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Displaying record number 56496

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HXB2 Location	Pol(646-656) RT(491-501) DNA(4020..4052)	Pol Epitope Map
Author Location	RT
Epitope	SEVNIVTDSQY	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(B*44:03)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	viral fitness and reversion, HLA associated polymorphism

Notes

• HLA-associated polymorphisms were studied in a cohort of 710 chronic subtype C patients from South Africa. 84 HLA Class I-associated polymorphisms were identified, 73% of them with HLA-B. The viral set points associated with HLA allele correlated with the number of reversions associated with that allele, (HLA-B in Gag, HLA-C in Pol).
• SEVNIVTDSQY is a previously described HLA-B*4403-restricted epitope (part of Pol(RT) reacting peptide AIQLALQDSGsEVNIVTDSQY) that contains a B*4403-associated reversion at residue S (sEVNIVTDSQY ).

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.