope, SQYALGII, Gag SI8 was found in 92.7% chronically infected Japanese individuals and 91.3% of them who were B*5201+. Variants of this WT epitope were found too, SQYALGIl, SI8-8L and SQYAiGII, SI8-5I. SI8-8L and SI8-5I were cross-recognized by SI8-specific CTL.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.