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Displaying record number 55364

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	(77-85)
Epitope	SLYNTVAAL	Epitope Alignment
Epitope Name	p41 (SL9 agonist)
Species (MHC/HLA)	human(A*02:01)
Immunogen	in vitro stimulation or selection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding, Tetramer binding
Keywords	binding affinity, immunodominance, dendritic cells

Notes

• CTL responses to the rarely recognized, subdominant HLA-A2-restricted Gag p24 epitope TLNAWKVV (TV9) were studied since its functional sensitivity and viral suppression is relatively high compared to other, dominant HLA-A2-restricted HIV-1 epitopes. Subdominant CTL responses to TV9 were not related to immunogenicity, availability of cognate TCR repertoires or HLA-epitope binding avidity.
• This epitope, p41, SLYNTVAAL, is the HIV-1 Gag agonist of SLYNTVATL. p41-specific CTLs bound tetramers as a single, homogeneous population, indicating distinct avidity to p41.

References

Schaubert2007 Keri L. Schaubert, David A. Price, Nicole Frahm, Jinzhu Li, Hwee L. Ng, Aviva Joseph, Elyse Paul, Biswanath Majumder, Velpandi Ayyavoo, Emma Gostick, Sharon Adams, Francesco M. Marincola, Andrew K. Sewell, Marcus Altfeld, Jason M. Brenchley, Daniel C. Douek, Otto O. Yang, Christian Brander, Harris Goldstein, and June Kan-Mitchell. Availability of a Diversely Avid CD8+ T Cell Repertoire Specific for the Subdominant HLA-A2-Restricted HIV-1 Gag p24(19-27) Epitope. J. Immunol., 178(12):7756-7766, 15 Jun 2007. PubMed ID: 17548613. Show all entries for this paper.