HIV molecular immunology database
Found 35 matching records:
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | SV9 | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | SV9 | |
Species (MHC/HLA) | human(A*68:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(16-24) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, acute/early infection |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(16-24) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Other | |
Keywords | characterizing CD8+ T cells, elite controllers |
Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(73-) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | Gag148 | |
Subtype | A | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection, vaccine | |
Country | Guinea-Bissau | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine-induced immune responses, vaccine antigen design, therapeutic vaccine, chronic infection |
Vaccine type | peptide |
---|---|
Vaccine strain | A clade |
Adjuvant | CAF01 |
Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(16-24) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(16-24) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | S9WV | |
Species (MHC/HLA) | human, transgenic mouse(B*07) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding | |
Keywords | vaccine-induced immune responses, vaccine antigen design |
Vaccine type | polyepitope |
---|---|
Vaccine strain | multiple epitope immunogen |
Vaccine component | HIV-1 |
Cardinaud2009 Sylvain Cardinaud, Romain Bouziat, Pierre-Simon Rohrlich, Sophie Tourdot, Laurence Weiss, Pierre Langlade-Demoyen, Anne Burgevin, Susana Fiorentino, Peter van Endert, and François A. Lemonnier. Design of a HIV-1-Derived HLA-B07.02-Restricted Polyepitope Construct. AIDS, 23(15):1945-1954, 24 Sep 2009. PubMed ID: 19644347. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | Gag-SV9; p24-SV9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*07, B*81) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HAART, ART |
Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Subtype | A, D | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 2230: A*01:01, A*03:01, B*07:02, B*58:02, C*06:06, C*07:02; 2044: A*03:08, A*29:01, B*07:02, B*08:01, C*07:02 | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other, Tetramer binding | |
Keywords | subtype comparisons, HIV exposed persistently seronegative (HEPS), assay or method development |
Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | SV9-p24 | |
Subtype | B, C | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Country | Japan, South Africa, United Kingdom, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | binding affinity, subtype comparisons |
Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(16-24) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | Subject 8: A*02:01, A*24:02, B*07:02, B*40:01, C*03:04, C*07:02 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | dynamics, acute/early infection, dendritic cells |
Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(16-24) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, HLA binding, Other | |
Keywords | computational epitope prediction, vaccine-induced immune responses, HLA cross-presentation |
Reche2006 Pedro A. Reche, Derin B. Keskin, Rebecca E. Hussey, Petronela Ancuta, Dana Gabuzda, and Ellis L. Reinherz. Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed against Conserved HIV-1 Epitopes. Med. Immunol., 5:1, 2006. PubMed ID: 16674822. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(148-) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | AV9 | |
Subtype | A3, B, C, CRF02_AG | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 1127: A*02:02, A*30:02, B*07:05, B*18:01; 1214: A*02:01, A*34:02, B*44:03, B*82:01; 1224: A*30:01, B*15:03, B*42:01 | |
Country | Denmark, Guinea-Bissau | |
Experimental methods | HLA binding, Intracellular cytokine staining, Tetramer binding | |
Keywords | binding affinity, vaccine antigen design |
Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(16-24) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | SV-9 | |
Subtype | B, C | |
Species (MHC/HLA) | human(B*07:02, B*81) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | Gag-SV9 | |
Subtype | C | |
Species (MHC/HLA) | human(B*42:01) | |
Immunogen | HIV-1 infection | |
Country | Botswana, South Africa, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other, Tetramer binding | |
Keywords | immunodominance, optimal epitope |
Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | SV9 | |
Species (MHC/HLA) | human(B*58:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | ||
Experimental methods | ||
Keywords |
Brander1997 Christian Brander and Bruce Walker. Systematic Identification of Optimal HIV-1 CTL Epitopes. In Systematic Identification of Optimal HIV-1 CTL Epitopes. pages IV--1--IV--11. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1997. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | SV9(p24) | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supertype, HLA cross-presentation |
Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | Gag148 | |
Subtype | B, CRF02_AG | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal | |
Experimental methods | Intracellular cytokine staining, Pentamer labeling | |
Keywords | vaccine antigen design |
Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.
Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | B7-SV9(p24) | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
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HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B | |
Keywords | characterizing CD8+ T cells |
Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(16-24) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | B7-SV9 Gag | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supervised treatment interruptions (STI), escape, early treatment, superinfection |
Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(16-24) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | B7-SV9 | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B7, Cw7 | |
Experimental methods | ||
Keywords | dynamics, supervised treatment interruptions (STI), acute/early infection |
Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Brodie2000 S. J. Brodie, B. K. Patterson, D. A. Lewinsohn, K. Diem, D. Spach, P. D. Greenberg, S. R. Riddell, and L. Corey. HIV-Specific Cytotoxic T Lymphocytes Traffic to Lymph Nodes and Localize at Sites of HIV Replication and Cell Death. J. Clin. Invest., 105:1407-1417, 2000. PubMed ID: 10811848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | Gag( subtype B) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*81:01, B7) | |
Immunogen | HIV-1 exposed seronegative | |
Experimental methods | ||
Keywords | subtype comparisons |
Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24( subtype B) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*81:01, B7) | |
Immunogen | HIV-1 exposed seronegative | |
Experimental methods | ||
Keywords |
Kaul2000 R. Kaul, F. A. Plummer, J. Kimani, T. Dong, P. Kiama, T. Rostron, E. Njagi, K. S. MacDonald, J. J. Bwayo, A. J. McMichael, and S. L. Rowland-Jones. HIV-1-Specific Mucosal CD8+ Lymphocyte Responses in the Cervix of HIV-1-Resistant Prostitutes in Nairobi. J. Immunol., 164:1602-1611, 2000. PubMed ID: 10640781. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | SV9 | |
Species (MHC/HLA) | human(B*81) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Epitope Name | SV9 | |
Subtype | C | |
Species (MHC/HLA) | human(B*81:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa, Zambia | |
Experimental methods | ||
Keywords | viral fitness and reversion, HLA associated polymorphism |
Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(16-24) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Subtype | A1 | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Proliferation | |
Keywords | assay or method development, characterizing CD8+ T cells |
Richmond2011 Meika Richmond, Lyle R. McKinnon, Sandra A. Koesters Kiazyk, Charles Wachihi, Makobu Kimani, Joshua Kimani, Francis A. Plummer, and T. Blake Ball. Epitope Mapping of HIV-Specific CD8+ T Cell Responses by Multiple Immunological Readouts Reveals Distinct Specificities Defined by Function. J. Virol., 85(3):1275-1286, Feb 2011. PubMed ID: 21084478. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Subtype | D | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Sweden | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, computational epitope prediction, vaccine antigen design |
Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Species (MHC/HLA) | chimpanzee | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Santra1999 S. Santra, P. N. Fultz, and N. L. Letvin. Virus-Specific Cytotoxic T Lymphocytes in Human Immunodeficiency Virus Type 1-Infected Chimpanzees. J. Virol., 73:7065-7069, 1999. PubMed ID: 10400811. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(148-156) p24(16-24) DNA(1231..1257) |
Gag Epitope Map |
---|---|---|
Author Location | p24(148-156) | |
Epitope |
SPRTLNAWV
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | assay or method development, protective allele |
Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.