HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 47 matching records:

Displaying record number 60274

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(311-319)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60277

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(311-319)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Species (MHC/HLA) human(A*6802)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59006

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(311-)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name Pol311
Subtype A
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA P2: A*6802, A*7401, B*3501, B*5301; P7: A*2601, A*6801, B*0801
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type peptide
Vaccine strain A clade
Adjuvant CAF01

Notes

References

Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.


Displaying record number 56388

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(156-164)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 57795

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 54181

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(156-164)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype C
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods Other
Keywords HLA associated polymorphism

Notes

References

Boutwell2007 Christian L. Boutwell and M. Essex. Identification of HLA Class I-Associated Amino Acid Polymorphisms in the HIV-1C Proteome. AIDS Res. Hum. Retroviruses, 23(1):165-174, Jan 2007. PubMed ID: 17263647. Show all entries for this paper.


Displaying record number 60272

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(311-319)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54087

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location  
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Species (MHC/HLA) human(B*07)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59136

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 57321

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype A, CRF02_AG, CRF06_cpx, CRF09_cpx
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country Burkina Faso
Experimental methods Other
Keywords drug resistance

Notes

References

Tebit2009 Denis M. Tebit, Lassana Sangaré, Fabrice Tiba, Yameogo Saydou, Aline Makamtse, Hermann Somlare, Guillaume Bado, Boris G. Kouldiaty, Inoussa Zabsonre, Sibiri L. Yameogo, Kanokporn Sathiandee, Joseph Y. Drabo, and Hans-Georg Kräusslich. Analysis of the Diversity of the HIV-1 pol Gene and Drug Resistance Associated Changes among Drug-Naïve Patients in Burkina Faso. J. Med. Virol., 81(10):1691-701, Oct 2009. PubMed ID: 19697403. Show all entries for this paper.


Displaying record number 56490

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype C
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 61858

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location  
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.


Displaying record number 61179

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(311-319)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Show epitope variants
Epitope Name SM9
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 59049

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9-RT
Subtype B, C
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country Japan, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, subtype comparisons

Notes

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 57995

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location  
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype C
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords computational epitope prediction, optimal epitope

Notes

References

ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.


Displaying record number 55346

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(156-164)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Show epitope variants
Epitope Name SM9
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords epitope processing, computational epitope prediction, escape

Notes

References

Zimbwa2007 Peter Zimbwa, Anita Milicic, John Frater, Thomas J. Scriba, Antony Willis, Philip J. R. Goulder, Tilly Pillay, Huldrych Gunthard, Jonathan N. Weber, Hua-Tang Zhang, and Rodney E. Phillips. Precise Identification of a Human Immunodeficiency Virus Type 1 Antigen Processing Mutant. J. Virol., 81(4):2031-2038, Feb 2007. PubMed ID: 17108020. Show all entries for this paper.


Displaying record number 61958

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(311-)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Subtype A3 (CRF02_AG+C), B
Species (MHC/HLA) human(B*0702, B*3501)
Immunogen HIV-1 infection
Patient MHC/HLA 1127: A*0202, A*3002, B*0705, B*1801; 1214: A*0201, A*3402, B*4403, B*8201; 1224: A*3001, B*1503, B*4201
Country Denmark, Guinea-Bissau
Experimental methods HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords binding affinity, vaccine antigen design

Notes

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.


Displaying record number 53312

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location ( C consensus)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype C
Species (MHC/HLA) human(B*0702, B*8101)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA cross-presentation, characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 60276

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(311-319)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Species (MHC/HLA) human(B*1517)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 440

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(311-319 SF2)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.


Displaying record number 1424

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(311-319)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 53113

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT Pol(311-319)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 441

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(311-319 SF2)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.


Displaying record number 60275

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(311-319)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Species (MHC/HLA) human(B*39)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59451

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(311-319)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name RT-SM9
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country Botswana, South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords immunodominance, optimal epitope

Notes

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 58721

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(146-154)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name RT-SM9
Subtype C
Species (MHC/HLA) human(B*4202)
Immunogen HIV-1 infection
Patient MHC/HLA A*3001, B*4202, Cw*1701
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA associated polymorphism, novel epitope

Notes

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 58722

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(146-154)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name RT-SM9
Subtype C
Species (MHC/HLA) human(B*4202)
Immunogen HIV-1 infection
Patient MHC/HLA A*3001, B*4202, Cw*1701
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA associated polymorphism, novel epitope

Notes

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 54000

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location ( C consensus)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype C
Species (MHC/HLA) human(B*4202)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 53368

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location ( B consensus)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B7, Cw7
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 54296

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name B7-SM9(RT)
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 53551

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(312-320)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B57, B7, Cw6, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 58419

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name Pol311
Subtype B, CRF02_AG
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.

Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.


Displaying record number 58677

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location  
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation, optimal epitope

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 53498

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 52820

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(156-164)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name B7-SM9 Pol
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supervised treatment interruptions (STI), escape, early treatment, superinfection

Notes

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 52167

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(156-164)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name B7-SM9
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B7, Cw7
Experimental methods  
Keywords dynamics, supervised treatment interruptions (STI), acute/early infection

Notes

References

Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.


Displaying record number 1547

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(323-331 SF2)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 61008

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(156-164)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA 44149: A*0101, A*2401, B*0701, B*0801, Cw*0701, Cw*0702; 63794: A*0201, A*0201, B*0701, B*4401, Cw*0702, Cw*0704
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 1493

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Islam2001 S. A. Islam, C. M. Hay, K. E. Hartman, S. He, A. K. Shea, A. K. Trocha, M. J. Dynan, N. Reshamwala, S. P. Buchbinder, N. O. Basgoz, and S. A. Kalams. Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression. J. Virol., 75(10):4907-11, May 2001. URL: http://jvi.asm.org/cgi/content/full/75/10/4907. PubMed ID: 11312363. Show all entries for this paper.


Displaying record number 442

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(156-164 HXB2)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Hay1999a C. Hay, D. Ruhl, N. Basgoz, C. Wilson, J. Billingsley, M. DePasquale, R. D'Aquila, S. M. Wolinsky, J. M Crawfod, D. Montefiori, and B. D. Walker. Lack of Viral Escape and Defective In Vivo Activation of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes in Rapidly Progressive Infection. J. Virol., 73:5509-5519, 1999. PubMed ID: 10364299. Show all entries for this paper.


Displaying record number 52914

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location  
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing, assay or method development

Notes

References

Draenert2004 Rika Draenert, Christian Brander, Xu G. Yu, Marcus Altfeld, Cori L. Verrill, Margeret E. Feeney, Bruce D. Walker, and Philip J. R. Goulder. Impact of Intrapeptide Epitope Location on CD8 T Cell Recognition: Implications for Design of Overlapping Peptide Panels. AIDS, 18(6):871-876, 9 Apr 2004. PubMed ID: 15060434. Show all entries for this paper.


Displaying record number 60273

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol(311-319)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Species (MHC/HLA) human(C*08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55980

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9(RT)
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords non-susceptible form

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 58067

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 57497

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT Pol(156-164)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Show epitope variants
Epitope Name SM9
Subtype A1, B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Somalia, Uganda, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.


Displaying record number 54196

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location RT(156-164)
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Epitope Name SM9
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords supertype, HLA cross-presentation, TCR usage, HLA associated polymorphism

Notes

References

Leslie2006 Alasdair Leslie, David A. Price, Pamela Mkhize, Karen Bishop, Almas Rathod, Cheryl Day, Hayley Crawford, Isobella Honeyborne, Tedi E. Asher, Graz Luzzi, Anne Edwards, Christine M. Rousseau, James I. Mullins, Gareth Tudor-Williams, Vas Novelli, Christian Brander, Daniel C. Douek, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol., 177(7):4699-4708, 1 Oct 2006. PubMed ID: 16982909. Show all entries for this paper.


Displaying record number 55480

HXB2 Location Pol(311-319)
RT(156-164)
DNA(3015..3041)
Pol Epitope Map
Author Location Pol
Epitope SPAIFQSSM Epitope Alignment
SPAIFQSSM epitope logo
Subtype A1, B, C, CRF01_AE, D
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


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