HIV molecular immunology database
Found 23 matching records:
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
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Author Location | Rev | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B14) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | escape |
Schutten2001 M. Schutten, C. A. van Baalen, C. Guillon, R. C. Huisman, P. H. Boers, K. Sintnicolaas, R. A. Gruters, and A. D. Osterhaus. Macrophage tropism of human immunodeficiency virus type 1 facilitates in vivo escape from cytotoxic T-lymphocyte pressure. J. Virol., 75(6):2706-9, Mar 2001. URL: http://jvi.asm.org/cgi/content/full/75/6/2706. PubMed ID: 11222694. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | ( LAI) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
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Subtype | B | |
Species (MHC/HLA) | (B14) | |
Immunogen | ||
Experimental methods | ||
Keywords |
vanBaalenPerCom2000 C. van Baalen and R. Gruters. Personal communication, 2000. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
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Epitope Name | B14-SL9(Rev) | |
Species (MHC/HLA) | human(B14) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(67-75) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B14) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | early-expressed proteins |
Addo2002a M. M. Addo, X. G. Yu, E. S. Rosenberg, B. D. Walker, and M. Altfeld. Cytotoxic T-Lymphocyte (CTL) Responses Directed against Regulatory and Accessory Proteins in HIV-1 Infection. DNA Cell Biol., 21(9):671-678, Sep 2002. PubMed ID: 12396610. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(67-75) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B14) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | acute/early infection, early-expressed proteins, kinetics |
vanBaalen2002 Carel A. van Baalen, Christophe Guillon, Minus van Baalen, Esther J. Verschuren, Patrick H. M. Boers, Albert D. M. E. Osterhaus, and Rob A. Gruters. Impact of Antigen Expression Kinetics on the Effectiveness of HIV-Specific Cytotoxic T Lymphocytes. Eur. J. Immunol., 32(9):2644-2652, Sep 2002. PubMed ID: 12207349. Show all entries for this paper.
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HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(67-75 IIIB) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B14, Cw8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
VanBaalen1998 C. A. van Baalen, M. Schutten, R. C. Huisman, P. H. Boers, R. A. Gruters, and A. D. Osterhaus. Kinetics of Antiviral Activity by Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes (CTL) and Rapid Selection of CTL Escape Virus In Vitro. J. Virol., 72:6851-6857, 1998. PubMed ID: 9658134. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(67-75) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Epitope Name | SL9 | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(67-75) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Epitope Name | SL9 | |
Species (MHC/HLA) | human(C*01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Env(2-10) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Species (MHC/HLA) | human(C*05:01) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | Intracellular cytokine staining, Other | |
Keywords | assay or method development, NK cells |
Partridge2018 Thomas Partridge, Annalisa Nicastri, Anna E. Kliszczak, Louis-Marie Yindom, Benedikt M. Kessler, Nicola Ternette, and Persephone Borrow. Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows. Front. Immunol., 9:912, 2018. PubMed ID: 29780384. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | ( LAI) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(C*05:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Addo2001 Marylyn M. Addo, Marcus Altfeld, Eric S. Rosenberg, Robert L. Eldridge, Mary N. Philips, Kathleen Habeeb, Ashok Khatri, Christian Brander, Gregory K. Robbins, Gail P. Mazzara, Philip J. R. Goulder, and Bruce D. Walker. The HIV-1 Regulatory Proteins Tat and Rev are Freqently Targeted by cytotoxic T Lymphocytes (CTL) Derived from HIV Infected Individuals. Proc. Natl. Acad. Sci. U.S.A., 98(4):1781-1786, 13 Feb 2001. PubMed ID: 11172028. Show all entries for this paper.
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(67-75) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Epitope Name | SL9 | |
Species (MHC/HLA) | human(C*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Epitope Name | SL9 | |
Subtype | B | |
Species (MHC/HLA) | human(Cw5) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A2, B18, B44, C*12, Cw5 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev( SF2) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Epitope Name | SL9 | |
Species (MHC/HLA) | human(Cw5) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | acute/early infection |
Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(67-75) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Species (MHC/HLA) | human(Cw5) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*02:01, A1, B44, B57, Cw5, Cw6 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | binding affinity, acute/early infection, early-expressed proteins |
Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(67-75) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | SL9 | |
Subtype | B | |
Species (MHC/HLA) | human(Cw5) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A2, B18, B44, C*12, Cw5 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | escape |
Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(67-75 SF2) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Species (MHC/HLA) | human(Cw5) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Epitope Name | SL9 | |
Subtype | B | |
Species (MHC/HLA) | human(Cw5) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding | |
Keywords | dynamics, characterizing CD8+ T cells, chronic infection |
Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(67-75) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(Cw5, Cw8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | early-expressed proteins |
Addo2002a M. M. Addo, X. G. Yu, E. S. Rosenberg, B. D. Walker, and M. Altfeld. Cytotoxic T-Lymphocyte (CTL) Responses Directed against Regulatory and Accessory Proteins in HIV-1 Infection. DNA Cell Biol., 21(9):671-678, Sep 2002. PubMed ID: 12396610. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(69-77 BRU) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Epitope Name | Rev SL9 | |
Species (MHC/HLA) | human(Cw8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, supervised treatment interruptions (STI), acute/early infection |
Addo2001 Marylyn M. Addo, Marcus Altfeld, Eric S. Rosenberg, Robert L. Eldridge, Mary N. Philips, Kathleen Habeeb, Ashok Khatri, Christian Brander, Gregory K. Robbins, Gail P. Mazzara, Philip J. R. Goulder, and Bruce D. Walker. The HIV-1 Regulatory Proteins Tat and Rev are Freqently Targeted by cytotoxic T Lymphocytes (CTL) Derived from HIV Infected Individuals. Proc. Natl. Acad. Sci. U.S.A., 98(4):1781-1786, 13 Feb 2001. PubMed ID: 11172028. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Epitope Name | Cw8-SL9(Rev) | |
Species (MHC/HLA) | human(Cw8) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(67-75) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | in vitro stimulation or selection, HIV-1 infection | |
Experimental methods | HLA binding | |
Keywords | assay or method development, characterizing CD8+ T cells |
vanBaalen2005 Carel A. van Baalen, David Kwa, Esther J. Verschuren, Mariska L. Reedijk, Adrianus C. M. Boon, Gerrie de Mutsert, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus, and Rob A. Gruters. Fluorescent Antigen-Transfected Target Cell Cytotoxic T Lymphocyte Assay for Ex Vivo Detection of Antigen-Specific Cell-Mediated Cytotoxicity. J. Infect. Dis., 192(7):1183-1190, 1 Oct 2005. PubMed ID: 16136460. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | ||
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | epitope processing, escape |
Yusim2002 Karina Yusim, Can Kesmir, Brian Gaschen, Marylyn M. Addo, Marcus Altfeld, S\oren Brunak, Alexandre Chigaev, Vincent Detours, and Bette T. Korber. Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation. J. Virol., 76(17):8757-8768, Sep 2002. PubMed ID: 12163596. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Rev(67-75) DNA(8501..8527) |
Rev Epitope Map |
---|---|---|
Author Location | Rev(65-77 BH10, LAI) | |
Epitope |
SAEPVPLQL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | computer prediction | |
Experimental methods | Other | |
Keywords | computational epitope prediction, T-cell crossreactivity to human proteins |
Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.