Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 52890

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HXB2 Location	gp160(110-118) gp120(110-118) DNA(6552..6578)	gp160 Epitope Map
Author Location	Env
Epitope	SLWDQSLKP	Epitope Alignment
Epitope Name	1328
Subtype	multiple
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A2, A3, B51, B8, Cw1, Cw7
Country	United States
Experimental methods	T-cell Elispot
Keywords	binding affinity, computational epitope prediction, immunodominance, novel epitope

Notes

• Epitopes defined using sequence parsing and matching algorithm Conservatrix, and epitope prediction tool EpiMatrix, were shown to be conserved in a broad range of HIV-1 sequences derived from different parts of the world. 31 novel highly conserved HIV-1 epitopes were found, among which four were recognized as promiscuous epitopes and five as MHC supertypes.
• Estimated binding probability for SLWDQSLKP: 50%.Immunodominant epitope.

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.

Displaying record number 55133

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HXB2 Location	gp160(110-118) gp120(110-118) DNA(6552..6578)	gp160 Epitope Map
Author Location	gp120(110-118)
Epitope	SLWDQSLKP	Epitope Alignment
Species (MHC/HLA)	human(A3)
Immunogen
Experimental methods
Keywords	subtype comparisons, viral fitness and reversion

Notes

• Determined the frequencies of known CD8+ and CD4+ Env epitope sequences among Brazilian HIV sequences of various subtypes.
• Present in 48/51 Brazilian HIV sequences.

References

Queiroz2007 Artur Trancoso Lopo de Queiroz, Luciane Amorim Santos, Domingos Ramon Moreau, Tulio de Oliveira, David I. Watkins, Bernardo Galvão-Castro, and Luiz Carlos Junior Alcantara. Identification and Characterization of Previously Described Epitopes in HIV-1 Subtypes B, C, F and BF in Brazil. Braz. J. Infect. Dis., 11(1):27-30, Feb 2007. PubMed ID: 17625722. Show all entries for this paper.