HIV molecular immunology database
Found 27 matching records:
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(375-383) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Epitope Name | SF9 | |
Species (MHC/HLA) | human(A*23) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(375-383 SF2) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B15) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(375-383) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B15) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, A32, B15, B51, C*03, Cw6, DQ7, DR4, DR8 | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, escape |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Epitope Name | SF9(gp120) | |
Subtype | B | |
Species (MHC/HLA) | human(B15) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(375-383) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B*15:16, B15, B63) | |
Immunogen | ||
Experimental methods | ||
Keywords | subtype comparisons, viral fitness and reversion |
Queiroz2007 Artur Trancoso Lopo de Queiroz, Luciane Amorim Santos, Domingos Ramon Moreau, Tulio de Oliveira, David I. Watkins, Bernardo Galvão-Castro, and Luiz Carlos Junior Alcantara. Identification and Characterization of Previously Described Epitopes in HIV-1 Subtypes B, C, F and BF in Brazil. Braz. J. Infect. Dis., 11(1):27-30, Feb 2007. PubMed ID: 17625722. Show all entries for this paper.
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HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(375-383 IIIB) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B15, B63) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Wilson1997 C. C. Wilson, S. A. Kalams, B. M. Wilkes, D. J. Ruhl, F. Gao, B. H. Hahn, I. C. Hanson, K. Luzuriaga, S. Wolinsky, R. Koup, S. P. Buchbinder, R. P. Johnson, and B. D. Walker. Overlapping Epitopes in Human Immunodeficiency Virus Type 1 gp120 Presented by HLA A, B, and C Molecules: Effects of Viral Variation on Cytotoxic T-Lymphocyte Recognition. J. Virol., 71:1256-1264, 1997. CTL clones were isolated from four individuals that interact with the same 25 amino-acid peptide using three different HLA presenting molecules. PubMed ID: 8995649. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(375-383) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B15, C*04:01, C*04:07, Cw4) | |
Immunogen | HIV-1 infection | |
Country | Philippines, Taiwan | |
Experimental methods | ||
Keywords | escape |
Liang2008 Binhua Liang, Ma Luo, T Blake Ball, Xiaojian Yao, Gary Van Domselaar, Wilfred R. Cuff, Mary Cheang, Steven J. M. Jones, and Francis A. Plummer. Systematic Analysis of Host Immunological Pressure on the Envelope Gene of Human Immunodeficiency Virus Type 1 by an Immunobioinformatics Approach. Curr. HIV Res., 6(4):370-379, Jun 2008. PubMed ID: 18691035. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*15:16) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*02:02, A*03:01, B*07:02, B*15:16 | |
Country | United States | |
Experimental methods | ||
Keywords | escape, acute/early infection |
Bernardin2005 Flavien Bernardin, Denice Kong, Lorraine Peddada, Lee Ann Baxter-Lowe, and Eric Delwart. Human Immunodeficiency Virus Mutations During the First Month of Infection are Preferentially Found in Known Cytotoxic T-Lymphocyte Epitopes. J. Virol., 79(17):11523-11528, Sep 2005. PubMed ID: 16103205. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(379-387 LAI) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*15:16) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*15:16, Cw4) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | binding affinity, immunodominance, optimal epitope |
Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(375-383) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Epitope Name | SF9 | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Subtype | B, C | |
Species (MHC/HLA) | human(B63) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HLA cross-presentation, optimal epitope, novel epitope |
Frahm2005a Nicole Frahm, Sharon Adams, Photini Kiepiela, Caitlyn H. Linde, Hannah S. Hewitt, Mathias Lichterfeld, Kaori Sango, Nancy V. Brown, Eunice Pae, Alysse G. Wurcel, Marcus Altfeld, Margaret E. Feeney, Todd M. Allen, Timothy Roach, M. Anne St. John, Eric S. Daar, Eric Rosenberg, Bette Korber, Francesco Marincola, Bruce D. Walker, Philip J. R. Goulder, and Christian Brander. HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load. J. Virol., 79(16):10218-10225, Aug 2005. PubMed ID: 16051815. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | Env Cw4-SF9 | |
Subtype | B | |
Species (MHC/HLA) | human(C*04) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 9213: A*01, A*24, B*38, B*44, C*04 | |
Country | Germany, Switzerland, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | escape, acute/early infection, assay or method development |
Henn2012 Matthew R. Henn, Christian L. Boutwell, Patrick Charlebois, Niall J. Lennon, Karen A. Power, Alexander R. Macalalad, Aaron M. Berlin, Christine M. Malboeuf, Elizabeth M. Ryan, Sante Gnerre, Michael C. Zody, Rachel L. Erlich, Lisa M. Green, Andrew Berical, Yaoyu Wang, Monica Casali, Hendrik Streeck, Allyson K. Bloom, Tim Dudek, Damien Tully, Ruchi Newman, Karen L. Axten, Adrianne D. Gladden, Laura Battis, Michael Kemper, Qiandong Zeng, Terrance P. Shea, Sharvari Gujja, Carmen Zedlack, Olivier Gasser, Christian Brander, Christoph Hess, Huldrych F. Günthard, Zabrina L. Brumme, Chanson J. Brumme, Suzane Bazner, Jenna Rychert, Jake P. Tinsley, Ken H. Mayer, Eric Rosenberg, Florencia Pereyra, Joshua Z. Levin, Sarah K. Young, Heiko Jessen, Marcus Altfeld, Bruce W. Birren, Bruce D. Walker, and Todd M. Allen. Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection. PLoS Pathog., 8(3):e1002529, 2012. PubMed ID: 22412369. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Epitope Name | SF9 | |
Species (MHC/HLA) | human(C*04) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | Chromium-release assay, Tetramer binding | |
Keywords | variant cross-reactivity |
Thananchai2009 Hathairat Thananchai, Tariro Makadzange, Katsumi Maenaka, Kimiko Kuroki, Yanchun Peng, Chris Conlon, Sarah Rowland-Jones, and Tao Dong. Reciprocal Recognition of an HLA-Cw4-Restricted HIV-1 gp120 Epitope by CD8+ T Cells and NK Cells. AIDS, 23(2):189-193, 14 Jan 2009. PubMed ID: 19098488. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(375-383) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Epitope Name | SF9 | |
Species (MHC/HLA) | human(C*04) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | Cw4-SF9 Env | |
Species (MHC/HLA) | human(C*04) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other | |
Keywords | escape |
Pandit2014 Aridaman Pandit and Rob J. de Boer. Reliable Reconstruction of HIV-1 Whole Genome Haplotypes Reveals Clonal Interference and Genetic Hitchhiking among Immune Escape Variants. Retrovirology, 11:56, 4 Jul 2014. PubMed ID: 24996694. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Epitope Name | SF9 | |
Subtype | A, B | |
Species (MHC/HLA) | (C*04:01) | |
Immunogen | HIV-1 infection | |
Country | Kenya, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding | |
Keywords |
Makadzange2010 Azure T. Makadzange, Geraldine Gillespie, Tao Dong, Peter Kiama, Job Bwayo, Joshua Kimani, Frank Plummer, Philippa Easterbrook, and Sarah L. Rowland-Jones. Characterization of an HLA-C-Restricted CTL Response in Chronic HIV Infection. Eur. J. Immunol., 40(4):1036-1041, Apr 2010. PubMed ID: 20104487. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(376-383 PV22) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Species (MHC/HLA) | human(C*04:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(375-383) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(C*04:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*01:01, A*03:01, B*08:01, B*35:03, C*04:01, C*07:01 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Herbeck2011 Joshua T. Herbeck, Morgane Rolland, Yi Liu, Sherry McLaughlin, John McNevin, Hong Zhao, Kim Wong, Julia N. Stoddard, Dana Raugi, Stephanie Sorensen, Indira Genowati, Brian Birditt, Angela McKay, Kurt Diem, Brandon S. Maust, Wenjie Deng, Ann C. Collier, Joanne D. Stekler, M. Juliana McElrath, and James I. Mullins. Demographic Processes Affect HIV-1 Evolution in Primary Infection before the Onset of Selective Processes. J. Virol., 85(15):7523-7534, Aug 2011. PubMed ID: 21593162. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Subtype | A | |
Species (MHC/HLA) | human(C*04:01, C*04:07) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS), HLA cross-presentation |
Bird2002 Thomas G. Bird, Rupert Kaul, Timothy Rostron, Joshua Kimani, Joanne Embree, Paul P. Dunn, Job J. Bwayo, Francis A. Plummer, Sarah L. Rowland-Jones, Tao Dong, and The Oxford-Nairobi HLA Collaborative Group. HLA Typing in a Kenyan Cohort Identifies Novel Class I Alleles that Restrict Cytotoxic T-Cell Responses to Local HIV-1 Clades. AIDS, 16(14):1899-1904, 27 Sep 2002. PubMed ID: 12351949. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(375-383) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Epitope Name | SF9 | |
Species (MHC/HLA) | human(C*14) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(376-383) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Species (MHC/HLA) | human(Cw4) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS), immunodominance |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Epitope Name | SF9 | |
Subtype | B | |
Species (MHC/HLA) | human(Cw4) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, TCR binding | |
Keywords | rate of progression, TCR usage, optimal epitope |
Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(376-383 PV22) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Species (MHC/HLA) | human(Cw4) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Johnson1993 R. P. Johnson, A. Trocha, T. M. Buchanan, and B. D. Walker. Recognition of a Highly Conserved Region of Human Immunodeficiency Virus Type 1 gp120 by an HLA-Cw4-Restricted Cytotoxic T-Lymphocyte Clone. J. Virol., 67:438-445, 1993. The epitope sequence FNCGGEFF stimulates CTL response; the natural variants FNCRGEFF (SF2), TNCRGEFL (ROD) and LNCGGEFF (NDK) do not serve as epitopes. This was the first report of an HIV antigen specific target cells restricted by an HLA-C molecule, Cw4. PubMed ID: 7677956. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(376-383 PV22) | |
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Species (MHC/HLA) | human(Cw4) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Wolinsky1996 S. M. Wolinsky, B. T. M. Korber, A. U. Neumann, M. Daniels, K. J. Kuntsman, A. J. Whetsell, M. R. Furtado, Y. Chao, D. D. Ho, J. T. Safrit, and R. A. Koup. Adaptive Evolution of Human Immunodeficiency Virus-Type 1 during the Natural Course of Infection. Science, 272:537-542, 1996. In a longitudinal study of six patients, epitope variation occurred only when there was a notable CTLp frequency and the individual had the appropriate HLA type. PubMed ID: 8614801. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
SFNCGGEFF
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, vaccine | |
Patient MHC/HLA | 402I03: A3, A33, B15, B27 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, acute/early infection |
Vaccine type | rabies virus, canarypox prime with recombinant protein boost |
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Vaccine strain | other |
Vaccine component | gp120 |
Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(375-383) gp120(375-383) DNA(7347..7373) |
gp160 Epitope Map |
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Author Location | Env | |
Epitope |
SFNCGGEFF
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Epitope Alignment
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Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*01:01, B*15:67, B*81:01, C*14:02, C*18:01 | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Proliferation | |
Keywords | assay or method development |
McKinnon2008 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Nyakio Chinga, Anne Maingi, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Substantial Intrapatient Differences in the Breadth and Specificity of HIV-Specific CD8+ T-Cell Interferon-gamma and Proliferation Responses. J. Acquir. Immune Defic. Syndr., 49(2):123-127, 1 Oct 2008. PubMed ID: 18769359. Show all entries for this paper.