HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 10 matching records:

Displaying record number 52121

HXB2 Location Nef(134-143)
DNA(9196..9225)
Nef Epitope Map
Author Location Nef(134-143 BRU)
Epitope RYPLTFGWCY Epitope Alignment
RYPLTFGWCY epitope logo
Subtype B
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, epitope processing

Notes

References

Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.


Displaying record number 52958

HXB2 Location Nef(134-143)
DNA(9196..9225)
Nef Epitope Map
Author Location Nef(134-143)
Epitope RYPLTFGWCY Epitope Alignment
RYPLTFGWCY epitope logo
Subtype B
Species (MHC/HLA) human(A24)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type lipopeptide
Vaccine strain B clade LAI
Vaccine component Env, Gag, Nef
Adjuvant QS21

Notes

References

Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.


Displaying record number 54673

HXB2 Location Nef(134-143)
DNA(9196..9225)
Nef Epitope Map
Author Location Nef(134-143)
Epitope RYPLTFGWCY Epitope Alignment
RYPLTFGWCY epitope logo
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A26, B51, B62; A2, B39, B60
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HAART, ART, escape, viral fitness and reversion

Notes

References

Asquith2006 Becca Asquith, Charles T. T. Edwards, Marc Lipsitch, and Angela R. McLean. Inefficient Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo. PLoS Biol., 4(4):e90, Apr 2006. PubMed ID: 16515366. Show all entries for this paper.


Displaying record number 53726

HXB2 Location Nef(134-143)
DNA(9196..9225)
Nef Epitope Map
Author Location Nef(134-143 BRU)
Epitope RYPLTFGWCY Epitope Alignment
RYPLTFGWCY epitope logo
Show epitope variants
Subtype B, CRF02_AG
Species (MHC/HLA) human(A24, B35)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 53770

HXB2 Location Nef(134-143)
DNA(9196..9225)
Nef Epitope Map
Author Location Nef(134-143 HXB2)
Epitope RYPLTFGWCY Epitope Alignment
RYPLTFGWCY epitope logo
Show epitope variants
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Country Viet Nam
Experimental methods HLA binding
Keywords subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.


Displaying record number 55578

HXB2 Location Nef(134-143)
DNA(9196..9225)
Nef Epitope Map
Author Location Nef(138-147 NL-432 or NL-M20A)
Epitope RYPLTFGWCY Epitope Alignment
RYPLTFGWCY epitope logo
Show epitope variants
Epitope Name Nef138-10
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Patient MHC/HLA A*2402
Country Japan
Experimental methods CTL suppression of replication, Chromium-release assay, HLA binding, Other, Tetramer binding
Keywords escape

Notes

References

Fujiwara2008 Mamoru Fujiwara, Junko Tanuma, Hirokazu Koizumi, Yuka Kawashima, Kazutaka Honda, Saori Mastuoka-Aizawa, Sachi Dohki, Shinichi Oka, and Masafumi Takiguchi. Different Abilities of Escape Mutant-Specific Cytotoxic T Cells to Suppress Replication of Escape Mutant and Wild-Type Human Immunodeficiency Virus Type 1 in New Hosts. J. Virol., 82(1):138-147, Jan 2008. PubMed ID: 17959671. Show all entries for this paper.


Displaying record number 59180

HXB2 Location Nef(134-143)
DNA(9196..9225)
Nef Epitope Map
Author Location Nef(134-143)
Epitope RYPLTFGWCY Epitope Alignment
RYPLTFGWCY epitope logo
Epitope Name nef 134-143
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 61753

HXB2 Location Nef(134-143)
DNA(9196..9225)
Nef Epitope Map
Author Location Nef(134-143)
Epitope RYPLTFGWCY Epitope Alignment
RYPLTFGWCY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(A*2402)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 61752

HXB2 Location Nef(134-143)
DNA(9196..9225)
Nef Epitope Map
Author Location Nef(134-143)
Epitope RYPLTFGWCY Epitope Alignment
RYPLTFGWCY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(Cw*07)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 61944

HXB2 Location Nef(134-143)
DNA(9196..9225)
Nef Epitope Map
Author Location Nef
Epitope RYPLTFGWCY Epitope Alignment
RYPLTFGWCY epitope logo
Show epitope variants
Epitope Name RY10
Subtype B
Species (MHC/HLA) human(Cw*0702)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Other
Keywords assay or method development, novel epitope

Notes

References

Stoll2015 Andrej Stoll, Silke Bergmann, Christiane Mummert, Sandra M. Mueller-Schmucker, Bernd M. Spriewald, Ellen G. Harrer, and Thomas Harrer. Identification of HLA-C Restricted, HIV-1-Specific CTL Epitopes by Peptide Induced Upregulation of HLA-C Expression. J. Immunol. Methods, 418:9-18, Mar 2015. PubMed ID: 25633660. Show all entries for this paper.


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