HIV molecular immunology database
Found 49 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(311-319) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Species (MHC/HLA) | human(A*30) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(311-319) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Species (MHC/HLA) | human(A*68:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(311-) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | Pol311 | |
Subtype | A | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection, vaccine | |
Patient MHC/HLA | P2: A*68:02, A*74:01, B*35:01, B*53:01; P7: A*26:01, A*68:01, B*08:01 | |
Country | Guinea-Bissau | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine-induced immune responses, vaccine antigen design, therapeutic vaccine, chronic infection |
Vaccine type | peptide |
---|---|
Vaccine strain | A clade |
Adjuvant | CAF01 |
Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(311-319) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(156-164) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other | |
Keywords | HLA associated polymorphism |
Boutwell2007 Christian L. Boutwell and M. Essex. Identification of HLA Class I-Associated Amino Acid Polymorphisms in the HIV-1C Proteome. AIDS Res. Hum. Retroviruses, 23(1):165-174, Jan 2007. PubMed ID: 17263647. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Country | Germany | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | elite controllers |
Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | computational epitope prediction, HLA associated polymorphism |
Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | A, CRF02_AG, CRF06_cpx, CRF09_cpx | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Country | Burkina Faso | |
Experimental methods | Other | |
Keywords | drug resistance |
Tebit2009 Denis M. Tebit, Lassana Sangaré, Fabrice Tiba, Yameogo Saydou, Aline Makamtse, Hermann Somlare, Guillaume Bado, Boris G. Kouldiaty, Inoussa Zabsonre, Sibiri L. Yameogo, Kanokporn Sathiandee, Joseph Y. Drabo, and Hans-Georg Kräusslich. Analysis of the Diversity of the HIV-1 pol Gene and Drug Resistance Associated Changes among Drug-Naïve Patients in Burkina Faso. J. Med. Virol., 81(10):1691-701, Oct 2009. PubMed ID: 19697403. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(156-164) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | escape, HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Country | South Africa, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | computational epitope prediction, optimal epitope |
ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(311-319) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | SM9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | acute/early infection, variant cross-reactivity |
Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection, vaccine | |
Country | Japan | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | vaccine-induced immune responses |
Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HLA associated polymorphism |
Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(156-164) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | SM9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | epitope processing, computational epitope prediction, escape |
Zimbwa2007 Peter Zimbwa, Anita Milicic, John Frater, Thomas J. Scriba, Antony Willis, Philip J. R. Goulder, Tilly Pillay, Huldrych Gunthard, Jonathan N. Weber, Hua-Tang Zhang, and Rodney E. Phillips. Precise Identification of a Human Immunodeficiency Virus Type 1 Antigen Processing Mutant. J. Virol., 81(4):2031-2038, Feb 2007. PubMed ID: 17108020. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9-RT | |
Subtype | B, C | |
Species (MHC/HLA) | human(B*07:02) | |
Immunogen | HIV-1 infection | |
Country | Japan, South Africa, United Kingdom, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | binding affinity, subtype comparisons |
Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(311-) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Subtype | A3, B, C, CRF02_AG | |
Species (MHC/HLA) | human(B*07:02, B*35:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 1127: A*02:02, A*30:02, B*07:05, B*18:01; 1214: A*02:01, A*34:02, B*44:03, B*82:01; 1224: A*30:01, B*15:03, B*42:01 | |
Country | Denmark, Guinea-Bissau | |
Experimental methods | HLA binding, Intracellular cytokine staining, Tetramer binding | |
Keywords | binding affinity, vaccine antigen design |
Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*07:02, B*81:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HLA cross-presentation, characterizing CD8+ T cells |
Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(311-319) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Species (MHC/HLA) | human(B*15:17) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT Pol(311-319) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*35) | |
Immunogen | HIV-1 infection | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(311-319 SF2) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | review |
Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.
Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(311-319) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(311-319 SF2) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | review |
Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.
Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(311-319) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Species (MHC/HLA) | human(B*39) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(311-319) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | RT-SM9 | |
Subtype | C | |
Species (MHC/HLA) | human(B*42:01) | |
Immunogen | HIV-1 infection | |
Country | Botswana, South Africa, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other, Tetramer binding | |
Keywords | immunodominance, optimal epitope |
Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(146-154) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | RT-SM9 | |
Subtype | C | |
Species (MHC/HLA) | human(B*42:02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*30:01, B*42:02, C*17:01 | |
Country | Botswana, South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HLA associated polymorphism, novel epitope |
Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*42:02) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, optimal epitope |
Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(146-154) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | RT-SM9 | |
Subtype | C | |
Species (MHC/HLA) | human(B*42:02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*30:01, B*42:02, C*17:01 | |
Country | Botswana, South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HLA associated polymorphism, novel epitope |
Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(156-164 HXB2) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, immunodominance |
Hay1999a C. Hay, D. Ruhl, N. Basgoz, C. Wilson, J. Billingsley, M. DePasquale, R. D'Aquila, S. M. Wolinsky, J. M Crawfod, D. Montefiori, and B. D. Walker. Lack of Viral Escape and Defective In Vivo Activation of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes in Rapidly Progressive Infection. J. Virol., 73:5509-5519, 1999. PubMed ID: 10364299. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, acute/early infection |
Islam2001 S. A. Islam, C. M. Hay, K. E. Hartman, S. He, A. K. Shea, A. K. Trocha, M. J. Dynan, N. Reshamwala, S. P. Buchbinder, N. O. Basgoz, and S. A. Kalams. Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression. J. Virol., 75(10):4907-11, May 2001. URL: http://jvi.asm.org/cgi/content/full/75/10/4907. PubMed ID: 11312363. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(323-331 SF2) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(156-164) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | B7-SM9 | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B7, Cw7 | |
Experimental methods | ||
Keywords | dynamics, supervised treatment interruptions (STI), acute/early infection |
Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(156-164) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | B7-SM9 Pol | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supervised treatment interruptions (STI), escape, early treatment, superinfection |
Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | epitope processing, assay or method development, optimal epitope |
Draenert2004 Rika Draenert, Christian Brander, Xu G. Yu, Marcus Altfeld, Cori L. Verrill, Margeret E. Feeney, Bruce D. Walker, and Philip J. R. Goulder. Impact of Intrapeptide Epitope Location on CD8 T Cell Recognition: Implications for Design of Overlapping Peptide Panels. AIDS, 18(6):871-876, 9 Apr 2004. PubMed ID: 15060434. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | ( B consensus) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B7, Cw7 | |
Experimental methods | Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | assay or method development, memory cells, characterizing CD8+ T cells |
Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(312-320) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A3, B57, B7, Cw6, Cw7 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | B7-SM9(RT) | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | Pol311 | |
Subtype | B, CRF02_AG | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal | |
Experimental methods | Intracellular cytokine staining, Pentamer labeling | |
Keywords | vaccine antigen design |
Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.
Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supertype, HLA cross-presentation, optimal epitope |
Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(156-164) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 44149: A*01:01, A*24:02, B*07:01, B*08:01, C*07:01, C*07:02; 63794: A*02:01:01G, B*07:02:01G, B*44:02:01G, C*07:04:01G | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(311-319) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Species (MHC/HLA) | human(C*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | A1, B, C, CRF01_AE, D | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Sweden | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design |
Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(156-164) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Subtype | C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other, Tetramer binding | |
Keywords | supertype, HLA cross-presentation, TCR usage, HLA associated polymorphism |
Leslie2006 Alasdair Leslie, David A. Price, Pamela Mkhize, Karen Bishop, Almas Rathod, Cheryl Day, Hayley Crawford, Isobella Honeyborne, Tedi E. Asher, Graz Luzzi, Anne Edwards, Christine M. Rousseau, James I. Mullins, Gareth Tudor-Williams, Vas Novelli, Christian Brander, Daniel C. Douek, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol., 177(7):4699-4708, 1 Oct 2006. PubMed ID: 16982909. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine-induced immune responses |
Vaccine type | adenovirus type 5 (Ad5), DNA prime with Ad5 boost |
---|---|
Vaccine strain | B clade IIIB, B clade JRFL, B clade CAM-1 |
Vaccine component | Gag, Nef, Pol |
Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT(156-164) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9 | |
Subtype | B, C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | acute/early infection, HLA associated polymorphism, chronic infection, protective allele |
Ojwach2018 Doty B. A. Ojwach, Daniel MacMillan, Tarylee Reddy, Vladimir Novitsky, Zabrina L. Brumme, Mark A. Brockman, Thumbi Ndung'u, and Jaclyn K. Mann. Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection. J. Virol., 92(19), 1 Oct 2018. PubMed ID: 29997209. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT Pol(156-164) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | SM9 | |
Subtype | A1, B | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Somalia, Uganda, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | variant cross-reactivity |
Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) DNA(3015..3041) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Epitope Name | SM9(RT) | |
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | non-susceptible form, chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(311-319) RT(156-164) |
Pol Epitope Map |
---|---|---|
Author Location | RT(156-164) | |
Epitope |
SPAIFQSSM
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | SM9 | |
Subtype | B, C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | structure, vaccine antigen design |
Ojwach2021 Doty B. A. Ojwach, Paradise Madlala, Michelle Gordon, Thumbi Ndung'u, and Jaclyn K. Mann. Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design. Virology, 554:1-8 doi, Feb 2021. PubMed ID: 33316731 Show all entries for this paper.