HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 247 matching records:

Displaying record number 57574

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location ( NL4-3)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods Relative replication capacity assay
Keywords  

Notes

References

Chen2011 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Antiviral Activity of Human Immunodeficiency Virus Type 1 Gag-Specific Cytotoxic T Lymphocyte Targeting Is Not Necessarily Intrinsically Superior to Envelope Targeting. J. Virol., 85(5):2474-2478, Mar 2011. PubMed ID: 21159882. Show all entries for this paper.


Displaying record number 1765

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 57609

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) (A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords acute/early infection

Notes

References

Heath2011 Sonya L. Heath, Steffanie Sabbaj, Anju Bansal, J Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Proliferative Capacity Is Compromised in Primary HIV-1 Infection. J. Acquir. Immune Defic. Syndr., 56(3):213-221, Mar 2011. PubMed ID: 21079516. Show all entries for this paper.


Displaying record number 57711

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supervised treatment interruptions (STI), escape

Notes

References

Schweighardt2010 Becky Schweighardt, Terri Wrin, Duncan A. Meiklejohn, Gerald Spotts, Christos J. Petropoulos, Douglas F. Nixon, and Frederick M. Hecht. Immune Escape Mutations Detected within HIV-1 Epitopes Associated with Viral Control During Treatment Interruption. J. Acquir. Immune Defic. Syndr., 53(1):36-46, Jan 2010. PubMed ID: 19910798. Show all entries for this paper.


Displaying record number 1981

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name Gag-SL9; p17-SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 55222

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B, C
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, epitope processing, rate of progression, escape, mutation acquisition, viral fitness and reversion, optimal epitope, HLA associated polymorphism, compensatory mutation

Notes

References

Blankson2006 Joel N. Blankson, Justin R. Bailey, and Robert F. Siliciano. Crosscurrents in HIV-1 Evolution. Nat. Immunol., 7(2):121-122, Feb 2006. PubMed ID: 16424885. Show all entries for this paper.


Displaying record number 57738

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name A2-SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 55278

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords characterizing CD8+ T cells

Notes

References

Addo2007 Marylyn M. Addo, Rika Draenert, Almas Rathod, Cori L. Verrill, Benjamin T. Davis, Rajesh T. Gandhi, Gregory K. Robbins, Nesli O. Basgoz, David R. Stone, Daniel E. Cohen, Mary N. Johnston, Theresa Flynn, Alysse G. Wurcel, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection. PLoS ONE, 2(3):e321, 2007. PubMed ID: 17389912. Show all entries for this paper.


Displaying record number 61471

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag( 90TH_BK132, US1_GS004/7, J3222, JR-CSF, NL4-3, LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, in vitro stimulation or selection, peptide-HLA interaction
Country Canada, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords assay or method development, memory cells

Notes

References

Jones2016 R. Brad Jones, Stefanie Mueller, Rachel O'Connor, Katherine Rimpel, Derek D. Sloan, Dan Karel, Hing C. Wong, Emily K. Jeng, Allison S. Thomas, James B. Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J. Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P. Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A. Ostrowski, Darrell J. Irvine, and Bruce D. Walker. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog., 12(4):e1005545, Apr 2016. PubMed ID: 27082643. Show all entries for this paper.


Displaying record number 58010

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Cytotoxicity assay, Other
Keywords epitope processing, escape

Notes

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 59272

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag( NL4-3)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen in vitro stimulation or selection
Patient MHC/HLA 285873: A*0201, A*0301, B*5101, Cw*1402, Cw*1502; controller: A*0201, A*0301, B*0702, B*4001, Cw*0304, Cw*0702
Experimental methods Other
Keywords kinetics

Notes

References

Foley2014 Maria Hottelet Foley, Talitha Forcier, Elizabeth McAndrew, Michael Gonzalez, Huabiao Chen, Boris Juelg, Bruce D. Walker, and Darrell J. Irvine. High Avidity CD8+ T Cells Efficiently Eliminate Motile HIV-Infected Targets and Execute a Locally Focused Program of Anti-Viral Function. PLoS One, 9(2):e87873, 2014. PubMed ID: 24551068. Show all entries for this paper.


Displaying record number 58361

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name A2 SL9
Subtype B, C
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, in vitro stimulation or selection, vaccine
Country South Africa, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords vaccine antigen design

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine strain B clade, C clade
Vaccine component Gag

Notes

References

Ndhlovu2011 Zaza M. Ndhlovu, Alicja Piechocka-Trocha, Seanna Vine, Ashley McMullen, Kegakilwe C. Koofhethile, Phillip J. R. Goulder, Thumbi Ndung'u, Dan H. Barouch, and Bruce D. Walker. Mosaic HIV-1 Gag Antigens Can Be Processed and Presented to Human HIV-Specific CD8+ T Cells. J. Immunol., 186(12):6914-6924, 15 Jun 2011. PubMed ID: 21576505. Show all entries for this paper.


Displaying record number 58380

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country France, Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords drug resistance

Notes

References

Pacheco2011 Yovana Pacheco, Clotilde Allavena, Yannick Guilloux, Sandra M. Mueller-Schmucker, Angela G. Hueckelhoven, Elisabeth André-Garnier, François Cleon, Virginie Ferré, Audrey Rodallec, Eric Billaud, Thomas Harrer, François Raffi, and Dorian McIlroy. The Immune Response to the RT181-189 Epitope in HIV-1-Infected Patients Is Associated with Viral Sequence Polymorphism Flanking the Epitope. J. Clin. Immunol., 31(4):681-689, Aug 2011. PubMed ID: 21491096. Show all entries for this paper.


Displaying record number 56152

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Canada
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008a Zabrina L. Brumme, Iris Tao, Sharon Szeto, Chanson J. Brumme, Jonathan M. Carlson, Dennison Chan, Carl Kadie, Nicole Frahm, Christian Brander, Bruce Walker, David Heckerman, and P Richard Harrigan. Human Leukocyte Antigen-Specific Polymorphisms in HIV-1 Gag and Their Association with Viral Load in Chronic Untreated Infection. AIDS, 22(11):1277-1286, 11 Jul 2008. PubMed ID: 18580606. Show all entries for this paper.


Displaying record number 58491

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 58599

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p24
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytotoxicity assay, Flow cytometric T-cell cytokine assay
Keywords assay or method development, elite controllers

Notes

References

Varadarajan2011 Navin Varadarajan, Boris Julg, Yvonne J. Yamanaka, Huabiao Chen, Adebola O. Ogunniyi, Elizabeth McAndrew, Lindsay C. Porter, Alicja Piechocka-Trocha, Brenna J. Hill, Daniel C. Douek, Florencia Pereyra, Bruce D. Walker, and J. Christopher Love. A High-Throughput Single-Cell Analysis of Human CD8+ T Cell Functions Reveals Discordance for Cytokine Secretion and Cytolysis. J. Clin. Invest., 121(11):4322-4331, Nov 2011. PubMed ID: 21965332. Show all entries for this paper.


Displaying record number 65

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia

Notes

References

Woodberry1999 T. Woodberry, J. Gardner, L. Mateo, D. Eisen, J. Medveczky, I. A. Ramshaw, S. A. Thomson, R. A. Ffrench, S. L. Elliott, H. Firat, F. A. Lemonnier, and A. Suhrbier. Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine. J. Virol., 73:5320-5325, 1999. PubMed ID: 10364278. Show all entries for this paper.


Displaying record number 58755

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name Gag-SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 58832

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords assay or method development, elite controllers

Notes

References

Varadarajan2012 Navin Varadarajan, Douglas S. Kwon, Kenneth M. Law, Adebola O. Ogunniyi, Melis N. Anahtar, James M. Richter, Bruce D. Walker, and J. Christopher Love. Rapid, Efficient Functional Characterization and Recovery of HIV-Specific Human CD8+ T Cells Using Microengraving. Proc. Natl. Acad. Sci. U.S.A., 109(10):3885-3890, 6 Mar 2012. PubMed ID: 22355106. Show all entries for this paper.


Displaying record number 56339

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Canada, South Africa
Experimental methods  
Keywords escape

Notes

References

Carlson2008 Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, Philippa Matthews, Carl Kadie, James I. Mullins, Bruce D. Walker, P. Richard Harrigan, Philip J. R. Goulder, and David Heckerman. Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag. PLoS Comput Biol, 4(11):e1000225, Nov 2008. PubMed ID: 19023406. Show all entries for this paper.


Displaying record number 1580

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, immunodominance

Notes

References

ScottAlgara2001 D. Scott-Algara, F. Buseyne, S. Blanche, C. Rouzioux, C. Jouanne, F. Romagne, and Y. Riviere. Frequency and phenotyping of human immunodeficiency virus (HIV)-specific CD8+ T cells in HIV-infected children, using major histocompatibility complex class I peptide tetramers. J. Infect. Dis., 183(11):1565-73, 1 Jun 2001. PubMed ID: 11343205. Show all entries for this paper.


Displaying record number 58969

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 NL4-3)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen in vitro stimulation or selection
Experimental methods CTL suppression of replication, In vitro proteasome digestion, Other
Keywords epitope processing, class I down-regulation by Nef, kinetics

Notes

References

Balamurugan2013 Arumugam Balamurugan, Ayub Ali, Julie Boucau, Sylvie Le Gall, Hwee L. Ng, and Otto O. Yang. HIV-1 Gag Cytotoxic T Lymphocyte Epitopes Vary in Presentation Kinetics Relative to HLA Class I Downregulation. J. Virol., 87(15):8726-8734, Aug 2013. PubMed ID: 23740989. Show all entries for this paper.


Displaying record number 59189

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 NL4.3)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods In vitro proteasome digestion, Other
Keywords epitope processing

Notes

References

Kourjian2014 Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain, and Sylvie Le Gall. Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. J. Immunol., 192(8):3496-3506, 15 Apr 2014. PubMed ID: 24616479. Show all entries for this paper.


Displaying record number 59116

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype CRF01_AE
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Patient MHC/HLA N107: A*0201, A*0201, B*2705, B*5701, Cw*0102, Cw*0602
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords rate of progression

Notes

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.


Displaying record number 59135

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 56711

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 HIV-1 NL4-3.1)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen virus
Experimental methods CTL suppression of replication
Keywords  

Notes

References

Cruz2009 Justin De La Cruz, Ayub Ali, Hwee L Ng, and Otto O Yang. Disruption of an env Tyrosine-Dependent Sorting Signal Does Not Affect Susceptibility of HIV-1 to Cytotoxic T Lymphocytes. AIDS, 23(11):1449-1451, 17 Jul 2009. PubMed ID: 19564727. Show all entries for this paper.


Displaying record number 62020

HXB2 Location Gag(77-85)
p17(77-85)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*02)
Immunogen in vitro stimulation or selection
Patient MHC/HLA OM9: A*02, A*03, B*07, B*52, Cw*07, Cw*12, DPB1*04, DQA1*01, DQB1*06, DRB1*15, DRB5*01
Experimental methods CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, Other
Keywords naive T cells

Notes

References

Patel2018a Shabnum Patel, Elizabeth Chorvinsky, Shuroug Albihani, Conrad Russell Cruz, R. Brad Jones, Elizabeth J. Shpall, David M. Margolis, Richard F. Ambinder, and Catherine M. Bollard. HIV-Specific T Cells Generated from Naive T Cells Suppress HIV In Vitro and Recognize Wide Epitope Breadths. Mol Ther, 26(6):1435-1446 doi, Jun 2018. PubMed ID: 29724686 Show all entries for this paper.


Displaying record number 1402

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Rinaldo2000 C. R. Rinaldo, Jr., X. L. Huang, Z. Fan, J. B. Margolick, L. Borowski, A. Hoji, C. Kalinyak, D. K. McMahon, S. A. Riddler, W. H. Hildebrand, R. B. Day, and J. W. Mellors. Anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) T-lymphocyte reactivity during combination antiretroviral therapy in HIV-1-infected patients with advanced immunodeficiency. J. Virol., 74(9):4127-38, May 2000. URL: http://jvi.asm.org/cgi/content/full/74/9/4127. PubMed ID: 10756025. Show all entries for this paper.


Displaying record number 53861

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name GAG
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country France
Experimental methods Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords responses in children, characterizing CD8+ T cells

Notes

References

Scott-Algara2005a Daniel Scott-Algara, Florence Buseyne, Françoise Porrot, Beatrice Corre, Nassima Bellal, Christine Rouzioux, Stephane Blanche, and Yves Riviere. Not All Tetramer Binding CD8+ T Cells Can Produce Cytokines and Chemokines Involved in the Effector Functions of Virus-Specific CD8+ T Lymphocytes in HIV-1 Infected Children. J. Clin. Immunol., 25(1):57-67, Jan 2005. PubMed ID: 15742158. Show all entries for this paper.


Displaying record number 56735

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location ( NL4-3)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen virus
Country United States
Experimental methods Relative replication capacity assay
Keywords rate of progression, elite controllers

Notes

References

Miura2009 Toshiyuki Miura, Mark A. Brockman, Zabrina L Brumme, Chanson J. Brumme, Florencia Pereyra, Alicja. Trocha, Brian L. Block, Arne Schneidewind, Todd M. Allen, David Heckerman, and Bruce D. Walker. HLA-Associated Alterations in Replication Capacity of Chimeric NL4-3 Viruses Carrying gag-protease from Elite Controllers of Human Immunodeficiency Virus Type 1. J. Virol., 83(1):140-149, Jan 2009. PubMed ID: 18971283. Show all entries for this paper.


Displaying record number 61202

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B, C
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords class I down-regulation by Nef

Notes

References

Anmole2015 Gursev Anmole, Xiaomei T. Kuang, Mako Toyoda, Eric Martin, Aniqa Shahid, Anh Q. Le, Tristan Markle, Bemuluyigza Baraki, R. Brad Jones, Mario A. Ostrowski, Takamasa Ueno, Zabrina L. Brumme, and Mark A. Brockman. A Robust and Scalable TCR-Based Reporter Cell Assay to Measure HIV-1 Nef-Mediated T Cell Immune Evasion. J. Immunol. Methods, 426:104-113, Nov 2015. PubMed ID: 26319395. Show all entries for this paper.


Displaying record number 61467

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords TCR usage

Notes

References

Mummert2016 Christiane Mummert, Christian Hofmann, Angela G. Hückelhoven, Silke Bergmann, Sandra M. Mueller-Schmucker, Ellen G. Harrer, Jan Dörrie, Niels Schaft, and Thomas Harrer. T-Cell Receptor Transfer for Boosting HIV-1-Specific T-Cell Immunity in HIV-1-Infected Patients. AIDS, 30(14):2149-2158, 10 Sep 2016. PubMed ID: 27258398. Show all entries for this paper.


Displaying record number 55518

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype A, B, C, D, F, G, K
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Chromium-release assay, Other
Keywords subtype comparisons

Notes

References

Bennett2008 Michael S. Bennett, Hwee L. Ng, Ayub Ali, and Otto O. Yang. Cross-Clade Detection of HIV-1-Specific Cytotoxic T Lymphocytes Does Not Reflect Cross-Clade Antiviral Activity. J. Infect. Dis., 197(3):390-397, 1 Feb 2008. PubMed ID: 18184090. Show all entries for this paper.


Displaying record number 1169

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Huang2000 X. L. Huang, Z. Fan, C. Kalinyak, J. W. Mellors, and C. R. Rinaldo. CD8+ T Cell Gamma Interferon Production Specific for Human Immunodeficiency Virus Type 1 (HIV-1) in HIV-1-Infected Subjects. Clin. Diagn. Lab. Immunol., 7:279-287, 2000. PubMed ID: 10702505. Show all entries for this paper.


Displaying record number 54792

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords class I down-regulation by Nef

Notes

References

Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.


Displaying record number 55700

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A*02)
Immunogen in vitro stimulation or selection
Experimental methods CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords escape, TCR usage

Notes

References

Varela-Rohena2008 Angel Varela-Rohena, Peter E. Molloy, Steven M. Dunn, Yi Li, Megan M. Suhoski, Richard G. Carroll, Anita Milicic, Tara Mahon, Deborah H. Sutton, Bruno Laugel, Ruth Moysey, Brian J. Cameron, Annelise Vuidepot, Marco A. Purbhoo, David K. Cole, Rodney E. Phillips, Carl H. June, Bent K. Jakobsen, Andrew K. Sewell, and James L. Riley. Control of HIV-1 Immune Escape by CD8 T Cells Expressing Enhanced T-Cell Receptor. Nat. Med., 14(12):1390-1385, Dec 2008. PubMed ID: 18997777. Show all entries for this paper.


Displaying record number 57280

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Barbados, Haiti, Jamaica
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords mother-to-infant transmission, elite controllers

Notes

References

Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.


Displaying record number 60268

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55737

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 53089

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 57398

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 54556

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 55153

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, in vitro stimulation or selection
Experimental methods Other
Keywords kinetics

Notes

References

Wick2005 W. David Wick, Otto O. Yang, Lawrence Corey, and Steven G. Self. How Many Human Immunodeficiency Virus Type 1-Infected Target Cells Can a Cytotoxic T-Lymphocyte Kill? J. Virol., 79(21):13579-13586, Nov 2005. PubMed ID: 16227278. Show all entries for this paper.


Displaying record number 52353

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(76-84)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA
Vaccine component HIV-1

Notes

References

Singh2002 Rana A. K. Singh, Lei Wu, and Michael A. Barry. Generation of Genome-Wide CD8 T Cell Responses in HLA-A*0201 Transgenic Mice by an HIV-1 Ubiquitin Expression Library Immunization Vaccine. J. Immunol., 168(1):379-391, 1 Jan 2002. PubMed ID: 11751984. Show all entries for this paper.

Sykes1999 Kathryn F. Sykes and Stephen Albert Johnston. Genetic live vaccines mimic the antigenicity but not pathogenicity of live viruses. DNA Cell Biol., 18(7):521-531, Jul 1999. PubMed ID: 10433551. Show all entries for this paper.


Displaying record number 57719

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords assay or method development, characterizing CD8+ T cells

Notes

References

Vollbrecht2010 Thomas Vollbrecht, Heike Brackmann, Nadja Henrich, Joerg Roeling, Ulrich Seybold, Johannes R. Bogner, Frank D. Goebel, and Rika Draenert. Impact of Changes in Antigen Level on CD38/PD-1 Co-Expression on HIV-Specific CD8 T Cells in Chronic, Untreated HIV-1 Infection. J. Med. Virol., 82(3):358-370, Mar 2010. PubMed ID: 20087935. Show all entries for this paper.


Displaying record number 57734

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen  
Experimental methods  
Keywords review

Notes

References

Motozono2010 Chihiro Motozono, Philip Mwimanzi, and Takamasa Ueno. Dynamic Interplay between Viral Adaptation and Immune Recognition during HIV-1 Infection. Protein Cell, 1(6):514-519, Jun 2010. PubMed ID: 21204005. Show all entries for this paper.


Displaying record number 84

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords epitope processing

Notes

References

Walter1997 J. B. Walter, C. Brander, M. Mammen, D. N. Garboczi, S. A. Kalams, G. M. Whiteside, B. D. Walker, and H. N. Eisen. Stimulation of Human Cytotoxic T Cells with HIV-1-Derived Peptides Presented by Recombinant HLA-A2 Peptide Complexes. Int. Immunol., 9:451-459, 1997. HLA-A2 heavy chain and beta 2-microglobulin refolded in the presence of peptides became susceptible to lysis by HLA-A2-restricted cytotoxic T lymphocyte (CTL) clones specific for the peptides. Recombinant HLA-A2 peptide complexes covalently immobilized on microspheres stimulated the development of HLA-A2 peptide-specific CTL. PubMed ID: 9088983. Show all entries for this paper.


Displaying record number 58001

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype C
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords computational epitope prediction, optimal epitope

Notes

References

ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.


Displaying record number 58427

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype A1, C
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Kenya
Experimental methods Other
Keywords assay or method development

Notes

References

Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.


Displaying record number 58642

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name Gag77-85
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen peptide-HLA interaction
Country United States
Experimental methods Chromium-release assay
Keywords enhancing activity

Notes

References

Dupuis1997 M. Dupuis, M. V. Peshwa, C. Benike, S.K> Kundu, E. G. Engleman, W. C. Van Schooten, and T. C. Merigan. Allogeneic Dendritic Cell Induction of HIV-Specific Cytotoxic T Lymphocyte Responses from T Cells of HIV Type 1-Infected and Uninfected Individuals. AIDS Res. Hum. Retroviruses, 13:33-39, 1997. The potential benefit of T cell-based vaccination for HIV-1 infection remains to be determined. Cytotoxic T lymphocytes (CTLs) appear to clear substantial populations of HIV-1 virus in vivo, although CTL activity may contribute to the decline in CD4+ T cell count observed in the course of the disease. To investigate further the role of specific CTL responses in the control of HIV-1 replication, we raised primary CTL lines against a panel of conserved HIV-1 epitopes using blood-derived dendritic cells as antigen-presenting cells (APCs). Specific primary human CTL responses were induced against HLA-A*0201-restricted peptides with dendritic cells from HIV-1-seronegative donors. This method of immunization elicited cytotoxic activities capable of recognizing endogenously processed antigen. The CTL induction protocol was extended in order to explore the capacity of HLA-matched allogeneic dendritic cells to evoke novel CTL responses in T cells from an HIV-seropositive asymptomatic individual. Allogeneic peptide-pulsed dendritic cells from a healthy sibling were capable of eliciting a CTL response directed against an HIV epitope (env814: SLLNATDIAV) that was initially not detected in the CTL effector population of the HIV-1- infected patient. The possibility of manipulating CTL specificity directed against multiple conserved HIV-1 epitopes represents a significant step in the evaluation of T cell-based vaccination for treatment of disease. PubMed ID: 8989425. Show all entries for this paper.


Displaying record number 58851

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Canada
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Trautmann2012 Lydie Trautmann, Florentin-Martial Mbitikon-Kobo, Jean-Philippe Goulet, Yoav Peretz, Yu Shi, Julien Van Grevenynghe, Francesco Andrea Procopio, Mohamad Rachid Boulassel, Jean-Pierre Routy, Nicolas Chomont, Elias K. Haddad, and Rafick-Pierre Sekaly. Profound Metabolic, Functional, and Cytolytic Differences Characterize HIV-Specific CD8 T Cells in Primary and Chronic HIV Infection. Blood, 120(17):3466-3477, 25 Oct 2012. PubMed ID: 22955926. Show all entries for this paper.


Displaying record number 58867

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, optimal epitope, HLA associated polymorphism

Notes

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 59171

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name gag 077-085
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 52444

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA A*0202, A*2501, B*1801, B62, Cw10, Cw*1203, DQB1*8, DRB1*1501
Experimental methods  
Keywords rate of progression, Th1, Th2

Notes

References

Imami2002 Nesrina Imami, Antonio Pires, Gareth Hardy, Jamie Wilson, Brian Gazzard, and Frances Gotch. A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection. J. Virol., 76(18):9011-9023, Sep 2002. PubMed ID: 12186885. Show all entries for this paper.


Displaying record number 103

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Brander1998 Christian Brander, Kelly E. Hartman, Alicja K. Trocha, Norman G. Jones, R. Paul Johnson, Bette Korber, Peggy Wentworth, Susan P. Buchbinder, Steve Wolinsky, Bruce D. Walker, and Spyros A. Kalams. Lack of Strong Immune Selection Pressure by the Immunodominant, HLA-A*0201-Restricted Cytotoxic T Lymphocyte Response in Chronic Human Immunodeficiency Virus-1 Infection. J. Clin. Invest., 101(11):2559-2566, 1 Jun 1998. PubMed ID: 9616227. Show all entries for this paper.


Displaying record number 52649

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A11, B51, B61, Cw*14, Cw2
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 74

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 SF2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

McAdam1998 S. McAdam, P. Kaleebu, P. Krausa, P. Goulder, N. French, B. Collin, T. Blanchard, J. Whitworth, A. McMichael, and F. Gotch. Cross-Clade Recognition of p55 by Cytotoxic T Lymphocytes in HIV-1 Infection. AIDS, 12:571-579, 1998. PubMed ID: 9583596. Show all entries for this paper.


Displaying record number 52701

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay, Cytokine production, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords  

Notes

References

Dagarag2003 Mirabelle Dagarag, Hwee Ng, Rachel Lubong, Rita B. Effros, and Otto O. Yang. Differential Impairment of Lytic and Cytokine Functions in Senescent Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes. J. Virol., 77(5):3077-3083, Mar 2003. PubMed ID: 12584333. Show all entries for this paper.


Displaying record number 105

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 HXB2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Hay1999a C. Hay, D. Ruhl, N. Basgoz, C. Wilson, J. Billingsley, M. DePasquale, R. D'Aquila, S. M. Wolinsky, J. M Crawfod, D. Montefiori, and B. D. Walker. Lack of Viral Escape and Defective In Vivo Activation of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes in Rapidly Progressive Infection. J. Virol., 73:5509-5519, 1999. PubMed ID: 10364299. Show all entries for this paper.


Displaying record number 52767

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Patient MHC/HLA A2.1
Experimental methods Chromium-release assay, Cytokine production
Keywords binding affinity, vaccine-induced immune responses

Vaccine Details

Vaccine type peptide
Vaccine component p24 Gag

Notes

References

Okazaki2003 Takahiro Okazaki, C. David Pendleton, François Lemonnier, and Jay A. Berzofsky. Epitope-Enhanced Conserved HIV-1 Peptide Protects HLA-A2-Transgenic Mice Against Virus Expressing HIV-1 Antigen. J. Immunol., 171(5):2548-2555, Sep 2003. PubMed ID: 12928405. Show all entries for this paper.


Displaying record number 52778

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods Tetramer binding
Keywords genital and mucosal immunity

Notes

References

Shacklett2003 Barbara L. Shacklett, Catherine A. Cox, Johan K. Sandberg, Neil H. Stollman, Mark A. Jacobson, and Douglas F. Nixon. Trafficking of Human Immunodeficiency Virus Type 1-Specific CD8+ T Cells to Gut-Associated Lymphoid Tissue During Chronic Infection. J. Virol., 77(10):5621-5631, May 2003. PubMed ID: 12719554. Show all entries for this paper.


Displaying record number 1164

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Kalams1999b S. A. Kalams, P. J. Goulder, A. K. Shea, N. G. Jones, A. K. Trocha, G. S. Ogg, and B. D. Walker. Levels of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Effector and Memory Responses Decline after Suppression of Viremia with Highly Active Antiretroviral Therapy. J. Virol., 73:6721-6728, 1999. PubMed ID: 10400770. Show all entries for this paper.


Displaying record number 1165

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Spiegel2000 H. M. Spiegel, G. S. Ogg, E. DeFalcon, M. E. Sheehy, S. Monard, P. A. Haslett, G. Gillespie, S. M. Donahoe, H. Pollack, W. Borkowsky, A. J. McMichael, and D. F. Nixon. Human Immunodeficiency Virus Type 1- and Cytomegalovirus-Specific Cytotoxic T Lymphocytes Can Persist at High Frequency for Prolonged Periods in the Absence of Circulating Peripheral CD4+ T Cells. J. Virol., 74:1018-1022, 2000. PubMed ID: 10623767. Show all entries for this paper.


Displaying record number 1166

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Larsson1999 M. Larsson, X. Jin, B. Ramratnam, G. S. Ogg, J. Engelmayer, M. A. Demoitie, A. J. McMichael, W. I. Cox, R. M. Steinman, D. Nixon, and N. Bhardwaj. A Recombinant Vaccinia Virus Based ELISPOT Assay Detects High Frequencies of Pol-Specific CD8 T Cells in HIV-1-Positive Individuals. AIDS, 13:767-777, 1999. PubMed ID: 10357375. Show all entries for this paper.


Displaying record number 53008

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, T-cell Elispot, Tetramer binding
Keywords epitope processing, escape, variant cross-reactivity

Notes

References

Jamieson2003 Beth D. Jamieson, Otto O. Yang, Lance Hultin, Mary Ann Hausner, Patricia Hultin, Jose Matud, Kevin Kunstman, Scott Killian, John Altman, Kristina Kommander, Bette Korber, Janis Giorgi, and Steven Wolinsky. Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. J. Immunol., 171(10):5372-5379, 15 Nov 2003. PubMed ID: 14607940. Show all entries for this paper.


Displaying record number 53010

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords epitope processing, rate of progression, immunodominance, acute/early infection, dendritic cells, TCR usage, memory cells

Notes

References

Kan-Mitchell2004 June Kan-Mitchell, Brygida Bisikirska, Flossie Wong-Staal, Keri L. Schaubert, Melissa Bajcz, and Michal Bereta. The HIV-1 HLA-A2-SLYNTVATL Is a Help-Independent CTL Epitope. J. Immunol., 172(9):5249-5261, 1 May 2004. PubMed ID: 15100263. Show all entries for this paper.


Displaying record number 1168

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17( SF2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.


Displaying record number 77

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ogg1998 G. S. Ogg, X. Jin, S. Bonhoeffer, P. R. Dunbar, M. A. Nowak, S. Monard, J. P. Segal, Y. Cao, S. L. Rowland-Jones, V. Cerundolo, A. Hurley, M. Markowitz, D. D. Ho, D. F. Nixon, and A. J. McMichael. Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA. Science, 279:2103-2106, 1998. PubMed ID: 9516110. Show all entries for this paper.


Displaying record number 53960

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location ( C consensus)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype C
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 68

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 54298

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords HAART, ART, responses in children, dendritic cells

Notes

References

Zhang2006 Zheng Zhang, Qing-xia Zhao, Jun-liang Fu, Jin-xia Yao, Yun He, Lei Jin, and Fu-sheng Wang. Characteristics of HIV-1-Specific CD8 T-Cell Responses and Their Role in Loss of Viremia in Children Chronically Infected with HIV-1 Undergoing Highly Active Antiretroviral Therapy. Chin. Med. J., 119(23):1949-1957, 5 Dec 2006. PubMed ID: 17199938. Show all entries for this paper.


Displaying record number 1494

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name G3
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.


Displaying record number 1517

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

GeaBanacloche2000 J. C. Gea-Banacloche, S. A. Migueles, L. Martino, W. L. Shupert, A. C. McNeil, M. S. Sabbaghian, L. Ehler, C. Prussin, R. Stevens, L. Lambert, J. Altman, C. W. Hallahan, J. C. de Quiros, and M. Connors. Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressors. J. Immunol., 165(2):1082-92, 15 Jul 2000. URL: http://www.jimmunol.org/v165n2/1082/1082-abs-frame.html. PubMed ID: 10878387. Show all entries for this paper.


Displaying record number 1591

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 SF2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, rate of progression

Notes

References

Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.


Displaying record number 54675

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HAART, ART, escape, viral fitness and reversion

Notes

References

Asquith2006 Becca Asquith, Charles T. T. Edwards, Marc Lipsitch, and Angela R. McLean. Inefficient Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo. PLoS Biol., 4(4):e90, Apr 2006. PubMed ID: 16515366. Show all entries for this paper.


Displaying record number 1639

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, rate of progression

Notes

References

Jin2000a X. Jin, G. Ogg, S. Bonhoeffer, J. Safrit, M. Vesanen, D. Bauer, D. Chen, Y. Cao, M. A. Demoitie, L. Zhang, M. Markowitz, D. Nixon, A. McMichael, and D. D. Ho. An antigenic threshold for maintaining human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. Mol Med, 6(9):803-9, Sep 2000. PubMed ID: 11071274. Show all entries for this paper.


Displaying record number 1700

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.


Displaying record number 54863

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen peptide-HLA interaction
Experimental methods Cytokine production, Flow cytometric T-cell cytokine assay
Keywords binding affinity, co-receptor, characterizing CD8+ T cells

Notes

References

Laugel2007a Bruno Laugel, David A. Price, Anita Milicic, and Andrew K. Sewell. CD8 Exerts Differential Effects on the Deployment of Cytotoxic T Lymphocyte Effector Functions. Eur. J. Immunol., 37(4):905-913, Apr 2007. PubMed ID: 17393387. Show all entries for this paper.


Displaying record number 61447

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) humanized mouse(A*0201)
Immunogen vaccine
Experimental methods Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type peptide
Vaccine strain B clade

Notes

References

Ding2016 Yong Ding, Jun Liu, Sheng Lu, Justice Igweze, Wen Xu, Da Kuang, Chris Zealey, Daheng Liu, Alex Gregor, Ardalan Bozorgzad, Lei Zhang, Elizabeth Yue, Shariq Mujib, Mario Ostrowski, and P. Chen. Self-Assembling Peptide for Co-Delivery of HIV-1 CD8+ T Cells Epitope and Toll-Like Receptor 7/8 Agonists R848 to Induce Maturation of Monocyte Derived Dendritic Cell and Augment Polyfunctional Cytotoxic T Lymphocyte (CTL) Response. J. Control. Release, 236:22-30, 28 Aug 2016. PubMed ID: 27297778. Show all entries for this paper.


Displaying record number 54982

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Spain
Experimental methods Tetramer binding
Keywords  

Notes

References

Lopez2006 Mariola López, Vincent Soriano, Sara Lozano, Pilar Martinez, José Sempere, Juan González-Lahoz, and José Benito. Impact of Gag Sequence Variability on Level, Phenotype, and Function of Anti-HIV Gag-Specific CD8+ Cytotoxic T Lymphocytes in Untreated Chronically HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 22(9):884-892, Sep 2006. PubMed ID: 16989614. Show all entries for this paper.


Displaying record number 70

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Ogg1999 G. S. Ogg, X. Jin, S. Bonhoeffer, P. Moss, M. A. Nowak, S. Monard, J. P. Segal, Y. Cao, S. L. Rowland-Jones, A. Hurley, M. Markowitz, D. D. Ho, A. J. McMichael, and D. F. Nixon. Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy. J. Virol., 73:797-800, 1999. PubMed ID: 9847391. Show all entries for this paper.


Displaying record number 55051

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords subtype comparisons, HLA cross-presentation, variant cross-reactivity

Notes

References

Currier2006 Jeffrey R. Currier, Unchalee Visawapoka, Sodsai Tovanabutra, Carl J. Mason, Deborah L. Birx, Francine E. McCutchan, and Josephine H. Cox. CTL Epitope Distribution Patterns in the Gag and Nef Proteins of HIV-1 from Subtype A Infected Subjects in Kenya: Use of Multiple Peptide Sets Increases the Detectable Breadth of the CTL Response. BMC Immunol, 7:8, 2006. PubMed ID: 16620386. Show all entries for this paper.


Displaying record number 1823

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder2000b P. J. Goulder, Y. Tang, C. Brander, M. R. Betts, M. Altfeld, K. Annamalai, A. Trocha, S. He, E. S. Rosenberg, G. Ogg, C. A. O'Callaghan, S. A. Kalams, R. E. McKinney, Jr., K. Mayer, R. A. Koup, S. I. Pelton, S. K. Burchett, K. McIntosh, and B. D. Walker. Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children. J. Exp. Med., 192(12):1819-32, 18 Dec 2000. URL: http://www.jem.org/cgi/content/full/192/12/1819. PubMed ID: 11120778. Show all entries for this paper.


Displaying record number 1834

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords dendritic cells

Notes

References

Ostrowski2000 M. A. Ostrowski, S. J. Justement, L. Ehler, S. B. Mizell, S. Lui, J. Mican, B. D. Walker, E. K. Thomas, R. Seder, and A. S. Fauci. The role of CD4+ T cell help and CD40 ligand in the in vitro expansion of HIV-1-specific memory cytotoxic CD8+ T cell responses. J. Immunol., 165(11):6133-41, 1 Dec 2000. URL: http://www.jimmunol.org/cgi/content/full/165/11/6133. PubMed ID: 11086046. Show all entries for this paper.


Displaying record number 61244

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, TCR usage

Notes

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.


Displaying record number 71

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Altman1996 J. D. Altman, P. A. H. Moss, P. J. R. Goulder, D. H. Barouch, M. G. McHeyzer-Williams, J. I. Bell, A. J. McMichael, and M. M. Davis. Phenotypic analysis of antigen-specific T lymphocytes. Science, 274:94-6, 1996. Comments in Science 1998 Jun 19;280(5371):1821. PubMed ID: 8810254. Show all entries for this paper.


Displaying record number 52075

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen vaccine
Experimental methods  
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type canarypox prime with gp120 boost, canarypox prime with gp160 boost
Vaccine strain B clade LAI, B clade MN, B clade SF2
Vaccine component Gag, gp120, gp41, Nef, Pol

Notes

References

Ferrari2001 Guido Ferrari, Wesley Neal, Anizsa Jones, Nancy Olender, Janet Ottinger, Richard Ha, M. Juliana McElrath, Paul Goepfert, and Kent J. Weinhold. CD8 CTL responses in vaccines: Emerging patterns of HLA restriction and epitope recognition. Immunol. Lett., 79(1-2):37-45, 1 Nov 2001. PubMed ID: 11595288. Show all entries for this paper.


Displaying record number 55351

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location ( LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name S9L
Subtype B
Species (MHC/HLA) human, transgenic mouse(A*0201)
Immunogen HIV-1 infection, vaccine
Country France
Experimental methods CD4 T-cell Elispot - IFNγ, Chromium-release assay, Other, Proliferation
Keywords computational epitope prediction, Th1

Vaccine Details

Vaccine type protein
Vaccine strain B clade
Vaccine component p24 Gag
Adjuvant Other

Notes

References

Pajot2007 Anthony Pajot, Aurélie Schnuriger, Arnaud Moris, Audrey Rodallec, David M. Ojcius, Brigitte Autran, François A. Lemonnier, and Yu-Chun Lone. The Th1 Immune Response against HIV-1 Gag p24-Derived Peptides in Mice Expressing HLA-A02.01 and HLA-DR1. Eur. J. Immunol., 37(9):2635-2644, Sep 2007. PubMed ID: 17668896. Show all entries for this paper.


Displaying record number 55361

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, dendritic cells

Notes

References

Schaubert2007 Keri L. Schaubert, David A. Price, Nicole Frahm, Jinzhu Li, Hwee L. Ng, Aviva Joseph, Elyse Paul, Biswanath Majumder, Velpandi Ayyavoo, Emma Gostick, Sharon Adams, Francesco M. Marincola, Andrew K. Sewell, Marcus Altfeld, Jason M. Brenchley, Daniel C. Douek, Otto O. Yang, Christian Brander, Harris Goldstein, and June Kan-Mitchell. Availability of a Diversely Avid CD8+ T Cell Repertoire Specific for the Subdominant HLA-A2-Restricted HIV-1 Gag p24(19-27) Epitope. J. Immunol., 178(12):7756-7766, 15 Jun 2007. PubMed ID: 17548613. Show all entries for this paper.


Displaying record number 52088

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Migueles2001 Stephen A. Migueles and Mark Connors. Frequency and Function of HIV-Specific CD8(+) T Cells. Immunol. Lett., 79(1-2):141-150, 1 Nov 2001. PubMed ID: 11595301. Show all entries for this paper.


Displaying record number 72

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Gray1999 C. M. Gray, J. Lawrence, J. M. Schapiro, J. D. Altman, M. A. Winters, M. Crompton, M. Loi, S. K. Kundu, M. M. Davis, and T. C. Merigan. Frequency of Class I HLA-Restricted Anti-HIV CD8+ T Cells in Individuals Receiving Highly Active Antiretroviral Therapy (HAART). J. Immunol., 162:1780-1788, 1999. PubMed ID: 9973442. Show all entries for this paper.


Displaying record number 61990

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen peptide-HLA interaction
Experimental methods Intracellular cytokine staining, Other
Keywords assay or method development, NK cells

Notes

References

Partridge2018 Thomas Partridge, Annalisa Nicastri, Anna E. Kliszczak, Louis-Marie Yindom, Benedikt M. Kessler, Nicola Ternette, and Persephone Borrow. Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows. Front. Immunol., 9:912, 2018. PubMed ID: 29780384. Show all entries for this paper.


Displaying record number 55744

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords class I down-regulation by Nef

Notes

References

Lewis2008 Martha J. Lewis, Arumugam Balamurugan, Ayako Ohno, Stephanie Kilpatrick, Hwee L. Ng, and Otto O. Yang. Functional Adaptation of Nef to the Immune Milieu of HIV-1 Infection In Vivo. J. Immunol., 180(6):4075-4081, 15 Mar 2008. PubMed ID: 18322217. Show all entries for this paper.


Displaying record number 66

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.


Displaying record number 97

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA 003: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 52263

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, immunodominance

Notes

References

Sewell2002 Andrew K. Sewell, Bruce L. Booth, Jr., Vincenzo Cerundolo, Rodney E. Phillips, and David A. Price. Differential Processing of HLA A2-Restricted HIV Type 1 Cytotoxic T Lymphocyte Epitopes. Viral Immunol., 15(1):193-196, 2002. PubMed ID: 11952141. Show all entries for this paper.


Displaying record number 55771

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen virus
Experimental methods  
Keywords immunotherapy, TCR usage

Notes

References

Joseph2008 Aviva Joseph, Jian Hua Zheng, Antonia Follenzi, Teresa Dilorenzo, Kaori Sango, Jaime Hyman, Ken Chen, Alicja Piechocka-Trocha, Christian Brander, Erik Hooijberg, Dario A. Vignali, Bruce D. Walker, and Harris Goldstein. Lentiviral Vectors Encoding Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Receptor Genes Efficiently Convert Peripheral Blood CD8 T Lymphocytes into Cytotoxic T Lymphocytes with Potent In Vitro and In Vivo HIV-1-Specific Inhibitory Activity. J. Virol., 82(6):3078-3089, Mar 2008. PubMed ID: 18184707. Show all entries for this paper.


Displaying record number 52283

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag( ADA)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL-9
Subtype B
Species (MHC/HLA) humanized mouse(A*0201)
Immunogen HIV-1 infected monocyte-derived
Experimental methods  
Keywords  

Notes

References

Poluektova2002 Larisa Y. Poluektova, David H. Munn, Yuri Persidsky, and Howard E. Gendelman. Generation of Cytotoxic T Cells Against Virus-Infected Human Brain Macrophages in a Murine Model of HIV-1 Encephalitis. J. Immunol., 168(8):3941-3949, 15 Apr 2002. PubMed ID: 11937550. Show all entries for this paper.


Displaying record number 56119

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Canada, United States
Experimental methods Intracellular cytokine staining, Other, Proliferation, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Jones2008 R. Brad Jones, Lishomwa C. Ndhlovu, Jason D. Barbour, Prameet M. Sheth, Aashish R. Jha, Brian R. Long, Jessica C. Wong, Malathy Satkunarajah, Marc Schweneker, Joan M. Chapman, Gabor Gyenes, Bahareh Vali, Martin D. Hyrcza, Feng Yun Yue, Colin Kovacs, Aref Sassi, Mona Loutfy, Roberta Halpenny, Desmond Persad, Gerald Spotts, Frederick M. Hecht, Tae-Wook Chun, Joseph M. McCune, Rupert Kaul, James M. Rini, Douglas F. Nixon, and Mario A. Ostrowski. Tim-3 Expression Defines a Novel Population of Dysfunctional T Cells with Highly Elevated Frequencies in Progressive HIV-1 Infection. J. Exp. Med., 205(12):2763-2779, 24 Nov 2008. PubMed ID: 19001139. Show all entries for this paper.


Displaying record number 61031

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords escape, neutralization by CTL, bispecific/trispecific

Notes

References

Yang2016 Hongbing Yang, Sandrine Buisson, Giovanna Bossi, Zoë Wallace, Gemma Hancock, Chun So, Rebecca Ashfield, Annelise Vuidepot, Tara Mahon, Peter Molloy, Joanne Oates, Samantha J. Paston, Milos Aleksic, Namir J. Hassan, Bent K. Jakobsen, and Lucy Dorrell. Elimination of Latently HIV-infected Cells from Antiretroviral Therapy-Suppressed Subjects by Engineered Immune-Mobilizing T-Cell Receptors. Mol. Ther., 24(11):1913-1925, Nov 2016. PubMed ID: 27401039. Show all entries for this paper.


Displaying record number 98

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 52293

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name LR23
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords binding affinity, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type peptide
Vaccine strain B clade LAI
Adjuvant Incomplete Freund's Adjuvant (IFA), Montanide (ISA 720), P30, PLG

Notes

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.


Displaying record number 52294

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name LR23
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type peptide
Vaccine strain B clade LAI
Adjuvant Incomplete Freund's Adjuvant (IFA), IL-12, P30

Notes

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.

Peter2002 Katrin Peter, Michael J. Brunda, and Giampietro Corradin. IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1-Restricted CTL Response in Transgenic Mice. J. Immunol., 169(1):63-67, 1 Jul 2002. PubMed ID: 12077229. Show all entries for this paper.


Displaying record number 56759

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Tetramer binding
Keywords  

Notes

References

Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.


Displaying record number 52308

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Species (MHC/HLA) (A*0201)
Immunogen computer prediction
Experimental methods Other
Keywords subtype comparisons, computational epitope prediction, vaccine-induced immune responses, escape

Notes

References

Schoenbach2002 Christian Schönbach, Yu Kun, and Vladimir Brusic. Large-scale Computational Identification of HIV T-Cell Epitopes. Immunol. Cell Biol., 80(3):300-306, Jun 2002. PubMed ID: 12067417. Show all entries for this paper.

Sewell1997 A. K. Sewell, G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. Antagonism of Cytotoxic T Lymphocyte-Mediated Lysis by Natural HIV-1 Altered Peptide Ligands Requires Simultaneous Presentation of Agonist and Antagonist Peptides. Eur. J. Immunol., 27:2323-2329, 1997. PubMed ID: 9341776. Show all entries for this paper.


Displaying record number 57066

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 DU422)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding
Keywords dendritic cells

Notes

References

Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.


Displaying record number 57182

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen peptide-HLA interaction
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Other
Keywords epitope processing

Notes

References

Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.


Displaying record number 57381

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Other
Keywords TCR usage

Notes

References

Bennett2010 Michael S. Bennett, Aviva Joseph, Hwee L. Ng, Harris Goldstein, and Otto O. Yang. Fine-Tuning of T-Cell Receptor Avidity to Increase HIV Epitope Variant Recognition by Cytotoxic T Lymphocytes. AIDS, 24(17):2619-2628, 13 Nov 2010. PubMed ID: 20881472. Show all entries for this paper.


Displaying record number 99

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Gray1999 C. M. Gray, J. Lawrence, J. M. Schapiro, J. D. Altman, M. A. Winters, M. Crompton, M. Loi, S. K. Kundu, M. M. Davis, and T. C. Merigan. Frequency of Class I HLA-Restricted Anti-HIV CD8+ T Cells in Individuals Receiving Highly Active Antiretroviral Therapy (HAART). J. Immunol., 162:1780-1788, 1999. PubMed ID: 9973442. Show all entries for this paper.


Displaying record number 61489

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(76-84)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name p76-84
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country United Kingdom, United States
Experimental methods Chromium-release assay, Other
Keywords  

Notes

References

Cella2010 Marina Cella, Rachel Presti, William Vermi, Kerry Lavender, Emma Turnbull, Christina Ochsenbauer-Jambor, John C. Kappes, Guido Ferrari, Lisa Kessels, Ian Williams, CHAVI Clinical Core B, Andrew J. McMichael, Barton F. Haynes, Persephone Borrow, Marco Colonna, and NIAID Center for HIV/AIDS Vaccine Immunology. Loss of DNAM-1 contributes to CD8+ T-Cell Exhaustion in Chronic HIV-1 Infection. Eur. J. Immunol., 40(4):949-954, Apr 2010. PubMed ID: 20201043. Show all entries for this paper.


Displaying record number 1394

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen  
Experimental methods  
Keywords binding affinity

Notes

References

Sandberg2000 J. K. Sandberg, A. C. Leandersson, C. Devito, B. Kohleisen, V. Erfle, A. Achour, M. Levi, S. Schwartz, K. Karre, B. Wahren, and J. Hinkula. Human immunodeficiency virus type 1 Nef epitopes recognized in HLA-A2 transgenic mice in response to DNA and peptide immunization. Virology, 273(1):112-9, 20 Jul 2000. PubMed ID: 10891413. Show all entries for this paper.


Displaying record number 88

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Lalvani1997 A. Lalvani, T. Dong, G. Ogg, A. A. Patham, H. Newell, A. V. Hill, A. J. McMichael, and S. Rowland-Jones. Optimization of a Peptide-Based Protocol Employing IL-7 for In Vitro Restimulation of Human Cytotoxic T Lymphocyte Precursors. J. Immunol. Methods, 210:65-77, 1997. PubMed ID: 9502585. Show all entries for this paper.


Displaying record number 89

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(76-84)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

vanderBurg1996 S. H. van der Burg, M. J. W. Visseren, R. M. P. Brandt, W. M. Kast, and C. J. M. Melief. Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability. J. Immunol., 156:3308-3314, 1996. Peptide-MHC dissociation rate is highly correlated with immunogenicity. In this study, HLA-A*0201 restricted epitopes from HPV, HBV and HIV were studied, some in the context of immunogenicity in peptide immunized HLA-A*0201/K$^b$ transgenic mice. PubMed ID: 8617954. Show all entries for this paper.


Displaying record number 53747

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords TCR usage, assay or method development, characterizing CD8+ T cells

Notes

References

Killian2005a M. Scott Killian, Rachel Lubong Sabado, Stephanie Kilpatrick, Mary Ann Hausner, Beth D. Jamieson, and Otto O. Yang. Clonal Breadth of the HIV-1-Specific T-Cell Receptor Repertoire In Vivo as Determined by Subtractive Analysis. AIDS, 19(9):887-986, Jun 10 2005. PubMed ID: 15905669. Show all entries for this paper.


Displaying record number 53790

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name S9L
Species (MHC/HLA) transgenic mouse(A*0201)
Immunogen vaccine
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords memory cells, vaccine antigen design, characterizing CD8+ T cells

Vaccine Details

Vaccine type measles virus (MV)
Vaccine strain multiple epitope immunogen
Vaccine component gp140, gp140ΔV3

Notes

References

Lorin2005a Clarisse Lorin, Frédéric Delebecque, Valérie Labrousse, Lucie Da Silva, François Lemonnier, Michel Brahic, and Frédéric Tangy. A Recombinant Live Attenuated Measles Vaccine Vector Primes Effective HLA-A0201-Restricted Cytotoxic T Lymphocytes and Broadly Neutralizing Antibodies against HIV-1 Conserved Epitopes. Vaccine, 23(36):4463-4472, 22 Aug 2005. PubMed ID: 15993518. Show all entries for this paper.


Displaying record number 1488

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag( LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords dendritic cells

Notes

References

Engelmayer2001 J. Engelmayer, M. Larsson, A. Lee, M. Lee, W. I. Cox, R. M. Steinman, and N. Bhardwaj. Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals. J. Virol., 75(5):2142-53, Mar 2001. URL: http://jvi.asm.org/cgi/content/full/75/5/2142. PubMed ID: 11160718. Show all entries for this paper.


Displaying record number 53157

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*2402, B*52, B75, Cw*03; A*0201, A*31, B*27, B*5101, Cw*02; A*0207, A*2402, B*46, B*52, Cw*01
Country Japan
Experimental methods Chromium-release assay
Keywords epitope processing, escape

Notes

References

Yokomaku2004 Yoshiyuki Yokomaku, Hideka Miura, Hiroko Tomiyama, Ai Kawana-Tachikawa, Masafumi Takiguchi, Asato Kojima, Yoshiyuki Nagai, Aikichi Iwamoto, Zene Matsuda, and Koya Ariyoshi. Impaired Processing and Presentation of Cytotoxic-T-Lymphocyte (CTL) Epitopes Are Major Escape Mechanisms from CTL Immune Pressure in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(3):1324-1332, Feb 2004. PubMed ID: 14722287. Show all entries for this paper.


Displaying record number 53208

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords vaccine-induced immune responses, immunodominance, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox prime with gp120 boost, vaccinia prime DNA boost
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag, gp120, gp41, Protease
Adjuvant GM-CSF

Notes

References

Ferrari2004 Guido Ferrari, Wesley Neal, Janet Ottinger, Anizsa M. Jones, Bradley H. Edwards, Paul Goepfert, Michael R. Betts, Richard A. Koup, Susan Buchbinder, M. Juliana McElrath, Jim Tartaglia, and Kent J. Weinhold. Absence of Immunodominant Anti-Gag p17 (SL9) responses among Gag CTL-Positive, HIV-Uninfected Vaccine Recipients Expressing the HLA-A*0201 Allele. J. Immunol., 173(3):2126-2133, 1 Aug 2004. PubMed ID: 15265949. Show all entries for this paper.


Displaying record number 53216

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, rate of progression, escape, acute/early infection

Notes

References

Goulder2004 Philip J R Goulder and David I Watkins. HIV and SIV CTL Escape: Implications for Vaccine Design. Nat. Rev. Immunol., 4(8):630-640, Aug 2004. PubMed ID: 15286729. Show all entries for this paper.


Displaying record number 53275

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location ( C consensus)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype C
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 1191

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 75

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords TCR usage

Notes

References

Wilson1998 J. D. Wilson, G. S. Ogg, R. L. Allen, P. J. Goulder, A. Kelleher, A. K. Sewell, C. A. O'Callaghan, S. L. Rowland-Jones, M. F. Callan, and A. J. McMichael. Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific. J. Exp. Med., 188(4):785-790, 1998. PubMed ID: 9705961. Show all entries for this paper.


Displaying record number 1284

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 SF2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape, acute/early infection

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 1314

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name p17 SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, computational epitope prediction

Notes

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.


Displaying record number 67

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tan1999 R. Tan, X. Xu, G. S. Ogg, P. Hansasuta, T. Dong, T. Rostron, G. Luzzi, C. P. Conlon, G. R. Screaton, A. J. McMichael, and S. Rowland-Jones. Rapid Death of Adoptively Transferred T Cells in Acquired Immunodeficiency Syndrome. Blood, 93:1506-1510, 1999. PubMed ID: 10029578. Show all entries for this paper.


Displaying record number 64

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 HXB2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, immunodominance, escape

Notes

References

Brander1999a C. Brander, O. O. Yang, N. G. Jones, Y. Lee, P. Goulder, R. P. Johnson, A. Trocha, D. Colbert, C. Hay, S. Buchbinder, C. C. Bergmann, H. J. Zweerink, S. Wolinsky, W. A. Blattner, S. A. Kalams, and B. D. Walker. Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope Despite Multiple Variations in the Epitope Flanking Sequences. J. Virol., 73:10191-10198, 1999. PubMed ID: 10559335. Show all entries for this paper.


Displaying record number 53621

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human, transgenic mouse(A*0201)
Immunogen HIV-1 infection, peptide-HLA interaction, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords vaccine-induced immune responses, immunodominance, escape, TCR usage, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type peptide
Vaccine strain multiple epitope immunogen
Vaccine component mimotopes
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Boggiano2005 César Boggiano, Rosa Moya, Clemencia Pinilla, Florian Bihl, Christian Brander, John Sidney, Alessandro Sette, and Sylvie E. Blondelle. Discovery and Characterization of Highly Immunogenic and Broadly Recognized Mimics of the HIV-1 CTL Epitope Gag 77-85. Eur. J. Immunol., 35(5):1428-1437, May 2005. PubMed ID: 15789356. Show all entries for this paper.


Displaying record number 1363

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name (SL9)
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goepfert2000 P. A. Goepfert, A. Bansal, B. H. Edwards, G. D. Ritter, Jr., I. Tellez, S. A. McPherson, S. Sabbaj, and M. J. Mulligan. A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon. J. Virol., 74(21):10249-55, Nov 2000. URL: http://jvi.asm.org/cgi/content/full/74/21/10249. PubMed ID: 11024158. Show all entries for this paper.


Displaying record number 1167

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17( subtype A)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype A
Species (MHC/HLA) human(A*0201, A*0214)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords  

Notes

References

Kaul2000 R. Kaul, F. A. Plummer, J. Kimani, T. Dong, P. Kiama, T. Rostron, E. Njagi, K. S. MacDonald, J. J. Bwayo, A. J. McMichael, and S. L. Rowland-Jones. HIV-1-Specific Mucosal CD8+ Lymphocyte Responses in the Cervix of HIV-1-Resistant Prostitutes in Nairobi. J. Immunol., 164:1602-1611, 2000. PubMed ID: 10640781. Show all entries for this paper.


Displaying record number 106

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0202)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 1170

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17( SF2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A*0202)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.


Displaying record number 61007

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0202)
Immunogen HIV-1 infection
Patient MHC/HLA 17543: A*0101, A*0202, B*0701, B*1503, Cw*0210, Cw*0702; 57604: A*0201, A*0201, B*1302, B*3501, Cw*0419, Cw*0602; 32645: A*0101, A*0201, B*0801, B*3503, Cw*0401, Cw*0701
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 101

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A*0202, A2)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons

Notes

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.


Displaying record number 1193

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A*0205)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53587

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 69

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen vaccine
Experimental methods  
Keywords immunodominance

Vaccine Details

Vaccine type canarypox
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag, gp120, gp41, Protease

Notes

References

Carruth1999 L. M. Carruth, T. F. Greten, C. E. Murray, M. G. Castro, S. N. Crone, W. Pavlat, J. P. Schneck, and R. F. Siliciano. An Algorithm for Evaluating Human Cytotoxic T Lymphocyte Responses to Candidate AIDS Vaccines. AIDS Res. Hum. Retroviruses, 15:1021-1034, 1999. PubMed ID: 10445814. Show all entries for this paper.


Displaying record number 73

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Birk1998 M. Birk, A. Vahlne, A. Sonnerborg, and M. Sallberg. Nonsynonymous Mutations within the Human Immunodeficiency Virus Type 1 p17 Gene Are Clustered to Sequences Binding to the Host Human Leukocyte Antigen Class I Molecules. AIDS Res. Hum. Retroviruses, 14:241-248, 1998. PubMed ID: 9491914. Show all entries for this paper.


Displaying record number 76

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Callan1998 M. F. C. Callan, L. Tan, N. Annels, G. S. Ogg, J. D. K. Wilson, C. A. O'Callghan, N. Steven, A. J. McMichael, and A. B. Rickinson. Direct Visualization of Antigen-Specific CD8+ T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo. J. Exp. Med., 187:1395-1402, 1998. PubMed ID: 9565632. Show all entries for this paper.


Displaying record number 78

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Wagner1998b L. Wagner, O. O. Yang, E. A. Zepeda, Y. Ge, S. A. Kalams, B. D. Walker, M. S. Pasternack, and A. D. Luster. Beta-Chemokines Are Released from HIV-1-Specific Cytolytic T Cell Granules Complexed to Proteoglycans. Nature, 391:908-911, 1998. PubMed ID: 9495345. Show all entries for this paper.


Displaying record number 79

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 HXB2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Collins1998 K. L. Collins, B. K. Chen, S. A. Kalams, B. D. Walker, and D. Baltimore. HIV-1 Nef Protein Protects Infected Primary Cells against Killing by Cytotoxic T Lymphocytes. Nature, 391:397-401, 1998. PubMed ID: 9450757. Show all entries for this paper.


Displaying record number 80

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Durali1998 D. Durali, J. Morvan, F. Letourneur, D. Schmitt, N. Guegan, M. Dalod, S. Saragosti, D. Sicard, J. P. Levy, and E. Gomard. Cross-Reactions between the Cytotoxic T-Lymphocyte Responses of Human Immunodeficiency Virus-Infected African and European Patients. J. Virol., 72:3547-3553, 1998. PubMed ID: 9557634. Show all entries for this paper.


Displaying record number 81

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords dendritic cells

Notes

References

Kundu1998 S. K. Kundu, E. Engleman, C. Benike, M. H. Shapero, M. Dupuis, W. C. van Schooten, M. Eibl, and T. C. Merigan. A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 14:551-560, 1998. PubMed ID: 9591709. Show all entries for this paper.


Displaying record number 82

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 IIIB)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 83

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 85

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA 9300868: A*02, A*24, B*27, B*35; 003: A*02, A*03, B*07, B*51
Experimental methods Chromium-release assay, HLA binding
Keywords binding affinity

Notes

References

Sewell1997 A. K. Sewell, G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. Antagonism of Cytotoxic T Lymphocyte-Mediated Lysis by Natural HIV-1 Altered Peptide Ligands Requires Simultaneous Presentation of Agonist and Antagonist Peptides. Eur. J. Immunol., 27:2323-2329, 1997. PubMed ID: 9341776. Show all entries for this paper.


Displaying record number 86

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 HXB2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords kinetics

Notes

References

Yang1997b O. O. Yang, A. C. Tran, S. A. Kalams, R. P. Johnson, M. R. Roberts, and B. D. Walker. Lysis of HIV-1-Infected Cells and Inhibition of Viral Replication by Universal Receptor T Cells. Proc. Natl. Acad. Sci. U.S.A., 94:11478-11483, 1997. PubMed ID: 9326635. Show all entries for this paper.


Displaying record number 87

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

Stuhler1997 G. Stuhler and S. F. Schlossman. Antigen organization regulates cluster formation and induction of cytotoxic T lymphocytes by helper T cell subsets. Proc. Natl. Acad. Sci. U.S.A., 94:622-627, 1997. Generation of cytolytic activity requires a three-cell type cluster consisting of APC's, Helper, and CTL's, and co-expression of helper and CTL epitopes on the same APC. PubMed ID: 9012834. Show all entries for this paper.


Displaying record number 90

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Yang1996 O. O. Yang, S. A. Kalams, M. Rosenzweig, A. Trocha, N. Jones, M. Koziel, B. D. Walker, and R. P. Johnson. Efficient Lysis of Human Immunodeficiency Virus Type 1-Infected Cells by Cytotoxic T Lymphocytes. J. Virol., 70:5799-5806, 1996. PubMed ID: 8709196. Show all entries for this paper.


Displaying record number 91

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords  

Notes

References

Yang1997 O. O. Yang, S. A. Kalams, A. Trocha, H. Cao, A. Luster, R. P. Johnson, and B. D. Walker. Suppression of Human Immunodeficiency Virus Type 1 Replication by CD8+ Cells: Evidence for HLA Class I-Restricted Triggering of Cytolytic and Noncytolytic Mechanisms. J. Virol., 71:3120-3128, 1997. Although CD8+ lymphocytes in human immunodeficiency virus type 1 (HIV-1)-infected individuals have been demonstrated to suppress viral replication, the mechanisms of inhibition have not been defined precisely. A large body of evidence indicates that these cells act via soluble inhibitory factors, but the potential role of HLA class I-restricted cytolysis has remained controversial. Here we demonstrate that HIV-1-specific cytotoxic T lymphocytes (CTL) mediate antiviral suppression by both cytolytic and noncytolytic mechanisms. The predominant mechanism requires direct contact of CTL with the infected cells, is HLA class I restricted, and can achieve complete elimination of detectable virus in infected cell cultures. Inhibition occurs even at high multiplicities of infection or at ratios of CTL to CD4 cells as low as 1:1,000. The other mechanism is mediated by soluble inhibitory factors which are triggered in an antigen-specific and HLA-restricted fashion but then act without HLA restriction. PubMed ID: 9060675. Show all entries for this paper.


Displaying record number 92

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Parker1992 K. C. Parker, M. A. Bednarek, L. K. Hull, U. Utz, B. Cunningham H. J. Zweerink, W. E. Biddison, and J. E. Coligan. Sequence Motifs Important for Peptide Binding to the Human MHC Class I Molecule, HLA-A2. J. Immunol., 149, 1992. PubMed ID: 1331239. Show all entries for this paper.

Parker1994 K. C. Parker, M. A. Bednarek, and J. E. Coligan. Scheme for Ranking Potential HLA-A2 Binding Peptides Based on Independent Binding of Individual Peptide Side-Chains. J. Immunol., 152, 1994. The authors conclude that peptide amino acid side-chain binding to the HLA-A2 molecule is independent of the sequence of the peptide, and developed a table of coefficients that can be used to help predict peptide binding to HLA-A2. PubMed ID: 8254189. Show all entries for this paper.


Displaying record number 93

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.


Displaying record number 94

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tsomides1994 T. J. Tsomides, A. Aldovini, R. P. Johnson, B. D. Walker, R. A. Young, and H. N. Eisen. Naturally Processed Viral Peptides Recognized by Cytotoxic T Lymphocytes on Cells Chronically Infected by Human Immunodeficiency Virus Type 1. J. Exp. Med., 180:1283-1293, 1994. Naturally processed peptides can be purified from trifluoroacetic acid lysates of HIV-1 infected cells. A gag and RT epitope were compared; both synthetic peptides are optimally active in CTL assays. The naturally processed gag peptide was more abundant than the RT peptide in HIV-1 infected HLA-A2 positive cells, and the gag specific CTL more effective, suggesting surface density of peptides may influence efficiency of CTL killing. PubMed ID: 7523570. Show all entries for this paper.


Displaying record number 95

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

Stuhler1997 G. Stuhler and S. F. Schlossman. Antigen organization regulates cluster formation and induction of cytotoxic T lymphocytes by helper T cell subsets. Proc. Natl. Acad. Sci. U.S.A., 94:622-627, 1997. Generation of cytolytic activity requires a three-cell type cluster consisting of APC's, Helper, and CTL's, and co-expression of helper and CTL epitopes on the same APC. PubMed ID: 9012834. Show all entries for this paper.


Displaying record number 96

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 100

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Dyer1999 W. B. Dyer, G. S. Ogg, M. A. Demoitie, X. Jin, A. F. Geczy, S. L. Rowland-Jones, A. J. McMichael, D. F. Nixon, and J. S. Sullivan. Strong Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Activity in Sydney Blood Bank Cohort Patients Infected with nef-Defective HIV Type 1. J. Virol., 73:436-443, 1999. PubMed ID: 9847349. Show all entries for this paper.


Displaying record number 104

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape

Notes

References

Harrer1998 T. Harrer, E. Harrer, P. Barbosa, F. Kaufmann, R. Wagner, S. Bruggemann, J. R. Kalden, M. Feinberg, R. P. Johnson, S. Buchbinder, and B. D. Walker. Recognition of Two Overlapping CTL Epitopes in HIV-1 p17 by CTL from a Long-Term Nonprogressing HIV-1-Infected Individual. J. Immunol., 161:4875-4881, 1998. PubMed ID: 9794421. Show all entries for this paper.


Displaying record number 1261

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 SF2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Altfeld2001c M. Altfeld, M. M. Addo, R. L. Eldridge, X. G. Yu, S. Thomas, A. Khatri, D. Strick, M. N. Phillips, G. B. Cohen, S. A. Islam, S. A. Kalams, C. Brander, P. J. Goulder, E. S. Rosenberg, B. D. Walker, and The HIV Study Collaboration.. Vpr is preferentially targeted by CTL during HIV-1 infection. J. Immunol., 167(5):2743-52, 1 Sep 2001. URL: http://www.jimmunol.org/cgi/content/full/167/5/2743. PubMed ID: 11509618. Show all entries for this paper.


Displaying record number 1318

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17( BRU)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords epitope processing, dendritic cells

Notes

References

Buseyne2001 F. Buseyne, S. Le Gall, C. Boccaccio, J. P. Abastado, J. D. Lifson, L. O. Arthur, Y. Riviere, J. M. Heard, and O. Schwartz. MHC-I-restricted presentation of HIV-1 virion antigens without viral replication. Nat. Med., 7(3):344-9, Mar 2001. PubMed ID: 11231634. Show all entries for this paper.


Displaying record number 1406

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Kostense2001 S. Kostense, G. S. Ogg, E. H. Manting, G. Gillespie, J. Joling, K. Vandenberghe, E. Z. Veenhof, D. van Baarle, S. Jurriaans, M. R. Klein, and F. Miedema. High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function. Eur. J. Immunol., 31(3):677-86, Mar 2001. PubMed ID: 11241270. Show all entries for this paper.


Displaying record number 1442

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 1482

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, immunodominance

Notes

References

Seth2001 A. Seth, J. Markee, A. Hoering, A. Sevin, D. E. Sabath, J. E. Schmitz, M. J. Kuroda, M. A. Lifton, M. S. Hirsch, A. C. Collier, N. L. Letvin, and M. J. McElrath. Alterations in T cell phenotype and human immunodeficiency virus type 1-specific cytotoxicity after potent antiretroviral therapy. J. Infect. Dis., 183(5):722-9, 1 Mar 2001. PubMed ID: 11181148. Show all entries for this paper.


Displaying record number 1491

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, TCR usage

Notes

References

Islam2001 S. A. Islam, C. M. Hay, K. E. Hartman, S. He, A. K. Shea, A. K. Trocha, M. J. Dynan, N. Reshamwala, S. P. Buchbinder, N. O. Basgoz, and S. A. Kalams. Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression. J. Virol., 75(10):4907-11, May 2001. URL: http://jvi.asm.org/cgi/content/full/75/10/4907. PubMed ID: 11312363. Show all entries for this paper.


Displaying record number 1579

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 SF2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1822

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords mother-to-infant transmission, escape

Notes

References

Goulder2001b P. J. Goulder, C. Pasquier, E. C. Holmes, B. Liang, Y. Tang, J. Izopet, K. Saune, E. S. Rosenberg, S. K. Burchett, K. McIntosh, M. Barnardo, M. Bunce, B. D. Walker, C. Brander, and R. E. Phillips. Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation. Immunol. Lett., 79(1-2):109-16, 1 Nov 2001. PubMed ID: 11595297. Show all entries for this paper.


Displaying record number 1850

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17( SF2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.


Displaying record number 52175

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, epitope processing, immunodominance

Notes

References

Kelleher2001a A. D. Kelleher, B. L. Booth, Jr., A. K. Sewell, A. Oxenius, V. Cerundolo, A. J. McMichael, R. E. Phillips, and D. A. Price. Effects of Retroviral Protease Inhibitors on Proteasome Function and Processing of HIV-Derived MHC Class I-Restricted Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 17(11):1063-1066, 20 Jul 2001. PubMed ID: 11485623. Show all entries for this paper.


Displaying record number 52193

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2002 Rupert Kaul, Sarah L. Rowland-Jones, Geraldine Gillespie, Joshua Kimani, Tao Dong, Peter Kiama, J. Neil Simonsen, Job J. Bwayo, Andrew J. McMichael, and Francis A. Plummer. Gonococcal Cervicitis is Associated with Reduced Systemic CD8+ T Cell Responses in Human Immunodeficiency Virus Type 1-Infected and Exposed, Uninfected Sex Workers. J. Infect. Dis., 185(10):1525-1529, 15 May 2002. PubMed ID: 11992292. Show all entries for this paper.


Displaying record number 52236

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 NL43)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords class I down-regulation by Nef

Notes

References

Yang2002 Xinzhen Yang, Juliette Lee, Erin M. Mahony, Peter D. Kwong, Richard Wyatt, and Joseph Sodroski. Highly Stable Trimers Formed by Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Fused with the Trimeric Motif of T4 Bacteriophage Fibritin. J. Virol., 76(9):4634-4642, May 2002. PubMed ID: 1932429. Show all entries for this paper.


Displaying record number 52285

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 BRU)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing

Notes

References

Cohen2002 W. M. Cohen, A. Bianco, F. Connan, L. Camoin, M. Dalod, G. Lauvau, E. Ferriés, B. Culmann-Penciolelli, P. M. van Endert, J. P. Briand, J. Choppin, and J. G. Guillet. Study of Antigen-Processing Steps Reveals Preferences Explaining Differential Biological Outcomes of Two HLA-A2-Restricted Immunodominant Epitopes from Human Immunodeficiency Virus Type 1. J. Virol., 76(20):10219-10225, Oct 2002. PubMed ID: 12239297. Show all entries for this paper.


Displaying record number 52338

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) mouse(A2)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine strain B clade IIIB
Vaccine component Gag, Pol
Adjuvant IL-12

Notes

References

Kmieciak2001 Dariusz Kmieciak, Elizabeth Bolesta, Toshio Naito, Jaroslaw Gzyl, Yutaro Kaneko, and Danuta Kozbor. Enhancement of Cellular and Humoral Immune Responses to Human Immunodeficiency Virus Type 1 Gag and Pol by a G/P-92 Fusion Protein Expressing Highly Immunogenic Gag p17/p24 and Pol p51 Antigens. J Hum Virol, 4(6):306-316, Nov-Dec 2001. PubMed ID: 12082397. Show all entries for this paper.


Displaying record number 52357

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B7, Bw6
Experimental methods  
Keywords HAART, ART

Notes

References

Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.


Displaying record number 52519

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 NL-43)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords class I down-regulation by Nef, escape

Notes

References

Ali2003 Ayub Ali, Satish Pillai, Hwee Ng, Rachel Lubong, Douglas D. Richman, Beth D. Jamieson, Yan Ding, M. Juliana McElrath, John C. Guatelli, and Otto O. Yang. Broadly Increased Sensitivity to Cytotoxic T Lymphocytes Resulting from Nef Epitope Escape Mutations. J. Immunol., 171(8):3999-4005, Oct 2003. PubMed ID: 14530319. Show all entries for this paper.


Displaying record number 52587

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords class I down-regulation by Nef

Notes

References

Bobbitt2003 Kevin R. Bobbitt, Marylyn M. Addo, Marcus Altfeld, Tracey Filzen, Adewunmi A. Onafuwa, Bruce D. Walker, and Kathleen L. Collins. Rev Activity Determines Sensitivity of HIV-1-Infected Primary T Cells to CTL killing. Immunity, 18(2):289-299, Feb 2003. PubMed ID: 12594955. Show all entries for this paper.


Displaying record number 52700

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name Gag77
Species (MHC/HLA) human, transgenic mouse(A2)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords binding affinity, subtype comparisons, computational epitope prediction

Vaccine Details

Vaccine type peptide
Vaccine component Gag
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


Displaying record number 52731

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods Intracellular cytokine staining
Keywords immunodominance, genital and mucosal immunity

Notes

References

Kaul2003 Rupert Kaul, Paul Thottingal, Joshua Kimani, Peter Kiama, Charles W. Waigwa, Job J. Bwayo, Francis A. Plummer, and Sarah L. Rowland-Jones. Quantitative Ex Vivo Analysis of Functional Virus-Specific CD8 T Lymphocytes in the Blood and Genital Tract of HIV-Infected Women. AIDS, 17(8):1139-1144, May 2003. PubMed ID: 12819514. Show all entries for this paper.


Displaying record number 52740

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A24, B38, B60, Cw12, Cw2
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supervised treatment interruptions (STI), early treatment

Notes

References

Montefiori2003 David C. Montefiori, Marcus Altfeld, Paul K. Lee, Miroslawa Bilska, Jintao Zhou, Mary N. Johnston, Feng Gao, Bruce D. Walker, and Eric S. Rosenberg. Viremia Control Despite Escape from a Rapid and Potent Autologous Neutralizing Antibody Response after Therapy Cessation in an HIV-1-Infected Individual. J. Immunol., 170(7):3906-3914, Apr 2003. PubMed ID: 12646660. Show all entries for this paper.


Displaying record number 52782

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) (A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B27, B51; A2, A3, B27, B57; A2, A23, B57
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production, Intracellular cytokine staining, Tetramer binding
Keywords assay or method development, memory cells

Notes

References

Sun2003 Y. Sun, E. Iglesias, A. Samri, G. Kamkamidze, T. Decoville, G. Carcelain, and B. Autran. A Systematic Comparison of Methods to Measure HIV-1 Specific CD8 T Cells. J. Immunol. Methods, 272(1-2):23-34, 15 Jan 2003. PubMed ID: 12505709. Show all entries for this paper.


Displaying record number 52791

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 NL43)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication, Chromium-release assay
Keywords escape, TCR usage

Notes

References

Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.


Displaying record number 52812

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17( 43)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen in vitro stimulation or selection
Experimental methods CTL suppression of replication
Keywords class I down-regulation by Nef, early-expressed proteins, kinetics

Notes

References

Ali2004 Ayub Ali, Rachel Lubong, Hwee Ng, David G. Brooks, Jerome A. Zack, and Otto O. Yang. Impacts of Epitope Expression Kinetics and Class I Downregulation on the Antiviral Activity of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes. J. Virol., 78(2):561-567, Jan 2004. PubMed ID: 14694087. Show all entries for this paper.


Displaying record number 52922

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85 B con)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Draenert2004b R. Draenert, C. L. Verrill, Y. Tang, T. M. Allen, A. G. Wurcel, M. Boczanowski, A. Lechner, A. Y. Kim, T. Suscovich, N. V. Brown, M. M. Addo, and B. D. Walker. Persistent Recognition of Autologous Virus by High-Avidity CD8 T Cells in Chronic, Progressive Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(2):630-641, Jan 2004. PubMed ID: 14694094. Show all entries for this paper.


Displaying record number 53034

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.


Displaying record number 53148

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay
Keywords binding affinity, TCR usage, characterizing CD8+ T cells

Notes

References

Yang2003a Otto O. Yang, Phuong T. Nguyen Sarkis, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL. J. Immunol., 171(7):3718-3724, 1 Oct 2003. PubMed ID: 14500671. Show all entries for this paper.


Displaying record number 53185

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords HAART, ART, memory cells, characterizing CD8+ T cells

Notes

References

Daniel2004 Nathalie Daniel, Bénédicte Charmeteau, Sophie Grabar, Gilles Pialoux, Dominique Salmon, Nelly Bonilla, Marion Dupuis, Christelle Troadec, Willy Rozenbaum, Hanne Gahéry-Ségard, Jean-Gérard Guillet, and Muriel Andrieu. Use of Well-Defined HIV-Derived Epitopes to Evaluate CD4+ and CD8+ T Cell Responses in Patients with Chronic HIV-1 Infection Treated with HAART. AIDS Res. Hum. Retroviruses, 20(8):827-835, Aug 2004. PubMed ID: 15320987. Show all entries for this paper.


Displaying record number 53345

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods Proliferation, T-cell Elispot, Tetramer binding
Keywords acute/early infection, characterizing CD8+ T cells

Notes

References

Lichterfeld2004 Mathias Lichterfeld, Daniel E. Kaufmann, Xu G. Yu, Stanley K. Mui, Marylyn M. Addo, Mary N. Johnston, Daniel Cohen, Gregory K. Robbins, Eunice Pae, Galit Alter, Alysse Wurcel, David Stone, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Loss of HIV-1-Specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-Induced HIV-1-Specific CD4+ T Cells. J. Exp. Med., 200(6):701-12, Sep 20 2004. PubMed ID: 15381726. Show all entries for this paper.


Displaying record number 53386

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name gag 77-85
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection, HIV-2 infection
Country Gambia
Experimental methods Intracellular cytokine staining, Tetramer binding
Keywords escape, TCR usage, variant cross-reactivity, characterizing CD8+ T cells, HIV-2

Notes

References

Lopes2003 A. Ross Lopes, Assan Jaye, Lucy Dorrell, Sehu Sabally, Abraham Alabi, Nicola A. Jones, Darren R. Flower, Anne De Groot, Phillipa Newton, R. Monica Lascar, Ian Williams, Hilton Whittle, Antonio Bertoletti, Persephone Borrow, and Mala K. Maini. Greater CD8+ TCR Heterogeneity and Functional Flexibility in HIV-2 Compared to HIV-1 Infection. J. Immunol., 171(1):307-316, 1 Jul 2003. PubMed ID: 12817012. Show all entries for this paper.


Displaying record number 53389

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay
Keywords assay or method development

Notes

References

Lubong2004 Rachel Lubong, Hwee L. Ng, Christel H. Uittenbogaart, and Otto O. Yang. Culturing of HIV-1-Specific Cytotoxic T Lymphocytes with Interleukin-7 and Interleukin-15. Virology, 325(2):175-180, 1 Aug 2004. PubMed ID: 15246257. Show all entries for this paper.


Displaying record number 53396

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 exposed seronegative
Patient MHC/HLA A*02, A*30, B*15, B*4402
Experimental methods T-cell Elispot, Tetramer binding
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Missale2004 Gabriele Missale, Laura Papagno, Amalia Penna, Massimo Pilli, Alessandro Zerbini, Piero Vitali, Giovanni Pieroni, Simona Urbani, Jacopo Uggeri, Susana Pinheiro, Sarah Rowland-Jones, and Carlo Ferrari. Parenteral Exposure to High HIV Viremia Leads to Virus-Specific T Cell Priming without Evidence of Infection. Eur. J. Immunol., 34(11):3208-3215, Nov 2004. PubMed ID: 15459901. Show all entries for this paper.


Displaying record number 53401

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods Intracellular cytokine staining, T-cell Elispot, Tetramer binding
Keywords rate of progression, acute/early infection, characterizing CD8+ T cells

Notes

References

Papagno2004 Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Victor Appay. Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol., 2(2):E20, Feb 2004. PubMed ID: 14966528. Show all entries for this paper.


Displaying record number 53495

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53622

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 HXB2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name 17A
Subtype B
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA
Vaccine strain multiple epitope immunogen
Vaccine component p17/p24 Gag, Pol
Adjuvant IL-12

Notes

References

Bolesta2005a Elizabeth Bolesta, Jaroslaw Gzyl, Andrzej Wierzbicki, Dariusz Kmieciak, Aleksandra Kowalczyk, Yutaro Kaneko, Alagarsamy Srinivasan, and Danuta Kozbor. Clustered Epitopes within the Gag-Pol Fusion Protein DNA Vaccine Enhance Immune Responses and Protection against Challenge with Recombinant Vaccinia Viruses Expressing HIV-1 Gag and Pol Antigens. Virology, 332(2):467-479, 20 Feb 2005. PubMed ID: 15680412. Show all entries for this paper.


Displaying record number 53627

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A2, B44, B70; A2, A31, B51, B58w4
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords HAART, ART

Notes

References

Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.


Displaying record number 53707

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, variant cross-reactivity, optimal epitope

Notes

References

Harrer2005b Ellen G. Harrer, Silke Bergmann, Kathrin Eismann, Marion Rittmaier, Andreas Goldwich, Sandra M. Müller, Bernd M. Spriewald, and Thomas Harrer. A Conserved HLA B13-Restricted Cytotoxic T Lymphocyte Epitope in Nef is a Dominant Epitope in HLA B13-Positive HIV-1-Infected Patients. AIDS, 19(7):734-735, 29 Apr 2005. PubMed ID: 15821402. Show all entries for this paper.


Displaying record number 53717

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85 BRU)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B, CRF02_AG
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 53742

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords binding affinity, rate of progression, escape, characterizing CD8+ T cells

Notes

References

Jansen2005a Christine A. Jansen, Stefan Kostense, Kristin Vandenberghe, Nening M. Nanlohy, Iris M. De Cuyper, Erwan Piriou, Erik H. Manting, Frank Miedema, and Debbie van Baarle. High Responsiveness of HLA-B57-Restricted Gag-Specific CD8+ T Cells In Vitro May Contribute to the Protective Effect of HLA-B57 in HIV-Infection. Eur. J. Immunol., 35(1):150-158, Jan 2005. PubMed ID: 15593302. Show all entries for this paper.


Displaying record number 53755

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A*02, A*68, B*14, B*52, Cw*08, Cw*12
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords escape, optimal epitope

Notes

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53802

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Country Canada
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS), immunodominance, genital and mucosal immunity, characterizing CD8+ T cells

Notes

References

Makedonas2005a George Makedonas, Julie Bruneau, Michel Alary, Christos M. Tsoukas, Catherine M. Lowndes, François Lamothe, and Nicole F. Bernard. Comparison of HIV-Specific CD8 T-Cell Responses among Uninfected Individuals Exposed to HIV Parenterally and Mucosally. AIDS, 19(3):251-259, 18 Feb 2005. PubMed ID: 15718835. Show all entries for this paper.


Displaying record number 53858

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART, characterizing CD8+ T cells, optimal epitope

Notes

References

Schmitt-Haendle2005 Matthias Schmitt-Haendle, Oliver Bachmann, Ellen Harrer, Barbara Schmidt, Michael Bäuerle, and Thomas Harrer. Recognition Patterns of HLA-A2-Restricted Human Immunodeficiency Virus-1-Specific Cytotoxic T-Lymphocytes in a Cohort of HIV-1-Infected Individuals. Viral Immunol., 18(4):627-636, 2005. PubMed ID: 16359229. Show all entries for this paper.


Displaying record number 54222

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name A2-SL9(p17)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54495

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen peptide-HLA interaction
Experimental methods Chromium-release assay, HLA binding
Keywords escape, TCR usage, structure, optimal epitope

Notes

References

Martinez-Hackert2006 Erik Martinez-Hackert, Nadia Anikeeva, Spyros A. Kalams, Bruce D. Walker, Wayne A. Hendrickson, and Yuri Sykulev. Structural Basis for Degenerate Recognition of Natural HIV Peptide Variants by Cytotoxic Lymphocytes. J. Biol. Chem., 281(29):20205-20212, 21 Jul 2006. PubMed ID: 16702212. Show all entries for this paper.


Displaying record number 54497

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human, mouse(A2)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords TCR usage, variant cross-reactivity

Notes

References

Kan-Mitchell2006 June Kan-Mitchell, Melissa Bajcz, Keri L. Schaubert, David A. Price, Jason M. Brenchley, Tedi E. Asher, Daniel C. Douek, Hwee L. Ng, Otto O. Yang, Charles R. Rinaldo, Jr., Jose Miguel Benito, Brygida Bisikirska, Ramakrishna Hegde, Franco M. Marincola, César Boggiano, Dianne Wilson, Judith Abrams, Sylvie E. Blondelle, and Darcy B. Wilson. Degeneracy and Repertoire of the Human HIV-1 Gag p17(77-85) CTL Response. J. Immunol., 176(11):6690-6701, 1 Jun 2006. PubMed ID: 16709828. Show all entries for this paper.


Displaying record number 54498

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords subtype comparisons, escape, acute/early infection, variant cross-reactivity, viral fitness and reversion, HLA associated polymorphism

Notes

References

Iversen2006 Astrid K. N. Iversen, Guillaume Stewart-Jones, Gerald H. Learn, Natasha Christie, Christina Sylvester-Hviid, Andrew E. Armitage, Rupert Kaul, Tara Beattie, Jean K. Lee, Yanping Li, Pojchong Chotiyarnwong, Tao Dong, Xiaoning Xu, Mark A. Luscher, Kelly MacDonald, Henrik Ullum, Bente Klarlund-Pedersen, Peter Skinhøj, Lars Fugger, Søren Buus, James I. Mullins, E. Yvonne Jones, P. Anton van der Merwe, and Andrew J. McMichael. Conflicting Selective Forces Affect T Cell Receptor Contacts in an Immunodominant Human Immunodeficiency Virus Epitope. Nat. Immunol., 7(2):179-189, Feb 2006. PubMed ID: 16388312. Show all entries for this paper.


Displaying record number 54501

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name Peptide 7027
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B44, B7
Country United Kingdom
Experimental methods Flow cytometric T-cell cytokine assay, Other
Keywords HAART, ART, immunodominance, TCR usage, memory cells

Notes

References

Weekes2006 Michael P. Weekes, Mark R. Wills, J. G. Patrick Sissons, and Andrew J. Carmichael. Large HIV-Specific CD8 Cytotoxic T-Lymphocyte (CTL) Clones Reduce Their Overall Size But Maintain High Frequencies of Memory CTL Following Highly Active Antiretroviral Therapy. Immunology, 118(1):25-38, May 2006. PubMed ID: 16630020. Show all entries for this paper.


Displaying record number 54526

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, subtype comparisons, acute/early infection

Notes

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54758

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85 HXB2)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay, Other
Keywords binding affinity, assay or method development

Notes

References

Bennett2007 Michael S. Bennett, Hwee L. Ng, Mirabelle Dagarag, Ayub Ali, and Otto O. Yang. Epitope-Dependent Avidity Thresholds for Cytotoxic T-Lymphocyte Clearance of Virus-Infected Cells. J. Virol., 81(10):4973-4980, May 2007. PubMed ID: 17329324. Show all entries for this paper.


Displaying record number 54762

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name A2-SL9 Gag (77-85)
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A32, B27, B39
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords binding affinity, immunodominance, TCR usage, characterizing CD8+ T cells

Notes

References

Almeida2007 Jorge R. Almeida, David A. Price, Laura Papagno, Zaïna Aït Arkoub, Delphine Sauce, Ethan Bornstein, Tedi E. Asher, Assia Samri, Aurélie Schnuriger, Ioannis Theodorou, Dominique Costagliola, Christine Rouzioux, Henri Agut, Anne-Geneviève Marcelin, Daniel Douek, Brigitte Autran, and Victor Appay. Superior Control of HIV-1 Replication by CD8+ T Cells Is Reflected by their Avidity, Polyfunctionality, and Clonal Turnover. J. Exp. Med., 204(10):2473-2485, 1 Oct 2007. PubMed ID: 17893201. Show all entries for this paper.


Displaying record number 54887

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 55012

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 55064

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*2402, B*4001, B*5001, Cw03, Cw4
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords immunodominance, escape, variant cross-reactivity

Notes

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.


Displaying record number 55089

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL-9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape, TCR usage, mutation acquisition

Notes

References

Yu2007 Xu G. Yu, Mathias Lichterfeld, Katie L. Williams, Javier Martinez-Picado, and Bruce D. Walker. Random T-Cell Receptor Recruitment in Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells from Genetically Identical Twins Infected with the Same HIV-1 Strain. J Virol, 81(22):12666-12669, Nov 2007. PubMed ID: 17804503. Show all entries for this paper.


Displaying record number 55155

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country South Africa, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords memory cells

Notes

References

Wherry2006 E John Wherry, Cheryl L. Day, Rika Draenert, Joseph D. Miller, Photini Kiepiela, Tonia Woodberry, Christian Brander, Marylyn Addo, Paul Klenerman, Rafi Ahmed, and Bruce D. Walker. HIV-Specific CD8 T Cells Express Low Levels of IL-7Ralpha: Implications for HIV-Specific T Cell Memory. Virology, 353(2):366-373, 30 Sep 2006. PubMed ID: 16860834. Show all entries for this paper.


Displaying record number 55182

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding
Keywords responses in children, rate of progression

Notes

References

Chakraborty2005 Rana Chakraborty, Anne-Sophie Morel, Julian K. Sutton, Victor Appay, Ruth M. Ripley, Tao Dong, Tim Rostron, Simon Ogola, Tresa Palakudy, Rachel Musoke, Angelo D'Agostino, Mary Ritter, and Sarah L. Rowland-Jones. Correlates of Delayed Disease Progression in HIV-1-Infected Kenyan Children. J. Immunol., 174(12):8191-8199, 15 Jun 2005. PubMed ID: 15944328. Show all entries for this paper.


Displaying record number 55339

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords rate of progression, acute/early infection, memory cells

Notes

References

Sabbaj2007 Steffanie Sabbaj, Sonya L. Heath, Anju Bansal, Sameera Vohra, J Michael Kilby, Allan J. Zajac, and Paul A. Goepfert. Functionally Competent Antigen-Specific CD127(hi) Memory CD8+ T Cells Are Preserved Only in HIV-Infected Individuals Receiving Early Treatment. J. Infect. Dis., 195(1):108-117, 1 Jan 2007. PubMed ID: 17152014. Show all entries for this paper.


Displaying record number 55395

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name Gag 77
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance, escape, variant cross-reactivity

Notes

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55514

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 55693

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9-A02
Subtype B, F
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Argentina
Experimental methods  
Keywords dynamics, escape, HLA associated polymorphism

Notes

References

Dilernia2008 Dario Alberto Dilernia, Leandro Jones, Sabrina Rodriguez, Gabriela Turk, Andrea E Rubio, Sandra Pampuro, Manuel Gomez-Carrillo, Christian Bautista, Gabriel Deluchi, Jorge Benetucci, María Beatriz Lasala, Leonardo Lourtau, Marcelo Horacio Losso, Héctor Perez, Pedro Cahn, and Horacio Salomón. HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations. PLoS ONE, 3(10):e3429, 2008. PubMed ID: 18941505. Show all entries for this paper.


Displaying record number 55752

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Switzerland
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords HAART, ART

Notes

References

Rehr2008 Manuela Rehr, Julia Cahenzli, Anna Haas, David A. Price, Emma Gostick, Milo Huber, Urs Karrer, and Annette Oxenius. Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy. J. Virol., 82(7):3391-404, Apr 2008. PubMed ID: 18199637. Show all entries for this paper.


Displaying record number 55755

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name Gag77
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression, acute/early infection

Notes

References

Fomsgaard2008 Anders Fomsgaard, Lasse Vinner, Dominic Therrien, Louise B. Jørgensen, Claus Nielsen, Lars Mathiesen, Court Pedersen, and Sylvie Corbet. Full-Length Characterization of A1/D Intersubtype Recombinant Genomes from a Therapy-Induced HIV Type 1 Controller during Acute Infection and His Noncontrolling Partner. AIDS Res. Hum. Retroviruses, 24(3):463-472, Mar 2008. PubMed ID: 18373434. Show all entries for this paper.


Displaying record number 55763

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human, transgenic mouse(A2)
Immunogen in vitro stimulation or selection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords variant cross-reactivity

Vaccine Details

Vaccine type peptide
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Blondelle2008 Sylvie E. Blondelle, Rosa Moya-Castro, Keiko Osawa, Kim Schroder, and Darcy B. Wilson. Immunogenically Optimized Peptides Derived from Natural Mutants of HIV CTL Epitopes and Peptide Combinatorial Libraries. Biopolymers, 90(5):683-694, 2008. PubMed ID: 18481808. Show all entries for this paper.


Displaying record number 55850

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen peptide-HLA interaction
Experimental methods Chromium-release assay, Other
Keywords TCR usage

Notes

References

Hofmann2008 Christian Hofmann, Thomas Harrer, Verena Kubesch, Katja Maurer, Karin J. Metzner, Kathrin Eismann, Silke Bergmann, Matthias Schmitt-Haendle, Gerold Schuler, Jan Dörrie, and Niels Schaft. Generation of HIV-1-Specific T Cells by Electroporation of T-Cell Receptor RNA. AIDS, 22(13):1577-1582, 20 Aug 2008. PubMed ID: 18670216. Show all entries for this paper.


Displaying record number 56582

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 or HIV-2 infection, HIV-2 infection
Country Gambia
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons, HIV-2

Notes

References

Ondondo2008 Beatrice O. Ondondo, Sarah L. Rowland-Jones, Lucy Dorrell, Kevin Peterson, Matthew Cotten, Hilton Whittle, and Assan Jaye. Comprehensive Analysis of HIV Gag-Specific IFN-gamma Response in HIV-1- and HIV-2-Infected Asymptomatic Patients from a Clinical Cohort in The Gambia. Eur. J. Immunol., 38(12):3549-3560, Dec 2008. PubMed ID: 19016530. Show all entries for this paper.


Displaying record number 56727

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type polyepitope

Notes

References

Blondelle2009 Sylvie E. Blondelle, Rosa Moya, Kim Schroder, Keiko Osawa, and Darcy B. Wilson. Natural Mutants of HIV CTL Epitopes with Enhanced Immunogenicity as Potential Vaccine Candidates. Adv. Exp. Med. Biol., 611:379-382, 2009. PubMed ID: 19400233. Show all entries for this paper.


Displaying record number 56758

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) humanized mouse(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords immunodominance

Notes

References

Brainard2009 Diana M. Brainard, Edward Seung, Nicole Frahm, Annaiah Cariappa, Charles C. Bailey, William K. Hart, Hae-Sook Shin, Sarah F. Brooks, Heather L. Knight, Quentin Eichbaum, Yong-Guang Yang, Megan Sykes, Bruce D. Walker, Gordon J. Freeman, Shiv Pillai, Susan V. Westmoreland, Christian Brander, Andrew D. Luster, and Andrew M. Tager. Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice. J. Virol., 83(14):7305-7321, Jul 2009. PubMed ID: 19420076. Show all entries for this paper.


Displaying record number 56873

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) (A2)
Immunogen in vitro stimulation or selection
Experimental methods Other
Keywords viral fitness and reversion

Notes

References

Christie2009 N. M. Christie, D. O. Willer, M. A. Lobritz, J. K. Chan, E. J. Arts, M. A. Ostrowski, A. Cochrane, M. A. Luscher, and K. S. MacDonald. Viral Fitness Implications of Variation within an Immunodominant CD8+ T-Cell Epitope of HIV-1. Virology, 388(1):137-146, 25 May 2009. PubMed ID: 19368950. Show all entries for this paper.


Displaying record number 57511

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name Gag p17 77-85
Species (MHC/HLA) human(A2)
Immunogen in vitro stimulation or selection
Experimental methods Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Alanio2010 Cécile Alanio, Fabrice Lemaitre, Helen K. W. Law, Milena Hasan, and Matthew L. Albert. Enumeration of Human Antigen-Specific Naive CD8+ T Cells Reveals Conserved Precursor Frequencies. Blood, 115(18):3718-3725, 6 May 2010. PubMed ID: 20200354. Show all entries for this paper.


Displaying record number 57512

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SLY
Subtype A, B, C
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods Flow cytometric T-cell cytokine assay
Keywords epitope processing, vaccine antigen design

Vaccine Details

Vaccine type DNA prime with vaccinia boost, polyepitope
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol, Vpr

Notes

References

Bazhan2010 S. I. Bazhan, L. I. Karpenko, T. N. Ilyicheva, P. A. Belavin, S. V. Seregin, N. K. Danilyuk, D. V. Antonets, and A. A. Ilyichev. Rational Design Based Synthetic Polyepitope DNA Vaccine for Eliciting HIV-Specific CD8+ T Cell Responses. Mol Immunol, 47(7-8):1507-1515, Apr 2010. PubMed ID: 20189249. Show all entries for this paper.


Displaying record number 57596

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, genital and mucosal immunity

Notes

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.


Displaying record number 57828

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 54597

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Subtype A, C, D
Species (MHC/HLA) human(A2, A68)
Immunogen HIV-1 infection
Country Tanzania
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons, immunodominance

Notes

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Displaying record number 60271

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60270

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59109

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human, mouse(H-2d)
Immunogen vaccine
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol, Tat

Notes

References

Reguzova2015 Alena Reguzova, Denis Antonets, Larisa Karpenko, Alexander Ilyichev, Rinat Maksyutov, and Sergei Bazhan. Design and Evaluation of Optimized Artificial HIV-1 Poly-T Cell-Epitope Immunogens. PLoS One, 10(3):e0116412, 2015. PubMed ID: 25786238. Show all entries for this paper.


Displaying record number 60502

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B, C, CRF01_AE
Species (MHC/HLA) human
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing

Notes

References

Steers2014 Nicholas J. Steers, Jeffrey R. Currier, Ousman Jobe, Sodsai Tovanabutra, Silvia Ratto-Kim, Mary A. Marovich, Jerome H. Kim, Nelson L. Michael, Carl R. Alving, and Mangala Rao. Designing the Epitope Flanking Regions for Optimal Generation of CTL Epitopes. Vaccine, 32(28):3509-3516, 12 Jun 2014. PubMed ID: 24795226. Show all entries for this paper.


Displaying record number 60505

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name A2-SL9
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA ACS 19957: A*01, A*02, B*0801, B*15; ACS 19885: A*01, A*02, B*0801, B*27; ACS 19861: A*01, A*02, B*0801, B*51; ACS 19453: A*01, A*02, B*0801, B*38; ACS 19342: A*01, A*02, B*0801, B*40; ACS 18840: A*02, B*0801, B*27; ACS 18839: A*0207, B*0801, B*27; ACS 18785: A*01, A*02, B*07, B*0801
Country Netherlands
Experimental methods Other, Tetramer binding
Keywords TCR usage

Notes

References

Costa2015 Ana I. Costa, Dan Koning, Kristin Ladell, James E. McLaren, Bart P. X. Grady, Ingrid M. M. Schellens, Petra van Ham, Monique Nijhuis, José A. M. Borghans, Can Keşmir, David A. Price, and Debbie van Baarle. Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1. J. Virol., 89(1):110-119, Jan 2015. PubMed ID: 25320304. Show all entries for this paper.


Displaying record number 56720

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human
Immunogen  
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords review

Notes

References

Mothe2009 Beatriz Mothe, Javier Ibarrondo, Anuska Llano, and Christian Brander. Virological, Immune and Host Genetics Markers in the Control of HIV Infection. Dis. Markers, 27(3):105-120, 2009. PubMed ID: 19893207. Show all entries for this paper.


Displaying record number 56209

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Garrison2007 Keith E. Garrison, R. Brad Jones, Duncan A. Meiklejohn, Naveed Anwar, Lishomwa C. Ndhlovu, Joan M. Chapman, Ann L. Erickson, Ashish Agrawal, Gerald Spotts, Frederick M. Hecht, Seth Rakoff-Nahoum, Jack Lenz, Mario A. Ostrowski, and Douglas F. Nixon. T Cell Responses to Human Endogenous Retroviruses in HIV-1 Infection. PLoS Pathog., 3(11):e165, Nov 2007. PubMed ID: 17997601. Show all entries for this paper.


Displaying record number 55467

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype A1, B, C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 55111

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords assay or method development

Notes

References

Willberg2007 C. B. Willberg, S. K. Pillai, E. R. Sharp, M. G. Rosenberg, J. D. Agudelo, J. D. Barbour, and D. F. Nixon. Rational Peptide Selection To Detect Human Immunodeficiency Virus Type 1-Specific T-Cell Responses under Resource-Limited Conditions. Clin. Vaccine Immunol., 14(6):785-788, Jun 2007. PubMed ID: 17409221. Show all entries for this paper.


Displaying record number 61337

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human
Immunogen vaccine
Country Australia, Brazil, Canada, Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, assay or method development, optimal epitope

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine component Gag, Nef, Pol

Notes

References

Fiore-Gartland2016 Andrew Fiore-Gartland, Bryce A. Manso, David P. Friedrich, Erin E. Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C. De Rosa, Nicole Frahm, Peter B. Gilbert, and M Juliana McElrath. Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. PLoS One, 11(2):e0147812, 2016. PubMed ID: 26863315. Show all entries for this paper.


Displaying record number 54941

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location  
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A*0201, A*1101; B*4002, B*5101
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type canarypox
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag-Pol, gp120, gp41

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


Displaying record number 54790

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen peptide-HLA interaction
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, HLA binding, Tetramer binding
Keywords binding affinity, co-receptor

Notes

References

Laugel2007 Bruno Laugel, Hugo A. van den Berg, Emma Gostick, David K. Cole, Linda Wooldridge, Jonathan Boulter, Anita Milicic, David A. Price, and Andrew K. Sewell. Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties. J. Biol. Chem., 282(33):23799-2810, 17 Aug 2007. PubMed ID: 17540778. Show all entries for this paper.


Displaying record number 52341

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85 LAI)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*0201
Experimental methods  
Keywords HAART, ART, responses in children

Notes

References

Luzuriaga2000 Katherine Luzuriaga, Margaret McManus, Michelle Catalina, Shane Mayack, Mark Sharkey, Mario Stevenson, and John L. Sullivan. Early Therapy of Vertical Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Control of Viral Replication and Absence of Persistent HIV-1-Specific Immune Responses. J. Virol., 74(15):6984-6991, Aug 2000. PubMed ID: 10888637. Show all entries for this paper.


Displaying record number 52187

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location ( SF2, HXBc2/Bal chimeric)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA)  
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, escape

Notes

References

Douek2002 Daniel C. Douek, Michael R. Betts, Jason M. Brenchley, Brenna J. Hill, David R. Ambrozak, Ka-Leung Ngai, Nitin J. Karandikar, Joseph P. Casazza, and Richard A. Koup. A Novel Approach to the Analysis of Specificity, Clonality, and Frequency of HIV-Specific T Cell Responses Reveals a Potential Mechanism for Control of Viral Escape. J. Immunol., 168(6):3099-3104, 15 Mar 2002. PubMed ID: 11884484. Show all entries for this paper.


Displaying record number 62013

HXB2 Location Gag(77-85)
p17(77-85)
Gag Epitope Map
Author Location Gag( A*0201)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name GAG
Species (MHC/HLA) human
Immunogen in vitro stimulation or selection
Experimental methods Other
Keywords co-receptor

Notes

References

Zhao2018 Xiang Zhao, Shvetha Sankaran, Jiawei Yap, Chien Tei Too, Zi Zong Ho, Garry Dolton, Mateusz Legut, Ee Chee Ren, Andrew K. Sewell, Antonio Bertoletti, Paul A. MacAry, Joanna Brzostek, and Nicholas R. J. Gascoigne. Nonstimulatory Peptide-MHC Enhances Human T-Cell Antigen-Specific Responses by Amplifying Proximal TCR Signaling. Nat. Commun., 9(1):2716, 13 Jul 2018. PubMed ID: 30006605. Show all entries for this paper.


Displaying record number 1480

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Sewell2000 A. K. Sewell, D. A. Price, A. Oxenius, A. D. Kelleher, and R. E. Phillips. Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape. Stem Cells, 18(4):230-44, 2000. URL: http://stemcells.alphamedpress.org/cgi/content/full/18/4/230. PubMed ID: 10924089. Show all entries for this paper.


Displaying record number 58026

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA A*0301, A*0301, B*3501, B*5101, Cw*0401, Cw*1402; A*0201, A*0206, B*5101, Cw*0401, Cw*1402
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 59391

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location Gag
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA LTNP/EC-3: A*02, A*29, B*44, B*49, Cw*07, Cw*16
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


Displaying record number 57315

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human
Immunogen peptide-HLA interaction
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords dendritic cells

Notes

References

Huang2009 Xiao-Li Huang, Zheng Fan, LuAnn Borowski, and Charles R. Rinaldo. Multiple T-Cell Responses to Human Immunodeficiency Virus Type 1 Are Enhanced by Dendritic Cells. Clin. Vaccine Immunol., 16(10):1504-1516, Oct 2009. PubMed ID: 19692626. Show all entries for this paper.


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