Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 55261

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HXB2 Location	Gag(368-376) p2p7p1p6(5-13) DNA(1891..1917)	Gag Epitope Map
Author Location	p15(5-13)
Epitope	SQVTNSATI	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords	assay or method development, optimal epitope

Notes

• HLA-A11-restricted CTL epitopes in 2 male Han Chinese subjects (one ART naive and one receiving HAART) were determined. A novel epitope was discovered and 5 other putative epitopes confirmed using 425 overlapping peptides spanning the entire HIV-1 clade B proteome. By employing intracellular cytokine staining, the authors developed a new method of mapping optimal epitopes and defining their HLA restriction efficiently. In spite of its being the most common HLA type in China, A*11-restricted epitopes were recognized less frequently than other epitopes, and A*11-restricted responses formed a mean of only 13% of the responses against HIV.
• This epitope, SQVTNSATI, was detected within overlapping peptide EAMSQVTNSATIMMQR.

References

Wang2007 Shaoyang Wang, Yongtao Sun, Song Zhai, Yan Zhuang, Shuguang Zhao, Whenzhen Kang, Xinhong Li, Dedong Huang, Xu G. Yu, Bruce D. Walker, and Marcus A. Altfeld. Identification of HLA-A11-Restricted HIV-1-Specific Cytotoxic T-Lymphocyte Epitopes in China. Curr. HIV Res., 5(1):119-128, Jan 2007. PubMed ID: 17266563. Show all entries for this paper.

Displaying record number 57193

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HXB2 Location	Gag(368-376) p2p7p1p6(5-13) DNA(1891..1917)	Gag Epitope Map
Author Location	Gag(368-376)
Epitope	SQVTNSATI	Epitope Alignment
Epitope Name	Gag 368-376
Subtype	B
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*02, B*57
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, autologous responses, elite controllers

Notes

• A longitudinal study of 6 elite controllers (ES) over 5 years examined proviral versus plasma Gag sequences for mutation, and compared it to CTL response of the autologous variants. ES were found to control viremia despite plasma viral replication and epitope evolution.
• Subject ES8 had mutations in this HLA-A*02-restricted epitope, but the variants were not targeted by ELISpot. The authors give epitope location as Gag 368-376, but do not list an epitope sequence.

References

OConnell2010 Karen A. O'Connell, Timothy P. Brennan, Justin R. Bailey, Stuart C. Ray, Robert F. Siliciano, and Joel N. Blankson. Control of HIV-1 in Elite Suppressors Despite Ongoing Replication and Evolution in Plasma Virus. J. Virol., 84(14):7018-7028, Jul 2010. PubMed ID: 20444904. Show all entries for this paper.