HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 23 matching records:

Displaying record number 1317

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Show epitope variants
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape

Notes

References

Schutten2001 M. Schutten, C. A. van Baalen, C. Guillon, R. C. Huisman, P. H. Boers, K. Sintnicolaas, R. A. Gruters, and A. D. Osterhaus. Macrophage tropism of human immunodeficiency virus type 1 facilitates in vivo escape from cytotoxic T-lymphocyte pressure. J. Virol., 75(6):2706-9, Mar 2001. URL: http://jvi.asm.org/cgi/content/full/75/6/2706. PubMed ID: 11222694. Show all entries for this paper.


Displaying record number 1206

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location ( LAI)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Subtype B
Species (MHC/HLA) (B14)
Immunogen  
Experimental methods  
Keywords  

References

vanBaalenPerCom2000 C. van Baalen and R. Gruters. Personal communication, 2000. Show all entries for this paper.


Displaying record number 54344

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Epitope Name B14-SL9(Rev)
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 52417

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(67-75)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords early-expressed proteins

Notes

References

Addo2002a M. M. Addo, X. G. Yu, E. S. Rosenberg, B. D. Walker, and M. Altfeld. Cytotoxic T-Lymphocyte (CTL) Responses Directed against Regulatory and Accessory Proteins in HIV-1 Infection. DNA Cell Biol., 21(9):671-678, Sep 2002. PubMed ID: 12396610. Show all entries for this paper.


Displaying record number 52351

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(67-75)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Subtype B
Species (MHC/HLA) human(B14)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection, early-expressed proteins, kinetics

Notes

References

vanBaalen2002 Carel A. van Baalen, Christophe Guillon, Minus van Baalen, Esther J. Verschuren, Patrick H. M. Boers, Albert D. M. E. Osterhaus, and Rob A. Gruters. Impact of Antigen Expression Kinetics on the Effectiveness of HIV-Specific Cytotoxic T Lymphocytes. Eur. J. Immunol., 32(9):2644-2652, Sep 2002. PubMed ID: 12207349. Show all entries for this paper.


Displaying record number 619

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(67-75 IIIB)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Species (MHC/HLA) human(B14, Cw8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

VanBaalen1998 C. A. van Baalen, M. Schutten, R. C. Huisman, P. H. Boers, R. A. Gruters, and A. D. Osterhaus. Kinetics of Antiviral Activity by Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes (CTL) and Rapid Selection of CTL Escape Virus In Vitro. J. Virol., 72:6851-6857, 1998. PubMed ID: 9658134. Show all entries for this paper.


Displaying record number 60243

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(67-75)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60241

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(67-75)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(C*01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60242

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(67-75)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(C*08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61998

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Env(2-10)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Species (MHC/HLA) human(Cw*0501)
Immunogen peptide-HLA interaction
Experimental methods Intracellular cytokine staining, Other
Keywords assay or method development, NK cells

Notes

References

Partridge2018 Thomas Partridge, Annalisa Nicastri, Anna E. Kliszczak, Louis-Marie Yindom, Benedikt M. Kessler, Nicola Ternette, and Persephone Borrow. Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows. Front. Immunol., 9:912, 2018. PubMed ID: 29780384. Show all entries for this paper.


Displaying record number 1212

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location ( LAI)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Subtype B
Species (MHC/HLA) human(Cw*0501)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

Addo2001 Marylyn M. Addo, Marcus Altfeld, Eric S. Rosenberg, Robert L. Eldridge, Mary N. Philips, Kathleen Habeeb, Ashok Khatri, Christian Brander, Gregory K. Robbins, Gail P. Mazzara, Philip J. R. Goulder, and Bruce D. Walker. The HIV-1 Regulatory Proteins Tat and Rev are Freqently Targeted by cytotoxic T Lymphocytes (CTL) Derived from HIV Infected Individuals. Proc. Natl. Acad. Sci. U.S.A., 98(4):1781-1786, 13 Feb 2001. PubMed ID: 11172028. Show all entries for this paper.

Llano2019 Anuska Llano, Samandhy CedeƱo, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53531

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(Cw5)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 1288

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev( SF2)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(Cw5)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 52643

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(67-75)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Species (MHC/HLA) human(Cw5)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A1, B44, B57, Cw5, Cw6
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 53477

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(67-75)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Show epitope variants
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(Cw5)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords escape

Notes

References

Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.


Displaying record number 1550

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(67-75 SF2)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Species (MHC/HLA) human(Cw5)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 55496

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Epitope Name SL9
Subtype B
Species (MHC/HLA) human(Cw5)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 52416

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(67-75)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Subtype B
Species (MHC/HLA) human(Cw5, Cw8)
Immunogen HIV-1 infection
Experimental methods  
Keywords early-expressed proteins

Notes

References

Addo2002a M. M. Addo, X. G. Yu, E. S. Rosenberg, B. D. Walker, and M. Altfeld. Cytotoxic T-Lymphocyte (CTL) Responses Directed against Regulatory and Accessory Proteins in HIV-1 Infection. DNA Cell Biol., 21(9):671-678, Sep 2002. PubMed ID: 12396610. Show all entries for this paper.


Displaying record number 1274

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(69-77 BRU)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Epitope Name Rev SL9
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI), acute/early infection

Notes

References

Addo2001 Marylyn M. Addo, Marcus Altfeld, Eric S. Rosenberg, Robert L. Eldridge, Mary N. Philips, Kathleen Habeeb, Ashok Khatri, Christian Brander, Gregory K. Robbins, Gail P. Mazzara, Philip J. R. Goulder, and Bruce D. Walker. The HIV-1 Regulatory Proteins Tat and Rev are Freqently Targeted by cytotoxic T Lymphocytes (CTL) Derived from HIV Infected Individuals. Proc. Natl. Acad. Sci. U.S.A., 98(4):1781-1786, 13 Feb 2001. PubMed ID: 11172028. Show all entries for this paper.


Displaying record number 54275

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Epitope Name Cw8-SL9(Rev)
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 53594

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(67-75)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, in vitro stimulation or selection
Experimental methods HLA binding
Keywords assay or method development, characterizing CD8+ T cells

Notes

References

vanBaalen2005 Carel A. van Baalen, David Kwa, Esther J. Verschuren, Mariska L. Reedijk, Adrianus C. M. Boon, Gerrie de Mutsert, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus, and Rob A. Gruters. Fluorescent Antigen-Transfected Target Cell Cytotoxic T Lymphocyte Assay for Ex Vivo Detection of Antigen-Specific Cell-Mediated Cytotoxicity. J. Infect. Dis., 192(7):1183-1190, 1 Oct 2005. PubMed ID: 16136460. Show all entries for this paper.


Displaying record number 52052

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location  
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, escape

Notes

References

Yusim2002 Karina Yusim, Can Kesmir, Brian Gaschen, Marylyn M. Addo, Marcus Altfeld, S\oren Brunak, Alexandre Chigaev, Vincent Detours, and Bette T. Korber. Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation. J. Virol., 76(17):8757-8768, Sep 2002. PubMed ID: 12163596. Show all entries for this paper.


Displaying record number 52227

HXB2 Location Rev(67-75)
DNA(8501..8527)
Rev Epitope Map
Author Location Rev(65-77 BH10, LAI)
Epitope SAEPVPLQL Epitope Alignment
SAEPVPLQL epitope logo
Species (MHC/HLA) human
Immunogen computer prediction
Experimental methods Other
Keywords computational epitope prediction, T-cell crossreactivity to human proteins

Notes

References

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.


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