HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 17 matching records:

Displaying record number 1769

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location gp41(813-822)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 877

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location Env(814-823 subtype B)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen vaccine
Experimental methods  
Keywords binding affinity

Vaccine Details

Vaccine type protein
Vaccine strain B clade MN
Vaccine component gp160

Notes

References

Kundu1998a S. K. Kundu, M. Dupuis, A. Sette, E. Celis, F. Dorner, M. Eibl, and T. C. Merigan. Role of preimmunization virus sequences in cellular immunity in HIV- infected patients during HIV type 1 MN recombinant gp160 immunization. AIDS Res. Hum. Retroviruses, 14:1669-78, 1998. PubMed ID: 9870321. Show all entries for this paper.


Displaying record number 1104

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location gp41(818-827 LAI)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen vaccine
Experimental methods  
Keywords optimal epitope

Vaccine Details

Vaccine type protein
Vaccine strain B clade MN
Vaccine component gp160

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 58639

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location Env(814-823)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Epitope Name Env814
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen peptide-HLA interaction, vaccine
Country United States
Experimental methods Chromium-release assay
Keywords dendritic cells, enhancing activity

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade
Vaccine component Env

Notes

References

Dupuis1997 M. Dupuis, M. V. Peshwa, C. Benike, S.K> Kundu, E. G. Engleman, W. C. Van Schooten, and T. C. Merigan. Allogeneic Dendritic Cell Induction of HIV-Specific Cytotoxic T Lymphocyte Responses from T Cells of HIV Type 1-Infected and Uninfected Individuals. AIDS Res. Hum. Retroviruses, 13:33-39, 1997. The potential benefit of T cell-based vaccination for HIV-1 infection remains to be determined. Cytotoxic T lymphocytes (CTLs) appear to clear substantial populations of HIV-1 virus in vivo, although CTL activity may contribute to the decline in CD4+ T cell count observed in the course of the disease. To investigate further the role of specific CTL responses in the control of HIV-1 replication, we raised primary CTL lines against a panel of conserved HIV-1 epitopes using blood-derived dendritic cells as antigen-presenting cells (APCs). Specific primary human CTL responses were induced against HLA-A*0201-restricted peptides with dendritic cells from HIV-1-seronegative donors. This method of immunization elicited cytotoxic activities capable of recognizing endogenously processed antigen. The CTL induction protocol was extended in order to explore the capacity of HLA-matched allogeneic dendritic cells to evoke novel CTL responses in T cells from an HIV-seropositive asymptomatic individual. Allogeneic peptide-pulsed dendritic cells from a healthy sibling were capable of eliciting a CTL response directed against an HIV epitope (env814: SLLNATDIAV) that was initially not detected in the CTL effector population of the HIV-1- infected patient. The possibility of manipulating CTL specificity directed against multiple conserved HIV-1 epitopes represents a significant step in the evaluation of T cell-based vaccination for treatment of disease. PubMed ID: 8989425. Show all entries for this paper.


Displaying record number 58646

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location Env(814-823 LAI)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Show epitope variants
Epitope Name Env814-823
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen vaccine
Country United States
Experimental methods Chromium-release assay
Keywords dendritic cells, enhancing activity, optimal epitope, novel epitope

Vaccine Details

Vaccine type protein
Vaccine strain B clade MN
Vaccine component gp160

Notes

References

Dupuis1995 M. Dupuis, S. K. Kundu, and T. C. Merigan. Characterization of HLA-A*0201-Restricted Cytotoxic T Cell Epitopes in Conserved Regions of the HIV Type 1 gp160 Protein. J. Immunol., 155:2232-2239, 1995. Five HLA-A2 HIV-1 seropositive HIV-1 MN rec gp160 vaccinees had their CTL activity assessed using peptides known to bind with high affinity to HLA-A*0201. Four of the patients had specific CTL activity for a minimum of at least three epitopes, thus the response appears heterogeneous. One of the four peptides was confirmed to be HLA A2 restricted. Epitopes were highly conserved. PubMed ID: 7543542. Show all entries for this paper.


Displaying record number 52298

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location gp41(814-823 LAI)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Epitope Name LR27
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords binding affinity, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type peptide
Vaccine strain B clade LAI
Adjuvant Incomplete Freund's Adjuvant (IFA), Montanide (ISA 720), P30, PLG

Notes

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.


Displaying record number 52299

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location gp41(814-823 LAI)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Epitope Name LR27
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type peptide
Vaccine strain B clade LAI
Adjuvant Incomplete Freund's Adjuvant (IFA), IL-12, P30

Notes

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.

Peter2002 Katrin Peter, Michael J. Brunda, and Giampietro Corradin. IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1-Restricted CTL Response in Transgenic Mice. J. Immunol., 169(1):63-67, 1 Jul 2002. PubMed ID: 12077229. Show all entries for this paper.


Displaying record number 60265

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location Env(813-822)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Epitope Name SV10
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 876

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location gp41(814-823)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords dendritic cells

Notes

References

Kundu1998 S. K. Kundu, E. Engleman, C. Benike, M. H. Shapero, M. Dupuis, W. C. van Schooten, M. Eibl, and T. C. Merigan. A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 14:551-560, 1998. PubMed ID: 9591709. Show all entries for this paper.


Displaying record number 1105

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location gp41(818-827)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 1530

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location gp41(77-85 SF2)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 52697

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location Env(813-)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Epitope Name Env813
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords binding affinity, subtype comparisons, computational epitope prediction

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


Displaying record number 53584

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location gp160(813-822)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 57929

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location Env(813-822)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*2402, B*3501, B*3503, Cw*0303, Cw*0401
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Herbeck2011 Joshua T. Herbeck, Morgane Rolland, Yi Liu, Sherry McLaughlin, John McNevin, Hong Zhao, Kim Wong, Julia N. Stoddard, Dana Raugi, Stephanie Sorensen, Indira Genowati, Brian Birditt, Angela McKay, Kurt Diem, Brandon S. Maust, Wenjie Deng, Ann C. Collier, Joanne D. Stekler, M. Juliana McElrath, and James I. Mullins. Demographic Processes Affect HIV-1 Evolution in Primary Infection before the Onset of Selective Processes. J. Virol., 85(15):7523-7534, Aug 2011. PubMed ID: 21593162. Show all entries for this paper.


Displaying record number 1312

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location gp41
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Epitope Name gp41 SV10
Species (MHC/HLA) human(A68)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.


Displaying record number 60267

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location Env(813-822)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Epitope Name SV10
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60266

HXB2 Location gp160(813-822)
gp41(302-311)
DNA(8661..8690)
gp160 Epitope Map
Author Location Env(813-822)
Epitope SLLNATDIAV Epitope Alignment
SLLNATDIAV epitope logo
Epitope Name SV10
Species (MHC/HLA) human(B*78)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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